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Birth weight,ideal cardiovascular health metrics in adulthood,and incident cardiovascular disease

Chinese Medical Journal 2024年第10期137卷 1160-1168页

作者： Ying Sun Bin Wang Yuefeng Yu Yuying Wang Xiao Tan Jihui Zhang lu Qi yingli lu Ningjian Wang Department of Endocrinology and Metabolism Institute of Endocrinology and MetabolismShanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China School of Public Health Zhejiang UniversityHangzhouZhejiang 310058China Department of Medical Sciences Uppsala UniversityUppsala 75105Sweden Center for Sleep and Circadian Medicine The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhouGuangdong 510370China Department of Epidemiology School of Public Health and Tropical MedicineTulane UniversityNew OrleansLA 70118USA Department of Nutrition Harvard T.H.Chan School of Public HealthBostonMA 02138USA Channing Division of Network Medicine Department of MedicineBrigham and Women’s Hospital and Harvard Medical SchoolBostonMA 02138USA

Background:Prenatal and postnatal factors may have joint effects on cardiovascular health,and we aimed to assess the joint association of birth weight and ideal cardiovascular health metrics(ICVHMs)prospectively in adulthood with incident cardiovascular disease(CVD).Methods:In the UK Biobank,227,833 participants with data on ICVHM components and birth weight and without CVD at baseline were *** ICVHMs included smoking,body mass index,physical activity,diet information,total cholesterol,blood pressure,and hemoglobin *** Cox proportional hazards model was used to estimate the hazard ratios(HRs)and 95%confidence intervals(CIs)in men and ***:Over a median follow-up period of 13.0 years(2,831,236 person-years),we documented 17,477 patients with incident *** with participants with birth weights of 2.5-4.0 kg,the HRs(95%CIs)of CVD among those with low birth weights was 1.08(1.00-1.16)in men and 1.23(1.16-1.31)in *** association between having a birth weight<2.5 kg and CVD risk in men was more prominent for those aged<50 years than for those of older age(P for interaction=0.026).Lower birth weight and non-ideal cardiovascular health metrics were jointly related to an increased risk of *** with birth weights<2.5 kg and ICVHMs score 0-1 had the highest risk of incident CVD(HR[95%CI]:3.93[3.01-5.13]in men;4.24[3.33-5.40]in women).The joint effect(HR[95%CI]:1.36[1.17-1.58])could be decomposed into 24.7%(95%CI:15.0%-34.4%)for a lower birth weight,64.7%(95%CI:56.7%-72.6%)for a lower ICVHM score,and 10.6%(95%CI:2.7%-18.6%)for their additive interaction in ***:Birth weight and ICVHMs were jointly related to CVD *** a normal birth weight and ideal ICVHMs may reduce the risk of CVD,and a simultaneous improvement of both prenatal and postnatal factors could further prevent additional cases in women.

关键词： Birth weight Health metrics Cardiovascular disease Adult Stroke Coronary heart disease

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Serum 25-hydroxyvitamin D,genetic susceptibility,and the risk of incident type 2 diabetes:A prospective cohort in East China

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Chinese Medical Journal 2024年第8期137卷 972-979页

作者： Ying Sun Haojie Zhang Bin Wang Yuying Wang Chi Chen Yi Chen yingli lu Ningjian Wang Institute and Department of Endocrinology and Metabolism Shanghai Ninth People’s HospitalShanghai JiaoTong University School of MedicineShanghai 200011China Department of Endocrinology and Metabolism and Department of Guideline and Rapid Recommendation Cochrane China CenterMAGIC China CenterChinese Evidence-Based Medicine CenterWest China HospitalSichuan UniversityChengduSichuan 610041China Department of Endocrinology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese MedicineShanghai 201203China

Background:The serum vitamin D level varies widely by population,and studies have linked vitamin D levels with the risk of type 2 diabetes mellitus(T2DM).However,the relationship is inconsistent and the impact of vitamin D on T2DM among East Chinese adults is *** study aimed to investigate the association between serum 25-hydroxyvitamin D(25[OH]D)levels and the risk of T2DM and evaluated whether the association is modified by genetic ***:In the Survey on Prevalence in East China for Metabolic Diseases and Risk Factors(SPECT-China)cohort,1862 participants free of T2DM at baseline were included.A weighted genetic risk score was calculated with 28 variants associated with *** logistic models were used to examine the association of serum 25(OH)D and genetic risk with ***:After a 5-year follow-up,132 cases of T2DM were *** observed no significant association between quartiles of serum 25(OH)D and T2DM risk after multivariable adjustment(χ^(2)=0.571,P_(for trend)=0.426).Compared to those in the lowest quartile of 25(OH)D,the odds ratios(ORs)(95%confidence interval[CI])for participants with increased quartiles were 1.29(0.74-2.25),1.35(0.77-2.36),and 1.27(0.72-2.24),*** observed a positive association of glycated hemoglobin(HbA1c)with 25(OH)D at baseline(β=1.752,P=0.001)and after follow-up(β=1.385,P=0.003),and a negative association of ln conversion homeostasis model assessment(HOMA)-βwith 25(OH)D at baseline(β=-0.982,P=0.021).There was no significant interaction between 25(OH)D and diabetes genetic predisposition on the risk of T2DM(χ^(2)=2.710,P_(for interaction)=0.100).The lowest OR(95%CI)of T2DM was among participants with low genetic risk and the highest quartile of 25(OH)D(0.17[0.05-0.62]).Conclusion:Serum 25(OH)D may be irrelevant to the risk of incident T2DM among East Chinese adults regardless of genetic predisposition.

关键词： Vitamin D Diabetes mellitus,Type 2 Genetic predisposition to disease Prospective cohort Glycated hemoglobin SPECT-China

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Life’s Essential 8 and risk of non-communicable chronic diseases:Outcome-wide analyses

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Chinese Medical Journal 2024年第13期137卷 1553-1562页

作者： Yuetian Yu Ying Sun Yuefeng Yu Yuying Wang Chi Chen Xiao Tan yingli lu Ningjian Wang Institute and Department of Endocrinology and Metabolism Shanghai Ninth People’s HospitalShanghai JiaoTong University School of MedicineShanghai 200011China School of Public Health Zhejiang UniversityHangzhou 310058ZhejiangChina Department of Medical Sciences Uppsala UniversityUppsala 75185Sweden

Background:Life’s Simple 7,the former construct of cardiovascular health(CVH)has been used to evaluate adverse non-communicable chronic diseases(NCDs).However,some flaws have been recognized in recent years and Life’s Essential 8 has been *** this study,we aimed to analyze the association between CVH defined by Life’s Essential 8 and risk of 44 common NCDs and further estimate the population attributable fractions(PAFs)of low-moderate CVH scores in the 44 ***:In the UK Biobank,170,726 participants free of 44 common NCDs at baseline were *** Life’s Essential 8 composite measure consists of four health behaviours(diet,physical activity,nicotine exposure,and sleep)and four health factors(body mass index,non-high density lipoprotein cholesterol,blood glucose,and blood pressure),and the maximum CVH score was 100 *** score was categorized into low,moderate,and high *** were followed up for 44 NCDs diagnosis across 10 human system disorders according to the International Classification of Diseases 10th edition(ICD-10)code using linkage to national health records until *** proportional hazard models were used in this *** hazard ratios(HRs)and PAFs of 44 NCDs associated with CVH score were ***:During the median follow-up of 10.85 years,58,889 incident NCD cases were *** linear dose-response associations were found between higher CVH score and lower risk of 25(56.8%)of 44 ***-moderate CVH(lung cancer(34.0%),and heart failure(34.0%)as the top *** the eight modifiable factors,overweight/obesity explained the largest number of cases of incident NCDs in endocrine,nutritional,and me

关键词： Life’s Essential 8 Cardiovascular risk score Non-communicable chronic disease Population health management Cohort analysis Healthy lifestyle UK Biobank

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Replacement of leisure-time sedentary behavior with various physical activities and the risk of dementia incidence and mortality:A prospective cohort study

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Journal of Sport and Health Science 2023年第3期12卷 287-294页

作者： Ying Sun Chi Chen Yuetian Yu Haojie Zhang Xiao Tan Jihui Zhang lu Qi yingli lu Ningjian Wang Institute and Department of Endocrinology and Metabolism Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Department of Medical Sciences Uppsala UniversityUppsala 75185Sweden School of Public Health Zhejiang UniversityHangzhou 310058China Center for Sleep and Circadian Medicine The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510180China Department of Epidemiology School of Public Health and Tropical MedicineTulane UniversityNew OrleansLA 70112USA Department of Nutrition Harvard T.H.Chan School of Public HealthBostonMA 02115USA Channing Division of Network Medicine Department of MedicineBrigham and Women's Hospital and Harvard Medical SchoolBostonMA 02115USA

Background:Whether or not there is targeted pharmacotherapy for dementia,an active and healthy lifestyle that includes physical activity(PA)may be a better option than medication for preventing *** examined the association between leisure-time sedentary behavior(SB)and the risk of dementia incidence and *** further quantified the effect on dementia risk of replacing sedentary time with an equal amount of time spent on different physical ***:In the UK Biobank,484,169 participants(mean age=56.5 years;45.2%men)free of dementia were followed from baseline(2006-2010)through July 30,2021.A standard questionnaire measured individual leisure-time SB(watching TV,computer use,and driving)and PA(walking for pleasure,light and heavy do-it-yourself activity,strenuous sports,and other exercise)frequency and duration in the 4 weeks prior to *** E(APOE)genotype data were available for a subset of 397,519(82.1%)individuals.A Cox proportional hazard model and an isotemporal substitution model were used in this ***:During a median 12.4 years of follow-up,6904 all-cause dementia cases and 2115 deaths from dementia were *** comparison to participants with leisure-time SB8 h/day,and the HR of dementia mortality was 1.35(1.12-1.61)for>8 h/day.A 1 standard deviation increment of sedentary time(2.33 h/day)was strongly associated with a higher incidence of dementia and mortality(HR=1.06,95%CI:1.03-1.08 and HR=1.07,95%CI:1.03-1.12,respectively).The association between sedentary time and the risk of developing dementia was more profound in subjects60 years(HR=1.26,95%CI:1.00-1.58 ***=1.21,95%CI:1.08-1.35 in>8 h/day,p for interaction=0.013).Replacing 30 min/day of leisure sedentary time with an equal time spent in total PA was associated with a6%decreased risk a

关键词： Alzheimer's disease Apolipoprotein E Dementia Isotemporal substitution model Physical activity Sedentary behavior

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Sex hormone-binding globulin,genetic susceptibility,and the risk of type 2 diabetes in men and postmenopausal women

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Chinese Medical Journal 2023年第16期136卷 1993-1995页

作者： Wen Zhang Haojie Zhang Bin Wang Yuying Wang Ningjian Wang yingli lu Institute and Department of Endocrinology and Metabolism Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China

To the Editor:Type 2 diabetes(T2D)is one of the most common and fastest growing non-communicable diseases *** hormone-binding globulin(SHBG)is a circulating homodimeric glycoprotein that can bind androgens and estrogens with high affinity in blood and regulate their bioavailability.[1]Emerging evidence has shown that low levels of SHBG are associated with T2D.[2]Genetic factors are important factors that affect the development of ***,the combined effect of SHBG and genetic factors on T2D risk is largely *** the current study,we analyzed data from the Survey on Prevalence in East China for Metabolic Diseases and Risk Factors(SPECT-China)to evaluate whether SHBG levels could interact with genetic predisposition to increase the T2D risk in men and postmenopausal women and examined the joint association of SHBG and genetic predisposition with T2D.

关键词： globulin postmenopausal diabetes

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Association between sex hormone-binding globulin and kidney function in men: results from the SPECT-China study

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Chinese Medical Journal 2022年第17期135卷 2083-2088页

作者： Haojie Zhang Chi Chen Xuan Zhang Yuying Wang Heng Wan Yi Chen Wen Zhang Fangzhen Xia yingli lu Ningjian Wang Institute and Department of Endocrinology and Metabolism Shanghai Ninth People's HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Department of Pharmacy The 305th Hospital of PLABejing 100017China

Background::The association between sex hormone-binding globulin(SHBG)and renal function has rarely been reported in *** aimed to investigate the above association in a community-based Chinese ***::A total of 5027 men were included from the survey on prevalence for metabolic diseases and risk factors,which is a population-based study conducted from 2014 to 2016 in Eastern *** estimated glomerular filtration rate(eGFR)was calculated according to the chronic kidney disease Epidemiology Collaboration *** eGFR was defined as eGFRlusions::Lower serum SHBG levels were significantly associated with lower eGFR and a higher prevalence of low eGFR in Chinese men independent of demographics,lifestyle,metabolic-related risk factors,and *** prospective cohort and basic mechanistic studies are warranted in the future.

关键词： Estimated glomerular filtration rate Sex hormone-binding globulin Testosterone

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MicroRNA expression profile and lipid metabolism characteristics in liver of rat undergoing high-fat diet

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BIOCELL 2019年第3期43卷 129-137页

作者： WEN JING CHUANFEN LI yingli lu LIANSHI FENG College of Physical Education Shandong Normal UniversityJinan250014China College of Life Science Shandong Normal UniversityJinan250014China Department of Neurology The 960th Hospital of the Joint Logistic Support Force of the Chinese People’s Liberation ArmyJinan250031China Biology Center China Institute of Sport ScienceBeijing100061China

This study aimed to investigate the microRNA expression profile and the characteristics of lipid metabolism in the livers of rats undergoing a high-fat *** male Sprague-Dawley(SD)rats were divided into a standard chow group(C group,N=10)and a high-fat diet group(H group,N=40).After 12 weeks,the rat body weight,body length,fat mass,and serum lipid concentration were *** expression profile of microRNAs and the gene and protein expression levels involved in lipid metabolism in rat liver were *** fat and serum lipid concentrations were all significantly higher in the H group than those in the C group(plusion,the high-fat diet increased the body fat and serum lipid levels and altered the 10 microRNA expression levels in the *** high-fat diet may affect hepatic carbohydrate metabolism and increase ectopic fat accumulation through let-7 family *** high-fat diet for 12 weeks decreased lipid metabolism level in the liver,thereby decreasing fatty acid synthesis,oxidation,and transport by down-regulating the PPARα,FAS,CPT1A,FAT/CD36,and ApoAI protein levels.

关键词： High-fat diet Lipid metabolism MicroRNA expression Rat liver Serum lipid concentration

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Identification of novel biomarkers for varicocele using iTRAQ LC-MS/MS technology

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Chinese Medical Journal 2024年第3期137卷 371-372页

作者： Xianfeng lu Na Li lufang Li Yongai Wu Xuefeng Lyu yingli Cao Jianrong Liu Qin Qin Department of Pediatrics Shanxi Provincial People’s HospitalTaiyuanShanxi 030012China Department of Reproductive Genetics Heping Hospital Affiliated to Changzhi Medical CollegeChangzhiShanxi 046099China Department of Biochemistry Basic Medicine CollegeShanxi Medical UniversityTaiyuanShanxi 030607China Reproductive Medical Department Shanxi Provincial People’s HospitalTaiyuanShanxi 030012China

To the Editor:Varicocele(VC)is a vascular disease and considered as the main cause of male infertility.^([1])The incidence of VC in the common male population was 4.4–22.6%,of which the incidence of primary infertility was 35–40%,while the incidence of secondary infertility was as high as 80%.^([2])The exact pathophysiological mechanism of male infertility caused by VC and regulative molecules are still *** and definite molecular markers of VC disease are helpful for early prevention and timely *** study aimed to screen candidate regulative molecules playing a role in male infertility caused by VC.

关键词： prevention incidence exact

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Trace glucose fluxes in individuals with prediabetes using stable isotopes

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Chinese Medical Journal 2014年第9期127卷 1726-1731页

作者： Du Shichun Xia Fangzhen Xu Xiao Zhang Huixin Zhu Chunfang lu yingli Institute and Department of Endocrinology and Metabolism Shanghai Ninth People's Hospital affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200011 China

Background The glucose fluxes of individuals with prediabetes in Chinese population are not *** study was to determine whether the endogenous glucose production （EGP）,oral glucose rate of appearance （Ra） and glucose rate of disappearance （Rd） were different in Chinese individuals with prediabetes under fasting conditions and following an oral glucose *** Five subjects with type 2 diabetes,5 subjects with prediabetes and 5 non-diabetic subjects matched for age,weight,fat free mass and body mass index underwent a 180 minute stable glucose isotope tracing （[6,6-2H2] glucose,[1-13C] glucose,and [U-13C] glucose） study under fasting and after ingestion of a 75 g oral glucose *** glucose enrichment was measured by gas chromatography-mass *** sensitivity was estimated using the oral glucose tolerance test （OGTT）-derived insulin sensitivity index,β cell function was determined by the insulinogenic index （△I30/△G30）.Results The insulin sensitivity index （P=0.043） and insulinogenic index （P=0.021） were decreased in subjects with prediabetes compared with *** EGP was slightly higher （P=0.29） and postprandial EGP was comparable in subjects with prediabetes and non-diabetes during 120 minutes after glucose ingestion,but nadir EGP occurred later in prediabetic than non-diabetic *** did not differ among the three *** was substantially lower in subjects with prediabetes than non-diabetes after glucose intake （P=0.013）.Conclusion The mild hyperglycemia observed among individuals with prediabetes may result from decreased Rd during the postprandial state.

关键词： prediabetes glucose metabolism stable isotope triple tracer

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国外教育“政策制定”研究的进展及启示

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外国教育研究 2023年第3期50卷 79-99页

作者：卢迎丽程红艳华中师范大学教育学院湖北武汉430079

教育“政策制定”研究关注抽象政策理念转化为情境化实践的动态过程,着力对行动者阐释、转译、再建构政策行为加以解释。通过对SSCI数据库中136篇文献的内容综述,发现该类研究进展迅速,已得到多个国家学者、期刊平台的关注。研究内容聚... 详细信息

教育“政策制定”研究关注抽象政策理念转化为情境化实践的动态过程,着力对行动者阐释、转译、再建构政策行为加以解释。通过对SSCI数据库中136篇文献的内容综述,发现该类研究进展迅速,已得到多个国家学者、期刊平台的关注。研究内容聚焦多种教育政策与行动者,诠释行动者意义建构政策的阶段表征与嵌入于阶段过程中的“制定”实践,并指明影响“制定”的情境因素。同时,学者基于研究发现建构理论模型指引后续研究者。此类研究启示我国学者,应融合多学科理论,剖析教育政策执行的微观复杂样态,并立足于本土情境,提炼理论模型。

关键词：教育“政策制定” 意义建构解释翻译理论模型

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