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Potential application of Nardostachyos Radix et Rhizoma-Rhubarb for the treatment of diabetic kidney disease based on network pharmacology and cell culture experimental verification

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World Journal of Diabetes 2024年第3期15卷 530-551页

作者： Meng-Ying Che Ling Yuan Jiao Min Duo-Jie Xu Dou-Dou Lu Wen-Jing liu Kai-Li wang Yan-Yan wang Yi Nan Key Laboratory of Ningxia Minority Medicine Modernization Ministry of Education Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina College of Pharmacy Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Traditional Chinese Medicine College Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina School of Clinical Medicine Ningxia Medical UniversityYinchuan 750004Ningxia Hui Autonomous RegionChina Department of Endocrinology Yinchuan Hospital of Traditional Chinese MedicineYinchuan 750004Ningxia Hui Autonomous RegionChina

BACKGROUND Diabetic kidney disease(DKD)is one of the serious complications of diabetes mellitus,and the existing treatments cannot meet the needs of today's *** Chinese medicine has been validated for its efficacy in DKD after many years of clinical ***,the specific mechanism by which it works is still *** the molecular mechanism of the Nardostachyos Radix et Rhizoma-rhubarb drug pair(NRDP)for the treatment of DKD will provide a new way of thinking for the research and development of new *** To investigate the mechanism of the NRDP in DKD by network pharmacology combined with molecular docking,and then verify the initial findings by in vitro *** The Traditional Chinese Medicine Systems Pharmacology(TCMSP)database was used to screen active ingredient targets of *** for DKD were obtained based on the Genecards,OMIM,and TTD *** VENNY 2.1 database was used to obtain DKD and NRDP intersection targets and their Venn diagram,and Cytoscape 3.9.0 was used to build a"drug-component-target-disease"*** String database was used to construct protein interaction *** Encyclopedia of Genes and Genomes(KEGG)enrichment analysis and Gene Ontology analysis were performed based on the DAVID *** selecting the targets and the active ingredients,Autodock software was used to perform molecular *** experimental validation using renal tubular epithelial cells(TCMK-1),we used the Cell Counting Kit-8 assay to detect the effect of NRDP on cell viability,with glucose solution used to mimic a hyperglycemic *** cytometry was used to detect the cell cycle progression and *** blot was used to detect the protein expression of STAT3,p-STAT3,BAX,BCL-2,Caspase9,and *** A total of 10 active ingredients and 85 targets with 111 disease-related signaling pathways were obtained for *** analysis of KEGG pathways was performed to determ

关键词： Nardostachyos Radix et Rhizoma-rhubarb Diabetic kidney disease Molecular docking Network pharmacology Experimental validation

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Data-driven mapping-relationship mining between hardness and mechanical properties of dual-phase titanium alloys via random forest and statistical analysis

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Rare Metals 2024年第2期43卷 829-841页

作者： Hai-Chao Gong Qun-Bo Fan Hong-Mei Zhang Xing-wang Cheng Wen-Qiang Xie Kai Chen Lin yang Jun-Jie Zhang Bing-Qiang Wei Shun Xu School of Materials Science and Engineering Beijing Institute of TechnologyBeijing100081China National Key Laboratory of Science and Technology on Materials Under Shock and Impact Beijing100081China Beijing Institute of Technology Chongqing Innovation Center Chongqing401135China Department of Mechanical and Materials Engineering University of Nebraska-LincolnLincolnNE68588USA

In order to accelerate the research on the property optimization of titanium alloy based on high-throughput methods,it is necessary to reveal the relationship between hardness and other mechanical properties which is still *** this work,taking Ti20C alloy as research object,almost all the microstructure of dual-phase titanium alloys were covered by traversing over 100 heat treatment ***,massive experiments including microstructure characterization and performance test were conducted,obtaining 51,590 pieces of microstructure data and 3591 pieces of mechanical property ***,based on large-scale data-driven technology,the quantitative mapping relationship between hardness and other mechanical properties was deeply *** results of random forest models showed that the correlation between hardness(H)and Charpy impact energy(A_(k))(or elongation,A)was hardly dependent on the microstructure types,while the relationship between H and tensile strength(R_(m))(or yield strength,R_(p0.2))was highly dependent on microstructure ***,combined with statistical analysis,it was found that the relationship between H and Ak(or A)were negatively ***,the relationship between H and strength was positively linear for equiaxed microstructure,and strength was linked to d^(−1/2)(d,equivalent circle diameter)ofα-grains in the form of classical Hall–Petch formula;but for other microstructures,the relationships were ***,the above rules were nearly the same in the rolling direction and transverse ***,a"four-quadrant partition map"between H and R_(p0.2)/R_(m) was established as a versatile material-screening tool,which can provide guidance for on-demand selection of titanium alloys.

关键词： Dual-phase titanium alloy Data-driven Hardness Mapping relationship

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改进的不完备差异关系及其扩充粗糙集模型

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中国科技论文 2018年第5期13卷 558-562页

作者：刘阳王卫华刘永坚汉理工大学理学院武汉430070 武汉理工大学计算机科学与技术学院武汉430070

针对基于粗糙集理论的不完备信息系统分类问题,本文在经典粗糙集的等价关系基础上,改进差异关系,完善容差关系,提出了改进的扩充粗糙集模型,并进行了实证分析。为了消除不完备信息系统中的噪声,进一步提高数据的处理能力,在不完备信息... 详细信息

针对基于粗糙集理论的不完备信息系统分类问题,本文在经典粗糙集的等价关系基础上,改进差异关系,完善容差关系,提出了改进的扩充粗糙集模型,并进行了实证分析。为了消除不完备信息系统中的噪声,进一步提高数据的处理能力,在不完备信息系统中引入变精度粗糙集。基于改进的差异关系,构建了变精度的扩充粗糙集模型,并通过实例验证了方法的可行性和理论的有效性。

关键词：粗糙集不完备信息系统差异关系变精度属性依赖度

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Colorimetric indicator based on zwitterionic anti-freezing hydrogel and alizarin for visual monitoring of salmon fillets freshness

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Journal of Future Foods 2024年第2期4卷 135-141页

作者： Yanan liu Huan Li Jian Chen Jiesi Feng Renjie Lian Linglin Fu Yanbo wang Food Safety Key Laboratory of Zhejiang Province School of Food Science and BiotechnologyZhejiang Gongshang UniversityHangzhou 310018China Jinghai Group Co. Ltd.Rongcheng 264300China School of Food and Health Beijing Technology and Business UniversityBeijing 100048China

Indicating hydrogels have shown the advantages of being fast, sensitive, and real-time in demonstrating the freshness of aquatic products due to their noticeable color change. In this work, an anti-freezing hydrogel embedded with pH-sensitive alizarin was developed as an original colorimetric indicator for monitoring the corruption of aquatic products at low temperatures. The anti-freezing hydrogel was prepared from 2-carboxyethyl acrylate, [2-(methacryloyloxy)ethyl]-trimethylammonium chloride, and 2-hydroxyethyl methacrylate monomers with triethylene glycol dimethacrylate as cross-linking agent. The hydrogel showed excellent anti-freezing capability, which was further incorporated with the pH-sensitive dye alizarin to gain the indicating capability. When applied in the indication of the freshness of salmon under low-temperature storage, it was found that the color changes of the indicator corresponded with the total volatile basic nitrogen contents of salmon, the correlation coefficient of which was 0.959 6. These results indicated the application potential of the hydrogels as freshness indicators during low-temperature storage or cold-chain transportation.

关键词： Colorimetric indicator Alizarin Zwitterionic hydrogel Food freshness Visual monitoring

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Analgesic nanomedicines for the treatment of chronic pain

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BMEMat(BioMedical Engineering Materials) 2024年第1期2卷 76-87页

作者： Hao liu Hongjun Zhuang Ya wang Yuen Yee Cheng Feixiang Chen Jian Chen Xinglei Song Run Zhang Yanyan liu Wenbo Bu State Key Laboratory of Molecular Engineering of Polymers Department of Materials ScienceFudan UniversityShanghaiChina Department of Rehabilitation Zhongshan HospitalFudan UniversityShanghaiChina Central Laboratory The First Affiliated Hospital of Xiamen UniversityXiamenChina Institute for Biomedical Materials&Devices(IBMD) Faculty of ScienceThe University of Technology SydneySydneyNew South WalesAustralia Department of Anatomy and Physiology Shanghai Jiao Tong University School of MedicineShanghaiChina Australian Institute for Bioengineering and Nanotechnology The University of QueenslandBrisbaneQueenslandAustralia

Chronic pain is a major cause of suffering that often accompanies diseases and therapies,affecting approximately 20%of individuals at some point in their ***,current treatment modalities,such as anesthetic and antipyretic analgesics,have limitations in terms of efficacy and side *** technology offers a promising avenue to overcome these challenges and introduce new therapeutic *** article reviews the recent research on nanomedicine analgesics,integrating analyses of neuroplasticity changes in neurons and pathways related to the transition from acute to chronic ***,it explores potential future strategies using nanomaterials,aiming to provide a roadmap for new analgesic development and improved clinical pain *** leveraging nanotechnology,these approaches hold the potential to revolutionize pain treatment by delivering targeted and effective relief while minimizing side effects.

关键词： analgesics chronic pain local anesthetics nanomedicine neuroplasticity

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Cellular angiofibroma arising from the rectocutaneous fistula in an adult: A case report

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World Journal of Clinical Cases 2024年第10期12卷 1778-1784页

作者： Hao-En Chen Yu-yang Lu Ruei-Yu Su Hong-Hau wang Chao-yang Chen Je-Ming Hu Jung-Cheng Kang Kuan-Hsun Lin Ta-Wei Pu Department of Surgery Taichung Armed Forces General HospitalTaichung 411Taiwan Department of Surgery Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Department of Pediatrics Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Department of Pathology Tri-Service General HospitalNational Defense Medical CenterTaipei 105Taiwan Department of Pathology and Laboratory Medicine Taoyuan Armed Forces General HospitalTaoyuan 32551Taiwan Department of Radiology Tri-Service General Hospital Songshan BranchNational Defense Medical CenterTaipei 105Taiwan Division of Colon and Rectal Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Colon and Rectal Surgery Department of SurgeryTaiwan Adventist HospitalTaipei 105Taiwan Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Colon and Rectal Surgery Department of SurgeryTri-Service General Hospital Songshan BranchNational Defense Medical CenterTaipei 105Taiwan

BACKGROUND Rectocutaneous fistulae are *** infection originates within the anal glands and subsequently extends into adjacent regions,ultimately resulting in fistula *** angiofibroma(CAF),also known as an angiomy ofibroblastoma-like tumor,is a rare benign soft tissue neoplasm predominantly observed in the scrotum,perineum,and inguinal area in males and in the vulva in *** describe the first documented case CAF that developed within a rectocutaneous fistula and manifested as a perineal *** SUMMARY In the outpatient setting,a 52-year-old male patient presented with a 2-year history of a growing perineal mass,accompanied by throbbing pain and minor scrotal *** examination revealed a soft,well-defined,non-tender mass at the left buttock that extended towards the perineum,without a visible *** initial assessment identified a soft tissue tumor,and the laboratory data were within normal *** and pelvic computed tomography(CT)revealed swelling of the abscess cavity that was linked to a rectal cutaneous fistula,with a track-like lesion measuring 6 cm×0.7 cm in the left perineal region and attached to the left *** examination found no significant inner orifices.A left medial gluteal incision revealed a thick-walled mass,which was excised along with the extending tract,and curettage was *** examination confirmed CAF *** patient achieved total resolution during follow-up assessments and did not require additional *** CT imaging supports perineal lesion diagnosis and *** angiofibromas,even with a cutaneous fistula,can be excised transperineally.

关键词： Angiofibroma Perineal mass Rectocutaneous fistula Anorectal fistula Anal fistula Case report

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重庆市麻疹疫苗补充免疫前后的流行病学特征分析

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疾病监测 2016年第12期31卷 1037-1040页

作者：刘洋王青重庆市疾病预防控制中心重庆400042

目的描述与分析补充免疫前后重庆市麻疹流行病学特征,为完善防控策略提供参考。方法采用描述性流行病学方法,对2006-2008年、2013-2015年麻疹高发年份发病资料进行统计分析。结果麻疹疫苗补充免疫前后,麻疹流行病学特征变化主要表现为... 详细信息

目的描述与分析补充免疫前后重庆市麻疹流行病学特征,为完善防控策略提供参考。方法采用描述性流行病学方法,对2006-2008年、2013-2015年麻疹高发年份发病资料进行统计分析。结果麻疹疫苗补充免疫前后,麻疹流行病学特征变化主要表现为：时间分布曲线不再保持2006-2008年较为一致的＂单峰＂分布特征,近3年每年流行时间明显延长;城镇病例构成比以及由主城区报告病例构成比上升明显,成为近3年7 9月流行高峰的主要来源;〈8月龄儿童发病比例上升明显,7-14岁补充免疫对象发病比例显著下降,病例以散居儿童为主。结论常规免疫质量下滑与疫情处置不及时导致疫情高发。应根据麻疹流行特征,加强重点季节、重点地区疫情监测,采取提高适龄儿童含麻疹成分疫苗首针及时接种率和全程接种率、加强查验接种证补种工作等措施,降低麻疹发病。

关键词：补充免疫麻疹流行特征分析

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Chinese expert consensus on refined diagnosis, treatment, and management of advanced primary liver cancer (2023 edition)

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Liver Research 2024年第2期8卷 61-71页

作者： Xiufeng liu Feng Xia Yue Chen Huichuan Sun Zhengqiang yang Bo Chen Ming Zhao Xinyu Bi Tao Peng Aizier Ainiwaer Zhiwen Luo Fusheng wang Yinying Lu Department of Medical Oncology Bayi Hospital Affiliated to Nanjing Chinese Medical University Nanjing Jiangsu China Department of Hepatobiliary Surgery Southwest Hospital Army Medical University Chongqing China Senior Department of Hepatology The Fifth Medical Center of PLA General Hospital Beijing China Department of Liver Surgery and Transplantation Liver Cancer Institute Zhongshan Hospital Fudan University Shanghai China Department of Interventional Therapy National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Minimally Invasive Interventional Therapy Liver Cancer Study and Service Group Sun Yat-sen University Cancer Center Guangzhou Guangdong China Department of Hepatobiliary Surgery National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Hepatobiliary Surgery The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi China Senior Department of Infectious Diseases The Fifth Medical Center of PLA General Hospital Beijing China Comprehensive Liver Cancer Center The Fifth Medical Center of PLA General Hospital Beijing China

Hepatocellular carcinoma (HCC), commonly known as primary liver cancer, is a major cause of malignant tumors and cancer-related deaths in China, accounting for approximately 85% of all cancer cases in the country. Several guidelines have been used to diagnose and treat liver cancer. However, these guidelines provide a broad definition for classifying advanced liver cancer, with an emphasis on a singular approach, without considering treatment options for individual patients. Therefore, it is necessary to establish a comprehensive and practical expert consensus, specifically for China, to enhance the diagnosis and treatment of HCC using the Delphi method. The classification criteria were refined for Chinese patients with HCC, and the corresponding optimal treatment regimen recommendations were developed. These recommendations took into account various factors, including tumor characteristics, vascular tumor thrombus grade, distant metastasis, liver function status, portal hypertension, and the hepatitis B virus replication status of patients with primary HCC, along with treatment prognosis. The findings and recommendations provide detailed, scientific, and reasonable individualized diagnosis and treatment strategies for clinicians.

关键词： Hepatocellular carcinoma (HCC) Targeted therapy Immunotherapy Refined diagnosis and treatment Expert consensus

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The quality control and hypoglycemic effect of Cinnamomi Cortex aqueous extract

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Journal of Future Foods 2024年第2期4卷 167-172页

作者： Xuting Hao Ziheng Jin Ruiyu Gao Shiming Li Changqin Li Lijun liu Jinmei wang National R&D Center for Edible Fungus Processing Technology Henan UniversityKaifeng 475004China Key Laboratory of Natural Pigment Preparation of Henan Province Luohe 462600China Department of Food Science Rutgers University New BrunswickNJ 08901USA Joint International Research Laboratory of Food&Medicine Resource Function of Henan Province Kaifeng 475004China Huaihe Hospital of Henan University Kaifeng 475000China

Cinnamomi Cortex was a material as medicinal and edible resources and it has been demonstrated that Cinnamomi Cortex aqueous extract(CCAE)possess hypoglycemic effect,but there were no active compounds identified as quality standard of CCAE to be used in the investigate of hypoglycemic ***,in this study,the quality standard and the hypoglycemic effect of CCAE were *** and coumarin as the quality control in CCAE were analyzed by high performance liquid chromatography(HPLC)*** results showed that the average yield of extraction was 10.06%.The concentration of coumarin was linear with peak area ranging from 0.02–1.00μg/mL(r=0.9996,n=6)and that of cinnamaldehyde also demonstrated a good linear relationship with peak area in the range of 1.05–52.50μg/mL(r=0.9997,n=6).The average recovery rate of coumarin and cinnamaldehyde was 99.42%and 100.11%,*** investigation of hypoglycemic effect revealed that CCAE could improve weight loss,lower liver and pancreas indices,improve organ damage caused by diabetes,and lower fasting blood glucose,glycosylated serum protein(GSP)and total cholesterol(TC)*** results showed that CCAE can reduce fasting blood glucose and blood lipid levels in diabetic mice.

关键词： Cinnamomi Cortex Cinnamaldehyde Coumarin Hypoglycemic effect

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circRNAs deregulation in exosomes derived from BEAS-2B cells is associated with vascular stiffness induced by PM_(2.5)

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Journal of Environmental Sciences 2024年第3期137卷 527-539页

作者： Qingping liu Yaling Zhang Bin Han Mengruo wang Huaifang Hu Jie Ning Wentao Hu Meiyu Chen Yaxian Pang Yuanyuan Chen Lei Bao Yujie Niu Rong Zhang Department of Toxicology Hebei Medical UniversityShijiazhuang 050017China State Key Laboratory of Environment Health(Incubation) Key Laboratory of Environment and HealthMinistry of EducationKey Laboratory of Environment and Health(Wuhan)Ministry of Environmental ProtectionSchool of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030China China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijing 100021China Occupational Health and Environmental Health Hebei Medical UniversityShijiazhuang 050017China Hebei Key Laboratory of Environment and Human Health Hebei Medical UniversityShijiazhuang 050017China

As an environmental pollutant,ambient fine particulate matter (PM_(2.5)) was linked to cardiovascular *** molecular mechanisms underlying PM_(2.5)-induced extrapulmonary disease has not been elucidated *** this study the ambient PM_(2.5)exposure mice model we established was to explore adverse effects of vessel and potential ***-term PM_(2.5)exposure caused reduced lung function and vascular stiffness in *** chronic PM_(2.5)induced migration and epithelial-mesenchymal transition (EMT) phenotype in BEAS-2B *** PM_(2.5)treatment,the circRNAs and mRNAs levels of exosomes released by BEAS-2B cells were detected by competing endogenous RNA (ceRNA) array,which contained 1664 differentially expressed circRNAs (DE-circRNAs) and 308 differentially expressed m RNAs (DE-mRNAs).By bioinformatics analysis on host genes of DE-circRNAs,vascular diseases and some pathways related to vascular diseases including focal adhesion,tight junction and adherens junction were ***,ceRNA network was constructed,and DE-mRNAs in ceRNA network were conducted functional enrichment analysis by Ingenuity Pathway Analysis,which indicated that hsa_circ_0012627,hsa_circ_0053261and hsa_circ_0052810 were related to vascular endothelial ***,it was verified experimentally that Exo^(PM2.5)could induce endothelial dysfunction by increased endothelial permeability and decreased relaxation in *** present study,we investigated in-depth knowledge into the molecule events related to PM_(2.5) toxicity and pathogenesis of vascular diseases.

关键词： Fine particulate matter Vascular stiffness Exosome ceRNA microarray Endothelial dysfunction

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