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The Role of Fracture Structure in Leachate Pollution at Landfills:A Case Study of a Landfill in Chongqing City

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Acta Geologica Sinica(English Edition) 2008年第5期82卷 1020-1026页

作者： luo yunju liu dongyan LI Xiulan ZHU Zhengwei College of Civil Engineering Chongqing University Chongqing 400045

This paper studies a landfill where there are three faults running through. As serious pollution has occurred to the geological environment, the landfill is to be closed up and renovated. The paper aims to explore the role of fracture structure in leachate pollution at the landfill. The research was carried out in several stages. First, mathematical models of the pre-renovation landfill with three faults running through and the landfill after renovation were established. And then, the boundary conditions and parameters of the two mathematical models were determined. The groundwater level of the landfills was simulated in order to modify the two mathematical models. As a result, a feasible mathematical model was achieved. Based on this model, a comparison was made of the COD concentration variations in the inside leachate and outside leachate between the two landfills. Accordingly, the impacts of the fracture structure on the pollution of leachate at the landfills could be identified. The study results show that while faults contribute to the migration of ieachate, they also serve as a confluence of leachate, thus further deteriorating the environment. The COD concentrations of the inside leachate and the outside leachate of the pre-renovation landfill are respectively 800 mg/L and 220 mg/L higher than those of the post-renovation landfill. Therefore, measures must be taken to handle the ieachate seepage in areas where there are faults as well as the neighboring areas so as to get the environmental pollution under control.

关键词： landfill fracture structure leachate COD concentration seepage

A statistical damage-based constitutive model for shearing of rock joints in brittle drop mode

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International Journal of Mining Science and Technology 2024年第8期34卷 1041-1058页

作者： xinrong liu Peiyao Li Xueyan Guo Xinyang luo Xiaohan Zhou Luli Miao Fuchuan Zhou Hao Wang School of Civil Engineering Chongqing UniversityChongqing 400045China National Joint Engineering Research Center of Geohazards Prevention in The Reservoir Areas(Chongqing) Chongqing 400045China Key Laboratory of New Technology for Construction of Cities in Mountain Area(Chongqing University) Ministry of EducationChongqing 400045China Chongqing Vocational Institute of Engineering Chongqing 402260China

Some rock joints exhibit significant brittleness,characterized by a sharp decrease in shear stress upon reaching the peak ***,existing models often fail to accurately represent this behavior and are encumbered by numerous parameters lacking clear mechanical *** study presents a new statistical damage constitutive model rooted in both damage mechanics and statistics,containing only three model *** proposed model encompasses all stages of joint shearing,including the compaction stage,linear stage,plastic yielding stage,drop stage,strain softening stage,and residual strength *** derive the analytical expression of the constitutive model,three boundary conditions are *** data from both natural and artificial rock joints is utilized to validate the model,resulting in average absolute relative errors ranging from 3%to 8%.Moreover,a comparative analysis with established models illustrates that the proposed model captures stress drop and post-peak strain softening more effectively,with model parameters possessing clearer mechanical ***,parameter analysis is conducted to investigate the impacts of model parameters on the curves and unveil the relationship between these parameters and the mechanical properties of rock ***,the proposed model is straightforward in form,and all model parameters can be obtained from direct shear tests,thus facilitating the utilization in numerical simulations.

关键词： Rock joints Brittle rock Direct shear test Damage-based constitutive model Parameters analysis

The effect of monosialylganglioside mix modifying the PEGylated liposomal epirubicin on the accelerated blood clearance phenomenon

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Asian Journal of Pharmaceutical Sciences 2017年第2期12卷 134-142页

作者： Ting Zhang Songlei Zhou Le Kang Xiang luo Yang liu Yanzhi Song xinrong liu Yihui Deng College of Pharmacy Shenyang Pharmaceutical University

PEGylated liposomes are potential candidates to improve the pharmacokinetic characteristics of encapsulated drugs, to extend their circulation half-life and facilitate their passive accumulation at tumour sites. However, PEG-modified liposomes can induce accelerated blood clearance(ABC) upon repeated administration, and the extent of ABC phenomenon on the cytotoxic drugs-containing PEGylated liposomes is related to the dose of the cytotoxic *** this study, EPI served as a model cytotoxic drug, a hydrophilic surfactant molecule,monosialylganglioside(GM1) was chosen and modified on the liposomes together with *** was shown that upon mixed modification, when GM1 contents reached 10% or 15% mol,the ABC phenomenon of the PEGylated liposomal EPI significantly reduced. We also found that GM1 played an important role in abrogating the ABC phenomenon in both the induction phase and the effectuation phase. The results suggested that GM1 incorporation unfortunately did not avoid occurrence of ABC phenomenon completely, but GM1 modification on PEGylated liposomes may provide a significant improvement in clinical practice of PEGylated liposomes. Further study must be necessary.

关键词： PEGylated liposomes Epirubicin Monosialylganglioside(GM1) Mixed modification Accelerated blood clearance (ABC) phenomenon

Effect of Kupffer cells depletion on ABC phenomenon induced by Kupffer cells-targeted liposomes

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Asian Journal of Pharmaceutical Sciences 2019年第4期14卷 455-464页

作者： Chaoyang Lai Cong Li Mengyang liu Qiujun Qiu Xiang luo xinrong liu Ling Hu Yihui Deng Yanzhi Song Shenyang Pharmaceutical University

Accelerated blood clearance(ABC) phenomenon is common in many PEGylated nanocarriers, whose mechanism has not been completely elucidated yet. In this study, the correlation between Kupffer cells(KCs) and ABC phenomenon has been studied by KCs-targeted liposomes inducing ABC phenomenon and KCs depletion. In other words, the 4-aminophenyl-α-D-mannopyranoside(APM) lipid derivative DSPE-PEG 2000-APM(DPM), and 4-aminophenyl-β-L-fucopyranoside(APF) lipid derivative DSPE-PEG 2000-APF(DPF) were conjugated and modified on alendronate sodium(AD) liposomes to specifically target and deplete KCs. The dualligand modified PEGylated liposomes(MFPL) showed stronger ability to damage KCs in vitro and in vivo, which also could indirectly illustrate that dual-ligand modification could better target KCs. Besides, the hepatic biodistribution and pharmacokinetics could directly prove that MFPL had a stronger targeting ability to KCs. In addition, in depletion rats, plasma concentration and splenic biodistribution of MFPL and PEGylated liposomes(PL) were significantly elevated and hepatic biodistribution was significantly reduced, which demonstrated that KCs played an important role on elimination of nanoparticles. What’s more, ABC phenomenon of the secondary injection of PL was stronger in KCs depletion rats than that in normal rats, which indicated that depletion of KCs prolonged the circulation of PL in the first injection repeatedly stimulating B-cells in the marginal region of the spleen and causing it to secrete more IgM antibodies. This could also illustrate that anti-PEG IgM takes up a major station compared with KCs. Most important of all, KCs-targeted liposomes could induce a stronger ABC phenomenon than PL in normal rats, which declared that based on the same IgM concentration, the more the KCs were stimulated, the stronger ABC phenomenon was induced. However, in depletion rats, this difference of ABC phenomenon between PL and MFPL could no more exist, further demonstrating tha

关键词： Accelerated blood clearance (ABC) phenomenon Kupffer cells Depletion Liposomes Bio-distribution

Reversible Audio Watermarking Algorithm Using Non-Causal Prediction

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Wuhan University Journal of Natural Sciences 2013年第5期18卷 455-460页

作者： HUO Yongjin XIANG Shijun liu Shangyi luo xinrong BAI Zhongliang School of Information Science and Technology Jinan University

Reversible watermarking technique enables to extract embedded information without any loss of the host signal. For the reduction of the embedding distortion, a desirable reversible watermarking approach should exploit efficient prediction way to generate prediction errors with a smaller magnitude for expansion embedding. In this paper, we present a reversible audio watermarking scheme based on a new non-causal prediction method and embedding strategy. The proposed non-causal prediction method provides non-integer prediction errors and the proposed expansion embedding strategy can proceed them for a lower embedding distortion. Experimental results have shown that the proposed reversible technique has a lower embedding distortion for the same embedding payload in comparison with the existing state-of-the-art works.

关键词： audio reversible watermarking non-causal prediction expansion embedding

Phyto-phospholipid complexes(phytosomes): A novel strategy to improve the bioavailability of active constituents

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Asian Journal of Pharmaceutical Sciences 2019年第3期14卷 265-274页

作者： Mei Lu Qiujun Qiu Xiang luo xinrong liu Jing Sun Cunyang Wang Xiangyun Lin Yihui Deng Yanzhi Song College of Pharmacy Shenyang Pharmaceutical UniversityShenyang110016China College of Pharmaceutical Engineering Shenyang Pharmaceutical UniversityShenyang110016China

Although active constituents extracted from plants show robust in vitro pharmacological effects, low in vivo absorption greatly limits the widespread application of these compounds. A strategy of using phyto-phospholipid complexes represents a promising approach to increase the oral bioavailability of active constituents, which is consist of ‘‘label-friendly'phospholipids and active constituents. Hydrogen bond interactions between active constituents and phospholipids enable phospholipid complexes as an integral part. This review provides an update on four important issues related to phyto-phospholipid complexes: active constituents, phospholipids, solvents, and stoichiometric ratios. We also discuss recent progress in research on the preparation, characterization, structural verification, and increased bioavailability of phyto-phospholipid complexes.

关键词： Phyto-phospholipid complexes Active constituents Hydrogen bonds Bioavailability

Evaluation of FGF10 as a candidate gene for high myopia in a Han Chinese population

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Eye and Vision 2019年第1期6卷 284-290页

作者： Lingxi Jiang dongyan luo Tingting Wang Rui Zheng Yaru Zhai Xiaoqi liu Bo Gong Zhengzheng Wu Yin Yang Zhenglin Yang Yi Shi Sichuan Provincial Key Laboratory for Human Disease Gene Study Department of Clinical LaboratorySichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of China32 the First Ring Road West 2Chengdu 610072SichuanChina Department of Ophthalmology Sichuan Academy of Medical Sciences&Sichuan Provincial People’s HospitalChengduChina. Chinese Academy of Sciences Sichuan Translational Medicine Research Hospital ChengduSichuanChina

Background:Fibroblast growth factor 10(FGF10)is implicated in the growth and development of the *** singles nucleotide polymorphisms(SNPs)in the FGF10 gene(including rs1384449,rs339501,rs12517396 and rs10462070)were found to be associated with extreme myopia(EM,refractive error≤−10.0 diopters)in Japanese and Chinese Taiwan *** case-control association study was conducted to explore the relationship between these four SNPs and high myopia in a western Chinese ***:A total of 869 high myopia patients(HM,including 485 EM patients)and 899 healthy controls were *** four SNPs were genotyped using the ABI SNaPshot *** genetic models(allelic,homozygous,heterozygous,dominant,and recessive)were applied to further evaluate the possible correlation between the SNPs and high *** linkage-disequilibrium block(LD)structure was tested by Haploview ***:In our study,no statistically significant differences were found between HM/EM patients and controls after Bonferroni multiple-correction(P>0.05)in the allele frequencies of these four SNPs in the FGF10 *** further found that rs12517396AA and rs10462070GG carriers showed a decreased risk of HM/EM compared with rs12517396AC+CC and rs10462070GA+AA carriers(P=0.045,OR=0.366;P=0.021,OR=0.131;P=0.03,OR=0.341;P=0.015,OR=0.122;respectively).Additionally,rs12517396AA and rs10462070GG carriers showed the same decreased risk of HM/EM compared with rs12517396CC and rs10462070AA carriers(P=0.048,OR=0.370;P=0.023,OR=0.133;P=0.032,OR=0.346;P=0.017,OR=0.126).However,these significant associations between rs12517396/rs10462070 and HM/EM disappeared after Bonferroni multiple-correction(P>0.05).Conclusion:Our findings indicate that rs12517396 and rs10462070 had marginal association with HM and *** other two common polymorphisms in FGF10 unlikely have significant effects in the genetic predisposition to HM/EM in western Chinese *** replication studies are needed

关键词： High myopia Extreme myopia Association study Fibroblast growth factor 10

Vaccine-Associated Paralytic Poliomyelitis--8 PLADs,China,October 2012–March 2014

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China CDC weekly 2020年第50期2卷 955-961页

作者： Ning Wen Fang Fang Wenbo Xu Huaqing Wang Yong Zhang Qiru Su Yao liu Haibo Wang Shuangli Zhu Xiaoxiao Zhang Wenzhou Yu Dongmei Yan Zhenguo Zhang Qiu Tan Fubao Ma Aihu Dong Yu liu Keli Li Li Zheng Lixin Hao dongyan Wang Chunxiang Fan Wendi Wu Huiming luo Aiqiang Xu Weizhong Yang Chinese Center for Disease Control and Prevention BeijingChina Department of Neurology Beijing Children’s HospitalCapital Medical UniversityBeijingChina National Institute for Viral Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijingChina Shenzhen Children’s Hospital ShenzhenGuangdongChina Shandong Provincial Key Laboratory of Infectious Disease Control and Prevention Shandong Provincial Center for Disease Control and Prevention/Academy of Preventive MedicineShandong UniversityJinanShangdongChina Clinical Research Institute Peking UniversityBeijingChina Henan Provincial Center for Disease Control and Prevention JinanHenanChina Hebei Provincial Center for Disease Control and Prevention ShijiazhuangHebeiChina Guangdong Provincial Center for Disease Control and Prevention GuangzhouGuangdongChina Jiangsu Provincial Center for Disease Control and Prevention NanjingJiangsuChina Guangxi Provincial Center for Disease Prevention and Control NanningGuangxiChina Sichuan Provincial Center for Disease Prevention and Control ChengduSichuanChina Hubei Provincial Center for Disease Prevention and Control WuhanHubeiChina

Introduction:Poliomyelitis is a highly contagious,seasonal viral disease caused by any of three poliovirus(PV)serotypes(types 1,2,or 3).Oral poliovirus vaccine(OPV)on rare occasions causes vaccineassociated paralytic poliomyelitis(VAPP)in recipients of OPV and close contacts of recently vaccinated *** study describes the epidemiology of VAPP when an all OPV schedule was used in the Expanded Program on Immunization(EPI).Methods:VAPP cases were identified using standardized diagnostic criteria from data reported by 8 provincial-level administrative divisions(PLADs)to the National Acute Flaccid Paralysis(AFP)Surveillance System in an 18-month period between October 2012 and March ***:During this period,28 VAPP cases were *** the number of births as a denominator,the estimated incidence of VAPP was 2.47 cases per million *** the number of OPV doses administered through routine immunization,the VAPP incidence was 0.55 cases per million *** vaccine-recipient VAPP cases,22(85%)were associated with the first dose of OPV;3 were associated with the second OPV *** relative risk of VAPP following the first dose compared with the second dose was *** and Implications for Public Health Practice:The per-dose and per-child incidences of VAPP were consistent with incidence estimates by the World Health Organization(WHO).The vast majority(85%)of VAPP in China was associated with the first dose of OPV in an all-OPV *** inactivated polio vaccine(IPV)is known to prevent VAPP from subsequent doses of OPV in immunocompetent children,this association provided strong evidence for using an IPV-first,sequential IPVOPV polio vaccination schedule in China during the globally-synchronized cessation of type 2 OPV and introduction of IPV in 2016.

关键词： doses epidemiology routine

Search for New Antiphytovirucides Ⅷ.Phosphorylation,Sulphonation and Carboxymethylation of Benzimidazole Derivatives and Antiviral Activity of Products

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Wuhan University Journal of Natural Sciences 1998年第2期3卷 201-204页

作者： Qu Fanqi, Dong xinrong, luo Xinxiang, liu Xin, Huang Xiaoling(College of Chemistry, Wuhan University, Wuhan 430072, China)

The Iead compound of substituted 2-(4-hydroxyphenyl)benzimidazol were modified by phos-phorylation sulfonation and carboxymethylation. The henzimldazoloamidophosphate (6) (7) have better activi-ty against tobacco mosaic virus (TMV). The benzimldazolophenoxyacetic acid, phenoxysuIfonic acid c0ntaining tri flu0r0methyl, and nitro gr0up have 77% ~85% efflclency f0r wheat rust disease.

关键词： 2-(4'-hydroxyphenyl) benzimidazole phosphorylation sulfonation carboxymethylation an-tiphytovirucide