Phyto-phospholipid complexes(phytosomes): A novel strategy to improve the bioavailability of active constituents

作     者：Mei Lu Qiujun Qiu Xiang Luo Xinrong Liu Jing Sun Cunyang Wang Xiangyun Lin Yihui Deng Yanzhi Song 

作者机构：College of PharmacyShenyang Pharmaceutical UniversityShenyang110016China College of Pharmaceutical EngineeringShenyang Pharmaceutical UniversityShenyang110016China 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)

年 卷 期：2019年第14卷第3期

页      面：265-274页

核心收录：

学科分类：100702[医学-药剂学] 1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Phyto-phospholipid complexes Active constituents Hydrogen bonds Bioavailability 

摘      要：Although active constituents extracted from plants show robust in vitro pharmacological effects, low in vivo absorption greatly limits the widespread application of these compounds. A strategy of using phyto-phospholipid complexes represents a promising approach to increase the oral bioavailability of active constituents, which is consist of ‘‘label-friendly phospholipids and active constituents. Hydrogen bond interactions between active constituents and phospholipids enable phospholipid complexes as an integral part. This review provides an update on four important issues related to phyto-phospholipid complexes: active constituents, phospholipids, solvents, and stoichiometric ratios. We also discuss recent progress in research on the preparation, characterization, structural verification, and increased bioavailability of phyto-phospholipid complexes.