Vaccine-Associated Paralytic Poliomyelitis--8 PLADs,China,October 2012–March 2014

作     者：Ning Wen Fang Fang Wenbo Xu Huaqing Wang Yong Zhang Qiru Su Yao Liu Haibo Wang Shuangli Zhu Xiaoxiao Zhang Wenzhou Yu Dongmei Yan Zhenguo Zhang Qiu Tan Fubao Ma Aihu Dong Yu Liu Keli Li Li Zheng Lixin Hao Dongyan Wang Chunxiang Fan Wendi Wu Huiming Luo Aiqiang Xu Weizhong Yang 

作者机构：Chinese Center for Disease Control and PreventionBeijingChina Department of NeurologyBeijing Children’s HospitalCapital Medical UniversityBeijingChina National Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijingChina Shenzhen Children’s HospitalShenzhenGuangdongChina Shandong Provincial Key Laboratory of Infectious Disease Control and PreventionShandong Provincial Center for Disease Control and Prevention/Academy of Preventive MedicineShandong UniversityJinanShangdongChina Clinical Research InstitutePeking UniversityBeijingChina Henan Provincial Center for Disease Control and PreventionJinanHenanChina Hebei Provincial Center for Disease Control and PreventionShijiazhuangHebeiChina Guangdong Provincial Center for Disease Control and PreventionGuangzhouGuangdongChina Jiangsu Provincial Center for Disease Control and PreventionNanjingJiangsuChina Guangxi Provincial Center for Disease Prevention and ControlNanningGuangxiChina Sichuan Provincial Center for Disease Prevention and ControlChengduSichuanChina Hubei Provincial Center for Disease Prevention and ControlWuhanHubeiChina 

出 版 物：《China CDC weekly》 (中国疾病预防控制中心周报（英文）)

年 卷 期：2020年第2卷第50期

页      面：955-961页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：supported by the Bill&Melinda Gates Foundation 

主　　题：doses epidemiology routine 

摘      要：Introduction:Poliomyelitis is a highly contagious,seasonal viral disease caused by any of three poliovirus(PV)serotypes(types 1,2,or 3).Oral poliovirus vaccine(OPV)on rare occasions causes vaccineassociated paralytic poliomyelitis(VAPP)in recipients of OPV and close contacts of recently vaccinated *** study describes the epidemiology of VAPP when an all OPV schedule was used in the Expanded Program on Immunization(EPI).Methods:VAPP cases were identified using standardized diagnostic criteria from data reported by 8 provincial-level administrative divisions(PLADs)to the National Acute Flaccid Paralysis(AFP)Surveillance System in an 18-month period between October 2012 and March ***:During this period,28 VAPP cases were *** the number of births as a denominator,the estimated incidence of VAPP was 2.47 cases per million *** the number of OPV doses administered through routine immunization,the VAPP incidence was 0.55 cases per million *** vaccine-recipient VAPP cases,22(85%)were associated with the first dose of OPV;3 were associated with the second OPV *** relative risk of VAPP following the first dose compared with the second dose was *** and Implications for Public Health Practice:The per-dose and per-child incidences of VAPP were consistent with incidence estimates by the World Health Organization(WHO).The vast majority(85%)of VAPP in China was associated with the first dose of OPV in an all-OPV *** inactivated polio vaccine(IPV)is known to prevent VAPP from subsequent doses of OPV in immunocompetent children,this association provided strong evidence for using an IPV-first,sequential IPVOPV polio vaccination schedule in China during the globally-synchronized cessation of type 2 OPV and introduction of IPV in 2016.