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Neuroscience Bulletin 2017年第3期33卷 354-356页

作者： Lu He linxi chen Lanfang Li Department of Neurosurgery First Affiliated HospitalUniversity of South China Institute of Pharmacy and Pharmacology Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study University of South China

Recently,Richter et al.[1]revealed the potential functions of the interaction between the serine/threonine kinase Tank-binding kinase 1（TBK1）and the autophagy receptor optineurin（OPTN）.The TBK1-OPTN axis targets damaged mitochondria for degradation via PINK1/parkin-mediated mitophagy[2,3].Indeed,TBK1 can phosphorylate OPTN at Ser177,Ser473,or Ser513 to enhance the binding capacity of OPTN with poly-ubiquitin（poly-UB）***,

关键词： mitochondria parkin chains phosphorylate ubiquitin Immune threonine Richter autophagy Axis

SUMOylation of Fragile X Mental Retardation Protein: A Critical Mechanism of FMRP-Mediated Neuronal Function

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Neuroscience Bulletin 2018年第6期34卷 1100-1102页

作者： Mingzhu Tang Liqun Lu Feng Xie linxi chen Institute of Pharmacy and Pharmacology Learning Key Laboratory for Pharmacoproteomics Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study University of South China

Recently, Khayachi et al.;showed that fragile X mental retardation protein （FMRP） is an active substrate of the small ubiquitin-like modifier （SUMO） pathway in *** SUMOylation is induced by the activation of metab... 详细信息

关键词： FXS AD In SUMOylation of Fragile X Mental Retardation Protein

Autophagy, a new target for disease treatment

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Science China(Life Sciences) 2013年第9期56卷 856-860页

作者： XIE Feng LI LanFang chen linxi Institute of Pharmacy and Pharmacology University of South China

Since Ashford and Porter first discovered that cells "eat themselves" in 1962, the process known as autophagy has generated intense interest in both biomedical research and clinical medicine. Autophagy is a regulated cellular pathway that transports damaged, modified or aging organelles and proteins to lysosomes/vacuoles for degradation.

关键词：自噬作用疾病治疗细胞器临床医学生物医学溶酶体蛋白质

Predicting sRNAs and Their Targets in Bacteria

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Genomics, Proteomics & Bioinformatics 2012年第5期10卷 276-284页

作者： Wuju Li Xiaomin Ying Qixuan Lu linxi chen Beiiing Institute of Basic Medical Sciences Beijing 100850China Institute of Pharmacy and Pharmacology University of South ChinaHengyang 421001China

Bacterial small RNAs （sRNAs） are an emerging class of regulatory RNAs of about 40-500 nucleotides in length and, by binding to their target mRNAs or proteins, get involved in many biological processes such as sensing environmental changes and regulating gene expres- sion. Thus, identification of bacterial sRNAs and their targets has become an important part of sRNA biology. Current strategies for discovery of sRNAs and their targets usually involve bioinformatics prediction followed by experimental validation, emphasizing a key role for bioinformatics prediction. Here, therefore, we provided an overview on prediction methods, focusing on the merits and limita- tions of each class of models. Finally, we will present our thinking on developing related bioinformafics models in future.

关键词： Bacterial sRNA Target Bioinformatics Prediction

Interleukin-27 decreases ghrelin production through signal transducer and activator of transcription 3—mechanistic target of rapamycin signaling

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Acta Pharmaceutica Sinica B 2020年第5期10卷 837-849页

作者： Heng Zhang Qingjie Li Yuxin Teng Yubi Lin Shaojian Li Tingfeng Qin linxi chen Jiana Huang Hening Zhai Quan Yu Geyang Xu Department of Physiology School of MedicineJinan UniversityGuangzhou 510632China Department of Cardiology and Cardiovascular Intervention Interventional Medical Centerthe Fifth Affiliated Hospital of Sun Yat-sen UniversityZhuhai 519000China Endoscopy Center the First Affiliated Hospital of Jinan UniversityGuangzhou 510630China Central Laboratory School of MedicineJinan UniversityGuangzhou 510632China

Interleukin-27(IL-27),a heterodimeric cytokine,plays a protective role in ***,a gastric hormone,provides a hunger signal to the central nervous system to stimulate food *** relationship between IL-27 and ghrelin is still *** we investigated that signal transducer and activator of transcription 3(STAT3)—mechanistic target of rapamycin(mTOR)signaling mediates the suppression of ghrelin induced by ***-localization of interleukin 27 receptor subunit alpha(WSX-1)and ghrelin was observed in mouse and human gastric *** injection of IL-27 markedly suppressed ghrelin synthesis and secretion while stimulating STAT3-mTOR signaling in both C57 BL/6 J mice and high-fat diet-induced-obese ***-27 inhibited the production of ghrelin in mHypoE-N42 *** of mTOR activity induced by mTOR siRNA or rapamycin blocked the suppression of ghrelin production induced by IL-27 in mHypoE-N42 *** 3 siRNA also abolished the inhibitory effect of IL-27 on ***-27 increased the interaction between STAT3 and mTOR in mHypoE-N42 *** conclusion,IL-27 suppresses ghrelin production through the STAT3-mTOR dependent mechanism.

关键词： IL-27 Ghrelin STAT3 mTOR Food intake

Apelin/APJ:a novel promising therapy target for pathological angiogenesis

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Apelin/APJ:a novel promising therapy target for pathological...

The Elabela/APJ pathway is essential for bone formation via limiting Sox32

2016年中国药学大会暨第十六届中国药师周

作者： Lele Wu linxi chen Lanfang Li Institute of Pharmacy and Pharmacology Hunan Province Cooperative Innovation Center for Molecular Target New Drug StudyLearning Key Laboratory for PharmacoproteomicsUniversity of South China

Apelin, which is the endogenous ligand of the orphan G protein-coupled receptor APJ, is isolated from bovine stomach. Both Apelin and APJ receptor are widely distributed in various tissues such as heart, brain, limbs, retina and liver. Recent researches indicate that the Apelin/APJ system plays an important role in pathological angiogenesis. Angiogenesis is a progress of new blood branches developing from preexisting vessels via sprouting. New blood branches supply blood and nutrient to damaged regions in various diseases. In this paper, we review the role of Apelin/APJ system in pathological angiogenesis. The Apelin/APJ system promotes angiogenesis in myocardial infarction, ischemic stroke, critical limb ischemia, tumor, retinal angiogenesis diseases, cirrhosis, obesity, diabetes and other related diseases. Furthermore, we illustrate the mechanism of pathological angiogenesis induced by Apelin/APJ system. In conclusion, the Apelin/APJ system would be a promising therapeutic target for angiogenesis-related diseases.

关键词： Apelin APJ angiogenesis-related diseases

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The Elabela/APJ pathway is essential for bone formation via ...

1,12-cyclic apelin-12 ameliorates Ang II and Apelin-13-induced cardiac hypertrophy by reducing mitochondrial oxidative damage

2016年中国药学大会暨第十六届中国药师周

作者： Liqun Lu Jiangang Cao Lanfang Li linxi chen Institute of Pharmacy and Pharmacology Hunan Province Cooperative Innovation Center for Molecular Target New Drug StudyLearning Key Laboratory for PharmacoproteomicsUniversity of South China

Elabela,a new endogenous ligand for APJ receptor,has been reported to play crucial roles in inducing cardiogenesis, facilitating vasculogenesis and regulating apoptosis during embryonic development. Furthermore, Elabela is also capable of enhancing cardiac contractility, promoting vasodilatory effects, mediating fluid homeostasis in the circulatory system and reducing food intake in the central nervous system. A recent research clarifies that the Elabela/APJ pathway limits Sox32 levels to up-regulate the proportion of Pou5 f3–Nanog complexes in ventrolateral endodermal cells, which may activate the BMP signaling to induce bone formation. Collectively, Elabela is biologically functional in both embryos and adult organisms. Therefore,Elabela may serve as a potential therapeutic peptide for dysontogenesis, cardiac repair/regeneration, blood-pressure control and kidney diseases.

关键词： Elabela APJ receptor Sox32 bone formation cardiovascular function

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Chinese Medical Journal 2024年第6期137卷 749-751页

作者： Xueqian Ouyang Wei chen Guolong Peng Huimei Liu Sisi Fan Qin Li Liwen Wang linxi chen Lanfang Li The Institute of Pharmacy and Pharmacology Hunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug ResearchUniversity of South ChinaHengyangHunan 421001China

To the Editor:Pathological cardiac hypertrophy is commonly stimulated by stress or induced by cardiovascular diseases,such as hypertension and myocardial infarction.A sustained pathological hypertrophic response can lead to declines in diastolic and systolic functions and eventually develop heart *** II(Ang II)can mediate cardiac hypertrophy through the angiotensin II type 1 receptor(AT1R).^([1])

关键词： hypertrophy cardiac Ang

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媒体融合的本质与驱动范式的选择

现代出版 2021年第4期 39-47页

作者：龙小农陈林茜中国传媒大学传播研究院中国传媒大学国家传播创新研究中心

媒介与社会一体同构,人机共生、人机共存,既是科技和符号发展逻辑驱动下媒体融合的最终形态和本质,也是完善国家治理体系、实现治理能力现代化的必然要求。媒介形态演进历程表明,媒介技术创新与符号演变是媒介融合的直接驱动力,媒体融... 详细信息

媒介与社会一体同构,人机共生、人机共存,既是科技和符号发展逻辑驱动下媒体融合的最终形态和本质,也是完善国家治理体系、实现治理能力现代化的必然要求。媒介形态演进历程表明,媒介技术创新与符号演变是媒介融合的直接驱动力,媒体融合则是媒介形态演进的必然进路,并具有不同的文化语境和制度色彩。基于对媒体融合态势及本质的不同认知,在媒体体制相异的国家,媒体融合发展的驱动范式亦不同。在媒体私有为主的国家,媒体融合一般选择市场驱动范式;在媒体国有为主的国家,媒体融合一般选择国家驱动范式。

关键词：媒体融合技术创新符号演变驱动范式媒体体制

Pannexin1-P2X7 signal pathway mediated apelin subtypesinduced thrombosis in vitro

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Pannexin1-P2X7 signal pathway mediated apelin subtypesinduce...