1,12-cyclic apelin-12 ameliorates Ang II and Apelin-13-induced cardiac hypertrophy by reducing mitochondrial oxidative damage

作     者：Xueqian Ouyang Wei Chen Guolong Peng Huimei Liu Sisi Fan Qin Li Liwen Wang Linxi Chen Lanfang Li Xueqian Ouyang;Wei Chen;Guolong Peng;Huimei Liu;Sisi Fan;Qin Li;Liwen Wang;Linxi Chen;Lanfang Li

作者机构：The Institute of Pharmacy and PharmacologyHunan Provincial Key Laboratory of Tumor Microenvironment Responsive Drug ResearchUniversity of South ChinaHengyangHunan 421001China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2024年第137卷第6期

页      面：749-751页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：supported by grants from the National Natural Science Foundation of China(No.81970431) the Hunan Provincial Natural Science Foundation of China(No.2023JJ50136) 

主　　题：hypertrophy cardiac Ang 

摘      要：To the Editor:Pathological cardiac hypertrophy is commonly stimulated by stress or induced by cardiovascular diseases,such as hypertension and myocardial infarction.A sustained pathological hypertrophic response can lead to declines in diastolic and systolic functions and eventually develop heart *** II(Ang II)can mediate cardiac hypertrophy through the angiotensin II type 1 receptor(AT1R).^([1])