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Labdane Diterpenoids from Coleus forskohlii （Willd.） Briq.

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Journal of Integrative Plant Biology 2006年第4期48卷 478-481页

作者： ling-ling Xu ling-yi kong Department of Natural Medicinal Chemistry China Pharmaceutical University Nanjing 210009 China

in order to investigate the active substances of Coleus forskohlii（Wiiid.） Brlq., a new labdane dlterpenold, 12- hydroxy-8,*** acid, together with two 8,13-epoxylabd-14-ene-11-one dlterpenolds, 6-acetyl-1- deoxyforskolln and 6-acetyl-1,9-dldeoxyforskolln, was Isolated on the basis of various chromatographic technlques and spectroscopic methods.

关键词： 6-acetyl-1-deoxyforskolin 6-acetyl-1 ,9-dideoxyforskolin Coleus forskohlii 12-hydroxy-8,13E-labdadien-15-oic acid labdane diterpenoid.

Synthesis of 2-aryl-5-alkyl-7-methoxylbenzo[b]furan derivatives

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Chinese Chemical Letters 2007年第4期18卷 380-382页

作者： Xue Fei Yang ling yi kong Department of Natural Medicinal Chemistry China Pharmaceutical University Nanjing 210009 China

A series of 2-aryl-5-alkyl-7-methoxylbenzo[b]furan derivatives have been synthesized by utilizing the coupling of methyl 3- methoxy-4hydroxy-5-bromocinnamate with cuprous phenylacetylide as the key step. The structures of the new compounds were confirmed by 1H NMR, IR and MS. The structure of compound 14 was further confirmed by single crystal X-ray. Compound 17 showed cytotoxic activity against human lung carcinoma A549.

关键词： 2-Aryl-5-alkyl-7-methoxylbenzo[b]furan Neolignans Synthesis Cytotoxicity

Sebiferone,a New Triterpenoid from Stem Bark of Sapium sebiferum (L.)Roxb.

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Chinese Chemical Letters 2002年第11期13卷 1079-1082页

作者： Run Hui LIU ling yi kong Department of Natural Medicinal Chemistry China Pharmaceutical UniversityNanjing 210038

From the stem bark of Sapium sebiferum a new triterpenoid, named sebiferone (1), was isolated. The structure of the new compound was elucidated as 3β-acetoxy-D-friedoolen-14-en -1-one-28-oic acid on the basis of spe... 详细信息

关键词： Sapium sebiferum Euphorbiaceae sebiferone.

METTL5 promotes cell proliferation,invasion,and migration by up-regulating Toll-like receptor 8 expression in colorectal cancer

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World Journal of Gastrointestinal Oncology 2024年第5期16卷 2006-2017页

作者： ling-Shang kong Ran Tao yi-Fan Li Wen-Bin Wang Xue Zhao Department of General Surgery The Second Affiliated Hospital of Anhui Medical UniversityHefei 230001Anhui ProvinceChina Department of Vascular Surgery The Second Affiliated Hospital of Anhui Medical UniversityHefei 230002Anhui ProvinceChina Department of General Surgery The First Affiliated Hospital of Anhui Medical UniversityHefei 230001Anhui ProvinceChina Anhui Public Health Clinical Center Hefei 230012Anhui ProvinceChina Department of Scientific Research Anhui Public Health Clinical CenterHefei 230012Anhui ProvinceChina Department of Scientific Research The First Affiliated Hospital of Anhui Medical UniversityHefei 230001Anhui ProvinceChina

BACKGROUND N6-methyladenosine(m6A)modification represents the predominant alteration found in eukaryotic messenger RNA and plays a crucial role in the progression of various ***,despite its significance,the comprehensive investigation of METTL5,a key m6A methyltransferase,in colorectal cancer(CRC)remains *** To investigate the role of METTL5 in *** We assessed METTL5 expression levels in clinical samples obtained from CRC patients as well as in CRC cell *** elucidate the downstream targets of METTL5,we performed RNA-sequencing analysis coupled with correlation analysis,leading us to identify Toll-like receptor 8(TLR8)as a potential downstream *** vitro functional assessments of METTL5 and TLR8 were conducted using CCK-8 assays,scratch assays,as well as assays measuring cell migration and *** Our findings reveal a pronounced upregulation of METTL5 expression in both CRC cells and tissues,which correlated significantly with an unfavorable *** vitro experiments unequivocally demonstrated the oncogenic role of METTL5,as evidenced by its promotion of CRC cell proliferation,invasion,and ***,we identified TLR8 as a downstream target of METTL5,and subsequent down-regulation of TLR8 led to a significant inhibition of CRC cell proliferation,invasion,and tumor *** The heightened expression of METTL5 in CRC is strongly associated with clinicopathological features and a poor prognosis,thereby underscoring its potential utility as a critical marker for facilitating early diagnosis and prognostication in CRC.

关键词： METTL5 Toll-like receptor 8 Colorectal cancer

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Light(Science & Applications) 2024年第2期13卷 333-346页

作者： yifan Sun Qian Li ling-Jun kong Xiangdong Zhang Key Laboratory of advanced optoelectronic quantum architecture and measurements of Ministry of Education Beijing Key Laboratory of Nanophotonics&Ultrafine Optoelectronic SystemsSchool of PhysicsBeijing Institute of Technology100081BeijingChina

Compared with electrical neural networks,optical neural networks(ONNs)have the potentials to break the limit of the bandwidth and reduce the consumption of energy,and therefore draw much attention in recent *** far,several types of ONNs have been ***,the current ONNs cannot realize the acceleration as powerful as that indicated by the models like quantum neural *** to construct and realize an ONN with the quantum speedup is a huge ***,we propose theoretically and demonstrate experimentally a new type of optical convolutional neural network by introducing the optical *** is called the correlated optical convolutional neural network(COCNN).We show that the COCNN can exhibit“quantum speedup”in the training *** character is verified from the two *** is the direct illustration of the faster convergence by comparing the loss function curves of the COCNN with that of the traditional convolutional neural network(CNN).Such a result is compatible with the training performance of the recently proposed quantum convolutional neural network(QCNN).The other is the demonstration of the COCNN’s capability to perform the QCNN phase recognition circuit,validating the connection between the COCNN and the ***,we take the COCNN analog to the 3-qubit QCNN phase recognition circuit as an example and perform an experiment to show the soundness and the feasibility of *** results perfectly match the theoretical *** proposal opens up a new avenue for realizing the ONNs with the quantum speedup,which will benefit the information processing in the era of big data.

关键词： process quantum convolution

Electrolyte effect on electrochemical behaviors of manganese fluoride material for aqueous asymmetric and symmetric supercapacitors

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Rare Metals 2024年第3期43卷 1048-1061页

作者： Zheng-Hua He Jian-Fei Gao ling-Bin kong State Key Laboratory of Advanced Processing and Recycling of Non-Ferrous Metals Lanzhou University of TechnologyLanzhou730050China School of Materials Science and Engineering Lanzhou University of TechnologyLanzhou730050China

Exploring wide voltage window materials is not only an available measure to enhance the energy density of hybrid supercapacitor(HSCs),but also avoids the dynamic mismatch caused by different energy storage mechanisms of two electrodes in assembled symmetrical ***,there are few reports about the wide potential window materials except Bi_(2)O_(3)and VO_(2).Therefore,the MnF_(2)synthesized by solvothermal reaction was served as the electrode for *** MnF_(2)exhibited electrochemical activity in alkaline solution in three-electrode system,especially with a wide potential window from-0.8 to+0.5 V in 2 mol·L^(-1)***,the assembled MnF_(2)//MnF_(2)symmetrical HSC had a potential window of 1.5 V,and it exhibited outstanding long-cycle ***,when MnF_(2)was taken as the negative and positive respectively,the potential windows of asymmetric devices CoMoO_(4)//MnF_(2)and MnF_(2)//Activated Carbon(AC)could reach 1.3 and 1.45 V,respectively,showing excellent cycle *** work shows that MnF_(2)material has great research value in HSC,and provides a new research direction for developing high-performance devices.

关键词： Manganese fluoride Potential window Hybrid supercapacitors Electrochemical performance

Steroids from the Roots of Asparagus officinalis and Their Cytotoxic Activity

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Journal of Integrative Plant Biology 2008年第6期50卷 717-722页

作者： Xue-Feng Huang Yu-ying Lin ling-yi kong Department of Natural Medicinal Chemistry China Pharmaceutical University Nanjing 210009 China

One new （Sarsasapogenin O） and seven known steroids were isolated from the roots of Asparagus offlcinalis L. Their structures were elucidated on the basis of spectroscopic analysis, including various 2D-NMR techniques, hydrolysis, and by comparison of spectral data of known compounds. These compounds together with nine steroids which were previously isolated from this plant, were tested for cytotoxic activity. Among them, eight compounds displayed significant cytotoxiciUes against human A2780, HO-8910, Eca-109, MGC-803, CNE, LTEP-a-2, KB and mouse L1210 tumor cells.

关键词： Asparagus officinalis cytotoxic activity Sarsasapogenin O steroid

Biotransformation of 4-Hydroxybenzen Derivatives by Hairy Root Cultures of Polygonum multiflorum Thunb

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Journal of Integrative Plant Biology 2007年第2期49卷 207-212页

作者： Chun-Yan Yan Rong-Min Yu Zhang Zhang ling-yi kong Department of Natural Medicinal Chemistry College of Traditional Chinese Medicines China Pharmaceutical University Nanjing 210038 China Department of Natural Medicinal Chemistry and Pharmacognosy College of Pharmacy Jinan University Guangzhou 510632 China

The biotransformation of four 4-hydroxybenzen derivatives （1,4-benzenediol （compound 1）, 4-hydroxybenzaldehyde （compound 2）, 4-hydroxybenzyl alcohol （compound 3） and 4-hydroxybenzoic acid （compound 4）） by the hairy root cultures of Polygonum multiflorum Thunb. as a new biocatalyst was investigated. It was found that the substrates were transformed to their corresponding glucosides, 4-hydroxyphenyl β-D-glucopyranoside （arbutin, compound la）, 4-hydroxymethylphenyl β-D-glucopyranoside （gastrodin, compounds 2a, 3a） and 4-carboxyphenyl α-D- glucopyranoside （compound 4a）, respectively. In the meantime, the hairy roots of P. multiflorum were able to stereoselectively and regioselectively glucosylate phenolic hydroxyl groups of compounds 1-4, but the cultures could not glucosylate the aldehyde group of compound 2 or the benzyllc hydroxyl group of compound 3, and no glucosyl esterification of carboxyl groups of compound 4 was detected. On the other hand, the result also showed that the hairy roots of P. multiflorum were able to reduce the 4-hydroxybenzaldehyde to its corresponding alcohol. This is the first report that substrate 4 has been converted into its α-D-glucopyranoside by a plant biotransformα- tion system.

关键词： 4-hydroxybenzen derivatives arbutin biotransformation gastrodin hairy root cultures Polygonum multiflorum.

New black-to-white hole solutions with improved geometry and energy conditions

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Science China(Physics,Mechanics & Astronomy) 2024年第7期67卷 30-43页

作者： Zhongwen Feng yi ling Xiaoning Wu Qingquan Jiang School of Physics and Astronomy China West Normal UniversityNanchong 637009China Institute of High Energy Physics Chinese Academy of SciencesBeijing 100049China School of Physics University of Chinese Academy of SciencesBeijing 100049China Institute of Mathematics Academy of Mathematics and System Science and Hua Loo-Keng Key Laboratory of MathematicsChinese Academy of SciencesBeijing 100190China School of Mathematical Sciences University of Chinese Academy of SciencesBeijing 100190China

We construct new black-to-white hole solutions which connect the geometry of spacetime at some gluing surface inside the *** continuity of the metric can be guaranteed up to the arbitrary order which is controlled by the power factor *** sort of black-to-white holes is characterized by the sub-Planckian scalar curvature,independent of the mass of black-to-white *** importantly,we show that the energy condition is only violated within a small region near the gluing *** geodesics of particles within the region from black hole to white hole is also *** turns out that the matter falling into the black hole may pass through the center without singularity and come out from the white *** scenario provides novel ideas for understanding the information loss paradox in traditional black hole physics.

关键词： regular black hole energy condition singularity quantum gravity