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强化有限元的考虑界面滑移的组合梁数值模拟

工程力学 2015年第8期32卷 129-140页

作者：林建平汪劲丰徐荣桥凌道盛浙江大学土木工程系浙江杭州310058

该文针对组合梁结构连接界面的非线性效应,采用物理区域与单元网格相独立的策略,并引入无厚度界面单元模拟界面的非连续变形,建立了基于强化有限元的考虑界面滑移的组合梁分析模型。该文所采用的物理区域与单元网格相独立的强化有限元,... 详细信息

该文针对组合梁结构连接界面的非线性效应,采用物理区域与单元网格相独立的策略,并引入无厚度界面单元模拟界面的非连续变形,建立了基于强化有限元的考虑界面滑移的组合梁分析模型。该文所采用的物理区域与单元网格相独立的强化有限元,数学单元和物理单元在空间上重合不再是必要条件,可以根据物理单元力学描述的需要选择数学单元的大小和形状。同时一个单元内可以分成多个区域,各分区可以是不同的材料,可以具有不同的几何形状,可以具有不同的受力特点,如板、梁等,从而可以大大减少复杂结构的网格数量。该文方法可以快速便捷得到剪切连接件抗剪刚度从零变化到无穷大时所对应的挠度、界面滑移以及截面应力的变化,可以直观地确定出抗剪刚度能够充分发挥作用的区间,为实际工程设计中确定经济合理的抗剪刚度提供依据。该文方法计算效率高,可以适用于实际工程复杂变截面及空间结构的计算分析,尤其是规模庞大、受力分析繁琐的桥梁结构。

关键词：组合梁部分抗剪连接界面滑移界面单元强化有限元

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粉砂地基深基坑工程土体渗透破坏机理及其影响研究

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岩土力学 2008年第11期29卷 2967-2972页

作者：胡琦凌道盛陈仁朋陈云敏贾官伟浙江大学软弱土与环境土工教育部重点实验室杭州310027

在砂土和粉土地区,渗透破坏是威胁基坑稳定性和周围环境的主要因素。基坑工程是由土、水以及围护结构组成的一个复杂系统,影响基坑工程渗透破坏的因素很多。在总结前人对土体渗透破坏与基坑工程渗透破坏模式的研究基础上,结合渗流对土... 详细信息

在砂土和粉土地区,渗透破坏是威胁基坑稳定性和周围环境的主要因素。基坑工程是由土、水以及围护结构组成的一个复杂系统,影响基坑工程渗透破坏的因素很多。在总结前人对土体渗透破坏与基坑工程渗透破坏模式的研究基础上,结合渗流对土体性质影响的试验成果,提出了考虑渗流、开挖卸荷以及围护结构变形共同作用的基坑工程渗透破坏分析方法,并分析了均质地基基坑工程的渗透破坏模式。将该方法运用于某粉砂地基基坑渗透破坏工程实例,通过有限元数值模拟,揭示了渗透破坏过程及其对围护结构的影响。通过对该基坑工程实例的分析认为,在进行基坑工程设计时不仅需要进行防止流砂、管涌等验算,还需考虑基坑工程整体破坏的可能性。

关键词：渗漏渗透破坏临界水力坡降应力路径试验

CsABF3-activated CsSUT1 pathway is implicated in pre-harvest water deficit inducing sucrose accumulation in citrus fruit

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Horticultural Plant Journal 2024年第1期10卷 103-114页

作者： Xiaochuan Ma Yuanyuan Chang Feifei Li Junfeng Yang Li Ye Tie Zhou Yan Jin ling sheng Xiaopeng Lu College of Horticulture Hunan Agricultural UniversityChangshaHunan 410128China National Center for Citrus Improvement ChangshaHunan 410128China Institute of Horticulture Hunan Academy of Agricultural ScienceChangshaHunan 410125China

Pre-harvest water deficit(PHWD)plays an important role in sugar accumulation of citrus ***,the mechanism is not known ***,it was confirmed that PHWD promoted sucrose accumulation of citrus fruit,but had limited effect on fructose,glucose and total acid.A sucrose transporter,Cs SUT1,which localizes to the plasma membrane,was demonstrated to function in sucrose transport induced by *** to wild-type,Cs SUT1 overexpression in citrus calli stimulated sucrose,fructose and glucose accumulation,while its silencing in juice sacs reduced sucrose *** sugar accumulation in transgenic lines enhanced plant drought tolerance,and resulted in decreased electrolyte leakage,malondialdehyde and hydrogen peroxide contents,as well as increased superoxide dismutase activity and proline *** abscisic acid(ABA)-responsive transcription factor,Cs ABF3,was found with a same expression pattern with Cs SUT1 under *** one-hybrid,electrophoretic mobility shift assay and dual-luciferase assays all revealed that Cs ABF3 directly bound with the Cs SUT1 promoter by ABA responsive *** Cs ABF3 was overexpressed in citrus calli,the sucrose,fructose and glucose concentration increased ***,transgenic studies demonstrated that Cs ABF3 could affect sucrose accumulation by regulating Cs ***,this study revealed a regulation of Cs ABF3 promoting Cs SUT1 expression and sucrose accumulation in response to *** results provide a detail insight into the quality formation of citrus fruit.

关键词： Citrus Water deficit Pre-harvest Sucrose CsABF3 CsSUT1

Lipid metabolism-related long noncoding RNA RP11-817I4.1 promotes fatty acid synthesis and tumor progression in hepatocellular carcinoma

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World Journal of Gastroenterology 2024年第8期30卷 919-942页

作者： Ren-Yong Wang Jia-ling Yang Ning Xu Jia Xu Shao-Hua Yang dao-Ming Liang Jin-Ze Li Hong Zhu Second Affiliated Hospital of Kunming Medical University Kunming 650106Yunnan ProvinceChina School of Basic Medical Sciences Nanjing Medical UniversityNanjing 211166Jiangsu ProvinceChina Wuhan Blood Center Wuhan 430030Hubei ProvinceChina Department of Gastrointestinal Surgery The Third People's Hospital of Hubei ProvinceWuhan 430071Hubei ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)is one of the most common types of *** influence of lipid metabolism disruption on the development of HCC has been demonstrated in published *** To establish an HCC prognostic model for lipid metabolism-related long non-coding RNAs(LMR-lncRNAs)and conduct in-depth research on the specific role of novel LMR-lncRNAs in *** Correlation and differential expression analyses of The Cancer Genome Atlas data were used to identify differentially expressed *** real-time polymerase chain reaction analysis was used to evaluate the expression of *** red staining was employed to observe intracellular lipid *** interaction between RP11-817I4.1,miR-3120-3p,and ATP citrate lyase(ACLY)was validated through the performance of dual-luciferase reporter gene and RIP *** Three LMR-lncRNAs(negative regulator of antiviral response,RNA transmembrane and coiled-coil domain family 1 antisense RNA 1,and RP11-817I4.1)were identified as predictive markers for HCC patients and were utilized in the construction of risk ***,proliferation,migration,and invasion were reduced by RP11-817I4.1 *** increase in lipid levels in HCC cells was significantly induced by RP11-817I4.1 through the miR-3120-3p/ACLY *** LMR-lncRNAs have the capacity to predict the clinical characteristics and prognoses of HCC patients,and the discovery of a novel LMR-lncRNAs,RP11-817I4.1,revealed its role in promoting lipid accumulation,thereby accelerating the onset and progression of HCC.

关键词： Hepatocellular carcinoma Lipid metabolism Immune microenvironment Prognostic markers Metabolic reprogramming

Mitochondrial dysfunction affects hepatic immune and metabolic remodeling in patients with hepatitis B virus-related acute-onchronic liver failure

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World Journal of Gastroenterology 2024年第8期30卷 881-900页

作者： Yu Zhang Xiao-ling Tian Jie-Qun Li Dong-sheng Wu Qiang Li Bin Chen Department of Hepatology Institute of HepatologyThe First Affiliated Hospital of Hunan University of Chinese MedicineChangsha 410021Hunan ProvinceChina Department of Liver Transplant Transplant Medical Research CenterThe Second Xiangya Hospital of Central South UniversityChangsha 410011Hunan ProvinceChina Department of Surgery The First Affiliated Hospital of Hunan University of Chinese MedicineChangsha 410021Hunan ProvinceChina

BACKGROUND Immune dysregulation and metabolic derangement have been recognized as key factors that contribute to the progression of hepatitis B virus(HBV)-related acute-on-chronic liver failure(ACLF).However,the mechanisms underlying immune and metabolic derangement in patients with advanced HBV-ACLF are *** To identify the bioenergetic alterations in the liver of patients with HBV-ACLF causing hepatic immune dysregulation and metabolic *** Liver samples were collected from 16 healthy donors(HDs)and 17 advanced HBV-ACLF patients who were eligible for liver *** mitochondrial ultrastructure,metabolic characteristics,and immune microenvironment of the liver were *** focus was given to organic acid metabolism as well as the function and subpopulations of macrophages in patients with *** Compared with HDs,there was extensive hepatocyte necrosis,immune cell infiltration,and ductular reaction in patients with *** patients,the liver suffered severe hypoxia,as evidenced by increased expression of hypoxia-inducible factor-1α.Swollen mitochondria and cristae were observed in the liver of *** number,length,width,and area of mitochondria were adaptively increased in *** metabolomics analysis revealed that mitochondrial oxidative phosphorylation decreased,while anaerobic glycolysis was enhanced in patients with *** findings suggested that,to a greater extent,hepa-tocytes used the extra-mitochondrial glycolytic pathway as an energy *** with HBV-ACLF had elevated levels of chemokine C-C motif ligand 2 in the liver homogenate,which stimulates peripheral monocyte infiltration into the *** and functional analysis of macrophage subsets revealed that patients with ACLF had a high abundance of CD68^(+)HLA-DR^(+)macrophages and elevated levels of both interleukin-1βand transforming growth factor-β1 in their *** abundance of CD206^(+)CD163^(+)macrophag

关键词： Acute-on-chronic liver failure Hypoxia-inducible factor-1α Mitochondria Metabolic phenotype Immune cells

Xuebijing improves intestinal microcirculation dysfunction in septic rats by regulating the VEGF-A/PI3K/Akt signaling pathway

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World Journal of Emergency Medicine 2024年第3期15卷 206-213页

作者： A-ling Tang Yan Li Li-chao Sun Xiao-yu Liu Nan Gao sheng-tao Yan Guo-qiang Zhang Department of Emergency China-Japan Friendship HospitalBeijing 100029China Graduate School Beijing University of Chinese MedicineBeijing 100105China

BACKGROUND:This study aims to explore whether Xuebijing(XBJ) can improve intestinal microcirculation dysfunction in sepsis and its ***:A rat model of sepsis was established by cecal ligation and puncture(CLP).A total of 30 male SD rats were divided into four groups:sham group,CLP group,XBJ + axitinib group,and XBJ *** was intraperitoneally injected 2 h before *** data(blood pressure and heart rate) were *** intestinal microcirculation data of the rats were analyzed via microcirculation ***-linked immunosorbent assay(ELISA) kits were used to detect the serum levels of interleukin-6(IL-6),C-reactive protein(CRP),and tumor necrosis factor-α(TNF-α) in the *** analysis and transmission electron microscopy were used to analyze the injury of small intestinal microvascular endothelial cells and small intestinal mucosa in *** expression of vascular endothelial growth factor A(VEGF-A),phosphoinositide 3-kinase(PI3K),phosphorylated PI3K(p-PI3K),protein kinase B(Akt),and phosphorylated Akt(p-Akt) in the small intestine was analyzed via Western ***:XBJ improved intestinal microcirculation dysfunction in septic rats,alleviated the injury of small intestinal microvascular endothelial cells and small intestinal mucosa,and reduced the systemic inflammatory ***,XBJ upregulated the expression of VEGF-A,p-PI3K/total PI3K,and p-Akt/total Akt in the rat small ***:XBJ may improve intestinal microcirculation dysfunction in septic rats possibly through the VEGF-A/PI3K/Akt signaling pathway.

关键词： Sepsis Xuebijing Vascular endothelial growth factor A Microcirculation Rat Phosphoinositide 3-kinase Protein kinase B

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模拟月壤中着陆器足垫滑移受力的试验研究

岩土力学 2013年第7期34卷 1847-1853页

作者：凌道盛蒋祝金蔡武军钟世英杨建中浙江大学软弱土与环境土工教育部重点实验室杭州310058 浙江大学岩土工程研究所杭州310058 上海市政工程设计研究总院(集团)有限公司上海200092 中国空间技术研究院总体部北京100094

月面着陆器着陆过程中巨大的冲击作用会影响着陆安全和精密仪器的正常工作,因此,研究着陆器足垫与月壤相互作用对着陆器软着陆具有重要意义。足垫的水平滑移是着陆过程中较为复杂的阶段,利用自行研制的水平拖曳模型试验装置,在模拟月壤... 详细信息

月面着陆器着陆过程中巨大的冲击作用会影响着陆安全和精密仪器的正常工作,因此,研究着陆器足垫与月壤相互作用对着陆器软着陆具有重要意义。足垫的水平滑移是着陆过程中较为复杂的阶段,利用自行研制的水平拖曳模型试验装置,在模拟月壤中开展足垫水平滑移的模型试验,研究滑移过程中足垫水平力和竖向轴力的变化,并进一步探讨模拟月壤的相对密实度、足垫的水平速度、刺入深度和转动角度等4个因素对足垫水平力和竖向轴力的影响。试验结果表明:足垫所受到的水平力与竖向轴力呈近似线性关系,当足垫受较大的水平力时,相应的竖向轴力也较大;足垫受力随相对密实度、水平速度和刺入深度的增加而增大;足垫的转动角度对其受力影响显著,当足垫的转动角度为(8°,26°)时,足垫所受到的竖向轴力和水平力最小,当转动角度为(0°,-26°)时,足垫的受力最大,在滑移过程中该角度姿态利于着陆器的缓冲机构对能量的耗散。

关键词：模拟月壤着陆器足垫着陆过程水平滑移模型试验

Application of nanoscale metal–organic frameworks in tumor immunotherapy

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Rare Metals 2024年第10期43卷 4867-4883页

作者： Xiao-Xuan Zeng Jing-sheng Lu Dong-Wei Ma Yu-Ting Huang ling Chen Gang Wang Qing Chen Ning Lin College of Pharmacy Guangxi Scientific Research Center of Traditional Chinese MedicineGuangxi University of Chinese Medicine Guangxi Zhuang Yao Medicine Center of Engineering and Technology

Immunotherapy has attracted wide attention because it can not only kill tumor cells but also effectively prevent tumor recurrence. However, due to the poor efficacy of the monotherapy in tumor immunotherapy, combination therapies are needed to enhance their efficacy,such as chemodynamic therapy/immunotherapy, photodynamic therapy/immunotherapy, sonodynamic therapy/immunotherapy and so on. Nanoscale metal–organic frameworks(nMOFs) are widely used for drug delivery because of their rich and variable composition, high drug loading capacity and good biodegradability. Compared with other conventional drug delivery systems(DDSs),nMOFs play more advantageous role in inducing immune cell death of tumor cells and combination therapies. This article focuses on the application of n MOFs in tumor immunotherapy in terms of their use as gatekeepers, supplementary agents and drug carriers, respectively, with the aim of providing some ideas and references for the design of smart nanoscale DDS for tumor immunotherapy.

关键词： Drug delivery system Immunotherapy Metal–organic frameworks Tumor

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离心模型试验物质运动非惯性系效应

岩土工程学报 2021年第2期43卷 226-235页

作者：凌道盛施昌宇郑建靖赵宇陈云敏浙江大学建筑工程学院岩土工程研究所浙江杭州310058 浙江大学超重力研究中心浙江杭州310058

离心机作为岩土工程学科开展缩尺模型试验的主要装置,随着试验能力的不断提高,在涉及物质高速运动的爆炸、滑坡等方面的应用越来越广泛。首先,严格地推导了运动坐标系中物质运动加速度的一般表达式。其次,针对匀速转动的离心机,基于New... 详细信息

离心机作为岩土工程学科开展缩尺模型试验的主要装置,随着试验能力的不断提高,在涉及物质高速运动的爆炸、滑坡等方面的应用越来越广泛。首先,严格地推导了运动坐标系中物质运动加速度的一般表达式。其次,针对匀速转动的离心机,基于Newton第二定律建立了质点在模型箱中运动的控制方程,获得了自由质点相对运动的解析解,指出控制质点相对运动的均匀离心力、非均匀离心力和科氏力的本质为非惯性系运动导致的质点"惯性"作用,称为非惯性系作用。在此基础上,研究了3种非惯性系作用引起的质点相对运动的非惯性系效应,定量分析了初始坐标、初始速度等影响因素的敏感性。分析表明,3种非惯性系作用以不同方式改变质点控制方程性态,耦合作用导致常规模型试验相似律对运动物质不能精确成立;科氏力对非惯性系效应的影响一般大于非均匀离心力;自由运动质点的非惯性系效应显著,但平行于离心机转轴方向的质点运动分量不受非惯性系效应影响。

关键词：离心模型试验非惯性系相对运动科氏力