Application of nanoscale metal-organic frameworks in tumor immunotherapy

作     者：Xiao-Xuan Zeng Jing-Sheng Lu Dong-Wei Ma Yu-Ting Huang Ling Chen Gang Wang Qing Chen Ning Lin Xiao-Xuan Zeng;Jing-Sheng Lu;Dong-Wei Ma;Yu-Ting Huang;Ling Chen;Gang Wang;Qing Chen;Ning Lin

作者机构：College of PharmacyGuangxi Scientific Research Center of Traditional Chinese MedicineGuangxi University of Chinese MedicineNanning 530200China Guangxi Zhuang Yao Medicine Center of Engineering and TechnologyNanning 530200China 

出 版 物：《Rare Metals》 (稀有金属（英文版）)

年 卷 期：2024年第43卷第10期

页      面：4867-4883页

核心收录：

学科分类：1002[医学-临床医学] 07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 100214[医学-肿瘤学] 0702[理学-物理学] 10[医学] 

基　　金：financially supported by the National Natural Science Foundation of China(No.21861009) the Thousands of Young and Middle-aged Backbone Teachers Training Project of Guangxi Colleges and Universities(No.Gui-Jiao 2020-58) Guangxi University of Traditional Chinese Medicine"Qihuang Project"High-level Talent Team Cultivation Programme(202408) the Gui Style Xinglin Top Talent Funding Project of Guangxi University of Chinese Medicine(Nos.2022C014 and 2022C005) the Innovation Project of Guangxi Graduate Education(Nos.YCSW2022342 and YCSW2023401) 

主　　题：Metal–organic frameworks Tumor Immunotherapy Drug delivery system 

摘      要：Immunotherapy has attracted wide attention because it can not only kill tumor cells but also effectively prevent tumor ***,due to the poor efficacy of the monotherapy in tumor immunotherapy,combination therapies are needed to enhance their efficacy,such as chemodynamic therapy/immunotherapy,photodynamic therapy/immunotherapy,sonodynamic therapy/immunotherapy and so *** metal-organic frameworks(nMOFs)are widely used for drug delivery because of their rich and variable composition,high drug loading capacity and good *** with other conventional drug delivery systems(DDSs),nMOFs play more advantageous role in inducing immune cell death of tumor cells and combination *** article focuses on the application of n MOFs in tumor immunotherapy in terms of their use as gatekeepers,supplementary agents and drug carriers,respectively,with the aim of providing some ideas and references for the design of smart nanoscale DDS for tumor immunotherapy.