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Optical redox imaging of ANT1-de-cient muscles

Journal of Innovative Optical Health Sciences 2024年第1期17卷 135-140页

作者： He N.Xu Ryan M.Morrow Min Feng Huaqing zhao Douglas Wallace lin z.li Britton Chance Laboratory of Redox Imaging Department of Radiology Perelman School of Medicine University of Pennsylvania PhiladelphiaPA 19104USA Center for Mitochondrial and Epigenomic Medicine Children's Hospital of Philadelphia Research Institute Philadelphia PA 19104USA Center for Biostatistics and Epidemiology Lewis Katz School of Medicine at Temple University Philadelphia PA 19140USA

Adenine nucleotide translocator(ANT)is a mitochondrial protein involved in the exchange of ADP and ATP across the mitochondrial inner *** plays a crucial role in cellular energy metabolism by facilitating the transport of ATP synthesized within the mitochondria to the *** isoform ANT1 predominately expresses in cardiac and skeletal *** or dysregulation in ANT1 have been implicated in various mitochondrial disorders and neuromuscular *** aimed to examine whether ANT1 deletion may affect mitochondrial redox state in our established ANT1-de-cient *** and quadriceps resected from age-matched wild type(WT)and ANT1-de-cient mice were snap-frozen in liquid *** Chance redox scanner was utilized to perform 3D optical redox *** sample underwent scanning across 3–5 *** averaging analysis showed no signi-cant differences in the redox indices(NADH,flavin adenine dinucleotide containing-flavoproteins Fp,and the redox ratio Fp/(NADH+Fp)between WT and ANT1-de-cient ***,quadriceps had higher Fp than hearts in both groups(p¼0:0004 and 0.01,respectively).Furthermore,the quadriceps were also more oxidized(a higher redox ratio)than hearts in WT group(p¼0:004).NADH levels were similar in all *** data suggest that under non-stressful physical condition,the ANT1-de-cient muscle cells were in the same mitochondrial state as WT ones and that the signi-cant difference in the mitochondrial redox state between quadriceps and hearts found in WT might be diminished in ANT1-de-cient *** imaging of muscles under physical stress can be conducted in future.

关键词： ANT1 redox ratio flavoproteins

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WORKING WITH AND LEARNING FROM BRIT

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Journal of Innovative Optical Health Sciences 2011年第4期4卷 479-482页

作者： lin z.li Molecular Imaging Lab Department of Radiology Britton Chance Lab of Redox Imaging Eldridge Reeves Johnson Research Foundation Department of Biochemistry and Biophysics Perelman School of MedicineUniversity of Pennsylvania PhiladelphiaPA 19014USA

I had been closely working with *** Chance from 2005-2010 on imaging mitochondrial redox state in cancer and stem cells.I had also learned much from him in daily work and personal *** I would like to share some of my memories and experiences including(1)Great science is not necessarily done with top-grade expensive instruments;(2)Brit was genuinely interested in and dedicated to science;(3)Brit's attention to detail and timely action;(4)Brit's open-mindedness;and(5)Brit being modest,appreciative,and caring for others.

关键词： Britton Chance mitochondria redox state cancer stem cell

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INTRODUCTION TO THE SPECIAL SECTION IN MEMORY OF DR. BRITTON CHANCE

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Journal of Innovative Optical Health Sciences 2011年第4期4卷 I0001-I0002页

作者： lin z.li ling FU Department of Biochemistry and Biophysics Molecular Imaging Lab Department of Radiology University of Pennsylvania PhiladelphiaPA19104USA Wuhan National Lab for Optoelectronics Huazhong University of Science and Technology Wuhan Hubei 430074China

Hanged on the wall outside the office of *** at the University of Pennsylvania is a thick plaque(4-1:5 feet)dedicated to *** by his students at his 90'th birthday,saying桃李天下(Tao li Tian Xia).This is a traditional... 详细信息

关键词： literal idiom outside

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Citation analysis of the scientific publications of Britton Chance in ISI citation indexes

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Journal of Innovative Optical Health Sciences 2014年第2期7卷 129-142页

作者： lin z.li Loet Leydesdorff Shoko Nioka Nannan Sun Eugene Garfield Departiment of Radiology PerelmanSchool of Medicine University of Penn.syluaninPhiladelphiaPA 19104USA Briton Chance Laboratory of Redoa Imaging Johnson Research FoundationDepartment of Biochemistryand BiophysicsPereiman School of Medicine University of Penn syluaniaPhiladelphiaPA 19104USA University of Amsterdam Amsterdam School of Communications Research(ASCoR) Netherlands Briton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan 430074P.R.China Inste for Scientific Informationo-Thomson Reuters Philadelphia PA 19180USA

Britton Chance was a pioneer in many scientifc fields such as enzymatic reaction kinetis,bioenergetics,metabolism,in vivo NMr,and *** an engineer,physical chemist,physicist,physiologist,biophysicist,biochemist,innovator and educator,he had worked indiversifed fields over extended periods bet ween 1926 until his death in 2010,at the age of *** to illustrate his scientific career and great impact on research from a new perspective,weemploy scientometric analysis tools to analyze the publications of Britton Chance with datadownloaded from the ISI Citation Indexes in April *** included articles,reviews andproceding papers but excluded meeting *** total,we obtained 1023 publication recordswith 1236 authors in 266 joumals with 17,114 citations from 1945 to *** show the annualpublications and citations that Britton Chance received from 1945 to 2013,and generate HistCitemaps on the basis of the global citations(GCS)and local(sel)citations(LCS)to show thecitation relationships among the top-30 publications of Britton *** and the development of physical methods to probe it appear to be the commecting thread of the lifelongresearch of Britton ***,we generate the joumal map and co-authorship maptoshow the broad scope of research topics and collaborators and the high impacts of the scientificoeuvre of Britton Chance ranging from physics,engineering,chemistry and biology to medicine.

关键词： Scientometric analysis impact Hist Cite citation tree metabolism mitochondria.

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Targeting epigenetic mechanisms in amyloid-β-mediated Alzheimer’s pathophysiology:unveiling therapeutic potential

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Neural Regeneration Research 2025年第1期20卷 54-66页

作者： Jennie z.li Nagendran Ramalingam Shaomin li Ann Romney Center for Neurologic Diseases Brigham and Women’s Hospital and Harvard Medical SchoolBostonMAUSA

Alzheimer’s disease is a prominent chronic neurodegenerative condition characterized by a gradual decline in memory leading to *** evidence suggests that Alzheimer’s disease is associated with accumulating various amyloid-βoligomers in the brain,influenced by complex genetic and environmental *** memory and cognitive deficits observed during the prodromal and mild cognitive impairment phases of Alzheimer’s disease are believed to primarily result from synaptic *** life,environmental factors can lead to enduring changes in gene expression and the emergence of brain *** changes,known as epigenetic modifications,also play a crucial role in regulating the formation of synapses and their adaptability in response to neuronal *** this context,we highlight recent advances in understanding the roles played by key components of the epigenetic machinery,specifically DNA methylation,histone modification,and microRNAs,in the development of Alzheimer’s disease,synaptic function,and activity-dependent synaptic ***,we explore various strategies,including enriched environments,exposure to non-invasive brain stimulation,and the use of pharmacological agents,aimed at improving synaptic function and enhancing long-term potentiation,a process integral to epigenetic ***,we deliberate on the development of effective epigenetic agents and safe therapeutic approaches for managing Alzheimer’s *** suggest that addressing Alzheimer’s disease may require distinct tailored epigenetic drugs targeting different disease stages or pathways rather than relying on a single drug.

关键词： Alzheimer’s disease DNA methylation enriched environments histone modification microRNAs non-invasive brain stimulation synaptic plasticity

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MITOCHONDRIAL REDOX IMAGING FOR CANCER DIAGNOSTIC AND THERAPEUTIC STUDIES

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Journal of Innovative Optical Health Sciences 2009年第4期2卷 325-341页

作者： lin z.li HE N.XU MAHSA RANJI SHOKO NIOKA BRITTON CHANCE Department of Radiology School of Medicine University of PennsylvaniaB6 Blockley Hall423 Guardian Drive PhiladelphiaPA 19104-6069USA The Institute for Translational Medicine and Therapeutics School of Medicine University of Pennsylvania PhiladelphiaPA 19104USA Biophotonics Laboratory Department of Electrical Engineering and Computer Science University of Wisconsin-Milwaukee MilwaukeeWI 53211USA Johnson Research Foundation Department of Biochemistry and Molecular Biophysics School of Medicine University of Pennsylvania 250 Anatomy Chemistry BuildingPhiladelphiaPA 19104USA

Mitochondrial redox states provide important information about energy-linked biological processes and signaling events in tissues for various disease phenotypes including *** redox scanning method developed at the Chance laboratory about 30 years ago has allowed 3D highresolution(∼50×50×10µm^(3))imaging of mitochondrial redox state in tissue on the basis of the fluorescence of NADH(reduced nicotinamide adenine dinucleotide)and Fp(oxidized flavoproteins including flavin adenine dinucleotide,i.e.,FAD).In this review,we illustrate its basic principles,recent technical developments,and biomedical applications to cancer diagnostic and therapeutic studies in small animal *** developed calibration procedures for the redox imaging using reference standards allow quantification of nominal NADH and Fp concentrations,and the concentration-based redox ratios,e.g.,Fp/(Fp+NADH)and NADH/(Fp+NADH)in *** calibration facilitates the comparison of redox imaging results acquired for different metabolic states at different times and/or with different instrumental settings.A redox imager using a CCD detector has been developed to acquire 3D images faster and with a higher in-plane resolution down to 10µ*** vivo imaging and in vivo imaging of tissue mitochondrial redox status have been demonstrated with the CCD *** of tissue redox imaging in small animal cancer models include metabolic imaging of glioma and myc-induced mouse mammary tumors,predicting the metastatic potentials of human melanoma and breast cancer mouse xenografts,differentiating precancerous and normal tissues,and monitoring the tumor treatment response to photodynamic *** future directions for the development of redox imaging are also discussed.

关键词： Redox ratio reduced nicotinamide adenine dinucleotide NADH flavoprotein flavin adenine dinucleotide FAD calibration

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Editorial--The centennial celebration of *** Chance

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Journal of Innovative Optical Health Sciences 2014年第2期7卷 106-108页

作者： lin z.li He.N.Xu Yu Chen Kyung Kang linda Powers Department of Radiology University of PennsylvaniaUSA Fischell Department of Bioengineering University of MarylandUSA Department of Chemical Engineering University of LouisvileUSA Department of Electric and Computer Engineering Department of Biomedical Engineering Uniuersity of ArizonaUSA

To celebrate the scientific legacy and spirit of the late *** Chance(1913-2010)and his 100thbir thday,t he Brit ton Chance International Symposium on Metabolic Imaging and Spectroscopy was heldat the Perelman School of Medicine,University of Pennsylvania on June 18-19th,*** symposium brought toget her over 200 physicists,engineers,biologists and clinicians from all over the world includingEurope,Asia and North *** latest research innovations and clinical progresses by optical,nuclear magnetic resonance(NMR)and nuclear medicine methods were presented and discussed extensively.

关键词： NMR Chance

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IMAGING REDOX STATE HETEROGENEITY WITHIN INDIVIDUAL EMBRYONIC STEM CELL COLONIES

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Journal of Innovative Optical Health Sciences 2011年第3期4卷 279-288页

作者： HE N.XU RUSSELL C.ADDIS DAVIDA F.GOINGS SHOKO NIOKA BRITTON CHANCE JOHN D.GEARHART lin z.li Molecular Imaging Laboratory Department of Radiology University of PennsylvaniaSchool of Medicine PhiladelphiaPA 19104USA Institute for Regenerative Medicine and Department of Cell and Developmental Biology University of Pennsylvania School of Medicine PhiladelphiaPA 19104USA Britton Chance Laboratory of Redox Imaging Johnson Research Foundation Department of Biochemistry and Biophysics University of Pennsylvania School of Medicine PhiladelphiaPA 19104USA Institute of Translational Medicine and Therapeutics University of Pennsylvania PhiladelphiaPA 19104USA

Redox state mediates embryonic stem cell(ESC)differentiation and thus offers an important complementary approach to understanding the pluripotency of stem *** redox ratio(NADH/(Fp t NADH)),where NADH is the reduced form of nicotinamide adenine dinucleotide and Fp is the oxidizedflavoproteins,has been established as a sensitive indicator of mitochondrial redox *** this paper,we report our redox imaging data on the mitochondrial redox state of mouse ESC(mESC)colonies and the implications *** low-temperature NADH/Fp redox scanner was employed to image mESC colonies grown on a feeder layer of gamma-irradiated mouse embryonicfibroblasts(MEFs)on glass cover *** result showed significant heterogeneity in the mitochondrial redox state within individual mESC colonies(size:~200-440μm),exhibiting a core with a more reduced state than the *** more reduced state positively correlates with the expression pattern of Oct4,a well-established marker of *** observation is thefirst to show the heterogeneity in the mitochondrial redox state within a mESC colony,suggesting that mitochondrial redox state should be further investigated as a potential new biomarker for the stemness of embryonic stem cells.

关键词： Redox imaging pluripotency NADH flavoproteins redox ratio

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INTRODUCTION SPECIAL ISSUE IN MEMORY OF PROFESSOR BRITTON CHANCE

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Journal of Innovative Optical Health Sciences 2011年第3期4卷 I0001-I0003页

作者： lin z.li Shoko Nioka Molecular Imaging Lab Department of Radiology Britton Chance Lab of Redox Imaging Johnson Foundation Department of Biochemistry and Biophysics University of Pennsylvania

Britton Chance:One of the Most Outstanding Scientists in the World On June 3rd and 4th,2011,over 300 scientists and professionals from all over the world gathered at the Translational Research Center of the University of Pennsylvania to attend a memorial symposium on\Britton Chance:His life,Times and Legacy"and a\Molecular Spectroscopy/Imaging Workshop:from bench top to bedside"dedicated to Britton Chance as well.

关键词： Times Chance symposium

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Quantitative redox imaging biomarkers for studying tissue metabolic state and its heterogeneity

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Journal of Innovative Optical Health Sciences 2014年第2期7卷 109-128页

作者： He N.Xu lin z.li Department of RadiologyBrtton Chance Laboratory of Redoa Imaging Johnson Research Foundation Departmentof Biochemistry and BiophysicsPerelman School of MedicineUniversity of Pennsyluania PhiladelphiaPAUSA

NAD+/NADH redox state has been implicated in many diseases such as cancer and diabetes aswell as in the regulation of embryonic development and aging,To fluorimetrically sssthemitochondrial redox state,*** and co-workers measured the fluorescence of NADH andoxidized flavoproteins(Fp)including favin-adenine-dinucleotide(FAD)and demonstrated theirratio(*** redox ratio)is a sensitive indicator of the mitochondrial redox states.,The Chanceredox sca mer was built to simult aneously measure NADH and Fp in tisue at submilimeter scalein 3D using the freeze-trap *** paper summarizes our recent research experience,development and new applications of the redox scanning technique in collaboration with *** beginning in *** initiated or actively involved in many of the projectsduring the last several years of his *** advanced the redox scanning technigue by measuringthe nominal concentrations(in reference to the frozen solution standards)of the endogenousfuorescent analy tes,i.e.,[NADH]and[rp]to quantify the redox ratios in various *** advancement has enabled us to identify an array of the redox indices as quantitativeimaging,biomarkers(including[NADH],[Fp],[Fp]/[NADH]+[Fp],[NADH]/[Fp],and theirstandard deviations)for studying some important biological questions on cancer and normaltsue *** found that the redox indices were asociated or changed with(NADH)tumorigenesis(cancer versus non-cancer of human breast tisue biopsies);(2)tumor metastaticpotential;(3)tumor glucose uptake;(4)tumor p53 stat us;(5)PI3K pathway activation in pre-malignant tissue;(6)therapeutic ffects on tumors;(7)embryonic stem cell diferentiation;(8)the heart under fasting,Together,our work demonstrated that the tisue redox indices obtainedfrom the redox scanning technique may provide usefil information about tisue met abolism and physiology status in normal and diseased *** Chance redox scanner and other redoximaging techniques may ha

关键词： Tumor progresion mitochondria met astasis met astatic potential pre-malignancy NADH Fp FAD redox ratio

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