检索结果-南通市图书馆

Phytoglycoprotein isolated from Dioscorea batatas Decne promotes intestinal epithelial wound healing

Chinese Journal of Natural Medicines 2020年第10期18卷 738-748页

作者： KIM Ji-Yun LEE Young-Min PARK Jong-Pil lim kye-taek LEE Sei-Jung Department of Pharmaceutical Engineering Daegu Haany UniversityGyeongsan 38610Republic of Korea Department of Food Science and Technology Chung-Ang UniversityAnseong 17546Republic of Korea Division of Animal Science Chonnam National UniversityGwangju61186Republic of Korea

Dioscorea batatas Decne(DBD)has been used to heal various illnesses of the kidney and intestine as an herbal medicine in *** a source of therapeutic agents,many glycoproteins have been isolated from mushrooms and plants,but the functional role of glycoprotein in intestinal epithelial wound healing has not been understood *** the present study,we investigated the wound healing potentials of the 30 kDa glycoprotein(DBD glycoprotein)isolated from DBD in human intestinal epithelial(INT-407)*** found that DBD glycoprotein(100μg·mL^-1)significantly increased the motility of INT-407 cells for 24 h by activating protein kinase C(PKC).DBD glycoprotein stimulated the activation of p38 mitogen-activated protein kinase(MAPK),which is responsible for the phosphorylation of NF-κB inhibitorα(IκBα).DBD glycoprotein increased the level of profilin-1(PFN1),α-actinin and F-actin expression via activation of transcription factor,nuclear factor-kappa B(NF-κB)during its promotion of cell *** mouse colitis was induced by adding dextran sulfate sodium(DSS)to the drinking water at a concentration of 4%(W/V)for 7 *** figured out that administration of DBD glycoprotein(10 and 20 mg·kg-1)lowers the levels of disease activity index and histological inflammation in DSS-treated ICR *** this regard,we suggest that DBD glycoprotein has ability to promote the F-actin-related migration signaling events via activation of PKC and NF-κB in intestinal epithelial cells and prevent inflammatory bowel disease.

关键词： Cell migration Dioscorea batatas Decne(DBD)glycoprotein Intestinal epithelial cells p38 MAPK F-actin Mouse colitis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Single-cell and spatial omics:exploring hypothalamic heterogeneity

引用

Neural Regeneration Research 2025年第6期20卷 1525-1540页

作者： Muhammad Junaid Eun Jeong Lee Su Bin lim Department of Biochemistry&Molecular Biology Ajou University School of MedicineSuwonSouth Korea Department of Biomedical Sciences Graduate School of Ajou UniversitySuwonSouth Korea Department of Brain Science Ajou University School of MedicineSuwonSouth Korea

Elucidating the complex dynamic cellular organization in the hypothalamus is critical for understanding its role in coordinating fundamental body functions. Over the past decade, single-cell and spatial omics technologies have significantly evolved, overcoming initial technical challenges in capturing and analyzing individual cells. These high-throughput omics technologies now offer a remarkable opportunity to comprehend the complex spatiotemporal patterns of transcriptional diversity and cell-type characteristics across the entire hypothalamus. Current single-cell and single-nucleus RNA sequencing methods comprehensively quantify gene expression by exploring distinct phenotypes across various subregions of the hypothalamus. However, single-cell/single-nucleus RNA sequencing requires isolating the cell/nuclei from the tissue, potentially resulting in the loss of spatial information concerning neuronal networks. Spatial transcriptomics methods, by bypassing the cell dissociation, can elucidate the intricate spatial organization of neural networks through their imaging and sequencing technologies. In this review, we highlight the applicative value of single-cell and spatial transcriptomics in exploring the complex molecular-genetic diversity of hypothalamic cell types, driven by recent high-throughput achievements.

关键词： cellular diversity hypothalamus multi-omics single-cell transcriptomics spatial transcriptomics

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Exercise therapy for sarcopenia and diabetes

引用

World Journal of Diabetes 2023年第5期14卷 565-572页

作者： Seung-taek lim Sunghwun Kang Institute of Sports and Arts Convergence(ISAC) Inha UniversityIncheon 22212South Korea Waseda Institute for Sport Sciences Waseda UniversitySaitama 341-0018Japan Laboratory of Exercise Physiology College of ArtCulture and EngineeringKangwon National UniversityChuncheon-si 24341South Korea Interdisciplinary Program in Biohealth-machinery convergence engineering Kangwon National UniversityChuncheon-si 24341South Korea

Aging is characterized by the gradual deterioration of function at the molecular,cellular,tissue,and organism levels in *** typical diseases caused by changes in body composition,as well as functional decline in the human body’s organs due to aging include sarcopenia and metabolic *** accumulation of dysfunctional agingβcells with age can cause decreased glucose tolerance and *** decline has a multifactorial origin,involving lifestyle habits,disease triggers,and age-dependent biological *** reduced function ofβcells in elderly people lowers insulin sensitivity,which affects protein synthesis and interferes with muscle *** functional decrease and aggravation of disease in elderly people with less regular exercise or physical activity causes imbalances in food intake and a continuous,vicious *** contrast,resistance exercise increases the function ofβcells and protein synthesis in elderly *** this review,we discuss regular physical activities or exercises to prevent and improve health,which is sarcopenia as decreased muscle mass and metabolic disorders as diabetes in the elderly.

关键词： Elderly Diabetes Sarcopenia Resistance exercise Aging Muscle

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

A Comparison of GPS- and NWP-derived PW Data over the Korean Peninsula

引用

Advances in Atmospheric Sciences 2010年第4期27卷 871-882页

作者： Ha-taek KWON Eui-Hyun JUNG Gyu-Ho lim School of Earth and Environmental Sciences Seoul National University Seoul 151-172 Korea

Precipitable Water （PW） derived from Global Positioning System （GPS） measurements and numerical weather prediction （NWP） model analysis data were compared to further evaluate the effcacy of applying GPS-derived PW to the NWP model. The spatial and temporal variations of GPS-derived PW during a rainfall event were also examined. GPS-derived PW measurements show good agreement with the behavior of water vapor at a high spatial resolution during the analysis period. Temporal anomalies of GPS-derived PW moving along with the front are successfully detected by the GPS array. Large positive anomalies of GPS-derived PW are indicated immediately before a rainfall event, and the intensity of these positive anomalies do not seem to decrease significantly as the precipitation system passes. These results indicate that the Korean GPS network may have great potential as a PW sensor over the Korean Peninsula. In contrast with GPS-derived PW, NWP-derived PW shows negative biases. These biases appear to stem mainly from the differences between modeled and actual GPS site elevations, as GPS sites were generally located at elevations lower than those employed by the NWP model. However, there still exists a discernable dry bias after a PW correction is applied to NWP-derived PW. GPS-derived PW better reflects the spatial and temporal moisture variations of precipitation systems, as compared to NWP-derived PW. These results provide entirely new information for improving the regional NWP system, since GPS-derived PW produced with data from the Korean GPS network may be incorporated into the NWP model to improve rainfall forecasts.

关键词： GPS precipitable water numerical weather prediction model dry bias

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A 75 kDa glycoprotein isolated from Cudrania tricuspidata Bureau induces colonic epithelial proliferation and ameliorates mouse colitis induced by dextran sulfate sodium

引用

Chinese Journal of Natural Medicines 2021年第1期19卷 46-55页

作者： Park Jeong-Bae Kim Do-Wan lim kye-Tack Oh Sejong Lee Sei-Jung Department of Pharmaceutical Engineering Daegu Haany UniversityGyeongsan 38610South Korea Division of Animal Science Chonnam National UniversityGwangju 61186South Korea

Cudrania tricuspidata Bureau(CTB),a species of the Moraceae plant,has been used as a bruise recovery *** study aimed to determine whether the 75 kDa phytoglycoprotein extracted from CTB has a regulatory effect on the proliferation of human colon epithelial cells and the pathological process of inflammatory bowel disease(IBD).We found that CTB glycoprotein significantly induces the proliferation of human colon epithelial HT-29 cells by activating protein kinase *** glycoprotein stimulated the phosphorylation of c-Jun N-terminal kinase and transcription factor nuclear factor-κB,which are responsible for the expression of cell-cycle-related proteins(CDK2,CDK4,cyclin D1 and cyclin E)during its promotion of cell *** colitis was induced in mice by adding dextran sulfate sodium to their drinking water at a concentration of 4%(W/V)for seven *** found that CTB glycoprotein ameliorates the pathological process of IBD and lowers the disease activity index score,which was composed of body weight change,diarrhea,and hematochezia in ICR mice treated with dextran sulfate ***,we suggest that CTB glycoprotein has the ability to prevent IBD by promoting cell proliferation signaling events via the activation of PKC,JNK and NF-κB in colon epithelial cells.

关键词： Cell cycle Cell proliferation Colon epithelial cells Cudrania tricuspidata Glycoprotein Inflammatory bowel disease Protein kinase C

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Unraveling the potential of 3D bioprinted immunomodulatory materials for regulating macrophage polarization:State-of-the-art in bone and associated tissue regeneration

引用

Bioactive Materials 2023年第10期28卷 284-310页

作者： Sayan Deb Dutta Tejal V.Patil Keya Ganguly Aayushi Randhawa Ki-taek lim Department of Biosystems Engineering Kangwon National UniversityChuncheon24341Republic of Korea Institute of Forest Science Kangwon National UniversityChuncheon24341Republic of Korea Interdisciplinary Program in Smart Agriculture Kangwon National UniversityChuncheon24341Republic of Korea

Macrophage-assisted immunomodulation is an alternative strategy in tissue engineering, wherein the interplay between pro-inflammatory and anti-inflammatory macrophage cells and body cells determines the fate of healing or inflammation. Although several reports have demonstrated that tissue regeneration depends on spatial and temporal regulation of the biophysical or biochemical microenvironment of the biomaterial, the underlying molecular mechanism behind immunomodulation is still under consideration for developing immunomodulatory scaffolds. Currently, most fabricated immunomodulatory platforms reported in the literature show regenerative capabilities of a particular tissue, for example, endogenous tissue (e.g., bone, muscle, heart, kidney, and lungs) or exogenous tissue (e.g., skin and eye). In this review, we briefly introduced the necessity of the 3D immunomodulatory scaffolds and nanomaterials, focusing on material properties and their interaction with macrophages for general readers. This review also provides a comprehensive summary of macrophage origin and taxonomy, their diverse functions, and various signal transduction pathways during biomaterial-macrophage interaction, which is particularly helpful for material scientists and clinicians for developing next-generation immunomodulatory scaffolds. From a clinical standpoint, we briefly discussed the role of 3D biomaterial scaffolds and/or nanomaterial composites for macrophage-assisted tissue engineering with a special focus on bone and associated tissues. Finally, a summary with expert opinion is presented to address the challenges and future necessity of 3D bioprinted immunomodulatory materials for tissue engineering.

关键词： Macrophage Immunomodulation Biomaterials 3D bioprinting Tissue engineering

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

FAK and Pyk2 in disease

引用

Frontiers in Biology 2016年第1期11卷 1-9页

作者： James M. Murphy Hyeonsoo Park Ssang-taek Steve lim Department of Biochemistry and Molecular Biology College of Medicine University of South Alabama Mobile Alabama 36688 USA

Focal adhesion kinase （FAK） and proline-rich tyrosine kinase 2 （Pyk2） are non-receptor protein tyrosine kinases that are involved in cell proliferation, migration and survival. Current research of FAK and Pyk2 is greatly focused in cancer biology and several small molecule inhibitors are being tested under clinical development. Like cancer, certain chronic diseases such as cardiovascular disease, bone disease, fibrosis, rheumatoid arthritis, and neurological disorders, share malignant characteristics of cancer. Accumulating evidence has demonstrated that FAK and Pyk2 contribute to other proliferative and degenerative diseases. Thus, the goal of this review is to briefly highlight studies that have implicated FAK and Pyk2 as players in disease progression.

关键词： FAK Pyk2 FRNK disease

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Understanding cell-extracellular matrix interactions for topology-guided tissue regeneration

引用

BIOCELL 2023年第4期47卷 789-808页

作者： AAYUSHI RANDHAWA SAYAN DEB DUTTA KEYA GANGULY TEJAL V.PATIL RACHMI LUTHFIKASARI KI-taek lim Department of Biosystems Engineering Kangwon National UniversityChuncheon24341Korea Interdisciplinary Program in Smart Agriculture Kangwon National UniversityChuncheon24341Korea

Tissues are made up of cells and the extracellular matrix(ECM)which surrounds *** cells and tissues are actively adaptable to enduring significant stress that occurs in daily *** astonishing mechanical stress develops due to the interaction between the live cells and the non-living *** in the matrix microenvironment can sense the signals and forces produced and initiate a signaling cascade that plays a crucial role in the body’s normal functioning and influences various properties of the native cells,including growth,proliferation,and ***,the matrix’s characteristic features also impact the repair and regeneration of the damaged *** current study reviewed how the cell-ECM interaction regulates cellular behavior and physicochemical ***,we have described the response of cells to mechanical stresses,the importance of substrate stiffness and geometry in tissue regeneration,and the development of scaffolds to mimic the nature of native ECM in 3D for tissue engineering applications has also been ***,the study summarizes the conclusions and promising prospects based on the cell-ECM interplay.

关键词： ECM Stress Mechanical force Scaffold Mechanotransduction Tissue engineering

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Mesenchymal stem cells,the secretome and biomaterials:Regenerative medicine application

引用

BIOCELL 2022年第10期46卷 2201-2208页

作者： KI-taek lim TEJAL V.PATIL DINESH KPATEL SAYAN DEB DUTTA KEYA GANGULY AAYUSHI RANDHAWA Department of Biosystems Engineering Interdisciplinary Program in Smart AgricultureKangwon National UniversityChuncheon341Korea

Mesenchymal stem cells(MSCs)are multipotent cells usually isolated from bone marrow,endometrium,adipose tissues,skin,and dental *** played a crucial role in regenerative therapy and have been introduced as an interdisciplinary field between cell biology and material ***,MSCs have been widely explored for their application in regenerative medicine and COVID-19 *** approaches to evaluate the future of biomaterials and stem cell properties have been ***,misconceptions and ethical issues still exist,such as MSCs being non-angiogenic,anti-apoptotic,and immunoregulatory *** stem cells isolation primarily requires the consent of donors and can include the killing of fertilized *** issues generate questions related to ethical and moral ***,MSCs have gained considerable attention for tissue regeneration owing to their differentiation ability with immunomodulatory *** are capable of secreting a broad range of biomolecules such as proteins,nucleic acids,exosomes,microRNAs,and membrane vesicles,collectively known as *** are released in response to the surrounding *** this article,we briefly address topics related to the therapeutic potential of MSCs as an advanced approach in the field of regenerative medicine and various perspectives.

关键词： Mesenchymal Stem Cells Secretome Biomaterials Regenerative Medicine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Factors associated with use of gastric cancer screening services in Korea

引用

World Journal of Gastroenterology 2009年第29期15卷 3653-3659页

作者： Young Min Kwon Hyung taek lim Kiheon Lee Be Long Cho Min Sun Park Ki Young Son Sang Min Park Department of Family Medicine Seoul National University Hospital Seoul National University College of Medicine 28 Yunkeon-dong Jongro-gu Seoul 110-744 South Korea Department of Medicine Yonsei University College of Medicine 134 Shinchon-dong Seodaemun-gu Seoul 120-752 South Korea Department of Family Medicine Seoul National University Bundang Hospital and Department of the History of Medicine and Medical Humanities Seoul National University College of Medicine 166 Gumi-ro Bundang-gu Seongnam-si Gyeonggi-do 463-707 South Korea

AIM: To identify the factors associated with participation in gastric cancer screening programs. METHODS: Using data from the Korea National Health and Nutrition Examination Survey 2005 (KNHANES Ⅲ), a nationwide health-related surveyin Korea, a cross-sectional study was performed to investigate the multiple factors associated with gastric cancer screening attendance among persons aged at least 40 years. The study population included 4593 individuals who completed a gastric cancer screening questionnaire and had no previous cancer history. Four groups ofindividual-level or environmental level covariates were considered as potential associated ***: Using KNHANES Ⅲdata, an estimated31.71% of Korean individuals aged at least 40 years adhered to gastric cancer screening recommendations. Subjects who graduated from elementary school[adjusted odds ratio (aOR), 1.66; 95% CI: 1.21-2.26], middle/high school (aOR, 1.38; 95% CI: 1.01-1.89), and university or higher (aOR, 1.64; 95% CI: 1.13-2.37) were more likely to undergo gastric cancer screening than those who received no formal education at all. The population with the highest income tertile had more attendance at gastric screening compared to those with the lowest income tertile (aOR, 1.36; 95% CI: 1.06-1.73). Gastric screening was also negatively associated with excessive alcohol consumption (aOR, 0.71; 95% CI: 0.53-0.96). A positive attitude to preventive medical evaluation was significantly associated with better participation in gastric cancer screening programs (aOR, 5.26; 95% CI: 4.35-6.35). CONCLUSION: Targeted interventions for vulnerable populations and public campaigns about preventive medical evaluation are needed to increase gastric cancer screening participation and reduce gastric cancer mortality.

关键词： Socioeconomic factors Health behavior Health status disparity Mental health Early detectionof cancer

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：