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Chordomas of the upper cervical spine： clinical characteristics and surgical management of a series of 21 patients

Chinese Medical Journal 2014年第15期127卷 2759-2764页

作者： Zhou Hua jiang liang Wei Feng Yu Miao Wu Fengliang Liu Xiaoguang Liu Zhongjun Dang Gengting Department of Orthopaedics Peking University Third HospitalBeijing Key Laboratory of Spinal Diseases Beijing 100191 China

Background Chordomas of the upper cervical spine are rare and present unique surgical *** study aimed to describe the clinical characteristics and surgical management of patients with chordomas of the upper cervical *** Twenty-one patients with chordomas of the upper cervical spine who were treated in Peking University Third Hospital from January 1999 to October 2012 were retrospectively *** was calculated by the Kaplan-Meier method and was compared between groups using the log-rank *** The postoperative diagnosis was classical chordoma in 20 cases and chondroid chordoma in one *** mean operative time was 9.5 hours （range 6-17 hours）,and the mean blood loss was 2 812 ml （range 700-4 800 ml）.There were two postoperative *** vertebral artery ligation was performed in six patients,cervical nerve roots were cut in six patients,and the external branch of the superior laryngeal nerve was repaired after being cut in one *** patients developed postoperative velopharyngeal incompetence,and loosening of the occipitocervical screws was observed in one *** recurrence rate was 66.7% （10/15） after a mean follow-up period of 46.8 months （range 14-150 months）.The 5-and 10-year overall survival rates were （39.8±13.1）% and （31.9±12.7）%,*** was a significant difference in survival rate between patients who underwent surgery and those who did *** In spite of the high rates of recurrence and complications after surgical treatment of chordomas of the upper cervical spine,intralesional resection combined with adjuvant radiotherapy remains the optimal treatment to prolong survival.

关键词： chordoma atlases general surgery therapeutics atlantoaxial

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Feasibility of cetuximab and chemoradiotherapy combination in Chinese patients with unresectable stage Ⅲ non-small cell lung cancer:a preliminary report

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Chinese Journal of Cancer Research 2015年第2期27卷 172-180页

作者： Di Liu Yu-Xin Shen Wei-Xin Zhao Guo-liang jiang Jia-Yan Chen Min Fan Department of Radiation Oncology Fudan University Shanghai Cancer Center Department of Radiation Oncology The First Affiliated Hospital of Nanjing Medical University

Objective： In recent years, the combination of cetuximab and chemoradiotherapy （CRT） has been used to treat stage III non-small cell lung cancer （NSCLC）; however, limited data are available for Chinese patients. Herein, we report preliminary data from a phase I/II study testing the combination of cetuximab with inductive chemotherapy, followed by concurrent CRT （CCRT） in Chinese patients with stage III NSCLC. Methods： Eligibility criteria were Zubrod performance status （PS） 0-1, forced expiratory volume in 1 second （FEV1）〉_1.2 L and adequate organ function. Enrolled patients received weekly cetuximab （initial dose of 400 mg/m2 on day 1 of week 1 and a maintenance dose of 250 mg/m2 on week 2 to the end of CCRT） with cisplatin/vinorelbine （NP） chemotherapy （every 3 weeks for 2 cycles from week 2, followed by two cycles of concomitant NP chemotherapy and intensity-modulated thoracic radiotherapy （TRT）（60-66 Gy/2 Gy）. The primary endpoints were toxicity and feasibility. All patients received positron emission tomography- computerized tomography （PET-CT） scans within the 2 weeks prior to enrollment. Univariate analyses were used to assess the correlation between SUV-T, SUV-N, SUV-TOTAL, gender, age, histology, tumor-node- metastasis （TNM） stage, PS and smoking status and survival. Survival curves were generated for different populations using the Kaplan-Meier method and compared using a log-rank test. Results： Seventeen patients were enrolled and 16 completed the full regime. The overall response rate （ORR） was 58.8% and 82.3% after the induction and CCRT phases, respectively. With a median follow-up duration of 27.6 months, the median survival was 27.6 months [95% confidence interval （CI）： 11.3-43.9 months] with 1- and 2-year survival rates of 88.2% （95% CI, 60.6-96.9%） and 58.8% （95% CI, 60.6-77.8%）, respectively. Three patients remain progression-free to date, and the median progression-free survival （PFS） was 13.5 months （95% CI, 6.8-20.2 months）. No treatment-rela

关键词： Cetuximab induction chemotherapy concurrent chemoradiotherapy (CRT) positron emission tomography-computerized tomography (PET-CT) locally advanced non-small cell lung cancer (NSCLC)

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新疆提孜那甫河流域2019-2021年地下水位动态特征分析

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地下水 2024年第1期46卷 69-70,264页

作者：赵晔刘智佳梁临江赵登锋王鹏喀什地区莫莫克水利枢纽工程建设管理局新疆喀什844000

以提孜那甫河流域平原区地下水为研究对象,通过对研究区内的30眼潜水监测井2019-2021年地下水埋深数据进行分析。结果表明:从时间维度看,研究区近3年地下水水位整体呈上升趋势。空间维度上,高、低水位期地下水埋深变幅分区均以减小为主... 详细信息

以提孜那甫河流域平原区地下水为研究对象,通过对研究区内的30眼潜水监测井2019-2021年地下水埋深数据进行分析。结果表明:从时间维度看,研究区近3年地下水水位整体呈上升趋势。空间维度上,高、低水位期地下水埋深变幅分区均以减小为主(埋深变幅-1.0~0.0 m),多分布在研究区南部和北部。低水位期地下水埋深增加区主要位于流域中部的泽普县、叶城县和麦盖提县,地下水埋深变幅以>0.5 m为主;而对于高水位期,地下水埋深变幅集中在0.0~0.5 m,主要分布于泽普县、莎车县和叶城县。随着提孜那甫河流域地表水供水工程的完善和用水总量控制方案的落实,研究区地下水超采状况得到基本缓解。

关键词：地下水位动态特征提孜那甫河流域

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新冠肺炎疫情前后临沂市儿童肠套叠的流行趋势变化

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中国实用医药 2024年第3期19卷 153-157页

作者：张荣鹏姜良富毛兴允崔正民刘宇山东省临沂市人民医院小儿外科 276000

目的了解新冠肺炎流行前后儿童肠套叠的发病及临床特点,为儿童肠套叠的防治提供参考。方法收集14岁以下儿童肠套叠的病历资料,回顾性分析年发病率,比较疫情前后的趋势变化。结果共纳入1815例患儿,男1271例(70.03%),女544例(29.97%),2017... 详细信息

目的了解新冠肺炎流行前后儿童肠套叠的发病及临床特点,为儿童肠套叠的防治提供参考。方法收集14岁以下儿童肠套叠的病历资料,回顾性分析年发病率,比较疫情前后的趋势变化。结果共纳入1815例患儿,男1271例(70.03%),女544例(29.97%),2017~2021年的发病率分别为18.32/10万、14.96/10万、12.17/10万、10.78/10万、12.63/10万。2020年发病率最低,无季节性变化趋势,2021年发病率及季节性恢复。流行前(2017、2018、2019年)和流行中(2020、2021年)的发病率比较差异有统计学意义(χ^(2)=11.254,P=0.0010.05),流行期的患儿年龄大于流行前的年龄(P0.05)。结论病毒感染是原发性儿童肠套叠的主要原因之一,新冠肺炎疫情期间儿童肠套叠的发病率明显下降,其中男性儿童发病率下降明显,月份分布与疫情前不同,可能与保持社交距离、戴口罩、手卫生等防控措施导致其他病毒感染下降相关。

关键词：肠套叠发病率新冠肺炎流行病学

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Intraosseous lipoma of adjacent upper cervical vertebral bodies with significant paravertebral expansion

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Chinese Medical Journal 2010年第21期123卷 3160-3162页

作者： ZHU Bin LIU Xiao-guang LIU Zhong-jun Hung-I Liao jiang liang WEI Feng Orthopaedic Department Peking University Third Hospital Beijing 100191 China

Intraosseous lipomas are rare, benign bone tumors,comprising less than 0. 1% of all primary bone *** sites of intraosseous lipomas include the os calcis and the metaphyses of the long bones of the lower limbs.2 Cases involving the spine are extremely rare; a meta-analysis of 206 cases reported that intraosseous lipomas involving the spine （including the sacrum）accounted for 6% of all cases.2 A review of the English literature reveals only 14 reported cases involving the spine （Table）.

关键词： intraosseous lipoma spine tumor upper cervical spine

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Ibuprofen induced drug loaded polymeric micelles

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Chinese Chemical Letters 2011年第9期22卷 1123-1126页

作者： Song Wei Tan Hong Jun Wang Ke Hua Tu Hong liang jiang Li Qun Wang MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang UniversityHangzhou 310027 China

Three model drugs with different function groups were chosen to dialyze with dextran-graft-poly （N-isopropylacrylalaide）. Only ibuprofen could induce the formation of drug loaded micelles, which was contirmed with dynamic light scattering and transmission electron microscope. Hydrogen-bonding between the amide groups of poly （N-isopropylacrylamide） and the carboxyl groups of ibuprofen was driving force for the drug-loaded micelle. It was also found thai the diameter of the ibuprofen-loaded micelles changed reversibly against temperature.

关键词： Micellc Thernlo-sensilive Drug Hydrogen-bonding Poly (N-isopropylacryhlmide)

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In silico identification of silkworm selenoproteomes

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Chinese Science Bulletin 2006年第23期51卷 2860-2867页

作者： CHEN Ping DUAN Jun jiang liang LIU Qiong ZHAO Ping XIA Qingyou XU Huibi Key Sericultural Laboratory of Agricultural Ministry Southwest University Chongqing 400716 China College of Life Science Shenzhen University Shenzhen 518060 China Department of Chemistry Huazhong University of Science and Technology Wuhan 430074 China

Selenium (Se) is an essential trace element in vivo. Its biological function is mainly exerted through selenoproteins. Selenocysteine (Sec), the active site of selenoproteins, is incorporated into the protein at an in-frame TGA codon under the guidance of Sec insertion sequence (SECIS) element in the 3′-untranslated region (UTR) of the gene. In this work, a method was developed and a series of programs were edited by PERL language to in silico identify selenoproteomes from the genome of domesticated silkworm (Bombyx mori). Out of 18510 annotated genes, 6348 was terminated with TGA codons, 249 containing both in-frame TGAs and SECIS elements in the 3′-UTRs. Alignments of those selenoprotein candidates with their cysteine (Cys)-containing homologs revealed that 52 genes had TGA/Cys pairs and similar flanking regions around the in-frame TGAs. Restricted by the patterns of SECIS elements only 5 genes were screened out to fully meet the requirements for selenoproteins. Among them glutathione S-transferase (GST) has been reported as a microbial selenoprotein, the other four are novel selenoproteins annotated as CG6024, CG5195, ATP-binding cassette transporter subfamily A (ABCA), and nuclear VCP-like protein. Derived from the general properties of GST, ABCA and VCP, silkworm selenoproteins may play important roles in redox regulation, Se storage and transportation, as well as cell apoptosis.

关键词：桑蚕硒 ABCA 细胞凋亡

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安徽省马鞍山市蜱携5种病原体的检测研究

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中国人兽共患病学报 2024年第4期40卷 308-314页

作者：杨国栋杨锟江良梁吴铭洪颖项可霞何佳龚磊宋丹丹包名家李兴洲秦天王艳华黑龙江省佳木斯大学公共卫生学院佳木斯154002 中国疾病预防控制中心传染病预防控制所传染病溯源预警与智能决策全国重点实验室北京102206 安徽省马鞍山市疾病预防控制中心马鞍山243000 安徽省疾病预防控制中心合肥230000 黑龙江省佳木斯市疾病预防控制中心佳木斯154002

目的了解安徽省马鞍山市蜱携5种重要病原体的感染情况,并分析其与我国既往检出病原体的亲缘关系。方法在马鞍山市周边13个村庄采蜱642只,采用形态学和线粒体COI基因鉴定蜱种。对于土拉弗朗西斯菌检测16S rRNA,巴尔通体检测ssrA,立克次... 详细信息

目的了解安徽省马鞍山市蜱携5种重要病原体的感染情况,并分析其与我国既往检出病原体的亲缘关系。方法在马鞍山市周边13个村庄采蜱642只,采用形态学和线粒体COI基因鉴定蜱种。对于土拉弗朗西斯菌检测16S rRNA,巴尔通体检测ssrA,立克次体检测16S rRNA、ompA和ompB,无形体检测16S rRNA和gltA,柯克斯体检测groEL和rpoB。在公共数据平台选取有代表性的序列,与本研究测序获得的基因序列比对,采用MEGA11.0构建系统进化树。结果在640只长角血蜱中共有36只蜱检出立克次体,其中20只蜱中检出黑龙江立克次体,16只蜱中检出敬信立克次体,2只蜱中检出牛无形体,186只蜱中检出柯克斯体样内共生体。本研究检出的黑龙江立克次体HY2和安徽省B8菌株聚在一个分支,敬信立克次体QL3和山西、江苏的聚在一个分支,而牛无形体JX4和山西省的聚在一个分支。经分析,还有17只蜱存在合并感染。5种病原体在2只龟形花蜱中均没有检测到。结论本研究首次在安徽省长角血蜱中检出敬信立克次体。对于斑点热立克次体和牛无形体,建议当地卫生部门做好相应的防控措施。

关键词：立克次体无形体柯克斯体长角血蜱安徽省系统进化分析

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Adenotonsillectomy outcomes regarding bone age and osteocalcin in treatment of obstructive sleep apnea syndrome in children

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World Journal of Pediatrics 2017年第2期13卷 158-164页

作者： Qing-Biao Zhang Yin-Feng Li Ming-Xiu Li Ling-Yu Kong liang-Fu jiang Hui-Wei Feng Xian-liang Fan Department of Pediatric Internal Medicine Linyi People's HospitalLinyiChina Department of Pediatric Surgery Linyi People's HospitalLinyiChina Department of Breast Surgery Linyi Cancer HospitalLinyiChina

Background:To investigate the effect of adenotonsillec tomy (AT) on bone development,quality of life and polysomnography evaluation in children with obstructive sleep apnea syndrome (OSA).Methods:Preoperative and postoperative (6 months) physical examination,PSG,bone age (BA) and osteocalcin (OC) evaluation were performed on the selected OSA children (n=92) and the healthy children (n=87).The OSA children were also scored based on the OSA 18-item questionnaire.A two-year follow-up was conducted to evaluate BA and OC ***:After AT,81 (88.04%) OSA children recovered completely,eight (8.70%) achieved remarkable improvements,and three (3.26%) achieved moderate *** the OSA children,postoperative OSA 18-item score and the scores of the five domains were significantly higher than preoperative *** with the preoperative,body mass index (BMI),weight for age Z-sores,height for age Z-sores,weight for height Z-sores and BMI Z-score in the OSA group 6 months after the operation were significantly increased,but no significant difference was detected between the OSA and the control *** changes of BA and chronological age in the OSA group were significantly different from those in the control *** years after AT,BA between the two groups was no longer significantly *** serum OC in the OSA group was lower than that in the control group,but increased to normal levels 6 months after *** analysis showed serum OC levels were negatively correlated with apnea hyponea index,obstructive apnea index,arousal index,and lowest oxygen ***:After AT,bone growth and development in children with OSA recovered gradually,and the serum OC levels decreased to the normal ***,preventive measures and positive treatments should be applied to minimize the negative effects of OSA in children.

关键词： obstructive sleep apnea syndrome OSA-18 score osteocalcin polysomnography

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A MONTE CARLO SIMULATION STUDY OF THE EFFECT OF CHAIN LENGTH ON THE HYDROLYSIS OF POLY(LACTIC ACID)

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Chinese Journal of Polymer Science 2013年第11期31卷 1554-1562页

作者： Zhuo-li Lin Jun Luo Zheng-jian Chen Jun Yi Hong-liang jiang Ke-hua Tu 王利群 MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and EngineeringZhejiang University

The intrinsic relationship between molecular chain length and the probability of chain reaction during poly（lactic acid）（PLA） hydrolysis was investigated by Monte Carlo simulation. The chain reaction rate was calculated by introducing a power function of different molecular chain lengths. The hydrolysis of both amorphous and extended-chain crystal PLA was selected as the model system. It is found that, the chain reaction probability was proportional to the chain length with a power of 0.4 for amorphous PLA and 0.7-1 for extended-chain crystal PLA, respectively. These results indicate that PLA with longer chain length usually exhibits larger reaction rate than that with shorter length. Comparing the hydrolysis of the two kinds of PLA, the competition between longer and shorter chains in the different condensed structures is different.

关键词： Monte Carlo Simulation Chain length Poly(lactic acid) Hydrolysis Molecular weight distribution.

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