Ibuprofen induced drug loaded polymeric micelles
Ibuprofen induced drug loaded polymeric micelles作者机构:MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang UniversityHangzhou 310027 China
出 版 物:《Chinese Chemical Letters》 (中国化学快报(英文版))
年 卷 期:2011年第22卷第9期
页 面:1123-1126页
核心收录:
学科分类:1007[医学-药学(可授医学、理学学位)] 10[医学]
基 金:financially supported by NSFC(No.20674069)
主 题:Micellc Thernlo-sensilive Drug Hydrogen-bonding Poly (N-isopropylacryhlmide)
摘 要:Three model drugs with different function groups were chosen to dialyze with dextran-graft-poly (N-isopropylacrylalaide). Only ibuprofen could induce the formation of drug loaded micelles, which was contirmed with dynamic light scattering and transmission electron microscope. Hydrogen-bonding between the amide groups of poly (N-isopropylacrylamide) and the carboxyl groups of ibuprofen was driving force for the drug-loaded micelle. It was also found thai the diameter of the ibuprofen-loaded micelles changed reversibly against temperature.