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Ibuprofen induced drug loaded polymeric micelles

Ibuprofen induced drug loaded polymeric micelles

作     者:Song Wei Tan Hong Jun Wang Ke Hua Tu Hong Liang Jiang Li Qun Wang 

作者机构:MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang UniversityHangzhou 310027 China 

出 版 物:《Chinese Chemical Letters》 (中国化学快报(英文版))

年 卷 期:2011年第22卷第9期

页      面:1123-1126页

核心收录:

学科分类:1007[医学-药学(可授医学、理学学位)] 10[医学] 

基  金:financially supported by NSFC(No.20674069) 

主  题:Micellc Thernlo-sensilive Drug Hydrogen-bonding Poly (N-isopropylacryhlmide) 

摘      要:Three model drugs with different function groups were chosen to dialyze with dextran-graft-poly (N-isopropylacrylalaide). Only ibuprofen could induce the formation of drug loaded micelles, which was contirmed with dynamic light scattering and transmission electron microscope. Hydrogen-bonding between the amide groups of poly (N-isopropylacrylamide) and the carboxyl groups of ibuprofen was driving force for the drug-loaded micelle. It was also found thai the diameter of the ibuprofen-loaded micelles changed reversibly against temperature.

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