Ibuprofen induced drug loaded polymeric micelles

作     者：Song Wei Tan Hong Jun Wang Ke Hua Tu Hong Liang Jiang Li Qun Wang 

作者机构：MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Zhejiang UniversityHangzhou 310027 China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2011年第22卷第9期

页      面：1123-1126页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：financially supported by NSFC(No.20674069) 

主　　题：Micellc Thernlo-sensilive Drug Hydrogen-bonding Poly (N-isopropylacryhlmide) 

摘      要：Three model drugs with different function groups were chosen to dialyze with dextran-graft-poly （N-isopropylacrylalaide）. Only ibuprofen could induce the formation of drug loaded micelles, which was contirmed with dynamic light scattering and transmission electron microscope. Hydrogen-bonding between the amide groups of poly （N-isopropylacrylamide） and the carboxyl groups of ibuprofen was driving force for the drug-loaded micelle. It was also found thai the diameter of the ibuprofen-loaded micelles changed reversibly against temperature.