Adenotonsillectomy outcomes regarding bone age and osteocalcin in treatment of obstructive sleep apnea syndrome in children

作     者：Qing-Biao Zhang Yin-Feng Li Ming-Xiu Li Ling-Yu Kong Liang-Fu Jiang Hui-Wei Feng Xian-Liang Fan 

作者机构：Department of Pediatric Internal MedicineLinyi People's HospitalLinyiChina Department of Pediatric SurgeryLinyi People's HospitalLinyiChina Department of Breast SurgeryLinyi Cancer HospitalLinyiChina 

出 版 物：《World Journal of Pediatrics》 (世界儿科杂志（英文版）)

年 卷 期：2017年第13卷第2期

页      面：158-164页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

主　　题：obstructive sleep apnea syndrome OSA-18 score osteocalcin polysomnography 

摘      要：Background:To investigate the effect of adenotonsillec tomy (AT) on bone development,quality of life and polysomnography evaluation in children with obstructive sleep apnea syndrome (OSA).Methods:Preoperative and postoperative (6 months) physical examination,PSG,bone age (BA) and osteocalcin (OC) evaluation were performed on the selected OSA children (n=92) and the healthy children (n=87).The OSA children were also scored based on the OSA 18-item questionnaire.A two-year follow-up was conducted to evaluate BA and OC ***:After AT,81 (88.04%) OSA children recovered completely,eight (8.70%) achieved remarkable improvements,and three (3.26%) achieved moderate *** the OSA children,postoperative OSA 18-item score and the scores of the five domains were significantly higher than preoperative *** with the preoperative,body mass index (BMI),weight for age Z-sores,height for age Z-sores,weight for height Z-sores and BMI Z-score in the OSA group 6 months after the operation were significantly increased,but no significant difference was detected between the OSA and the control *** changes of BA and chronological age in the OSA group were significantly different from those in the control *** years after AT,BA between the two groups was no longer significantly *** serum OC in the OSA group was lower than that in the control group,but increased to normal levels 6 months after *** analysis showed serum OC levels were negatively correlated with apnea hyponea index,obstructive apnea index,arousal index,and lowest oxygen ***:After AT,bone growth and development in children with OSA recovered gradually,and the serum OC levels decreased to the normal ***,preventive measures and positive treatments should be applied to minimize the negative effects of OSA in children.