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业财融合背景下公立医院管理会计人才能力框架构建与实施

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中国卫生经济 2024年第2期43卷 84-86,91页

作者：邓连府北京大学人民医院北京100044

公立医院在新医改的进程中被赋予更高的运营管理要求,基于业财融合的管理会计对公立医院财务管理工作的优化具有积极的促进作用,可提升管理水平并实现可持续发展。研究首先强调了管理会计人才在实现业财融合和提高管理效能方面的重要作... 详细信息

公立医院在新医改的进程中被赋予更高的运营管理要求,基于业财融合的管理会计对公立医院财务管理工作的优化具有积极的促进作用,可提升管理水平并实现可持续发展。研究首先强调了管理会计人才在实现业财融合和提高管理效能方面的重要作用,在分析公立医院管理会计能力现状及需求的基础上,构建覆盖3类能力要素、4个层级的管理会计人才能力框架,并提出了公立医院管理会计人才能力框架实施建议,从而提升管理会计人才能力,助力公立医院高质量发展。

关键词：业财融合公立医院管理会计能力框架

Hydration-Enhanced Lubricating Electrospun Nanofibrous Membranes Prevent Tissue Adhesion

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Research 2020年第1期2020卷 812-823页

作者： Liang Cheng Yi Wang Guoming Sun Shizhu Wen lianfu deng Hongyu Zhang Wenguo Cui Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of Medicine197 Ruijin 2nd RoadShanghai 200025China State Key Laboratory of Tribology Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China College of Chemistry and Environmental Science Hebei UniversityBaoding 071002China Affiliated Hospital of Hebei University Baoding 071000China

Lubrication is the key to efficient function of human tissues and has significant impact on the comfort ***,the construction of a lubricating nanofibrous membrane has not been reported as yet,especially using a one-step surface modification ***,bioinspired by the superlubrication mechanism of articular cartilage,we successfully construct hydration-enhanced lubricating nanofibers via one-step in situ grafting of a copolymer synthesized by dopamine methacrylamide(DMA)and 2-methacryloyloxyethyl phosphorylcholine(MPC)onto electrospun polycaprolactone(PCL)*** zwitterionic MPC structure provides the nanofiber surface with hydration lubrication *** coefficient of friction(COF)of the lubricating nanofibrous membrane decreases significantly and is approximately 65%less than that of pure PCL nanofibers,which are easily worn out under friction regardless of *** lubricating nanofibers,however,show favorable wear-resistance ***,they possess a strong antiadhesion ability of fibroblasts compared with pure PCL *** cell density decreases approximately 9-fold,and the cell area decreases approximately 12 times on day ***,the in vivo antitendon adhesion data reveals that the lubricating nanofiber group has a significantly lower adhesion score and a better antitissue ***,our developed hydration-enhanced lubricating nanofibers show promising applications in the biomedical field such as antiadhesive membranes.

关键词： fibers hydration friction

Erythropoietin upregulates growth associated protein-43 expression and promotes retinal ganglion cell axonal regeneration in vivo after optic nerve crush

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Neural Regeneration Research 2012年第4期7卷 295-301页

作者： Haibo Tan Xin Kang Yisheng Zhong Xi Shen Yu Cheng Qin Jiao lianfu deng Department of Ophthalmology Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200025 China Department of Clinical Pharmacology Changhai Hospital Affiliated to Second Mifitary Medical University Shanghai 200433 China Shanghai Institute of Traumatology and Orthopedics Shanghai 200025 China

In this study, we established a rat model of optic nerve crush to explore the effects of erythropoietin on retinal ganglion cell axonal regeneration. At 15 days after injury in erythropoietin treated rats, retinal ganglion cell densities in regions corresponding to the 1/6, 3/6 and 5/6 ratios of the retinal radius were significantly increased. In addition, the number of growth associated protein-43 positive axons was significantly increased at different distances （50, 250 and 500 pm） from the crush site after erythropoietin treatment. Erythropoietin significantly increased growth associated protein-43 protein levels in the retina after crush injury, as determined by westem blot and immunofluorescence analysis. These results demonstrate that erythropoietin protects injured retinal ganglion cells and promotes axonal regeneration.

关键词： erythropoietin retinal ganglion cells axonal regeneration optic nerve crush neural regeneration

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新型步态辅助医学诊疗系统

国际骨科学杂志 2024年第5期45卷 349-352页

作者：黄萍张曼陈博钟慧敏邓廉夫上海交通大学医学院附属瑞金医院骨科、上海市伤骨科研究所、上海市中西医结合防治骨与关节病损重点实验室 200025

步态分析日益成为疾病监测、辅助诊疗的重要医学检测方法。然而,由于缺乏低成本、实用的临床步态分析系统,目前的临床步态分析十分依赖昂贵的精密仪器、苛刻的实验环境、复杂的操作流程,难以大规模部署,中小医院无力开展相关医疗服务。... 详细信息

步态分析日益成为疾病监测、辅助诊疗的重要医学检测方法。然而,由于缺乏低成本、实用的临床步态分析系统,目前的临床步态分析十分依赖昂贵的精密仪器、苛刻的实验环境、复杂的操作流程,难以大规模部署,中小医院无力开展相关医疗服务。该文介绍一套不依赖穿戴设备,实用、精准、非接触式的新型步态辅助医学诊疗系统,有望在临床逐步应用及推广,改善对国外昂贵设备和繁琐技术的严重依赖,降低临床步态分析的应用门槛,造福更多患者。

关键词：步态步态分析辅助医学诊疗系统

Regulated macrophage immune microenvironment in 3D printed scaffolds for bone tumor postoperative treatment

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Bioactive Materials 2023年第1期19卷 474-485页

作者： Cuidi Li Changwei Li Zhenjiang Ma Hongfang Chen Huitong Ruan lianfu deng Jinwu Wang Wenguo Cui Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025PR China Shanghai Key Laboratory of Orthopedic Implant Department of Orthopedic SurgeryShanghai Ninth People’s Hospital Affiliated Shanghai Jiao Tong University School of MedicineShanghai200011PR China

The 3D printing technique is suitable for patient-specific implant preparation for bone repair after bone tumor ***,improving the survival rate due to tumor recurrence remains a challenge for *** macrophage polarization induction to M2-type tumor-associated macrophages(TAMs)by the tumor microenvironment is a key factor of immunosuppression and tumor *** this study,a regenerative scaffold regulating the macrophage immune microenvironment and promoting bone regeneration in a dual-stage process for the postoperative treatment of bone tumors was constructed by binding a colony-stimulating factor 1 receptor(CSF-1R)inhibitor GW2580 onto in situ cosslinked hydroxybutylchitosan(HBC)/oxidized chondroitin sulfate(OCS)hydrogel layer covering a 3D printed calcium phosphate scaffold based on electrostatic *** hydrogel layer on scaffold surface not only supplied abundant sulfonic acid groups for stable loading of the inhibitor,but also acted as the cover mask protecting the bone repair part from exposure to unhealthy growth factors in the microenvironment at the early treatment *** local prolonged release of inhibitor being realized via the functional material design,CSF-1R,the main pathway that induces polarization of TAMs,can be efficiently blocked,thus regulating the immunosuppressive microenvironment and inhibiting tumor development at a low therapeutic *** the later stage of treatment,calcium phosphate component of the scaffold can facilitate the repair of bone defects caused by tumor *** conclusion,the difunctional 3D printed bone repair scaffold regulating immune microenvironment in stages proposed a novel approach for bone tumor postoperative treatment.

关键词： 3D printing Drug delivery Microenvironment Macrophage polarization Bone regeneration

Fullerol-hydrogel microfluidic spheres for in situ redox regulation of stem cell fate and refractory bone healing

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Bioactive Materials 2021年第12期6卷 4801-4815页

作者： Jielai Yang Jing Liang Yuan Zhu Mu Hu lianfu deng Wenguo Cui Xiangyang Xu Department of Orthopedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of Medicine197 Ruijin 2nd RoadShanghai200025PR China

The balance of redox homeostasis is key to stem cell maintenance and ***,this balance is disrupted by the overproduced reactive oxygen species(ROS)in pathological conditions,which seriously impair the therapeutic efficacy of stem *** the present study,highly dispersed fullerol nanocrystals with enhanced bioreactivity were incorporated into hydrogel microspheres using one-step innovative microfluidic technology to construct fullerol-hydrogel microfluidic spheres(FMSs)for in situ regulating the redox homeostasis of stem cells and promoting refractory bone *** was demonstrated that FMSs exhibited excellent antioxidant activity to quench both intracellular and extracellular ROS,sparing stem cells from oxidative stress ***,these could effectively promote the osteogenic differentiation of stem cells with the activation of FoxO1 signaling,indicating the intrinsically osteogenic property of *** injecting the stem cells-laden FMSs into rat calvarial defects,the formation of new bone was remarkably reinforced,which is a positive synergic effect from modulating the ROS microenvironment and enhancing the osteogenesis of stem ***,the antioxidative FMSs,as injectable stem cell carriers,hold enormous promise for refractory bone healing,which can also be expanded to deliver a variety of other cells,targeting diseases that require in situ redox regulation.

关键词： Microfluidics Fullerol Reactive oxygen species Stem cell Refractory bone healing

Black phosphorus-based 2D materials for bone therapy

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Bioactive Materials 2020年第4期5卷 1026-1043页

作者： Liang Cheng Zhengwei Cai Jingwen Zhao Fei Wang Min Lu lianfu deng Wenguo Cui Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025PR China Jiaxing Key Laboratory of Basic Research and Clinical Translation on Orthopedic Biomaterials Department of OrthopaedicsThe Second Affiliated Hospital of Jiaxing University1518 North Huancheng RoadJiaxing 314000PR China

Since their discovery,Black Phosphorus(BP)-based nanomaterials have received extensive attentions in the fields of electromechanics,optics and biomedicine,due to their remarkable properties and excellent *** most essential feature of BP is that it is composed of a single phosphorus element,which has a high degree of homology with the inorganic components of natural bone,therefore it has a full advantage in the treatment of bone *** review will first introduce the source,physicochemical properties,and degradation products of BP,then introduce the remodeling process of bone,and comprehensively summarize the progress of BP-based materials for bone therapy in the form of hydrogels,polymer membranes,microspheres,and three-dimensional(3D)printed ***,we discuss the challenges and prospects of BP-based implant materials in bone immune regulation and outlook the future clinical application.

关键词： Tissue engineering Nanomaterial Black phosphorus Bone therapy

Gelatin-based composite hydrogels with biomimetic lubrication and sustained drug release

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Friction 2022年第2期10卷 232-246页

作者： Kuan ZHANG Jielai YANG Yulong SUN Yi WANG Jing LIANG Jing LUO Wenguo CUI lianfu deng Xiangyang XU Bo WANG Hongyu ZHANG State Key Laboratory of Tribology Department of Mechanical EngineeringTsinghua UniversityBeijing 100084China School of Chemical and Biological Engineering Shandong University of Science and TechnologyQingdao 266590China Department of Orthopedics Ruijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint Diseases Shanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai 200025China Beijing Research Institute of Automationfor Machinery Industry Co. Ltd.Beijing 100120China

The occurrence of osteoarthritis is closely related to progressive and irreversible destruction of the articular cartilage,which increases the friction significantly and causes further inflammation of the ***,a scaffold for articular cartilage defects should be developed via lubrication restoration and drug *** this study,we successfully synthesized gelatin-based composite hydrogels,namely GelMA–PAM–PMPC,with the properties of biomimetic lubrication and sustained drug release by photopolymerization of methacrylic anhydride modified gelatin(GelMA),acrylamide(AM),and 2-methacryloyloxyethyl phosphorylcholine(MPC).Tribological test showed that the composite hydrogels remarkably enhanced lubrication due to the hydration lubrication mechanism,where a tenacious hydration shell was formed around the zwitterionic phosphocholine *** addition,drug release test indicated that the composite hydrogels efficiently encapsulated an anti-inflammatory drug(diclofenac sodium)and achieved sustained ***,the in vitro test revealed that the composite hydrogels were biocompatible,and the mRNA expression of both anabolic and catabolic genes of the articular cartilage was suitably *** indicated that the composite hydrogels could effectively protect chondrocytes from inflammatory cytokine-induced *** summary,the composite hydrogels that provide biomimetic hydration lubrication and sustained local drug release represent a promising scaffold for cartilage defects in the treatment of osteoarthritis.

关键词： hydrogel articular cartilage zwitterionic polymer hydration lubrication drug delivery

In Situ-Activated Phospholipid-Mimic Artemisinin Prodrug via Injectable Hydrogel Nano/Microsphere for Rheumatoid Arthritis Therapy

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Research 2023年第3期2022卷 187-203页

作者： Yawei Du Chao Li Yu Zhang Wei Xiong Fei Wang Juan Wang Yingze Zhang lianfu deng Xinsong Li Wei Chen Wenguo Cui Department of Orthopaedics Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of Medicine197 Rujin 2nd RoadShanghai 200025China Department of Orthopaedic Surgery the Third Hospital of Hebei Medical UniversityNo.139 Ziqiang RoadShijiazhuang 050051China School of Chemistry and Chemical Engineering Southeast University2 Southeast University RoadNanjing 21189China

In situ-activated therapy is a decent option for localized diseases with improved efficacies and reduced side effects,which is heavily dependent on the local conversion or activation of bioinert *** this work,we applied a phospholipid-mimic artemisinin prodrug(ARP)for preparing an injectable nano/microsphere to first realize an in situ-activated therapy of the typical systemically administrated artemisinin-based medicines for a localized rheumatoid arthritis(RA)*** is simultaneously an alternative of phospholipids and an enzyme-independent activable prodrug,which can formulate“drug-in-drug”co-delivery liposomes with cargo of partner drugs(e.g.,methotrexate).To further stabilize ARP/methotrexate“drug-in-drug”liposomes(MTX/ARPL)for a long-term intra-articular retention,a liposome-embedded hydrogel nano/microsphere(MTX/ARPL@MS)was *** the local injection,the MTX/ARPL could be slowly released because of imine hydrolysis and targeted to RA synovial macrophages and fibroblasts *** assembly is relatively stable before cellular internalization but disassembled ARP after lysosomal escape and converted into dihydroartemisinin rapidly to realize the effective in situ *** together,phospholipid-mimic ARP was applied for the firstly localized in situ-activated RA therapy of artemisinin-based drugs,which also provided a brand-new phospholipid-mimic strategy for other systemically administrated prodrugs to realize a remodeling therapeutic schedule for localized diseases.

关键词： activation drugs preparing