Black phosphorus-based 2D materials for bone therapy

作     者：Liang Cheng Zhengwei Cai Jingwen Zhao Fei Wang Min Lu Lianfu Deng Wenguo Cui 

作者机构：Shanghai Key Laboratory for Prevention and Treatment of Bone and Joint DiseasesShanghai Institute of Traumatology and OrthopaedicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025PR China Jiaxing Key Laboratory of Basic Research and Clinical Translation on Orthopedic BiomaterialsDepartment of OrthopaedicsThe Second Affiliated Hospital of Jiaxing University1518 North Huancheng RoadJiaxing 314000PR China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2020年第5卷第4期

页      面：1026-1043页

核心收录：

学科分类：0710[理学-生物学] 0831[工学-生物医学工程（可授工学、理学、医学学位）] 1002[医学-临床医学] 08[工学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 080502[工学-材料学] 0836[工学-生物工程] 10[医学] 

基　　金：financially supported by the National Key R&D Program of China(2018YFC1106200) Shanghai Municipal Health and Family Planning Commission(201840027) Shanghai Municipal Education Commission-Gaofeng Clinical Medicine Grant Support(20171906) Shanghai Jiao Tong University“Medical and Research”Program(ZH2018ZDA04) 

主　　题：Tissue engineering Nanomaterial Black phosphorus Bone therapy 

摘      要：Since their discovery,Black Phosphorus(BP)-based nanomaterials have received extensive attentions in the fields of electromechanics,optics and biomedicine,due to their remarkable properties and excellent *** most essential feature of BP is that it is composed of a single phosphorus element,which has a high degree of homology with the inorganic components of natural bone,therefore it has a full advantage in the treatment of bone *** review will first introduce the source,physicochemical properties,and degradation products of BP,then introduce the remodeling process of bone,and comprehensively summarize the progress of BP-based materials for bone therapy in the form of hydrogels,polymer membranes,microspheres,and three-dimensional(3D)printed ***,we discuss the challenges and prospects of BP-based implant materials in bone immune regulation and outlook the future clinical application.