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Analysis of the anti-T2DM components in dichloromethane fraction of Schisandra sphenanthera and its mechanism

Traditional Medicine Research 2025年第1期10卷 27-43页

作者： Shi-Bo Feng Hai-Hui Jiang Hui-li kang Yi Jiang Hua-Wei Zhang Xiao-Mei Song Yu-Ze li Wen-li Huang Dong-Dong Zhang Chong Deng School of Pharmacy Shaanxi University of Chinese MedicineXianyang 712046China School of Pharmacy and Shaanxi Qinling Application Development and Engineering Center of Chinese Herbal Medicine Shaanxi University of Chinese MedicineXianyang 712046China Key Laboratory for Research and Development of“Qin Medicine”of Shaanxi Administration of Traditional Chinese Medicine Xianyang 712046China Shaanxi Key Laboratory of Research and Application of“Taibai Qi Yao” Xianyang 712046China

Background:The type 2 diabetes mellitus(T2DM)pharmacodynamic study of various parts of Schisandra sphenanthera was conducted in the previous stage,and it was found that dichloromethane extracted part(SDP)had a significant hypoglycemic ***,the components of SDP were analyzed,and the specific mechanism of its anti-T2DM was ***:We used a high-fat,high-sugar diet in combination with streptozotocin to induce a T2DM rat model,and the model rats were divided into two groups according to body weight and blood ***,oral glucose tolerance test,fasting blood glucose,low density lipoprotein cholesterol,superoxide dismutase,insulin,glycated hemoglobin,total cholesterol,nonesterified free fatty acids,alanine aminotransferase,high-density lipoprotein cholesterol,aspartate aminotransferase,malondialdehyde,and glutathione peroxidase were measured,organ indices were calculated,and pathological sections of pancreas and liver were *** 16S rRNA V3–V4 region of intestinal flora was sequenced to explore the effect of SDP on biochemical indicators and intestinal *** on the above indicators,the anti-T2DM mechanism of SDP in Schisandra sphenanthera was ***:After six weeks of administration,the biochemical indices of diabetic rats were diminished compared to the control *** SDP could significantly increase the gut microbialα-diversity index,resulting in significant changes in the flora of T2DM rats,with increased richness and diversity,reduced harmful flora,and significantly back-regulated the levels of acetic acid,propionic acid,and butyric ***:SDP can improve the symptoms associated with elevated blood glucose,dyslipidemia,elevated fasting insulin levels,and damaged glucose tolerance in *** against T2DM may be through the control of intestinal flora to normalize and exert anti-diabetic effect;its main active components may be lignans and terpenoids.

关键词： Schisandra sphenanthera T2DM intestinal flora HPLC

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Impacts of Nutlin-3a and exercise on murine double minute 2-enriched glioma treatment

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Neural Regeneration Research 2025年第4期20卷 1135-1152页

作者： Yisheng Chen Zhongcheng Fan Zhiwen Luo Xueran kang Renwen Wan Fangqi li Weiwei lin Zhihua Han Beijie Qi Jinrong lin Yaying Sun Jiebin Huang Yuzhen Xu Shiyi Chen Department of Sport Medicine Huashan HospitalFudan UniversityShanghaiChina Department of Orthopedic Surgery Hainan Province Clinical Medical CenterHaikou Affiliated Hospital of Central South University Xiangya School of MedicineHaikouHainan ProvinceChina Department of Basic Medicine Shanghai Jiao Tong University School of MedicineShanghai Jiao Tong UniversityShanghaiChina Department of Neurosurgery Second Affiliated Hospital of Zhejiang University School of MedicineZhejiang UniversityHangzhouZhejiang ProvinceChina Department of Orthopedics Shanghai General HospitalSchool of Medicine Shanghai Jiao Tong UniversityShanghaiChina Department of Infectious Diseases Children’s Hospital of Fudan UniversityNational Children’s Medical CenterShanghaiChina Department of Rehabilitation The Second Affiliated Hospital of Shandong First Medical UniversityTaianShandong ProvinceChina

Recent research has demonstrated the impact of physical activity on the prognosis of glioma patients,with evidence suggesting exercise may reduce mortality risks and aid neural *** role of the small ubiquitin-like modifier(SUMO)protein,especially post-exercise,in cancer progression,is gaining attention,as are the potential anti-cancer effects of *** used machine learning to create the exercise and SUMO-related gene signature(ESLRS).This signature shows how physical activity might help improve the outlook for low-grade glioma and other *** demonstrated the prognostic and immunotherapeutic significance of ESLRS markers,specifically highlighting how murine double minute 2(MDM2),a component of the ESLRS,can be targeted by *** underscores the intricate relationship between natural compounds such as nutlin-3 and immune *** comprehensive CRISPR screening,we validated the effects of specific ESLRS genes on low-grade glioma *** also revealed insights into the effectiveness of Nutlin-3a as a potent MDM2 inhibitor through molecular docking and dynamic ***-3a inhibited glioma cell proliferation and activated the p53 *** efficacy decreased with MDM2 overexpression,and this was reversed by Nutlin-3a or *** using a low-grade glioma mouse model highlighted the effect of physical activity on oxidative stress and molecular pathway ***,both physical exercise and Nutlin-3a administration improved physical function in mice bearing tumors derived from MDM2-overexpressing *** results suggest the potential for Nutlin-3a,an MDM2 inhibitor,with physical exercise as a therapeutic approach for glioma *** research also supports the use of natural products for therapy and sheds light on the interaction of exercise,natural products,and immune regulation in cancer treatment.

关键词： exercise and SUMO-related gene signatures(ESLRS) glioblastoma management low-grade glioma natural bioactives neural regeneration physical exercise

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应用iTRAQ技术对滩羊裘皮差异表达蛋白的研究

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中国畜牧兽医 2017年第9期44卷 2682-2691页

作者：杨佐青陶金忠李颖康丁伟刘永斌魏炳栋宁夏大学农学院银川750021 宁夏农林科学院银川750002 内蒙古自治区农牧业科学院呼和浩特010031 吉林省农业科学院动物营养所公主岭136100

为了研究与滩羊羊毛纤维粗细及弯曲度和特定花穗构成相关的差异蛋白,试验应用同位素标记相对和绝对定量(iTRAQ)蛋白质组学方法,联合多维液相色谱串联质谱(LC-MS/MS)技术对滩羊、内蒙古苏尼特羊、中卫山羊和新吉细毛羊的羊皮肤蛋白进行... 详细信息

为了研究与滩羊羊毛纤维粗细及弯曲度和特定花穗构成相关的差异蛋白,试验应用同位素标记相对和绝对定量(iTRAQ)蛋白质组学方法,联合多维液相色谱串联质谱(LC-MS/MS)技术对滩羊、内蒙古苏尼特羊、中卫山羊和新吉细毛羊的羊皮肤蛋白进行鉴定和筛选,并应用Proteome Discoverer 1.4软件进行定量分析,结合数据库搜索,鉴定出差异蛋白;最后应用生物信息学技术对差异蛋白进行GO分析和Pathway分析。4种羊皮肤中共鉴定到1 161个蛋白,其中内蒙古苏尼特羊与滩羊比对发现30个差异蛋白,中卫山羊与滩羊比对发现112个差异蛋白,新吉细毛羊与滩羊比对发现107个差异蛋白,对各比对组的皮肤差异蛋白进行分析,发现14-3-3蛋白σ亚型、KRT25、KRT34、KRT85、TCHH、KAP6和KAP11.1可能与滩羊羊毛纤维粗细及弯曲度和特定花穗形状的形成有关。本研究可为滩羊优质二毛裘皮选育研究提供科学依据。

关键词：滩羊皮肤 iTRAQ 差异表达蛋白

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Flexible molecules dedicate to release strain of inverted inorganic perovskite solar cell

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Journal of Energy Chemistry 2025年第1期100卷 87-93页

作者： Hongrui Sun Sanlong Wang Pengyang Wang Yali liu Shanshan Qi Biao Shi ying Zhao Xiaodan Zhang Institute of Photoelectronic Thin Film Devices and Technology Renewable Energy Conversion and Storage Center State Key Laboratory of Photovoltaic Materials and CellsNankai University Key Laboratory of Photoelectronic Thin Film Devices and Technology of Tianjin Haihe Laboratory of Sustainable Chemical Transformations Engineering Research Center of Thin Film Photoelectronic Technology of Ministry of Education Collaborative Innovation Center of Chemical Science and Engineering (Tianjin)

The tensile strain in inorganic perovskite films induced by thermal annealing is one of the primary factors contributing to the inefficiency and instability of inorganic perovskite solar cells （IPSCs）,which reduces the defect formation ***,a flexible molecule 5-maleimidovaleric acid （5-MVA） was introduced as a strain buffer to release the residual strain of *** anhydride and carboxyl groups in 5-MVA interact strongly with the uncoordinated Pb2+through Lewis acid-base reaction,thus tightly“pull”the perovskite *** in-between soft carbon chain increased the structural flexibility of CsPbI2.85Br0.15perovskite materials,which effectively relieved the intrinsic internal strain of CsPbI2.85Br0.15,resisted the corrosion of external strain,and also reduced the formation of defects such as VIand *** addition,the introduction of 5-MVA improved crystal quality,passivated residual defects,and narrowed energy level ***,power conversion efficiency （PCE） of NiOxbased inverted IPSCs increased from 19.25% to 20.82% with the open-circuit voltage enhanced from 1.164 V to 1.230 *** release of strain also improved the stability of CsPbI2.85Br0.15perovskite films and devices.

关键词： Inverted inorganic perovskite solar cells Flexible molecules Strain release Crystallization Energy barrier High PCE

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ALA-PDT对正常人角质形成细胞生物效应的实验研究

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激光生物学报 2011年第3期20卷 309-314页

作者：谢光辉李康英刘宏伟李嘉佩暨南大学附属第一医院整形美容激光科广东广州510630

目的:探讨ALA-PDT抑制角质形成细胞(KC)增殖的可行性和最佳效果。方法:新鲜包皮组织经两次酶消化法进行KC分离与培养,分设对照组、单纯ALA组、单纯照光组及0.1mmol/L、0.6mmol/L、1.2mmol/L、1.8mmol/L、3.6mmol/L ALA五个浓度组,经0.5h... 详细信息

目的:探讨ALA-PDT抑制角质形成细胞(KC)增殖的可行性和最佳效果。方法:新鲜包皮组织经两次酶消化法进行KC分离与培养,分设对照组、单纯ALA组、单纯照光组及0.1mmol/L、0.6mmol/L、1.2mmol/L、1.8mmol/L、3.6mmol/L ALA五个浓度组,经0.5h、1h、3h、5h四个避光孵育时间后PDT。酶标仪检测PDT后KC存活率、FCM检测KC中PpⅨ荧光强度,确定ALA最佳药物浓度和最佳用药时间;吖啶橙染色和AnnexinⅤ/PI双染法检测KC凋亡率和生长周期的影响。结果:0.6mmol/L ALA(用药1h)-PDT组为最佳药物浓度和最佳用药孵育时间,显示PpⅨ荧光强度表达与KC凋亡率最高,能明显抑制S期与G2期的细胞增殖,使细胞增殖指数降至最低。结论:0.6mmol/L ALA(用药孵育1h)-PDT能明显抑制KC增殖,更有效地促进正常KC凋亡。

关键词： ALA—PDT 角质形成细胞凋亡

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Increase in the variability of terrestrial carbon uptake in response to enhanced future ENSO modulation

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 32-38页

作者： Younong li li Dan Jing Peng Qidong Yang Fuqiang Yang Key Laboratory of Regional Climate-Environment for Temperate East Asia Institute of Atmospheric PhysicsChinese Academy of SciencesBeijingChina Key Laboratory of Atmospheric Environment and Processes in the Boundary Layer over the Low-Latitude Plateau Region Department of Atmospheric ScienceYunnan UniversityKunmingChina

El Niño-Southern Oscillation(ENSO)is a major driver of climate change in middle and low latitudes and thus strongly influences the terrestrial carbon cycle through land-air *** the ENSO modulation and carbon flux variability are projected to increase in the future,but their connection still needs further *** investigate the impact of future ENSO modulation on carbon flux variability,this study used 10 CMIP6 earth system models to analyze ENSO modulation and carbon flux variability in middle and low latitudes,and their relationship,under different scenarios simulated by CMIP6 *** results show a high consistency in the simulations,with both ENSO modulation and carbon flux variability showing an increasing trend in the *** higher the emissions scenario,especially SSP5-8.5 compared to SSP2-4.5,the greater the increase in *** flux variability in the middle and low latitudes under SSP2-4.5 increases by 30.9%compared to historical levels during 1951-2000,while under SSP5-8.5 it increases by 58.2%.Further analysis suggests that ENSO influences mid-and low-latitude carbon flux variability primarily through *** occurrence may potentially be attributed to the increased responsiveness of gross primary productivity towards regional temperature fluctuations,combined with the intensified influence of ENSO on land surface temperatures.

关键词： Carbon variability ENSO modulation CMIP6 models

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芝麻过敏原Ses i 2核酸适体的筛选与鉴定研究

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核农学报 2025年第1期39卷 59-67页

作者：李洋于宁康文瀚张九凯杜欣军陈颖天津科技大学食品科学与工程学院天津300457 中国检验检疫科学研究院北京100176

芝麻是八大类食物过敏原之一,快速准确识别芝麻过敏原对预防其过敏有重要意义。核酸适配体可以高效识别靶标过敏原,在过敏原检测中有良好的应用前景。为了获得芝麻主要过敏原Ses i 2的特异性核酸适体,本研究以Ses i 2为靶标,通过磁珠筛... 详细信息

芝麻是八大类食物过敏原之一,快速准确识别芝麻过敏原对预防其过敏有重要意义。核酸适配体可以高效识别靶标过敏原,在过敏原检测中有良好的应用前景。为了获得芝麻主要过敏原Ses i 2的特异性核酸适体,本研究以Ses i 2为靶标,通过磁珠筛选法(磁珠-SELEX)开展10轮筛选,经由高通量测序获得6条候补序列(S1~S6),并进行家族性、同源性分析及二级结构预测。结果表明,6条候选核酸适体的重复率可达46.38%,其自由能在-9.02到-2.47 kcal·moL^(-1)之间,根据自由能能量稳定原则,S1和S5吉布斯自由能最低最稳定,分别为-6.70和-9.02 kcal·moL^(-1)。利用EliSA试验进行亲和力测试,结果表明核酸适体S1和S2的亲和能力较强,S1:KD=67.02 nmol·L^(-1),R2=0.925 8,S2:KD=97.65 nmol·L^(-1),R2=0.795 1。核酸适体S1与过敏原Ses i 2的结合力和其他过敏原蛋白相比有显著差异,可视为具有特异性。本研究最终获得一条兼具良好亲和力和特异性的核酸适体S1,为芝麻过敏原快速检测提供了技术支撑。

关键词：芝麻过敏原 Ses i 2 核酸适体亲和力

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Primary parenchymal squamous cell carcinoma of the kidney:A case report

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World Journal of Clinical Cases 2025年第4期13卷 34-40页

作者： Zhi-Hui Zheng Bo Shao Chao-Min Xu Ke Wang Jia-Zhu Wen li-kang Luo Jia-Cheng Guan Department of Ultrasound The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Radiology Shulan(Quzhou)HospitalQuzhou 324000Zhejiang ProvinceChina Department of Radiology The Second People’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina Department of Pathology The Second people’s Hospital of QuzhouQuzhou 324000Zhejiang ProvinceChina

BACKGROUND Primary squamous cell carcinoma(SCC)of the renal parenchyma is extremely rare,with only nine cases *** SUMMARY This study reports a 51-year-old man with primary SCC of the renal *** patient was admitted with recurrent dull pain and discomfort in the right lumbar region,which had worsened over 2 weeks,accompanied by painful gross *** antigen(SCCA)levels were elevated,and imaging revealed a renal mass with associated *** patient underwent laparoscopic unilateral nephrectomy and lymph node *** pathology confirmed highly differentiated SCC with necrosis in the right renal parenchyma,with negative renal pelvis and *** pathological stage was *** months after surgery,the tumor recurred with involvement of the liver,right psoas major muscle,and inferior vena *** patient refused chemotherapy and succumbed to the disease 6 months postoperatively due to disease *** We report a case of primary SCC of the renal parenchyma,a rare renal *** clinical symptoms,laboratory tests,and imaging findings are nonspecific,making accurate and timely diagnosis *** to the literature,for patients with renal calculi accompanied by a renal mass,elevated serum SCCA levels,and magnetic resonance imaging showing cystic or cystic-solid masses within the kidney with pseudocapsules and heterogeneous mild enhancement,the possibility of this disease should be considered.

关键词： Renal tumor Renal parenchyma Squamous cell carcinoma Renal calculi Computed tomography Case report

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Met-Controlled Allosteric Module of Neural Generation as A New Therapeutic Target in Rodent Brain Ischemia

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Chinese Journal of Integrative Medicine 2021年第12期27卷 896-904页

作者： li kang-ning ZHANG ying-ying YU Ya-nan WU Hong-li WANG Zhong Department of Traditional Chinese Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijing(100070)China Institute of Basic Research in Clinical Medicine China Academy of Chinese Medical SciencesBeijing(100700)China

Objective To investigate a Met-controlled allosteric module(AM)of neural generation as a potential therapeutic target for brain *** We selected Markov clustering algorithm(MCL)to mine functional modules in the related target *** to the topological similarity,one functional module was predicted in the modules of baicalin(BA),jasminoidin(JA),cholic acid(CA),compared with I/R model *** functional module included three genes:Inppl1,Met and Dapk3(IMD).By gene ontology enrichment analysis,biological process related to this functional module was *** functional module participated in generation of *** blotting was applied to present the compound-dependent regulation of ***-immunoprecipitation was used to reveal the relationship among the three *** used IF to determine the number of newborn neurons between compound treatment group and ischemia/reperfusion *** expressions of vascular endothelial growth factor(VEGF)and matrix metalloproteinase 9(MMP-9)were supposed to show the changing circumstances for neural generation under cerebral *** Significant reduction in infarction volume and pathological changes were shown in the compound treatment groups compared with the I/R model group(Plidated successfully in *** neurons increased in BJC treatment group(Pying pharmacological mechanisms in cere

关键词： allosteric module InppM-Met-Dapk3 generation of neurons brain ischemia

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Peridynamic Modeling and Simulation of Ice Craters By Impact

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Computer Modeling in Engineering & Sciences 2019年第11期121卷 465-492页

作者： ying Song Jiale Yan Shaofan li Zhuang kang College of Shipbuilding Engineering Harbin Engineering UniversityHarbin150001China Department of Civil and Environmental Engineering University of CaliforniaBerkeleyCAUSA

In the present work,a state-based peridynamics with adaptive particle refinement is proposed to simulate water ice crater formation due to impact loads.A modified Drucker-Prager constitutive model was adopted to model ice and was implemented in the state-based peridynamic equations to analyze the elastic-plastic deformation of *** simulations,we use the fracture toughness failure criterion in peridynamics to simulate the quasi-brittle failure of *** adaptive particle refinement method in peridynamics was proposed to improve computational *** results obtained using the peridynamic model were compared with the experiments in previous *** was found that the peridynamic simulation results and the experiments matched well except for some minor differences discussed,and the state-based peridynamic model has shown the specific predictive capacity to capture the detailed crater features of the ice.

关键词： Peridynamics ice constitutive model adaptive particle refinement ice craters impact

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