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International Journal of Ophthalmology(English edition) 2019年第6期12卷 943-948页

作者： Jia-Qing Zhang Xu-Yuan Zou Dan-Ying Zheng Wei-Rong Chen Ao Sun li-xia luo State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University

AIM: To evaluate the effect of different lens constant optimization methods on the accuracy of intraocular lens(IOL) power calculation formulas for highly myopic ***: This study comprised 108 eyes of 94 consecutive patients with axial length(AL) over 26 mm undergoing phacoemulsification and implantation of a Rayner(Hove, UK) 920H IOL. Formulas were evaluated using the following lens constants: manufacturer’s lens constant, User Group for Laser Interference Biometry(UliB) constant, and optimized constant for long eyes. Results were compared with Barrett Universal II formula, original Wang-Koch AL adjustment method, and modified Wang-Koch AL adjustment method. The outcomes assessed were mean absolute error(MAE) and percentage of eyes with IOL prediction errors within ±0.25, ±0.50, and ±1.0 diopter(D). The nonparametric method, Friedman test, was used to compare MAE performance among ***: Optimized constants could significantly reduce the MAE of SRK/T, Hoffer Q, and Holladay 1 formulas compared with manufacturer’s lens constant, whereas the percentage of eyes with IOL prediction errors within ±0.25, ±0.50, and ±1.0 D had no statistically significant differences. Optimized lens constant for long eyes alone showed non-significant refractive advantages over the UliB constant. Barrett Universal II formula and formulas with AL adjustment showed significantly higher accuracy in highly myopic eyes(Plimited extent for highly myopic eyes.

关键词： high myopia cataract intraocular lens power lens constant optimization prediction error

Hotspots and frontiers of genetic research on pediatric cataracts from 2013 to 2022:a scientometric analysis

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International Journal of Ophthalmology(English edition) 2023年第10期16卷 1682-1691页

作者： Yuan Tan Wei Jiang Le-Yi Hu Yan-Yu Shen Hui Chen Ying-Shi Zou li-xia luo Guang-Ming Jin Zhen-Zhen liu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060Guangdong ProvinceChina Zhongshan Medical School Sun Yat-sen UniversityGuangzhou 510060Guangdong ProvinceChina

AIM:To explore the hotspots and frontiers of genetic research on pediatric ***:Global publications from 2013 to 2022 related to genes in pediatric cataracts were extracted from the Web of Science Core Collection,and were analyzed in terms of the publication counts,countries,journals,authors,keywords,cited references,subject categories,and the underlying hotspots and ***:Totally 699 publications were included in the final *** predominant actors were identified,with China(n=240)and PLoS One(n=33)being the most productive country and journal *** research hotspots extracted from keywords were crystallin gene mutations,pathogenicity evaluation,phenotypes of ocular and neurodevelopmental abnormalities,genes encoding membrane proteins,and diagnosis of multisystemic *** co-cited articles formed 10 clusters of research topics,including FYCO1(56 items),mutation screening(43 items),gap junction(29 items),the Warburg Micro syndrome(29 items),ephrin-A5(28 items),novel mutation(24 items),eye development and function(22 items),cholestanol(7 items),OCRL(6 items),and pathogenicity prediction(3 items).The research frontiers were FYCO1,ephrin-A5,and *** biology showed the strongest bridging effects among different disciplines in the field(betweenness centrality=0.44).CONCLUSION:With the progress in next-generation sequencing and multidisciplinary collaboration,genetic research on pediatric cataracts broadens the knowledge scope of the crystalline lens,as well as other organs and systems,shedding light on the molecular mechanisms of systemic *** biology may integrate multidisciplinary content to address cutting-edge issues in the field.

关键词： gene pediatric cataract next generation sequencing genotype phenotype association

Timing and approaches in congenital cataract surgery:a four-year,two-layer randomized controlled trial

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International Journal of Ophthalmology(English edition) 2017年第12期10卷 1835-1843页

作者： Hao-Tian lin Er-Ping Long Jing-Jing Chen Zhen-Zhen liu Zhuo-ling lin Qian-Zhong Cao xia-Yin Zhang xiao-Hang Wu Qi-Wei Wang Duo-Ru lin xiao-Yan li Jin-Chao liu li-xia luo Bo Qu Wei-Rong Chen Yi-Zhi liu State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Ya-sen UniversityGuangzhou 510060Guangdong ProvinceChina

AIM：To compare visual prognoses and postoperative adverse events of congenital cataract surgery performed at different times and using different surgical ***：In this prospective,randomized controlled trial,we recruited congenital cataract patients aged 3 mo or younger before cataract ***-one eligible patients were randomly assigned to two groups according to surgical timing：a 3-month-old group and a 6-month-old *** eye underwent one of three randomly assigned surgical procedures,as follows：surgery A,lens aspiration（I/A）;surgery B,lens aspiration with posterior continuous curvilinear capsulorhexis（I/A＋PCCC）;and surgery C,lens aspiration with posterior continuous curvilinear capsulorhexis and anterior vitrectomy（I/A＋PCCC＋A-Vit）.The long-term best-corrected visual acuity（BCVA） and the incidence of complications in the different groups were compared and ***：A total of 57 participants（114 eyes） with a mean follow-up period of 48.7 mo were included in the final *** overall log MAR BCVA in the 6-month-old group was better than that in the 3-month-old group（0.81±0.28 vs 0.96±0.30;P=0.02）.The overall log MAR BCVA scores in the surgery B group were lower than the scores in the A and C groups（A：0.80±0.29,B：1.02±0.28,and C：0.84±0.28;P=0.007）.A multivariate linear regression revealed no significant relationships between the incidence of complications and long-term ***：It might be safer and more beneficial for bilateral total congenital cataract patients to undergosurgery at 6 mo of age than 3 ***,with rigorous follow-up and timely intervention,the postoperative complications in these patients are treatable and do not compromise visual outcomes.

关键词： pediatric cataract surgery postoperativecomplications long-term visual function

Brain endothelial cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway in aging and neurodegeneration

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Neural Regeneration Research 2025年第7期20卷 2005-2007页

作者： Bryan Sun Lulin li Jian luo Palo Alto Veterans Institute for Research VA Palo Alto Health Care SystemPalo AltoCAUSA Polytrauma System of Care VA Palo Alto Health Care SystemPalo AltoCAUSA

The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway has emerged as a key mediator of *** current studies primarily attribute its effects to neurons and glial cells,emerging research suggests that cGAS-STING signaling may play a critical role in cerebral vasculature,particularly in brain endothelial ***,studying the role 7of inflammation caused by the cGAS-STING pathway in brain endothelial cells could provide a more comprehensive understanding of neuroinflammatory disease and new avenues for therapeutic ***,we review the multifaceted role of global cGAS-STING signaling in various neurological and neuroinflammatory diseases and the potential contribution of cGAS-STING in brain endothelial cells.

关键词： stimulator interferon inflammation

玻璃体切除术后白内障发生或进展的机制及其影响因素

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国际眼科杂志 2021年第12期21卷 2076-2080页

作者：张妙罗莉霞中山大学中山眼科中心眼科学国家重点实验室中国广东省广州市510060

玻璃体切除术(pars plana vitrectomy,PPV)自1972年由O'Malley提出后已成为眼科治疗史的一大革命,打破了既往的手术禁区,为无数玻璃体视网膜疾病的患者带去了希望。随着玻璃体切除术的不断发展,其安全性及有效性增加,手术适应证扩大,目... 详细信息

玻璃体切除术(pars plana vitrectomy,PPV)自1972年由O'Malley提出后已成为眼科治疗史的一大革命,打破了既往的手术禁区,为无数玻璃体视网膜疾病的患者带去了希望。随着玻璃体切除术的不断发展,其安全性及有效性增加,手术适应证扩大,目前玻璃体切除术已成为治疗眼后段疾病最常用的手术方式。虽然玻璃体切除术后并发症越来越少,但白内障的发生或进展仍为PPV术后最常见的高发并发症,严重影响患者术后视力及眼底的观察,且目前尚无有效办法预防,白内障摘除手术为其主要治疗方法,严重增加了患者的负担。PPV术后白内障进展的影响因素众多,对其发病机制有多种假说,包括晶状体周围氧分压增高、玻璃体正常结构的破坏、光毒性等,但尚无定论。本文将从PPV术后白内障发生或进展的发生率、发生机制、影响因素几方面对玻璃体切除术后白内障发生或进展进行综述,以期为其后续的研究及临床预防和治疗提供参考。

关键词：玻璃体切除术白内障机制影响因素

Eye health is everyone's responsibility: China's first Western-style eye hospital improves in the prevention of blindness

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International Journal of Ophthalmology(English edition) 2012年第5期5卷 638-640页

作者： Hao-Tian lin, li-xia luo, Wei-Rong Chen, Yi-Zhi liu State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, Guangdong Province, China The first three authors contributed equally to this work. State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat-sen University Guangzhou 510060 Guangdong Province China

AIM: To investigate the relationship between China's first Western-style eye hospital development and the prevention of blindness in China and determine the main factor influencing eye health today. METHODS: Data about eye health, blindness and cataract surgery rate of China from public website of World Health Organization (WHO), ORBIS International, Ministry of Health (MOH) of China, Pubmed center and Historical Archives of Zhongshan Ophthalmic Center (ZOC) were reviewed and analyzed. RESULTS: ZOC is China's first Western-style eye hospital. In 2012, the ORBIS Flying Eye Hospital has chosen ZOC once again as one of its destinations, 30 years after ORBIS expanded internationally to train eye care professionals and treat underserved patients in developing countries in 1982. During the past 30 years, cataract surgery rate and public awareness of blindness prevention were improved greatly in China, in which ZOC plays a very important role. CONCLUSION: ZOC, as China's first Western-style eye hospital,has improved in the prevention of blindness. Eye health has become everyone’s responsibility.

关键词： eye health blindness cataract surgery rate

Efficient OpenMP Based Z-curve Encoding and Decoding Algorithms

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Computers, Materials & Continua 2025年第1期82卷 1313-1327页

作者： Zicheng Zhou Shaowen Sun Teng liang Mengjuan li Fengling xia School of Electronic Science and Engineering University of Electronic Science and Technology of ChinaChengdu611731China Faculty of Information Engineering and Automation Kunming University of Science and TechnologyKunming650500China School of Communications Information Engineering Yunnan Communications Vocational and Technical CollegeKunming650500China library Yunnan Normal UniversityKunming650500China Faculty of Civil Aviation and Aeronautics Kunming University of Science and TechnologyKunming650500China

Z-curve’s encoding and decoding algorithms are primely important in many Z-curve-based *** bit interleaving algorithm is the current state-of-the-art algorithm for encoding and decoding *** simple,its efficiency is hindered by the step-by-step coordinate shifting and bitwise *** tackle this problem,we first propose the efficient encoding algorithm LTFe and the corresponding decoding algorithm LTFd,which adopt two optimization methods to boost the algorithm’s efficiency:1)we design efficient lookup tables(LT)that convert encoding and decoding operations into table-lookup operations;2)we design a bit detection mechanism that skips partial order of a coordinate or a Z-value with consecutive 0s in the front,avoiding unnecessary iterative *** propose order-parallel and point-parallel OpenMP-based algorithms to exploit the modern multi-core *** results on discrete,skewed,and real datasets indicate that our point-parallel algorithms can be up to 12.6×faster than the existing algorithms.

关键词： Z-curve lookup table OpenMP bit detection mechanism

Perfluoropentane-based oxygen-loaded nanodroplets reduce microglial activation through metabolic reprogramming

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Neural Regeneration Research 2025年第4期20卷 1178-1191页

作者： Wanxian luo Chuanhui Xu linxi li Yunxiang Ji Yezhong Wang Yingjia li Yongyi Ye Department of Medicine Ultrasonics Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Institute of Neuroscience Department of NeurosurgeryThe Second Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina

Microglia,the primary immune cells within the brain,have gained recognition as a promising therapeutic target for managing neurodegenerative diseases within the central nervous system,including Parkinson’s *** perfluorocarbon droplets have been reported to not only possess a high oxygen-carrying capacity,but also exhibit remarkable anti-inflammatory ***,the role of perfluoropentane in microglia-mediated central inflammatory reactions remains poorly *** this study,we developed perfluoropentane-based oxygen-loaded nanodroplets(PFP-OLNDs)and found that pretreatment with these droplets suppressed the lipopolysaccharide-induced activation of M1-type microglia in vitro and in vivo,and suppressed microglial activation in a mouse model of Parkinson’s *** suppression led to a reduction in the inflammatory response,oxidative stress,and cell migration capacity in ***,the neurotoxic effects were mitigated,which alleviated neuronal ***,ultrahigh-performance liquid chromatography–tandem mass spectrometry showed that the anti-inflammatory effects of PFP-OLNDs mainly resulted from the modulation of microglial metabolic *** further showed that PFP-OLNDs regulated microglial metabolic reprogramming through the AKT-mTOR-HIF-1α***,our findings suggest that the novel PFP-OLNDs constructed in this study alleviate microglia-mediated central inflammatory reactions through metabolic reprogramming.

关键词： metabolic reprogramming microglia microglial migration nanotherapy neurodegenerative diseases neuroinflammation oxygen-loaded nanodroplets Parkinson’s disease perfluoropentane ultra-performance liquid chromatography–mass spectrometry

白内障合并高度近视患者术后屈光力预测的研究进展

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国际眼科杂志 2019年第6期19卷 929-932页

作者：张佳晴罗莉霞中山大学中山眼科中心眼科学国家重点实验室

白内障合并高度近视患者术后实际屈光力与术前目标屈光力存在差异,常见远视漂移。针对这类患者术后的屈光误差,除了传统的预留近视度数的方法外,国际上出现了更精准、有效的解决方法,如优化眼轴长度、采用新一代公式(Barrett Universal... 详细信息

白内障合并高度近视患者术后实际屈光力与术前目标屈光力存在差异,常见远视漂移。针对这类患者术后的屈光误差,除了传统的预留近视度数的方法外,国际上出现了更精准、有效的解决方法,如优化眼轴长度、采用新一代公式(Barrett UniversalⅡ、Olsen、Hill-RBF、Ladas Super公式以及FullMonte方法)、术中屈光生物测量。本文将以高度近视患者的术后屈光误差为核心,阐述现有方法的研究进展。

关键词：高度近视白内障术后屈光误差人工晶状体计算

有晶状体眼后房型人工晶状体长度选择和拱高的研究进展

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国际眼科杂志 2018年第1期18卷 68-71页

作者：张佳晴罗莉霞中山大学中山眼科中心眼科学国家重点实验室中国广东省广州市510060

有晶状体眼后房型人工晶状体植入术已在全世界广泛开展,安全性和有效性得到了证实。如何准确地选择植入人工晶状体的长度以获得理想的拱高,从而减少术后并发症,一直是学者们研究的焦点。本文以有晶状体眼后房型人工晶状体长度选择和拱... 详细信息

有晶状体眼后房型人工晶状体植入术已在全世界广泛开展,安全性和有效性得到了证实。如何准确地选择植入人工晶状体的长度以获得理想的拱高,从而减少术后并发症,一直是学者们研究的焦点。本文以有晶状体眼后房型人工晶状体长度选择和拱高为中心,对相关问题作一综述。

关键词：有晶状体眼后房型人工晶状体拱高可植入型胶原人工晶状体