Brain endothelial cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway in aging and neurodegeneration

作     者：Bryan Sun Lulin Li Jian Luo 

作者机构：Palo Alto Veterans Institute for ResearchVA Palo Alto Health Care SystemPalo AltoCAUSA Polytrauma System of CareVA Palo Alto Health Care SystemPalo AltoCAUSA 

出 版 物：《Neural Regeneration Research》 (中国神经再生研究（英文版）)

年 卷 期：2025年第20卷第7期

页      面：2005-2007页

核心收录：

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：partially supported by a grant(RF1AG059694)from the U.S.National Institutes of Health by Polytrauma System of Care,VAPAHCS(to JL) 

主　　题：stimulator interferon inflammation 

摘      要：The cyclic GMP-AMP synthase(cGAS)-stimulator of interferon genes(STING)signaling pathway has emerged as a key mediator of *** current studies primarily attribute its effects to neurons and glial cells,emerging research suggests that cGAS-STING signaling may play a critical role in cerebral vasculature,particularly in brain endothelial ***,studying the role 7of inflammation caused by the cGAS-STING pathway in brain endothelial cells could provide a more comprehensive understanding of neuroinflammatory disease and new avenues for therapeutic ***,we review the multifaceted role of global cGAS-STING signaling in various neurological and neuroinflammatory diseases and the potential contribution of cGAS-STING in brain endothelial cells.