Timing and approaches in congenital cataract surgery:a four-year,two-layer randomized controlled trial
Timing and approaches in congenital cataract surgery:a four-year,two-layer randomized controlled trial作者机构：State Key Laboratory of OphthalmologyZhongshan Ophthalmic CenterSun Ya-sen UniversityGuangzhou 510060Guangdong ProvinceChina
出 版 物：《International Journal of Ophthalmology(English edition)》 (国际眼科杂志（英文版）)
年 卷 期：2017年第10卷第12期
页 面：1835-1843页
核心收录：
学科分类：1002[医学-临床医学] 100212[医学-眼科学] 10[医学]
基 金：Supported by the 973 Program(No.2015CB964600) National Natural Science Foundation of China(No.91546101 No.81300750) the Guangdong Provincial Natural Science Foundation for Distinguished Young Scholars(No.2014A030306030) the Tip-top Scientific and Technical Innovative Youth Talents of Guangdong Special Support Program(No.2014TQ01R573) the Clinical Research and Translational Medical Center of Pediatric Cataracts in Guangzhou(No.201505032017516)
主 题：pediatric cataract surgery postoperativecomplications long-term visual function
摘 要：AIM：To compare visual prognoses and postoperative adverse events of congenital cataract surgery performed at different times and using different surgical ***：In this prospective,randomized controlled trial,we recruited congenital cataract patients aged 3 mo or younger before cataract ***-one eligible patients were randomly assigned to two groups according to surgical timing：a 3-month-old group and a 6-month-old *** eye underwent one of three randomly assigned surgical procedures,as follows：surgery A,lens aspiration（I/A）;surgery B,lens aspiration with posterior continuous curvilinear capsulorhexis（I/A＋PCCC）;and surgery C,lens aspiration with posterior continuous curvilinear capsulorhexis and anterior vitrectomy（I/A＋PCCC＋A-Vit）.The long-term best-corrected visual acuity（BCVA） and the incidence of complications in the different groups were compared and ***：A total of 57 participants（114 eyes） with a mean follow-up period of 48.7 mo were included in the final *** overall log MAR BCVA in the 6-month-old group was better than that in the 3-month-old group（0.81±0.28 vs 0.96±0.30;P=0.02）.The overall log MAR BCVA scores in the surgery B group were lower than the scores in the A and C groups（A：0.80±0.29,B：1.02±0.28,and C：0.84±0.28;P=0.007）.A multivariate linear regression revealed no significant relationships between the incidence of complications and long-term ***：It might be safer and more beneficial for bilateral total congenital cataract patients to undergosurgery at 6 mo of age than 3 ***,with rigorous follow-up and timely intervention,the postoperative complications in these patients are treatable and do not compromise visual outcomes.
维普期刊数据库