检索结果-南通市图书馆

Bovine Serum Albumin Loaded Solid lipid Nanoparticles Prepared by Double Emulsion Method

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2010年第1期26卷 136-141页

作者： li Zhen li Xin-wei ZHENG li-qiang liN Xiao-hong GENG Fei YU li Key Laboratory of Colloid and Interface Chemistry Ministry of Education Shandong University Jinan 250100 P. R. China

Solid lipid nanoparticles loaded with bovine serum albumin（BSA） were prepared by a double emulsion method. As the mass fraction of the model drug BSA increased from 0 to 15%, the particle size gradually increased. The physical stability of the nanoparticles was investigated by zeta potential measurement and they were shown to be quite stable. Fluorescence spectroscopy confirmed that the loaded position of BSA was on the interface between the inner aqueous phase and the solid lipid phase. Both Fourier-transform infrared spectroscopy and circular dichroism spectra indicate that BSA in the nanoparticles was not destroyed, but the secondary structure was disrupted slightly.

关键词： Solid lipid nanoparticle Double emulsion Bovine serum albumin Drug model

An efficient synthesis of 3-(guaiazulene-1-yl)succinimides by addition of guaiazulene to maleimides

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2011年第7期22卷 789-792页

作者： Dao lin Wang Shao Fei li wei li Yuan Feng li li Nan lin Key Laboratory of Synthesis & Application of Functional Compound College of Chemistry & Chemical Engineering Bohai University Jinzhou 121001 China

A facile, efficient synthesis of 3-（guaiazulen-l-yl）succinimides was developed by Michael-type addition of guaiazulene to maleimides in the presence of p-toluenesulfonic acid under mild reaction conditions.

关键词： Guaiazulene Succinimidcs Michael-type addition p-Toluenesulfonic acid

Rapid Detection of rpoB Gene Mutations in Rif-resistant *** Isolates by Oligonucleotide Microarray

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2009年第3期22卷 253-258页

作者： AI-HUA SUN XING-li FAN li-wei li li-FANG WANG WEN-YING AN JIE YAN Department of Basic Medicine Zhejiang Medical College Hangzhou 310053 Zhejiang China Department of Medical Microbiology and Parasitology Zhejiang University Hangzhou 310058 Zhejiang China School of lnternational Stud3 Zhejiang University Hangzhou 310058 Zhejiang China

Objective To detect the specific mutations in rpoB gene of Mycobacterium tuberculosis by oligonucleotide microarray. Methods Four wild-type and 8 mutant probes were used to detect rifampin resistant strains. Target DNA of M. tuberculosis was amplified by PCR, hybridized and scanned. Direct sequencing was performed to verify the results of oligonucleotide microarray Results Of the 102 rifampin-resistant strains 98 （96.1%） had mutations in the rpoB genes. Conclusion Oligonucleotide microarray with mutation-specific probes is a reliable and useful tool for the rapid and accurate diagnosis of rifampin resistance in M. tuberculosis isolates.

关键词： Mycobacterium tuberculosis Rifampin resistance rpoB gene / site mutation Oligonucleotide microarray/detection

Economic Status and Social Attitudes of Migrant Workers in China

在线全文

学校读者我要写书评

暂无评论

China & World Economy 2007年第4期15卷 1-16页

作者： Peilin li, wei li Professor Institute of Sociology Chinese Academy of Social Sciences Beijing China. Email: lipl@*** Associate Professor Institute of Sociology Chinese Academy of Social Sciences Beijing China. Email: li.wei@***.

Migrant workers, meaning those who used to be farmers but have left rural areas and found jobs in cities as a result of economic reform and rapid development in China, have made a significant contribution to the burgeoning labor market and played an important role in speeding up the transition from a planned to a market economy. This present paper considers the economic status and social attitudes of migrant workers. It is based on the analysis of a large-scale survey in 2006, which was conducted using questionnaires and covered 28 provinces, municipalities and autonomous regions throughout the country. It was found that the income status of migrant workers depends heavily on the education and technical skills that they have developed, rather than on identity-based discrimination. Surprisingly, it was also found that those on less income and of lower economic and social status show more positive attitudes to society than those who are affluent and considered of higher social status. It is concluded that the decisive factor in attitude and behavior of migrant workers is historic rather than economic.

关键词： China economic status migrant worker social attitude

Synthesis and Spectroscopic Properties of a Series of New tetra-Substituted Metal Phthalocyanines

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2008年第2期24卷 123-128页

作者： YU Hai-ling YANG Jin, FU Qiang MA Ji-cheng li wei-li Faculty of Chemistry Northeast Normal University Changehun 130024 P. R. China

A new class of metal phthalocyanines（MPcs） containing four 8-quinolinol（8-QH） derivative moieties were successfully synthesized and characterized by mass spectroscopy, IR, UV-Vis and element analysis, the results of which were consistent with the proposed structures. All of them can dissolve in common organic solvents, such as dichloromethane, chloroform, and acetone. The effect of metal ion on the absorption of Q band was studied with UV-Vis spectra. The fluorescent properties for those complexes were also investigated.

关键词： Metal phthalocyanines Soluble 8-Quinolinol UV-Vis spectrum

Effects of Sc and Zr microalloying on the microstructure and mechanical properties of high Cu content 7xxx Al alloy

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2019年第12期26卷 1559-1569页

作者： Chong-yu liu Guang-biao Teng Zong-yi Ma li-li wei Bing Zhang Yong Chen College of Material Science and Engineering Guilin University of TechnologyGuilin 541004China Guangdong JMA Aluminum Profile Factory(Group)Co. Ltd.Foshan 528200China Institute of Metal Research Chinese Academy of SciencesShenyang 110016China State Key Laboratory of Metastable Materials Science and Technology Yanshan UniversityQinhuangdao 066004China

The effects of Sc and Zr microalloying on the microstructure and mechanical properties of a 7xxx Al alloy with high Cu content(7055)during casting,deformation,and heat treatment were *** addition of Sc and Zr not only refined the grains but also transformed theθ-phase into the W-phase in the 7055 *** Sc and Zr additions enhanced the hardness and yield strength of the 7055-T6 alloy by strengthening the grain boundaries and Al3(Sc,Zr)***,a further increase in the Sc and Zr fractions did not refine the grains but instead resulted in the formation of the large-sized W-phase and primary coarse Al3(Sc,Zr)phase and subsequently deteriorated the mechanical properties of the *** 7055 alloy with 0.25Sc addition exhibited the best mechanical property among the prepared alloys.

关键词： aluminum alloys microstructural evolution mechanical property grain refinement

Preparation and Ethanol Sensing Properties of ZnO Nanofibers

在线全文

学校读者我要写书评

暂无评论

Chemical Research in Chinese Universities 2011年第5期27卷 720-723页

作者： FENG Cai-hui RUAN Sheng-ping ZHU ling-hui li Chao li wei CHEN wei-you CHEN li-hua ZHANG Xin-dong State Key Laboratory on Integrated Optoelectronics College of Electronic Science and Engineering Jilin University Changehun 130012 P. R. China

ZnO nanofibers with an average diameter of about 90 nm were prepared by an electrospinning method combined with a calcination process. The as-electrospun nanofibers before and after calcination were characterized by means of differential thermal analysis（DTA）, thermal gravimetric analysis（TGA）, X-ray diffraction（XRD） and scanning electron microscopy（SEM）. The fibers after calcination at 600 °C belong to the hexagonal wurtzite structure. The sensor based on ZnO nanofibers exhibited excellent ethanol sensing properties at 206 °C such as good linear dependence in the low concentration（1―100 μL/L）, high response, and good selectivity. Fast response（less than 2 s） and recovery（about 16 s） were also observed in our investigations.

关键词： Electrospinning method ZnO Nanofiber Ethanol Gas sensor

Inhibitory Effect of PPARδAgonist GW501516 on Proliferation of Hypoxia-induced Pulmonary Arterial Smooth Muscle Cells by Regulating the mTOR Pathway

在线全文

学校读者我要写书评

暂无评论

Current Medical Science 2023年第5期43卷 979-987页

作者： Chang-gui CHEN Chun-feng YI Chang-fa CHEN li-qun TIAN li-wei li li YANG Zuo-min li li-qun HE Department of Cardiology Wuhan No.1 HospitalWuhan Hospital of Traditional Chinese and Western MedicineWuhan 430022China Shanghai Smartide Biotechnology Co.Ltd. Shanghai 201203China

Objective This study aimed to investigate the effects of the peroxisome proliferator-activated receptorδ(PPARδ)agonist GW501516 on the proliferation of pulmonary artery smooth muscle cells(PASMCs)induced by hypoxia,in order to search for new drugs for the treatment and prevention of pulmonary vascular *** PASMCs were incubated with different concentrations of GW501516(10,30,100 nmol/L)under the hypoxic *** proliferation was determined by a CCK-8 *** cell cycle progression was analyzed by flow *** expression of PPARδ,S phase kinase-associated protein 2(Skp2),and cell cycle-dependent kinase inhibitor p27 was detected by Western *** PASMCs were treated with 100 nmol/L GW501516,100 nmol/L mammalian target of rapamycin(mTOR)inhibitor rapamycin and/or 2µmol/L mTOR activator MHY1485 to explore the molecular mechanisms by which GW501516 reduces the proliferation of *** The presented data demonstrated that hypoxia reduced the expression of PPARδin an oxygen concentration-and time-dependent manner,and GW501516 decreased the proliferation of PASMCs induced by hypoxia by blocking the progression through the G0/G1 to S phase of the cell *** accordance with these findings,GW501516 downregulated Skp2 and upregulated p27 in hypoxia-exposed *** experiments showed that rapamycin had similar effects as GW501516 in inhibiting cell proliferation,arresting the cell cycle,regulating the expression of Skp2 and p27,and inactivating mTOR in hypoxia-exposed ***,MHY1485 reversed all the beneficial effects of GW501516 on hypoxia-stimulated *** GW501516 inhibited the proliferation of PASMCs induced by hypoxia through blocking the mTOR/Skp2/p27 signaling pathway.

关键词： peroxisome proliferator-activated receptorδ GW501516 hypoxia pulmonary artery smooth muscle cells proliferation mammalian target of rapamycin

Modification and refinement effects of Sb and Sr on Mg_(17)Al_(12) and Mg_2Si phases in Mg-12Al-0.7Si alloy

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

China Foundry 2016年第5期13卷 310-315页

作者： Zhi-wen Wang Hong-xia Wang Jia-lin Gong Ming li wei-li Cheng wei liang Key Laboratory of lnterface Science and Engineering in Advanced Materials Taiyuan University of Technology Ministry of Education Taiyuan 030024 Shanxi China

The effects of Sb and Sr on the modification and refinement of Mg17Al12 and Mg2Si phases in Mg- 12Al-0.7Si alloy were investigated and compared. The microstructure and mechanical properties of Mg-12Al0.7Si alloy and its modification mechanism by Sb and Sr were investigated using a scanning electron microscope （SEM）, an energy dispersive spectrometer （EDS）, X-ray diffraction （XRD） and differential thermal analysis （DTA）. The results indicate that by adding 0.5wt.% Sb to the Mg-12Al-0.7Si alloy, the Mg17Al12 phase was refined and broken into some discontinuous island structures. However, some network Mg17Al12 phases still can be detected in Mg-12Al-0.7Si-0.09Sr alloy. Therefore, Sb performs better in modification and refinement of Mg17Al12 phase than does Sr. Small amounts of fine polygonal shaped Mg2Si phases were found in Mg-12AI-0.7Si-0.5Sb alloy, while the morphology of Mg2Si phases in Mg-12Al-0.7Si-0.09Sr alloy changed from the coarse Chinese script shapes to fine granule and irregular polygonal shapes, indicating that the effects of modification and refinement on Mg2Si phase are more significant by adding 0.09wt.% Sr than 0.5wt.% Sb. The ultimate tensile strengths of the Sb and Sr modified Mg-12Al-0.7Si alloys were considerably increased both at room temperature and at 200 ℃.

关键词： magnesium alloy Sb Sr Mg17Al12 phase Mg2Si phase