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Changes in sea surface temperature in western South China Sea over the past 450 ka

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Chinese Science Bulletin 2009年第18期54卷 3335-3343页

作者： li li wang Hui li jianru ZHAO MeiXun wang pinxian State Key Laboratory of Marine Geology Tongji University Shanghai 200092 China

Sea surface temperature over the past 450 ka was obtained by the unsaturation of molecular fossil-long chain alkenone with a resolution of about 1 ka from the western South China Sea. This is the longest temperature profile in the South China Sea at such high resolution. The U3k7′-SST results revealed similar glacial-interglacial cycles as the δ18O profile of planktonic foraminifera, with SST variability of 23―25.5℃ for glacial and 25―28℃ for interglacial periods. The highest SST (28.4℃) was recorded at MIS5.5 and lowest SST (22.6℃) during MIS2. The SST record preceded the planktonic foraminiferal δ18O on five glacial-interglacial transitions. Comparison of temperature records from the Southern and Northern Hemispheres indicated a more Southern Hemisphere-like pattern for the temperature variation in the SCS. Strong precession and semiprecession signals in the spectra of our SST record manifest the tropical phenomena.

关键词：华南西部海表温度中国浮游有孔虫海温变化海上间冰期表面温度

Genetic and lipidomic analyses reveal the key role of lipid metabolism for cold tolerance in maize

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Journal of Genetics and Genomics 2024年第3期51卷 326-337页

作者： Lei Gao Haifang Jiang Minze li Danfeng wang Hongtao Xiang Rong Zeng limei Chen Xiaoyan Zhang jianru Zuo Shuhua Yang Yiting Shi State Key Laboratory of Plant Environmental Resilience College of Biological SciencesFrontiers Science Center for Molecular Design BreedingCenter for Crop Functional Genomics and Molecular BreedingChina Agricultural UniversityBeijing 100193China State Key Laboratory of Wheat&Maize Crop Science College of Life SciencesHenan Agricultural UniversityZhengzhouHenan 450002China State Key Laboratory of Plant Genomics Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Suihua Branch of Heilongjiang Academy of Agricultural Machinery Sciences SuihuaHeilongjiang 152052China

lipid remodeling is crucial for cold tolerance in ***,the precise alternations of lipidomics during cold responses remain elusive,especially in maize(Zea mays L.).In addition,the key genes responsible for cold tolerance in maize lipid metabolism have not been ***,we integrate lipidomic,transcriptomic,and genetic analysis to determine the profile of lipid remodeling caused by cold *** find that the homeostasis of cellular lipid metabolism is essential for maintaining cold tolerance of ***,we detect 210 lipid species belonging to 13 major classes,covering phospholipids,glycerides,glycolipids,and free fatty *** lipid metabolites undergo specific and selective alterations in response to cold stress,especially mono-/di-unsaturated lysophosphatidic acid,lysophosphatidylcholine,phosphatidylcholine,and phosphatidylinositol,as well as polyunsaturated phosphatidic acid,monogalactosyldiacylglycerol,diacylglycerol,and *** addition,we identify a subset of key enzymes,including ketoacyl-acyl-carrier protein synthase II(KAS II),acyl-carrier protein 2(ACP2),male sterility33(Ms33),and stearoyl-acyl-carrier protein desaturase 2(SAD2)involved in glycerolipid biosynthetic pathways are positive regulators of maize cold *** results reveal a comprehensive lipidomic profile during the cold response of maize and provide genetic resources for enhancing cold tolerance in crops.

关键词： Maize Cold stress lipid metabolism Transcriptome lipidomic

Genetic variation in a heat shock transcription factor modulates cold tolerance in maize

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Molecular Plant 2024年第9期17卷 1423-1438页

作者： Lei Gao lingling Pan Yiting Shi Rong Zeng Minze li Zhuoyang li Xuan Zhang Xiaoming Zhao Xinru Gong Wei Huang Xiaohong Yang Jinsheng Lai jianru Zuo Zhizhong Gong Xiqing wang Weiwei Jin Zhaobin Dong Shuhua Yang State Key Laboratory of Plant Environmental Resilience Frontiers Science Center for Molecular Design BreedingCollege of Biological SciencesCenter for Crop Functional Genomics and Molecular BreedingChina Agricultural UniversityBeijing 100193China State Key Laboratory of Maize Bio-breeding National Maize Improvement CenterFrontiers Science Center for Molecular Design BreedingDepartment of Plant Geneticsand BreedingChinaAgricultural UniversityBeijingChina State Key Laboratory of Plant Genomics and National Plant Gene Research Center Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing100101China

Understanding how maize(Zea mays)responds to cold stress is crucial for facilitating breeding programs of cold-tolerant *** extensive utilization of the genome-wide association study(GWAs)approach for exploring favorable natural alleles associated with maize cold tolerance,few studies have successfully identified candidate genes that contribute to maize cold *** this study,we used a diverse panel of inbred maize lines collected from different germplasm sources to perform a GWAS on var-iations in the relative injured area of maize true leaves during cold stress-a trait very closely correlated with maize cold *** identified HsF21,which encodes a B-class heat shock transcription factor(HSF)that positively regulates cold tolerance at both the seedling and germination *** varia-tions in the promoter of the cold-tolerant HSF21Hap1 allele led to increased HSF21 expression under cold stress by inhibiting binding of the basic leucine zipper bziP68 transcription factor,a negative regulator of cold *** integrating transcriptome deep sequencing,DNA affinity purification sequencing,and targeted lipidomic analysis,we revealed the function of HsF21 in regulating lipid metabolism homeo-stasis to modulate cold tolerance in *** addition,we found that HsF21 confers maize cold tolerance without incurring yield ***,this study establishes HsF21 as a key regulator that en-hances cold tolerance in maize,providing valuable genetic resources for breeding of cold-tolerant maize varieties.

关键词： heat shock factor HSF21 cold tolerance natural variation bZiP68 lipid metabolism maize

提升弱电网新能源集群送出能力的调相机优化配置方法

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电力自动化设备 2024年第7期44卷 30-36,44页

作者：王泽森刘苗李海波秦建茹郭金智白恺国网冀北电力有限公司北京100054 清华四川能源互联网研究院四川成都610213

针对提升送端弱电网系统强度及新能源消纳能力的技术需求,分析了短路比指标与新能源集群送出能力之间的关联;分析了调相机接入对短路比指标的影响;建立了兼顾弱电网系统强度和集群新能源消纳的调相机配置双层优化模型,内层模型以各新能... 详细信息

针对提升送端弱电网系统强度及新能源消纳能力的技术需求,分析了短路比指标与新能源集群送出能力之间的关联;分析了调相机接入对短路比指标的影响;建立了兼顾弱电网系统强度和集群新能源消纳的调相机配置双层优化模型,内层模型以各新能源场站出力最大为目标,确定短路比约束下各新能源场站最大出力限值,外层模型以调相机配置容量最小为目标,计算各新能源场站实际出力与该场站最大出力限值的差值,对调相机配置容量进行校核。通过实际典型电网仿真分析表明,调相机优化配置后系统强度大幅提升,同时,98%的新能源场站最大可消纳空间达到各新能源场站理论最大可消纳空间的95%。

关键词：弱电网系统短路比新能源消纳调相机优化配置

基于单细胞测序技术解析冠状动脉粥样硬化患者平滑肌细胞的细胞间通信及关键基因

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上海交通大学学报（医学版） 2024年第2期44卷 169-182页

作者：司春婴王建茹李晓辉王永霞关怀敏河南中医药大学第一临床医学院(中西医结合学院) 郑州450003 河南中医药大学第一附属医院心脏中心/国家区域(中医)心血管诊疗中心郑州450003

目的·利用单细胞RNA测序技术(single-cell RNA sequencing,scRNA-Seq)阐释冠状动脉粥样硬化(coronary atherosclerosis,CA)的细胞通信景观,挖掘主导细胞亚群及其关键基因。方法·下载GSE131778数据集并进行预处理、质控、降维聚类及注... 详细信息

目的·利用单细胞RNA测序技术(single-cell RNA sequencing,scRNA-Seq)阐释冠状动脉粥样硬化(coronary atherosclerosis,CA)的细胞通信景观,挖掘主导细胞亚群及其关键基因。方法·下载GSE131778数据集并进行预处理、质控、降维聚类及注释;利用CellChat包进行细胞通信分析,识别主导细胞亚群。利用FindAllMarker函数,筛选主导细胞亚群与其他细胞亚群间的差异表达基因(differentially expressed genes,DEGs),并构建其蛋白相互作用(protein-protein interaction,PPI)网络,将Degree算法排序前五位的DEGs作为关键基因。将关键基因与CellChat分析出的细胞通信网络进行匹配和挖掘,获取关键基因参与的配体-受体对(ligand-receptor pair,L-R)及其介导的信号通路,并对结果进行可视化。构建动脉粥样硬化小鼠模型,并利用反转录聚合酶链式反应检测关键基因在颈动脉粥样硬化病变处的表达情况。结果·在CA病变处共鉴定出11个细胞亚群,包括平滑肌细胞、内皮细胞、巨噬细胞、单核细胞等。细胞通信分析结果显示,CellChat在11个细胞亚群中检测到70对显著的L-R和26条相关的信号通路;平滑肌细胞处于通信活跃状态,与其他细胞亚群间相互作用的次数和强度最显著,是主导细胞亚群。DEGs筛选结果显示,平滑肌细胞亚群和其他细胞亚群之间共有206个DEGs,其中ITGB2、PTPRC、CCL2、DCN、IGF1被识别为关键基因。关键基因介导的细胞通信分析结果显示:CCL2与ACKR1形成L-R,通过介导CCL信号通路参与平滑肌细胞与内皮细胞间的通信网络;ITGB2分别与ITGAM、ITGAX组成受体复合物,再与C3形成L-R介导补体信号通路,参与平滑肌细胞与巨噬细胞、单核细胞间的通信网络。动物实验对关键基因的验证结果同生物信息学分析的结果一致。结论·平滑肌细胞在CA病理过程中是主导细胞,与其他细胞间有广泛的通信网络,可通过CCL2-ACKR1、C3-(ITGAM+ITGB2)和C3-(ITGAX+ITGB2)介导的CCL和补体信号通路,与内皮细胞、巨噬细胞和单核细胞构建细胞通信网络。

关键词：冠状动脉粥样硬化单细胞RNA测序平滑肌细胞细胞通信

Transforming growth factor β1 is a differentially expressed candidate protein of congestive heart failure with Qi-deficiency-blood-stasis syndrome

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Journal of Traditional Chinese Medicine 2020年第2期40卷 311-316页

作者： li Xiaoqian Huang pinxian wang Shijun Cao Xuebin He Jiancheng Research Centre on Application of Classical Prescriptions Basic Medical CollegeShanghai University of Traditional Chinese MedicineShanghai 201230China Department of Cardiology Shanghai Institute of Cardiovascular DiseasesZhongshan HospitalFudan UniversityShanghai 200032China Department of Cardiology The PLA 252 HospitalBaoding 71000China

OBJECTIVE: To investigate the role of tongue coating fluid protein in regulation of congestive heart failure(CHF) in Qi-deficiency-blood-stasis ***: We studied patients with CHF(3 patients with Qi-deficiency-blood-stasis syndrome and 3 without Qi-deficiency-blood-stasis syndrome) to investigate differentially expressed proteins. We also included a control group. A biotin label-based antibody array was used for testing tongue coating fluid samples from patients. Net-work analysis of these differentially expressed proteins was conducted using the STRING database,which can predict the relations between differentially expressed proteins and CHF with Qi-deficiency-blood-stasis ***: A total of seven differentially expressed proteins were identified, and among these, transforming growth factor β1(TGF-β1) gets a particular attention for us has drawn specific *** analysis showed a homologous relationship of TGF-β1 with bone morphogenetic protein15, which is associated with myocardial ***: Occurrence and development of CHF may result from certain DE-proteins and associated signaling pathways. TGF-β1 protein may be a candidate marker for assessing the risk of CHF in Qideficiency-blood-stasis syndrome.

关键词： Congestive heart failure Qi-deficiency blood-stasis Transforming growth factorβ1 Bone morphogenetic protein 15 Differentially expressed protein

Variations of opal accumulation rates and paleoproductivity over the past 12 Ma at ODP Site 1143, southern South China Sea

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Chinese Science Bulletin 2002年第7期47卷 596-598页

作者： li jianru wang Rujian li Baohua Laboratory of Marine Geology MEOTongji University200092ShanghaiChina Nanjing Institute of Geology and Paleontology Chinese Academy of Sciences210008NanjingChina

The biogenic silica analysis was performed on 463 samples from ODP 184 Site 1143, the southern South China Sea. The results show that the opal content and MAR evidently increased between 12.3 and 5.7 Ma, which was contemporary with the high carbonate and total MARs, reflecting the high biogenic productivity in the late Miocene. This demonstrates the occurrence of the late Miocene 'Biogenic Bloom Event' in the southern South China Sea, corresponding to the late Miocene-early Pliocene 'Biogenic Bloom Event' in the Indian-Pacific Ocean. The increases of opal content and MAR after the middle Pleistocene (about 0.7 Ma) is inferred to result from the enhanced upwelling and nutrient supply, which was induced by the intensified monsoon circulation after the 'Mid-Pleistocene Revolution'.

关键词： opal MAR biogenic productivity Biogenic Bloom Event late Miocene South China Sea.

Temporal and spatial evolution of a deep-reaching anticyclonic eddy in the South China Sea

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Science China Earth Sciences 2019年第6期62卷 1002-1023页

作者： Meng wang Yanwei ZHANG Zhifei liU Yulong ZHAO jianru li State Key Laboratory of Marine Geology Tongji University

The temporal and spatial evolution of a deep-reaching anticyclonic eddy(AE) is studied using a combination of satellite measurements, moored observations and ocean model reanalysis data in the South China Sea(SCS). Three evolutionary stages in eddy's lifecycle are identified from changes in eddy dynamical characteristics estimated from satellite altimetry: birth(22 days), growth(64 days), and decay(47 days). Similar patterns are also distinguished from dynamic signals in ***, flows reversal and upwelling of cold water below 1500 m were captured by the in-situ records when this energetic,highly nonlinear and long-lived(over 19 weeks) AE passed by our mooring position. Its detailed vertical structure is examined through temperature anomalies, vertical shear of horizontal velocities, and horizontal streamlines estimated from ocean model reanalysis data. Results from the model reveal a mesoscale AE with first-mode baroclinic structure: a bowl-shaped anticyclonic flow in the upper ocean connected to a slant-cylinder cyclonic flow at depth, with a transition layer at depths between 400 and 700 m. It is in good agreement with moored observations but showing a shallower transition depth, suggesting a slight deficiency in the model due to limited deep-sea observations. Last, we estimate eddy heat transport at different depths and stages along the AE's path based on the model data. The result reveals that pronounced heat fluxes occur during growth stage(depths 700–1500 m).Dynamical characteristics suggest that the vertical structure and temporal evolution of the eddy play significant roles in basinscale movement and heat transferring. Considering that mesoscale eddies are ubiquitous in the SCS, our results support a recently-proposed mechanism, whereby upper ocean flows produce changes in the deep-sea circulation, potentially influencing boundary l

关键词： Deep-reaching mesoscale eddy Evolution HYCOM The South China Sea

The Arabidopsis BE1 Gene,Encoding a Putative Glycoside Hydrolase Localized in Plastids,Plays Crucial Roles during Embryogenesis and Carbohydrate Metabolism

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Journal of Integrative Plant Biology 2010年第3期52卷 273-288页

作者： Xingchun wang li Xue Jiaqiang Sun jianru Zuo College of life Sciences Shanxi Agricultural University Taigu 030801 China State Key Laboratory of Plant Genomics and National Plant Gene Research Center Institute of Genetics and Developmental Biology the Chinese Academy of Sciences Beijing 100101 China

Carbohydrate metabolism is central to plant growth and development. However, little is known about its role in embryogenesis. Here, we report the characterization of multiple alleles of the BRANCHING ENZYME1 （BE1） gene （also known as EMB2729）. The weak allele of be1-3, characterized by positional cloning, carries a single-nucleotide substitution in an exon-intron junction and shows various developmental defects during post-germination growth. This mutation causes a reduced level of BE1 mRNA that, likely generated from cryptically spliced pre-mRNA, contains a Glu-to-Lys substitution at codon 366. In four null alleles, BE1 is disrupted by T-DNA insertions, causing embryo developmental arrests at the heart stage. light microscopy reveals reduced cell divisions and abnormal cell differentiation, thereby leading to defects in setting up the shoot apical meristem, embryonic vascular tissues and cotyledons. Overexpression of BE1 results in a pleiotropic phenotype, indicating that the fine-tuned BE1 level is crucial for plant growth and development. BE1 encodes a putative glycoside hydrolase that is highly conserved in higher plants. A BE1-GFP fusion protein, which is fully functional in complementing be1 mutants, is localized in plastids. The be1-3 phenotype can be partially rescued by glucose, fructose or sucrose, implying the involvement of BE1 in carbohydrate metabolism in plastids.

关键词： ARABIDOPSIS GLYCOSIDES PLASTIDS EMBRYOLOGY CARBOHYDRATE metabolism