Transforming growth factor β1 is a differentially expressed candidate protein of congestive heart failure with Qi-deficiency-blood-stasis syndrome

作     者：Li Xiaoqian Huang Pinxian Wang Shijun Cao Xuebin He Jiancheng Li Xiaoqian;Huang Pinxian;Wang Shijun;Cao Xuebin;He Jiancheng

作者机构：Research Centre on Application of Classical PrescriptionsBasic Medical CollegeShanghai University of Traditional Chinese MedicineShanghai 201230China Department of CardiologyShanghai Institute of Cardiovascular DiseasesZhongshan HospitalFudan UniversityShanghai 200032China Department of CardiologyThe PLA 252 HospitalBaoding 71000China 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2020年第40卷第2期

页      面：311-316页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by the Natural Science Foundation of China(No.81803996) the Major Clinical Research Project of the Army(No.2006021003) the Training Plan on Excellent Academic Leader of Shanghai Health System(No.XBR2011070) Construction of Clinical Basic Discipline of TCM(No.A1-Z183020110) 

主　　题：Congestive heart failure Qi-deficiency blood-stasis Transforming growth factorβ1 Bone morphogenetic protein 15 Differentially expressed protein 

摘      要：OBJECTIVE: To investigate the role of tongue coating fluid protein in regulation of congestive heart failure(CHF) in Qi-deficiency-blood-stasis ***: We studied patients with CHF(3 patients with Qi-deficiency-blood-stasis syndrome and 3 without Qi-deficiency-blood-stasis syndrome) to investigate differentially expressed proteins. We also included a control group. A biotin label-based antibody array was used for testing tongue coating fluid samples from patients. Net-work analysis of these differentially expressed proteins was conducted using the STRING database,which can predict the relations between differentially expressed proteins and CHF with Qi-deficiency-blood-stasis ***: A total of seven differentially expressed proteins were identified, and among these, transforming growth factor β1(TGF-β1) gets a particular attention for us has drawn specific *** analysis showed a homologous relationship of TGF-β1 with bone morphogenetic protein15, which is associated with myocardial ***: Occurrence and development of CHF may result from certain DE-proteins and associated signaling pathways. TGF-β1 protein may be a candidate marker for assessing the risk of CHF in Qideficiency-blood-stasis syndrome.