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Acta Pharmaceutica Sinica B 2024年第9期14卷 3901-3915页

作者： Yumeng Wang chengxi li Jianping li Shu Zhang Qinyu Zhang Jinao Duan Jianming Guo Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources Industrialization Nanjing University of Chinese MedicineNanjing 210023China Jiangsu Key Laboratory for High Technology Research of TCM Formulae Nanjing University of Chinese MedicineNanjing 210023China

The intestinal mucus barrier is an important line of defense against gut *** to this barrier brings bacteria into close contact with the epithelium,leading to intestinal ***,its restoration is a promising strategy for alleviating intestinal *** study showed that Abelmoschus manihot polysaccharide(AMP)fortifies the intestinal mucus barrier by increasing mucus production,which plays a crucial role in the AMP-mediated amelioration of ***-10-deficient mouse models demonstrated that the effect of AMP on mucus production is dependent on ***,bacterial depletion and replenishment confirmed that the effects of AMP on IL-10 secretion and mucus production were mediated by Akkermansia *** findings suggest that plant polysaccharides fortify the intestinal mucus barrier by maintaining homeostasis in the gut *** demonstrates that targeting mucus barrier is a promising strategy for treating intestinal inflammation.

关键词： Plant polysaccharide Abelmoschus manihot Intestinal inflammation Mucus barrier Interleukin 10 Gut microbiota A.muciniphila Mucin 2

Multi-network-region traffic cooperative scheduling in large-scale LEO satellite networks

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Journal of Systems Engineering and Electronics 2024年第4期35卷 829-841页

作者： li chengxi WANG Fu YAN Wei CUI Yansong FAN Xiaodong ZHU Guangyu XIE Yanxi YANG lixin ZHOU Luming ZHAO Ran WANG Ning School of Electronic Engineering Beijing University of Posts and TelecommunicationsBeijing 100876China The 6th Research Institute of China Electronics Corporation Beijing 102209China China Satellite Network Share Operation Co. LtdBeijing 100876China Weihai Electronic Information Technology Comprehensive Research Center of the Ministry of Industry and Information Technology Weihai 264200 China

A low-Earth-orbit(LEO)satellite network can provide full-coverage access services worldwide and is an essential candidate for future 6G ***,the large variability of the geographic distribution of the Earth’s population leads to an uneven service volume distribution of access ***,the limitations on the resources of satellites are far from being able to serve the traffic in hotspot *** enhance the forwarding capability of satellite networks,we first assess how hotspot areas under different load cases and spatial scales significantly affect the network throughput of an LEO satellite network ***,we propose a multi-region cooperative traffic scheduling *** algorithm migrates low-grade traffic from hotspot areas to coldspot areas for forwarding,significantly increasing the overall throughput of the satellite network while sacrificing some latency of end-to-end *** algorithm can utilize all the global satellite resources and improve the utilization of network *** model the cooperative multi-region scheduling of large-scale LEO *** on the model,we build a system testbed using OMNET++to compare the proposed method with existing *** simulations show that our proposed method can reduce the packet loss probability by 30%and improve the resource utilization ratio by 3.69%.

关键词： low-Earth-orbit(LEO)satellite network satellite communication load balance multi-region scheduling latency optimization

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精细化工过滤装置应用设计

化工设计通讯 2024年第4期50卷 132-134页

作者：李成蹊山东海王化工股份有限公司山东潍坊261000

在精细化工生产中,尤其是在溴系阻燃剂化工行业生产中,存在强氧化性、强酸/强碱等强腐蚀性、高渗透性、溶剂性、高温环境等特殊工况对过滤装置的需求。通过提出一系列的措施针对上述特殊工况,对过滤器进行改进和设计,以达到工业化应用... 详细信息

在精细化工生产中,尤其是在溴系阻燃剂化工行业生产中,存在强氧化性、强酸/强碱等强腐蚀性、高渗透性、溶剂性、高温环境等特殊工况对过滤装置的需求。通过提出一系列的措施针对上述特殊工况,对过滤器进行改进和设计,以达到工业化应用的目的。

关键词：过滤装置精细化工溴系阻燃剂

高管薪酬结构与企业创新——基于高管风险承担视角

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北京工商大学学报（社会科学版） 2024年第2期39卷 85-99页

作者：张宏亮李成蹊王靖宇北京工商大学商学院北京100048 北京物资学院会计学院北京101149

创新是企业获得技术优势的重要行为,有助于国家实现高水平科技自立自强,高管是企业做出创新决策的主体。以2008—2021年中国沪深A股上市公司为研究对象,对高管薪酬结构影响企业创新的效应及作用机制进行了实证检验。研究发现,随着高管... 详细信息

创新是企业获得技术优势的重要行为,有助于国家实现高水平科技自立自强,高管是企业做出创新决策的主体。以2008—2021年中国沪深A股上市公司为研究对象,对高管薪酬结构影响企业创新的效应及作用机制进行了实证检验。研究发现,随着高管薪酬结构中股权薪酬比例的提升,企业创新投入水平呈先上升后下降的倒“U”型趋势。进一步地,以激励物的Delta指数和Vega指数为度量的高管风险承担在薪酬结构影响企业创新的路径中发挥了中介作用。异质性分析表明,高管股权薪酬对企业创新的正向激励效果仅显著存在于非国有企业和位于高市场化程度地区的企业当中。因此,企业要制定合理的薪酬结构,适当提高股权薪酬占比,并注重改善激励环境提升高管的风险承担能力,为企业创新创造良好的内外部环境。

关键词：高管薪酬结构企业创新高管风险承担倒“U”型 Delta效应 Vega效应

Progress in non-invasive detection of liver fibrosis

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Cancer Biology & Medicine 2018年第2期15卷 124-136页

作者： chengxi li Rentao li Wei Zhang Department of Mechanical Engineering Massachusetts Institute of TechnologyCambridgeMA 02139USA Department of Hepatobiliary Surgery Tianjin Medical University Cancer Institute and HospitalNational Clinical Research Center for CancerKey Laboratory of Cancer Prevention and TherapyTianjin Tianjin's Clinical Research Center for Cancer Tianjin 300060China

liver fibrosis is an important pathological precondition for hepatocellular *** degree of hepatic fibrosis is positively correlated with liver *** fibrosis is a series of pathological and physiological process related to liver cell necrosis and degeneration after chronic liver injury,which finally leads to extracellular matrix and collagen *** early detection and precise staging of fibrosis and cirrhosis are very important for early diagnosis and timely initiation of appropriate therapeutic *** risk of severe liver fibrosis finally progressing to liver carcinoma is＆gt;50%.It is known that biopsy is the gold standard for the diagnosis and staging of liver ***,this method has some limitations,such as the potential for pain,sampling variability,and low patient ***,the necessity of obtaining a tissue diagnosis of liver fibrosis still remains *** increasing number of reliable non-invasive approaches are now available that are widely applied in clinical practice,mostly in cases of viral hepatitis,resulting in a significantly decreased need for liver *** fact,the noninvasive detection and evaluation of liver cirrhosis now has good accuracy due to current serum markers,ultrasound imaging,and magnetic resonance imaging quantification techniques.A prominent advantage of the non-invasive detection and assessment of liver fibrosis is that liver fibrosis can be monitored repeatedly and easily in the same *** biomarkers have the advantages of high applicability（〉95%）and good ***,their results can be influenced by different patient conditions because none of these markers are *** most promising techniques appear to be transient elastography and magnetic resonance elastography because they provide reliable results for the detection of fibrosis in the advanced stages,and future developments promise to increase the reliability and accuracy of the stag

关键词： liver fibrosis non-invasive detection computer-aided quantitative deep learning

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美欧日数据治理政策及实践的比较分析与启示

数字图书馆论坛 2024年第7期20卷 11-18页

作者：李成熙吴新年中国科学院西北生态环境资源研究院兰州730000 甘肃省知识计算与决策智能重点实验室兰州730000 中国科学院大学经济与管理学院北京100190

数据主权是国家主权在网络空间中的重要体现,加强全球数据治理成为当下国际战略共识。研究发达国家的数据治理政策及实践经验,对我国当前数据治理体系与能力建设具有重要借鉴意义。通过文献调研、网络调研等方式对美欧日代表性数据治理... 详细信息

数据主权是国家主权在网络空间中的重要体现,加强全球数据治理成为当下国际战略共识。研究发达国家的数据治理政策及实践经验,对我国当前数据治理体系与能力建设具有重要借鉴意义。通过文献调研、网络调研等方式对美欧日代表性数据治理政策及实践进行梳理,采用“内容—价值—实践”的分析框架厘清美欧日数据治理政策核心内容、价值导向和实践路径的异同点。研究发现,美欧日数据治理政策的核心内容和价值导向存在相似性,但数据治理实践存在基于地区情况的差异。结合我国国情和数据治理发展需求,建议从完善数据治理体制和配套法规建设、抢抓数据治理话语权与规则制定权、重视加强数据治理领域的国际合作和推动数据要素利用及价值实现4个方面入手,不断提升数据立法域外效力、数据治理国际竞争力,并推动构建开放共赢的数据治理新格局。

关键词：全球治理数据治理数据主权数据立法数据政策

祛魅与存真——人工智能时代的艺术存在方式探析

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民族艺术研究 2024年第1期37卷 93-101页

作者：高迎刚李成蹊山东大学艺术学院山东济南250100 山东大学公共文化研究中心

伴随着人工智能技术的快速更新迭代,艺术的存在方式也重新引起了人们的关注。人工智能时代的艺术存在方式,其最核心的内容依然是亘古常新的艺术与技术之间的关系问题。如果说19世纪以来摄影与录像、扫描与复制等技术的不断进步,已经促... 详细信息

伴随着人工智能技术的快速更新迭代,艺术的存在方式也重新引起了人们的关注。人工智能时代的艺术存在方式,其最核心的内容依然是亘古常新的艺术与技术之间的关系问题。如果说19世纪以来摄影与录像、扫描与复制等技术的不断进步,已经促使人们对传统艺术的存在方式产生了越来越深的怀疑;那么20世纪中后期以来逐渐发展起来的数字技术、网络技术以及方兴未艾的人工智能技术,则彻底颠覆了人们对传统艺术存在方式的认知。伴随着技术性因素的不断发展,艺术的本质属性也在“祛魅”与“存真”的变迁与坚持中愈发清晰。未来的人工智能技术能否具备艺术创意的能力,已经不是技术本身的问题。艺术之为艺术,归根结底并不取决于技术性因素的变迁。

关键词：人工智能艺术存在方式祛魅存真

基于动静态结合的上海市城市生命体征监测指标体系探索

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建设科技 2024年第13期 8-11,20页

作者：邹寒李程希章怡上海市建筑科学研究院有限公司 201108 上海临港新片区住房建设发展(集团)有限公司上海201108

本研究通过调研城市体检、城市运行管理等方面标准、平台和相关政策规划,以动态监测预警与静态评价相结合为目标,建立了能够体现上海城市运行、管理、服务特征的城市生命体征监测指标体系,实现对城市生命体征状态的可展示、可评估、可预... 详细信息

本研究通过调研城市体检、城市运行管理等方面标准、平台和相关政策规划,以动态监测预警与静态评价相结合为目标,建立了能够体现上海城市运行、管理、服务特征的城市生命体征监测指标体系,实现对城市生命体征状态的可展示、可评估、可预警,为上海市城市精细化管理水平的提升和智慧城市管理提供技术支撑。

关键词：城市生命体征监测动静态结合精细化管理

Bond energy enabled amine distinguishing strategy:chemo-,regioselective 1,3-diamination of(trifluoromethyl)alkenes with different amines by two C(sp^(3))-F bond cleavages

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Organic Chemistry Frontiers 2022年第5期9卷 1383-1388页

作者： Hao Zeng Hengyuan li chengxi li Huanfeng Jiang Chuanle Zhu School of Chemistry and Chemical Engineering Key Laboratory of Functional Molecular Engineering of Guangdong ProvinceSouth China University of TechnologyGuangzhou 510640China

The methods to distinguish between amines are rarely *** this article,a bond energy enabled amine distinguishing strategy is ***(trifluoromethyl)alkenes as linchpins,a chemo-,regio-selective three-component defluorina... 详细信息

关键词： amines alkenes energy

Controlling assembly-induced symmetry-breaking by tuning the vortex-responsive nanostructures

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Nano Research 2023年第12期16卷 13450-13456页

作者： chengxi li Kang Huang Chen Xiao Yonghong Shi Pengfei Duan CAS Key Laboratory of Nanosystem and Hierarchical Fabrication National Center for Nanoscience and Technology(NCNST)Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China

The generation of chirality in supramolecular structures from achiral building blocks has remained a challenge for a long *** this study,we present a vortex-assisted chiral supramolecular polymerization from a series of achiral C3-symmetric monomers,where the mechanism of symmetry-breaking is systematically *** increasing the supersaturation,at the early stage of nucleation and growth,highly ordered assemblies can be generated as the initial chiral ***,chiral assemblies from high supersaturation are hard to interwind into clusters,where clusters as nuclei are not conducive to being fractured by sheer force of vortex ***,it is concluded that chiral assemblies in the nucleation stage possess low energy barrier,so that chiral nuclei could be fractured and replicated by the *** enlarging the initial chiral bias,the major chiral nuclei can evolute into the final chiral polymers.

关键词： supramolecular polymer symmetry-breaking chirality assembly vortex