Abelmoschus manihot polysaccharide fortifies intestinal mucus barrier to alleviate intestinal inflammation by modulating Akkermansia muciniphila abundance

作     者：Yumeng Wang Chengxi Li Jianping Li Shu Zhang Qinyu Zhang Jinao Duan Jianming Guo 

作者机构：Jiangsu Collaborative Innovation Center of Chinese Medicinal Resources IndustrializationNanjing University of Chinese MedicineNanjing 210023China Jiangsu Key Laboratory for High Technology Research of TCM FormulaeNanjing University of Chinese MedicineNanjing 210023China 

出 版 物：《Acta Pharmaceutica Sinica B》 (药学学报（英文版）)

年 卷 期：2024年第14卷第9期

页      面：3901-3915页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：the National Natural Science Foundation of China(82074136) High level key discipline construction project of the National Administration of Traditional Chinese Medicine-Resource Chemistry of Chinese Medicinal Materials(No.zyyzdxk-2023083,China) 

主　　题：Plant polysaccharide Abelmoschus manihot Intestinal inflammation Mucus barrier Interleukin 10 Gut microbiota A.muciniphila Mucin 2 

摘      要：The intestinal mucus barrier is an important line of defense against gut *** to this barrier brings bacteria into close contact with the epithelium,leading to intestinal ***,its restoration is a promising strategy for alleviating intestinal *** study showed that Abelmoschus manihot polysaccharide(AMP)fortifies the intestinal mucus barrier by increasing mucus production,which plays a crucial role in the AMP-mediated amelioration of ***-10-deficient mouse models demonstrated that the effect of AMP on mucus production is dependent on ***,bacterial depletion and replenishment confirmed that the effects of AMP on IL-10 secretion and mucus production were mediated by Akkermansia *** findings suggest that plant polysaccharides fortify the intestinal mucus barrier by maintaining homeostasis in the gut *** demonstrates that targeting mucus barrier is a promising strategy for treating intestinal inflammation.