检索结果-南通市图书馆

Immunoregulatory influence of Sargassum carpophyllum polyphenol on the allergic reactions induced by shrimp tropomyosin

在线全文

学校读者我要写书评

暂无评论

Food Science and Human Wellness 2024年

作者： Yueying Han Ziye Zhang Zihao li zhenxing li hong lin State Key Laboratory of Marine Food Processing & Safety Control， College of Food Science and Engineering， Ocean University of China

Polyphenol is a kind of natural active substance with immunoregulatory activity. In this study， the immunoregulatory activities of Sargassum carpophyllum polyphenol (SCP) on the allergic reactions induced by shrimp tropomyosin were investigated. As the results， the SCP performed high hyaluronidase inhibition ability， which even greater than sodium chromoglycate (an anti-allergic medicine). SCP was able to affect the allergic reactions of RAW 264.7 macrophage cells via regulating the NF-κB， JNK1/2， Erk1/2 and p38 MAPK cellular signaling pathways， weakened the degranulation degree and secretion of IL-4， TNF-α and histamine， and promoted the secretion of IL-10 from RBL-2H3 mast cells. In BALB/c mouse model assay， after gavage of SCP， the mouse allergic symptoms got significantly alleviated， the cytokine (IL-4， IL-10 and IFN-γ) secretion of mouse spleen lymphocytes were significantly declined and the allergic lung damage was relieved， which indicated SCP performed strong both in vitro and in vivo anti-allergic functions. Therefore， SCP could serve as candidate anti-allergic bioactive substances for shrimp induced allergy via immunoregulation.

关键词：

More than just aligning the teeth:Clear aligners with multifunctional prowess

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Nano Research 2024年第8期17卷 7665-7674页

作者： Yang Chen Lei-Ming cao Nian-Nian Zhong Zi-Zhan li lin-lin Bu Fang-Yi Huo hong He State Key Laboratory of Oral and Maxillofacial Reconstruction and Regeneration Key Laboratory of Oral Biomedicine Ministry of EducationHubei Key Laboratory of StomatologySchool and Hospital of StomatologyWuhan UniversityWuhan 430079China Department of Oral and Maxillofacial-Head Neck Oncology School and Hospital of StomatologyWuhan UniversityWuhan 430079China Department of Zhuankou Clinical Branches School and Hospital of StomatologyWuhan UniversityWuhan 430000China Department of Orthodontics School and Hospital of StomatologyWuhan UniversityWuhan 430079China

With the increasing demand for beauty and health,clear aligners(CAs)have been widely applied among patients with ***,patients treated with CAs also face some potential complications,such as demineralization,dental caries,and periodontal *** addition,some patients have additional needs to improve their quality of life,such as bleaching *** order to prevent or solve these problems,the modification of CAs is a promising method because their extensive long-term contact with tooth surfaces makes them ideal devices for implementing adjuvant medical *** this review,we discuss various advanced CAs with medical functions based on the clinical needs of *** far as we know,the additional functions of CAs mainly include antibacterial,remineralization,whitening,and accelerating tooth *** functions are achieved by two major pathways,the combination of CAs with drugs/biomaterials and increasing the capacity or affinity of *** addition,we discuss the current limitations of in vitro experiments which are designed to explore the effectiveness and properties of novel CAs,and the challenges of bringing a multifunctional appliance from proposal to clinical *** the end of this review,we provide insights into the broader prospects for the improvement of CAs.

关键词： advanced clear aligners medical device modification drug delivery system personalized medicine

Distribution of per-and polyfluoroalkyl substances in blood,serum,and urine of patients with liver cancer and associations with liver function biomarkers

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第5期139卷 418-427页

作者： cao Dai lin Peng Yanjie li Zhendong li Da Chen Fei Wang Nan lin Department of Hepatobiliary Surgery The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China School of Environment Guangdong Key Laboratory of Environmental Pollution and HealthJinan UniversityGuangzhou 510632China State Key Laboratory of Environmental and Biological Analysis Department of ChemistryHong Kong Baptist UniversityHong Kong 999077China South China Institute of Environmental Sciences MEEGuangzhou 510655China

Studies have shown that per-and polyfluoroalkyl substances(PFASs)may be hepatotoxic in animals or ***,data on clinical epidemiology are very *** this study,21PFASs were determined in patients with liver diseases,with the highest median concentrations detected in the serum sample(26.7 ng/mL),followed by blood(10.7 ng/mL)and urine(5.02 ng/mL).Higher total PFAS concentrations were found in hepatocellular carcinoma(HCC)patients compared to non-HCC patients,with significant discrepancies in serum and blood ***,significant correlations were also found among PFAS concentrations and age,gender,body mass index(BMI),and liver function biomarkers *** example,PFAS concentrations are significantly higher in males than in females;Several serum PFASs concentrations increase with age and BMI,while the serum perfluorohexane sulfonic acid(PFHxS)concentrations are negatively correlated with *** addition,multiple regression models adjusted for age,gender and BMI found that increased serum perfluorobutane sulfonic acid(PFBS),perfluoroheptane sulfonic acid(PFHpS)and perfluorohexylphosphonic acid(PFHxPA)conentrations are correlated with elevated alkaline phosphatase(ALP),aspartate aminotransferase(AST),and alpha-fetoprotein(AFP)(plinical hepatotoxicity of PFAS.

关键词： Per-and polyfluoroalkyl substances(PFASs) liver cancer Serum Blood Urine liver function biomarkers

Enhancing solar-driven overall water splitting via both sacrifice and noble metal free photocatalysis: copper cluster/boron-doped carbon nitride catalysts

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第11期67卷 3886-3896页

作者： Yun-Dong cao Yuxi Zhang Jian Song hong liu Zhiyuan Song lin-lin Fan Cai-li Lv Guang-Gang Gao School of Materials Science and Engineering University of Jinan

The major impediment to the additional industrialization of water splitting is the high cost of the co-catalyst made of noble metals and the sacrificial reagent. A binary photocatalytic system, consisting of B-doped g-C3N4nanosheets(Cu20@BCN-X) and atomically accurate copper clusters, is designed in this study. The copper clusters serve as co-catalysts for H2evolution and exhibit Pt-like activity, whereas the nanosheets serve as carriers and semiconductor components for O2evolution. Such binary system, created using simple techniques, demonstrates hydrogen bonding interactions that promote synergistic effects and efficient binding and charge transfer across the interface between the two components. Band position manipulation of carbon nitride nanosheets demonstrates a Z-scheme charge transfer mechanism between the nanosheets and copper clusters. This photocatalytic system can accomplish the photocatalytic overall water splitting process(259.9 μmol g-1h-1of H2and 129.4 μmol g-1h-1of O2) without using sacrificial agents or noble metal co-catalysts. This work lays the foundation for the design of overall water splitting catalysts by precisely manipulating the energy levels, and it also paves the way for commercialized photocatalytic catalysts that do not require noble metals or sacrificial chemicals.

关键词： copper clusters band modulation photocatalysts water splitting

Dissection of molecular mechanisms of liver injury induced by microcystin-leucine arginine via single-cell RNA-sequencing

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Environmental Sciences 2024年第11期145卷 164-179页

作者： Yunmeng Bai Yali Song Miaoran li Jinhuan Ou hong Hu Nan Xu Min cao SiyuWang lin Chen Guangqing Cheng Zhijie li Gang liu Jigang Wang Wei Zhang Chuanbin Yang Dongguan Maternal and Child Health Care Hospital Postdoctoral Innovation Practice Base of Southern Medical UniversityDongguan 523125China Department of Rehabilitation Medicine Nanfang HospitalSouthern Medical UniversityGuangzhou 510515China Division of Thyroid and Breast Surgery Shenzhen People’s Hospital(The Second Clinical Medical CollegeJinan UniversityThe First Affiliated HospitalSouthern University of Science and Technology)Shenzhen 518020China Faculty of Brain Sciences University College LondonWC1E 6BTUK State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical SciencesBeijing 100700China

The occurrence of poisoning incidents caused by cyanobacterial blooms has aroused wide public ***-leucine arginine(MC-LR)is a well-established toxin produced by cyanobacterial blooms,which is widely distributed in eutrophic ***-LR is not only hazardous to the water environment but also exerts multiple toxic effects including liver toxicity in both humans and ***,the underlying mechanisms of MCLR-induced liver toxicity are ***,we used advanced single-cell RNA sequencing technology to characterize MC-LR-induced liver injury in *** established the first single-cell atlas ofmouse livers in response to *** results showed that the differentially expressed genes and pathways in diverse cell types of liver tissues of mice treatedwith MC-LR are highly *** analysis showed that MC-LR induced an increase in a subpopulation of hepatocytes that highly express Gstm3,which potentially contributed to hepatocyte apoptosis in response to ***,MC-LR increased the proportion and multiple subtypes of Kupffer cells with M1 phenotypes and highly expressed proinflammatory ***,the MC-LR increased several subtypes of CD8+T cells with highly expressed multiple cytokines and ***,apart from directly inducing hepatocytes apoptosis,MC-LR activated proinflammatory Kupffer cell and CD8+T cells,and their interaction may constitute a hostile microenvironment that contributes to liver *** findings not only present novel insight into underlying molecular mechanisms but also provide a valuable resource and foundation for additional discovery of MC-LR-induced liver toxicity.

关键词： MC-LR liver toxicity Single-cell RNA sequencing Immune response Inflammatory responses

Clinicopathological features,psychological status,and prognosis of 33 patients with occult breast cancer

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2024年第1期14卷 76-87页

作者： hong-Mei Wang Ao-Yang Yu lin-lin li Lu-Yao Ma Meng-Han cao Yu-Le Yang Xiao-Bing Qin Juan-JuanTang Zheng-Xiang Han Department of Oncology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina Graduate School Xuzhou Medical UniversityXuzhou 221004Jiangsu ProvinceChina Department of Pathology The Affiliated Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACKGROUND Occult breast cancer(OBC)has traditionally been considered to be a carcinoma of unknown primary origin with a favorable prognosis and can be treated as stage II-III breast *** to the small number of cases and limited clinical experience,treatments vary greatly around the world and no standardized treatment has yet been *** To investigate the clinicopathological features,psychological status and prognostic features of patients with *** The clinicopathological data of 33 OBC patients diagnosed and treated in the Affiliated Hospital of Xuzhou Medical University and Xuzhou Central Hospital from November 2015 to November 2022 were retrospectively *** psychological status of OBC patients was evaluated by the Self-rating Anxiety Scale and Self-rating Depression ***’emotions,stress perception and psychological resilience were evaluated by the Positive and Negative Affect Schedule,the Chinese Perceived Stress Scale,and the Connor-Davidson Resilience Scale(CD-RISC),*** survival was calculated using the Kaplan-Meier method,and survival curves were plotted for analysis with the log-rank *** and multivariate survival analyses were performed using the Cox regression *** The 33 OBC patients included 32 females and 1 *** the 33 patients,30(91%)had axillary tumors,3(9%)had a neck mass as the primary symptom;18(54.5%)had estrogen receptor-positive tumors,17(51.5%)had progesterone receptor-positive tumors,and 18(54.5%)had Her-2-positive tumors;24(72.7%)received surgical treatment,including 18 patients who underwent modified radical mastectomy,1 patient who underwent breast-conserving surgery plus axillary lymph node dissection(ALND),and 5 patients who underwent ALND alone;12 patients received preoperative neoadjuvant *** 30 patients developed anxiety and depression,with low positive affect scores and high negative affect scores,accompanied by a high stress level and poor psycho

关键词： Occult breast cancer Breast cancer Perceived Stress Scale Axillary lymph node dissection

Fluorine-doped carbon quantum dots with deep-red emission for hypochlorite determination and cancer cell imaging

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第6期35卷 433-438页

作者： Boran Cheng Lei cao Chen li Fang-Yi Huo Qian-Fang Meng Ganglin Tong Xuan Wu lin-lin Bu Lang Rao Shubin Wang Department of Oncology Shenzhen Key Laboratory of Gastrointestinal Cancer Translational ResearchCancer InstitutePeking University Shenzhen HospitalShenzhen-Peking University-Hong Kong University of Science and Technology Medical CenterShenzhen 518036China Institute of Biomedical Health Technology and Engineering Shenzhen Bay LaboratoryShenzhen 518132China The State Key Laboratory Breeding Base of Basic Science of Stomatology(Hubei-MOST)&Key Laboratory of Oral Biomedicine Ministry of Education School&Hospital of StomatologyWuhan UniversityWuhan 430079China

As a type of new carbon-based nanomaterials,carbon dots(CDs)possess exceptional optical properties,making them highly desirable for use in fluorescent ***,the CDs with deep-red(DR)or near-infrared(NIR)emission have rarely been *** this work,we prepared deep-red emissive fluorine-doped carbon quantum dots(F-CDs)by introducing a precursor simultaneously containing fluorine and *** synergistic effect of nitrogen doping and D-π-A pattern production contributed to the maximum emission of F-CDs at 636 nm with an absolute quantum yield of 36.00%±0.68%.Moreover,we designed an F-CDs-based fluorescence assay to determine the content of hypochlorite(ClO^(-)),with a limit of detection(LOD)as low as 15.4 nmol/L,indicating the high sensitivity of F-CDs to ClO^(-).In real samples,the F-CDs-based fluorescent sensor exhibited excellent sensitivity and selectivity in the detection of ClO^(-),with an error below 2%,suggesting their great potential in daily *** cancer cell imaging,the F-CDs not only demonstrated high sensitivity to ClO^(-)but also exhibited excellent mitochondria targeting,as evidenced by the high Pearson's correlation coefficient(PCC)of 0.93 in colocalization *** work presented here suggests the great potential of replacing commercial dyes with F-CDs for highly specific mitochondria labeling and cell imaging.

关键词： Carbon dots Near-infrared Cell imaging Mitochondria labeling Hypochlorite determination

Expert consensus on the diagnosis, treatment, and prevention of respiratory syncytial virus infections in children

在线全文

学校读者我要写书评

暂无评论

World Journal of Pediatrics 2024年第1期20卷 11-25页

作者： Xian-li Zhang Xi Zhang Wang Hua Zheng-De Xie Han-Min liu Hai-lin Zhang Bi-Quan Chen Yuan Chen Xin Sun Yi Xu Sai-Nan Shu Shun-Ying Zhao Yun-Xiao Shang ling cao Yan-Hui Jia Luo-Na lin Jiong li Chuang-li Hao Xiao-Yan Dong Dao-Jiong lin hong-Mei Xu De-Yu Zhao Mei Zeng Zhi-Min Chen li-Su Huang Department of Infectious Disease Children's HospitalZhejiang University School of Medicine3333 Binsheng RoadBinjiang DistrictHangzhou 310052China Clinical Research Unit Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Beijing Pediatric Research Institute Beijing Children's HospitalCapital Medical UniversityBeijingChina Department of Pediatric Pulmonology West China Second University HospitalSichuan UniversityChengduChina Department of Pediatric Pulmonology the Second Affiliated Hospital&Yuying Children's HospitalWenzhou Medical UniversityWenzhouChina Department of Infectious Disease Anhui Provincial Children's HospitalHefeiChina Department of Pediatrics the Second Hospital of Hebei Medical UniversityShijiazhuangChina Department of Pediatrics Xijing Hospitalthe Fourth Military Medical UniversityXi'anChina Department of Infectious Disease Guangzhou Women and Children's Medicine CenterGuangzhou Medicine UniversityGuangzhouChina Department of Pediatrics Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Department of Respiratory Disease Beijing Children's HospitalCapital Medical UniversityBeijingChina Department of Pediatric Respiratory Shengjing Hospital of China Medical UniversityShenyangChina Respiratory Department Children's Hospital Affiliated to Capital Institute of PediatricsBeijingChina Department of Clinical Epidemiology Aarhus UniversityAarhusDenmark Department of Respirology Children's Hospital of Soochow UniversitySuzhouChina Department of Respiratory Children's Hospital of ShanghaiChildren's Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghaiChina Department of Infectious Disease Hainan Women and Children's Medical CenterHaikouChina Department of Infectious Disease Children's Hospital of Chongqing Medical UniversityChongqingChina Department of Respiratory Children's Hospital of Nanjing Medical UniversityNanjingChina Department of Infectious Di

Background Respiratory syncytial virus(RSV)is the leading global cause of respiratory infections and is responsible for about 3 million hospitalizations and more than 100,000 deaths annually in children younger than 5 years,representing a major global healthcare *** is a great unmet need for new agents and universal strategies to prevent RSV infections in early life.A multidisciplinary consensus development group comprising experts in epidemiology,infectious diseases,respiratory medicine,and methodology aims to develop the current consensus to address clinical issues of RSV infections in *** sources The evidence searches and reviews were conducted using electronic databases,including PubMed,Embase,Web of Science,and the Cochrane library,using variations in terms for"respiratory syncytial virus","RSV","lower respiratory tract infection","bronchiolitis","acute","viral pneumonia","neonatal","infant""children",and"pediatric".Results Evidence-based recommendations regarding diagnosis,treatment,and prevention were proposed with a high degree of *** supportive care remains the cornerstone for the management of RSV infections,new monoclonal antibodies,vaccines,drug therapies,and viral surveillance techniques are being rolled *** This consensus,based on international and national scientific evidence,reinforces the current recommendations and integrates the recent advances for optimal care and prevention of RSV *** improvements in the management of RSV infections will require generating the highest quality of evidence through rigorously designed studies that possess little bias and sufficient capacity to identify clinically meaningful end points.

关键词： Consensus prevention Respiratory syncytial virus Treatment

Chinese Medicine Prolongs Overall Survival of Chinese Patients with Advanced Gastric Cancer: Treatment Pattern and Survival Analysis of a 20-Year Real-World Study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Integrative Medicine 2024年第6期30卷 489-498页

作者： cao Ni-da ZHU Xiao-hong MA Fang-qi XU Yan DONG Jia-huan QIN Meng-meng liU Tian-shu ZHU Chun-chao GUO Wei-jian DING hong-hua GUO Yuan-biao liU li-kun SONG Jin-jie WU Ji-ping CHENG Yue-lei ZENG lin ZHAO Ai-guang Oncology Department I Longhua Hospital Shanghai University of Traditional Chinese MedicineShanghai200032China Oncology Department Zhongshan HospitalFudan UniversityShanghai200032China Gastrointestinal Surgery Department Renji HospitalShanghai Jiaotong University School of MedicineShanghai200127China Oncology Department Fudan University Shanghai Cancer CenterShanghai200032China Oncology Department Shanghai General HospitalShanghai Jiaotong University School of MedicineShanghai200080China Traditional Chinese Medicine Department Ruijin HospitalShanghai Jiaotong University School of MedicineShanghai200025China Oncology Department Shanxi Traditional Chinese Medicine HospitalTaiyuan030012China Oncology Department Xiyuan HospitalChina Academy of Chinese Medical ScienceBeijing102445China Oncology Department Yunnan Province Hospital of Traditional Chinese MedicineKunming650021China Oncology Department Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai201203China Shanghai NewCore Biotechnology Co. Ltd.Shanghai200240China

Objective To describe the treatment patterns and survival status of advanced gastric cancer(AGC)in China in the past two decades,and objectively evaluate the impact of standardized Chinese medicine(CM)treatment on the survival of AGC *** This multicenter registry designed and propensity score analysis study described the diagnosis characteristics,treatment-pattern development and survival status of AGC from 10 hospitals in China between January 1,2000 and July 31,*** survival(OS)was evaluated between non-CM cohort(standard medical treatment)and CM cohort(integrated standard CM treatment≥3 months).Propensity score matching(PSM)and inverse probability of treatment weighting(IPTW)were performed to adjust any difference in average outcomes for *** A total of 2,001 patients histologically confirmed locally advanced and/or metastasis stomach and gastroesophageal junction adenocarcinoma were *** them,1,607 received systemic chemotherapy,215(10.74%)accepted molecular targeted therapy,44(2.2%)received checkpoint inhibitor therapy,and 769(38.43%)received ***-drug regimen was the main choice for first-line treatment,with fluoropyrimidine plus platinum as the most common regimen(530 cases,60.09%).While 45.71%(16 cases)of patients with HER2 amplification received trastuzumab in *** application of apatinib increased(33.33%)in *** application of checkpoint inhibitors has increased since *** analysis showed that Lauren mixed type(P=0.017),cycles of first-line treatment>6(P=0.000),CM(P=0.000),palliative gastrectomy(P=0.000),trastuzumab(P=0.011),and apatinib(P=0.008)were independent prognostic factors for the OS of *** PSM and IPTW,the median OS of CM cohort and non-CM cohort was 18.17 and 12.45 months,respectively(Pline *** CM treatment was an independent

关键词： advancedgastriccancer real-world study treatment pattern survival analysis Chinese medicine