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The circadian clock in enamel development

International Journal of Oral Science 2024年第3期16卷 371-380页

作者： Ke Wu xiaochan li Yunyang Bai Boon Chin Heng Xuehui Zhang Xuliang Deng Department of Geriatric Dentistry Peking University School and Hospital of StomatologyBeijingChina th Division Peking University School and Hospital of StomatologyBeijingChina Department of Dental Materials&Dental Medical Devices Testing Center Peking University School and Hospital of StomatologyBeijingChina National Engineering Research Center of Oral Biomaterials and Digital Medical Devices NMPA Key Laboratory for Dental MaterialsBeijing Laboratory of Biomedical Materials&Beijing Key Laboratory of Digital StomatologyPeking University School and Hospital of StomatologyBeijingChina Oral Translational Medicine Research Center Joint Training base for Shanxi Provincial Key Laboratory in Oral and Maxillofacial Repair Reconstruction and Regeneration The First People’s Hospital of Jinzhong JinzhongChina

Circadian rhythms are self-sustaining oscillations within biological systems that play key roles in a diverse multitude of physiological *** circadian clock mechanisms in brain and peripheral tissues can oscillate independently or be synchronized/disrupted by external *** enamel is a type of mineralized tissue that forms the exterior surface of the tooth *** Retzius lines are readily observable microstructures of mature tooth enamel that indicate the regulation of amelogenesis by circadian *** enamel is formed by enamel-forming cells known as ameloblasts,which are regulated and orchestrated by the circadian clock during *** review will first examine the key roles of the circadian clock in regulating ameloblasts and *** physiological processes are involved,including gene expression,cell morphology,metabolic changes,matrix deposition,ion transportation,and ***,the potential detrimental effects of circadian rhythm disruption on enamel formation are *** rhythm disruption can directly lead to Enamel Hypoplasia,which might also be a potential causative mechanism of amelogenesis ***,future research trajectory in this field is *** is hoped that this review will inspire more intensive research efforts and provide relevant cues in formulating novel therapeutic strategies for preventing tooth enamel developmental abnormalities.

关键词： enamel crown exterior

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新文科背景下高校艺术实践策划课程的教学改革策略分析

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邵阳学院学报（社会科学版） 2024年第4期23卷 106-111页

作者：陈姝璇李晓婵湖南交通工程学院人文与艺术学院湖南衡阳421001 怀化师范高等专科学校学前教育学院湖南怀化418000

新文科是传统文科教育创新与发展的产物,强调现代信息技术的融入,培养具备跨学科知识和创新能力的人才,其给高校艺术专业教育带来了从“闭环”转为“开源”、教学模式从“分科”转向“融合”、学生培养路径从“单一”变为“多元”等影... 详细信息

新文科是传统文科教育创新与发展的产物,强调现代信息技术的融入,培养具备跨学科知识和创新能力的人才,其给高校艺术专业教育带来了从“闭环”转为“开源”、教学模式从“分科”转向“融合”、学生培养路径从“单一”变为“多元”等影响。当前高校艺术实践策划课程存在教学资源相对匮乏、教师综合素养有待提升、教学理念滞后且方法单一以及教学评价体系不健全等问题。鉴于此,建议强化教学资源支撑作用、加大师资队伍建设力度、创新教学理念与方法以及建立健全教学评价体系。

关键词：新文科高校艺术实践策划课程教学改革

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深度学习导向的PAD与PBL融合教学模式的高校行动研究

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高等继续教育学报 2024年第4期37卷 23-31页

作者：李彬彬杨洁李晓婵天津商业大学宝德学院天津300384

对分课堂(PAD)和项目化学习(PBL)根源于相似的理论基础,能够促进学生深度学习能力的提升,但在一线教学实践中均存在一定的局限。课程组多位教师在应用型本科高校一线教学中进行了两轮严谨的行动研究,以学生深度学习体验为目标,对教学要... 详细信息

对分课堂(PAD)和项目化学习(PBL)根源于相似的理论基础,能够促进学生深度学习能力的提升,但在一线教学实践中均存在一定的局限。课程组多位教师在应用型本科高校一线教学中进行了两轮严谨的行动研究,以学生深度学习体验为目标,对教学要素整合重构后创新提出“1体2翼3环4向的Pp-AD-P”立体教学实施体系,多源数据从不同维度验证了所构建教学模式具有一定的科学性和可操作性。

关键词：对分课堂项目化学习行动研究深度学习教学创新

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Extrapolating neurogenesis of mesenchymal stem/stromal cells on electroactive and electroconductive scaffolds to dental and oral-derived stem cells

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International Journal of Oral Science 2022年第2期14卷 123-131页

作者： Boon Chin Heng Yunyang Bai xiaochan li Xuehui Zhang Xuliang Deng Central Laboratory Peking University School and Hospital of StomatologyBeijingChina School of Medical and life Sciences Sunway UniversitySubang JayaSelangor Darul EhsanMalaysia Department of Geriatric Dentistry Peking University School and Hospital of StomatologyBeijingChina Department of Dental Materials&Dental Medical Devices Testing Center Peking University School and Hospital of StomatologyBeijingChina National Engineering Laboratory for Digital and Material Technology of Stomatology NMPA Key Laboratory for Dental MaterialsBeijing Laboratory of Biomedical Materials&Beijing Key Laboratory of Digital StomatologyPeking University School and Hospital of StomatologyBeijingChina

The high neurogenic potential of dental and oral-derived stem cells due to their embryonic neural crest origin,coupled with their ready accessibility and easy isolation from clinical waste,make these ideal cell sources for neuroregeneration ***,these cells also have high propensity to differentiate into the osteo-odontogenic *** strategy to enhance neurogenesis of these cells may be to recapitulate the natural physiological electrical microenvironment of neural tissues via electroactive or electroconductive tissue engineering ***,to date,there had been hardly any such studies on these *** relevant scientific information comes from neurogenesis of other mesenchymal stem/stromal cell lineages(particularly bone marrow and adipose tissue)cultured on electroactive and electroconductive scaffolds,which will therefore be the focus of this *** there are larger number of similar studies on neural cell lines(***12),neural stem/progenitor cells,and pluripotent stem cells,the scientific data from such studies are much less relevant and less translatable to dental and oral-derived stem cells,which are of the mesenchymal *** extrapolation work is needed to validate that electroactive and electroconductive scaffolds can indeed promote neurogenesis of dental and oral-derived stem cells,which would thus facilitate clinical applications in neuroregeneration therapy.

关键词： mesenchymal conductive neural

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Electrical charge on ferroelectric nanocomposite membranes enhances SHED neural differentiation

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Bioactive Materials 2023年第2期20卷 81-92页

作者： xiaochan li Boon Chin Heng Yunyang Bai Qianqian Wang Min Gao Ying He Xinwen Zhang Xuliang Deng Xuehui Zhang Department of Geriatric Dentistry Peking University School and Hospital of StomatologyBeijing100081PR China Department of Dental Materials&Dental Medical Devices Testing Center Peking University School and Hospital of StomatologyBeijing100081PR China Department of Prosthodontics Peking University School and Hospital of StomatologyBeijing100081PR China Central Laboratory Peking University School and Hospital of StomatologyBeijing100081PR China Center of Implant Dentistry School and Hospital of StomatologyChina Medical UniversityLiaoning Provincial Key Laboratory of Oral DiseasesShenyang110002PR China National Engineering Research Center of Oral Biomaterials and Digital Medical Devices NMPA Key Laboratory for Dental MaterialsBeijing Laboratory of Biomedical MaterialsPeking University School and Hospital of StomatologyBeijing100081PR China

Stem cells from human exfoliated deciduous teeth(SHED)uniquely exhibit high proliferative and neurogenic *** biomaterials have been demonstrated to promote neural differentiation of stem cells,but the dose-response effect of electrical stimuli from these materials on neural differentiation of SHED remains to be ***,by utilizing different annealing temperatures prior to corona poling treatment,BaTiO_(3)/P(VDF-TrFE)ferroelectric nanocomposite membranes with varying charge polarization intensity(d_(33)≈0,4,12 and 19 pC N^(-1))were *** expression of neural markers,increased cell elongation and more prominent neurite outgrowths were observed with increasing surface charge of the nanocomposite membrane indicating a dose-response effect of surface electrical charge on SHED neural *** investigations of the underlying molecular mechanisms revealed that intracellular calcium influx,focal adhesion formation,FAK-ERK mechanosensing pathway and neurogenic-related ErbB signaling pathway were implicated in the enhancement of SHED neural differentiation by surface electrical ***,this study confirms the dose-response effect of biomaterial surface charge on SHED neural differentiation and provides preliminary insights into the molecular mechanisms and signaling pathways involved.

关键词： Surface charge Electric polarization Dose-response effect Electrical microenvironment Neurogenesis

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The bioelectrical properties of bone tissue

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Animal Models and Experimental Medicine 2023年第2期6卷 120-130页

作者： Boon Chin Heng Yunyang Bai xiaochan li Yanze Meng Yanhui Lu Xuehui Zhang Xuliang Deng Department of Dental Materials&Dental Medical Devices Testing Center Peking University School and Hospital of StomatologyBeijingPR China Central Laboratory Peking University School and Hospital of StomatologyBeijingPR China School of Medical and life Sciences Sunway UniversitySubang JayaMalaysia Department of Geriatric Dentistry Peking University School and Hospital of StomatologyBeijingPR China National Engineering Research Center of Oral Biomaterials and Digital Medical Devices NMPA Key Laboratory for Dental MaterialsBeijing Laboratory of Biomedical Materials&Beijing Key Laboratory of Digital StomatologyPeking University School and Hospital of StomatologyBeijingPeople's Republic of China

Understanding the bioelectrical properties of bone tissue is key to developing new treatment strategies for bone diseases and injuries,as well as improving the design and fabrication of scaffold implants for bone tissue *** bioelectrical properties of bone tissue can be attributed to the interaction of its various cell lineages(osteocyte,osteoblast and osteoclast)with the surrounding extracellular matrix,in the presence of various biomechanical stimuli arising from routine physical activities;and is best described as a combination and overlap of dielectric,piezoelectric,pyroelectric and ferroelectric properties,together with streaming potential and *** is close interdependence and interaction of the various electroactive and electrosensitive components of bone tissue,including cell membrane potential,voltage-gated ion channels,intracellular signaling pathways,and cell surface receptors,together with various matrix components such as collagen,hydroxyapatite,proteoglycans and *** is the remarkably complex web of interactive cross-talk between the organic and non-organic components of bone that define its electrophysiological properties,which in turn exerts a profound influence on its metabolism,homeostasis and regeneration in health and *** has spurred increasing interest in application of electroactive scaffolds in bone tissue engineering,to recapitulate the natural electrophysiological microenvironment of healthy bone tissue to facilitate bone defect repair.

关键词： bone dielectric electric ferroelectric homeostasis metabolism piezoelectric pyroelectric regeneration

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Enhancement of light output powers of GaN-based light emitting diodes with textured indium tin oxide transparent layer by using corrosive liquid

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Science China(Physics,Mechanics & Astronomy) 2011年第10期54卷 1787-1790页

作者： li Yun li xiaochan ZHANG Tao HE AnHe HU CanDong WANG Xin HE Miao ZHANG Yong NIU Qiaoli ZHAO lingZhi li ShuTi CHEN XianWen Key Laboratory of Electroluminescent Devices of Guangdong Provincial Education Department Institute of Optoelectronic Materials & Technology South China Normal University Guangzhou 510631 China College of Information Science and Engineering Wuhan University of Science & Technology Wuhan 430081 China Sanan Optoelectronics Co. Ltd. Xiamen 361009 China

In order to promote the light output powers of GaN-based light emitting diodes (LEDs), two kinds of novel corrosive liquidshave been developed in this paper to roughen the surface of the indium tin oxide (ITO) current spreading layer of LEDs. As aresult, the textured transparent ITO layer greatly enhanced the external quantum efficiency of the LEDs. Provided that a wafersample was dipped in a kind of corrosive liquid developed by us for only about 60 s, the light output powers of the LEDs canbe promoted by 24.7%, compared with conventional GaN-based LEDs. It is obvious that the presented method is simple, rapidand cost-effective.

关键词： GaN-based light emitting diodes (LEDs) corrosive liquid light output power textured ITO

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Novel sol-gel material for fabrication of a long period waveguide grating filter as a precise thermometer

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Science China(Physics,Mechanics & Astronomy) 2011年第11期54卷 1967-1971页

作者： WANG Xin li xiaochan ZHANG Tao HU CanDong ZHU QiuXiang CHEN SiHai li Yun XU Jia HE Miao NIU Qiaoli ZHAO lingZhi li ShuTi ZHANG Yong Key Laboratory of Electroluminescent Devices of Guangdong Provincial Education Department Institute of Optoelectronic Materials ＆ Technology South China Normal University Guangzhou 510631 China College of Information Science ＆ Engineering Wuhan University of Science ＆ Technology Wuhan 430081 China Wuhan National Laboratory for Optoelectronics Huazhong University of Science ＆ Technology Wuhan 430074 China

A new kind of organic-inorganic hybrid HfO2/SiO2 sol-gel material with a large thermo-optic coefficient and a wide linear tunable temperature range has been developed for fabrication of a long period waveguide grating （LPWG） filter, whose parameters were optimized and designed by using finite difference time domain （FDTD） simulations. The LPWG filter, a periodic rectangle-corrugated grating structure, was easily fabricated with soft-lithography technique. At a temperature range from 19~C to 70~C, the fabricated LPWG filter element demonstrated a high temperature sensitivity of about 6.5 nm/~C and a wide linear tunable temperature range of 51℃, so that it can be used as a precise thermometer. Our results are useful for the designs of LPWG filters for the implementation of a wide range of thermo-optic functions.

关键词： LPWG filter soft-lithography sol-gel material temperature sensitivity

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PST视域下应用型高校混合式实践教学模式的内在机理——基于扎根理论的研究

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职业技术教育 2023年第23期44卷 63-68页

作者：李晓婵天津商业大学宝德学院天津300380

混合式实践教学模式对于推动教学改革发展、提高人才培养成效具有重要价值。运用扎根理论对天津商业大学宝德学院、桂林旅游学院和山东枣庄学院3所应用型高校的实践教学模式进行比较研究,结合已有研究成果,建立了基于PST视域下的混合实... 详细信息

混合式实践教学模式对于推动教学改革发展、提高人才培养成效具有重要价值。运用扎根理论对天津商业大学宝德学院、桂林旅游学院和山东枣庄学院3所应用型高校的实践教学模式进行比较研究,结合已有研究成果,建立了基于PST视域下的混合实践教学模型,刻画出模型的3个流程及其内在机理:混合实践教学设置期强调结合多方需求,校企共同制订人才培养方案;混合实践教学实施期突出特点是异地空间的学习,师生与生生互动式教学过程需要多方积极配合参与;混合实践教学精益期强调多元化考核与实施形式多样化。总体来说,混合实践教学创新是不断演化、完善的过程,为应用型本科实践教学提供有益参考。

关键词： PST理论模型混合式实践教学扎根理论应用型高校内在机理

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复合高功率脉冲磁控溅射Ti的放电特性及薄膜制备

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金属学报 2014年第7期50卷 879-885页

作者：李小婵柯培玲刘新才汪爱英中国科学院宁波材料技术与工程研究所、中国科学院海洋新材料与应用技术重点实验室宁波315201 宁波大学理学院宁波315211 宁波大学材料科学与化学工程学院宁波315211

采用高功率脉冲磁控溅射与直流磁控溅射并联的复合高功率脉冲磁控溅射技术,研究直流磁控溅射部分耦合直流电流变化对Ti靶在Ar气氛中放电及等离子体特性的影响.采用表面轮廓仪、扫描探针显微镜、X射线衍射与纳米压痕仪对Ti薄膜厚度、结... 详细信息

采用高功率脉冲磁控溅射与直流磁控溅射并联的复合高功率脉冲磁控溅射技术,研究直流磁控溅射部分耦合直流电流变化对Ti靶在Ar气氛中放电及等离子体特性的影响.采用表面轮廓仪、扫描探针显微镜、X射线衍射与纳米压痕仪对Ti薄膜厚度、结构特征以及力学性能进行表征.结果表明:耦合直流电流增加,靶平均功率增加,脉冲作用期间靶电流降低,等离子体电子密度增加;在耦合直流电流为2.0A时,等离子体电子密度和电子温度获得较大值,分别为2.98 V和0.93 eV;耦合直流电流增加,Ti薄膜沉积速率近似线性增加,粗糙度增加,硬度和弹性模量略有降低;相同靶平均功率时,采用复合高功率脉冲磁控溅射技术制备Ti薄膜与采用传统直流磁控溅射技术相比,沉积速率相当;靶平均功率650W时复合高功率脉冲磁控溅射所制Ti薄膜比传统直流磁控溅射所制Ti薄膜更加光滑,平均粗糙度降低1.32 nm,力学性能更加优异,硬度提高2.68GPa.

关键词：复合高功率脉冲磁控溅射直流放电特性 Ti薄膜

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