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中国调味品 2014年第11期39卷 56-58页

作者：李德坤沈阳开笛科技有限公司沈阳110000

针对目前在酿造和发酵工艺中,制曲设备的设计参数偏差大,依据的技术条件模糊,通过对各种生产要素的分析,为制曲设备的设计或选用提出一套有关参数的计算方案,供新建厂和技术改造时技术人员参考选用。

关键词：制曲设备温度湿度调气参数

Kuicolong-yu enema decoction retains traditional Chinese medicine enema attenuates inflammatory response ulcerative colitis through TLR4/NF-κB signaling pathway

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World Journal of Gastrointestinal Surgery 2024年第4期16卷 1149-1154页

作者： li Han kun Tang Xiao-li Fang Jing-Xi Xu Xi-Yun Mao Ming li department of Anorectal Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Anhui HospitalHefei 230001Anhui ProvinceChina Anorectal Center The First Affiliated Hospital of Anhui University of Traditional Chinese MedicineHefei 230001Anhui ProvinceChina department of Spleen and Stomach Diseases Department of GastroenterologyAffiliated Wuhu Hospital of Traditional Chinese Medicine of Anhui College of Traditional Chinese MedicineWuhu 241000Anhui ProvinceChina

BACKGROUND Ulcer colitis(UC)is a chronic,nonspecific,and noninfectious inflammatory bowel ***,Toll-like receptors(TLRs)have been found to be closely associated with clinical inflammatory *** complete remission in patients with intermittent periods of activity followed by dormancy is ***,no study has explored the mechanism by which Kuicolong-yu enema decoction retains traditional Chinese medicine enemas to attenuate the inflammatory response in *** To explore the mechanism by which Kuicolong-yu enema decoction retains traditional Chinese medicine enemas to attenuate the inflammatory response in *** This prospective clinical study included patients who met the exclusion criteria in 2020 and *** patients with UC were divided into two groups(control and experimental).The peripheral blood of the experimental and control groups were collected under aseptic *** expression of TLR4 protein,NF-κB,IL-6,and IL-17 was detected in the peripheral blood of patients in the experimental group and control group before and 1 month after taking the *** co rrelation analysis was used to analyze the relationship between the expression level of TLR4 protein and the expression levels of downstream signal NF-κB and inflammatory factors IL-6 and IL-17,and Pdered statistically *** There were no significant differences in the patient characteristics between the control and experimental *** results showed that the expression levels of TLR4 and NF-κB in the experimental group were significantly lower than those in the control group(P<0.05).The levels of IL-6 and IL-17 in the experimental group were significantly lower than those in the control group(P<0.05).The TLR4 protein expression in the experimental group was positively correlated with the expression level of downstream signal NF-κB and was positively correlated with the levels of downstream inflammatory cytokines IL-6 and IL-

关键词： Ulcerative colitis TLR4 NF-κB signaling pathway Kuicolong-yu enema

Efficiency and safety of laparoscopic left hemihepatectomy: A study of intrathecal vs extrathecal Glissonean pedicle techniques

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2612-2619页

作者： li-Min Kang Lei Xu Fu-Wei Zhang Fa-kun Yu li Lang department of Hepatobiliary and Pancreatic Surgery Puer People's HospitalPuer 665000Yunnan ProvinceChina department of Outpatient Puer People's HospitalPuer 665000Yunnan ProvinceChina

BACKGROUND Selective hemihepatic vascular occlusion is utilized in both right and left hemihepatectomies to preserve blood supply to the intact lobe,maintain hemo-dynamic stability,and mitigate surgical *** this technique encompasses both intrathecal and extrathecal Glissonean pedicle transection methods,there is a lack of systematic comparative reports on these two *** To retrospectively analyze the clinical data of patients with hepatocellular carcinoma(HCC)undergoing laparoscopic anatomical hepatectomy in our hospital to explore the feasibility,safety,and short-and long-term efficacy of extrathecal and intrathecal Glissonean pedicle transection methods in laparo-scopic left *** A retrospective study was performed to analyze the clinical data of 49 HCC patients who underwent laparoscopic left hemihepatectomy from January 2019 to december 2022 in our *** patients were divided into extrathecal Glissonean pedicle transection(EGP)group(n=24)and intrathecal Glissonean pedicle transection(IGP)group(n=25)according to the different approaches used for selective hemihepatic vascular *** perioperative indicators,liver function indexes,complications,and follow-up findings were compared between these two *** The surgeries were smooth in both groups,and no perioperative death was *** hepatic pedicle transection time and the operation time were(16.1±2.3)minutes and(129.6±19.0)minutes,respectively,in the EGP group,which were significantly shorter than those in the IGP group[(25.5±2.4)minutes and(184.8±26.0)minutes,respectively],both Pling time,and postoperative liver function between the two groups(all P>0.05).The incidence of postoperative complications showed no significant difference[16.67%(4/24)vs 16.0%(4/25),P>0.05].All the 49 HCC patients were followed up after surgery(range:11.2

关键词： Hepatocellular carcinoma Laparoscopy Extra-Glissonian approach Intra-Glissonian approach Surgical efficiency Surgical safety

Intravitreal injection practice patterns among Chinese ophthalmologists

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International Journal of Ophthalmology(English edition) 2024年第9期17卷 1717-1722页

作者： li Su Yin-Chen Shen Hong li Bo Mou kun liu Xun Xu department of Ophthalmology Shanghai General HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200080China National Clinical Research Center for Eye Diseases Shanghai 200080China Shanghai Key Laboratory of Ocular Fundus Diseases Shanghai 200080China Shanghai MicroCall Information Technology Co. Ltd.Shanghai 200436China

AIM:To describe the practice patterns of intravitreal injections(IVIs)among ophthalmologists in ***:This was a cross-sectional online *** who had performed accumulated more than 100 injections were contacted by the Brightness Center,a hospital-based national network,to complete an anonymous,24-question,internet-based *** were surveyed on practices in injection techniques,pre-,and post-injections ***:A total of 333 ophthalmologists from 28 provinces/municipalities/autonomous regions responded to the survey(50.68%response rate).The 91.29%of the respondents evaluated systemic risk factors by medical history,electrocardiogram(ECG)and blood *** the respondents used pre-injection prophylactic *** checked intraocular pressure(IOP,99.1%)and blood pressure(96.1%)before injections.A majority of the respondents performed injections in the operating room(98.8%),wore masks(99.7%),gloves(99.4%)and sterile surgical clothing(96.1%),performed topical anesthetics(97.9%),and applied povidone-iodine(95.8%)*** 61.26%of the respondents dilated *** half of the respondents(51.05%)performed bilateral injections in the same *** temporal quadrant(40.54%)was the most frequent site of *** three quarters used 30-gauge *** respondents(97.9%)measured the site of injection from *** than half(53.45%)performed conjunctiva displacement prior to *** 32.43%of the respondents checked IOP post-injection and 87.99%physicians checked hand motion(HM)or counting fingers(CF)after injection,while 36.94%observed optic nerve *** participants used topical antibiotics *** physicians(91.89%)reviewed patients on the following ***:This study provides a description of the real-world practice patterns in IVIs in China and offers critical information regarding education and training of ophthalmologists and amendment of local society guideli

关键词： intravitreal injections practice pattern topical antibiotics Chinese ophthalmologists

Photoredox-Catalyzed Metal-Free Regio-&Stereoselective C(sp^(2))-H Amination of Enamides with N-Aminopyridium Salts

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Chinese Journal of Chemistry 2024年第18期42卷 2235-2242页

作者： Zheng-Bao Qin kun Ni li Wang Xiao-Di Wu Yu Zhang Kai Zhao Institute of Advanced Synthesis School of Chemistry and Molecular EngineeringJiangsu National Synergetic Innovation Center for Advanced MaterialsNanjing Tech UniversityNanjingJiangsu211816China college of Chemical Engineering Nanjing Forestry UniversityNanjingJiangsu 210037China

A visible-light-induced photoredox-catalyzed regioselective and stereoselective C(sp')-H amination of enamides with bench-stable and A visible-light-induced photoredox-catalyzed regioselective and stereoselective C(sp)-H amination of enamides with bench-stable and easily accessible N-aminopyridium salts is developed,affording synthetically and biologically prominent vicinal 1,2-diamine scaffolds with broad substrate scope and excellent functional group *** transformation proceeded through a radical pathway involving the Giese addition of the relatively electrophilic N-centered sulfonamidyl radical species to nucleophilicβ-olefinic position of enamides followed by the ensuing single electron oxidation andβ-H elimination,delivering geometrically-defined Z-configuredβ-sulfonamidylated *** operational simplicity,environmental friendliness and cost efficiency of this methodology allowed it to pave a new avenue to enrich the arsenal of synthetically crucial functionalized enamides and their related derivatives.

关键词： Enamides Amination Photoredox catalysis Regioselective Stereoselective Metal-free

Cationic surface polarization centers on ionic carbon nitride for efficient solar-driven H_(2)O_(2) production and pollutant abatement

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Chinese Chemical Letters 2024年第10期35卷 383-388页

作者： Zhenyu Hu Zhenchun Yang Shiqi Zeng kun Wang lina li Chun Hu Yubao Zhao MOE Key Laboratory for Water Quality and Conservation of the Pearl River delta Institute of Environmental Research at Greater BayGuangzhou UniversityGuangzhou510006China

Solar-driven H_(2)O_(2)production and emerging organic pollutants(EOPs)elimination are of great significance from the perspective of environmental *** efficiency of the photocatalytic reaction system is the key challenge to be *** this work,the strategy of constructing surface ionic local polarization centers to enhance the exciton dissociation of the polymeric photocatalytic is *** bipyridinium cation(TMAP)is complexed on a K^(+)-incorporated carbon nitride(CNK)framework,and the combination of local polarization centers both on the surface(bipyridinium cation)and bulk(K+cation)contributes to a superior photocatalytic H_(2)O_(2)production performance,affording a remarkable H_(2)O_(2)generation rate of 46.8μmol h^(-1)mg^(-1)and a high apparent quantum yield(AQY)value of 77.5%under irradiation of 405 nm *** substantiated experimentally by steady state/transient spectroscopy techniques,the surface local polarization centers increase the population of the long-lived trapped electrons,and thereby promote the interfacial charge transfer process for chemical conversion *** strategy is potentially applicable to the design of a wide range of efficient solar-to-chemical conversion systems.

关键词： Local polarization Oxygen reductionreaction Hydrogen peroxide production Pollutantdegradation Polymeric carbon nitride

A genome-wide association study uncovers that TaPI4K-2A regulates pre-harvest sprouting in wheat

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Plant Communications 2024年第5期5卷 1-4页

作者： li Tai Jianhui Wu Yexing Jing Huaizeng liu Qingdong Zeng Xiaojing Xu Shengdixin Shi Hongjin Wang Wenting liu Jiaqiang Sun de-Jun Han kun-Ming Chen National Key Laboratory of Crop Improvement for Stress Tolerance and Production College of Life SciencesNorthwest A&F UniversityYangling 712100ShaanxiP.R.China National Key Laboratory of Crop Improvement for Stress Tolerance and Production College of AgronomyNorthwest A&F UniversityYangling 712100ShaanxiP.R.China State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural SciencesBeijing 100081P.R.China National Key Laboratory of Crop Improvement for Stress Tolerance and Production College of Plant ProtectionNorthwest A&F UniversityYangling 712100ShaanxiP.R.China

dear Editor,Pre-harvest sprouting(PHS)is a major challenge to cereal crop production in areas with frequent rainfall at harvest time and has significant effects on grain yield and end-use quality(Lang et al.,2021).PHS is quantified by the dormancy/germination ratio of seeds and is largely regulated by two opposing phytohormones,abscisic acid(ABA)and gibberellin(GA)(Tai et al.,2021).ABA induces dormancy and suppresses PHS,whereas GA exerts the opposite effects(Finkelstein et al.,2008).Because of the complexity of the genome,only a few genes involved in regulation of PHS have been identified in wheat,and the underlying molecular regulatory mechanisms of PHS remain largely unknown in this species.

关键词： PHS harvest largely

Mitochondrial Regulation of Macrophages in Innate Immunity and Diverse Roles of Macrophages During Cochlear Inflammation

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Neuroscience Bulletin 2024年第2期40卷 255-267页

作者： Yuan Zhang Fanglei Ye Xiaolong Fu Shen li Le Wang Yutian Chen Hongmin li Shaojuan Hao kun Zhao Qi Feng Peipei li department of Otology The First Afliated Hospital of Zhengzhou UniversityZhengzhou 450052China Shandong Provincial Hospital Shandong First Medical UniversityJinan 250000China department of Neurology The First Afliated Hospital of Zhengzhou UniversityZhengzhou 450052China The department of Endovascular Surgery The First Afliated Hospital of Zhengzhou UniversityZhengzhou 450052China department of Integrated Traditional and Western Nephrology The First Afliated Hospital of Zhengzhou UniversityZhengzhou 450052China Henan Province Research Center of Kidney Disease Zhengzhou 450052China

Macrophages are essential components of the innate immune system and constitute a non-specific first line of host defense against pathogens and *** regulate macrophage activation and innate immune responses in various inflammatory diseases,including cochlear *** distribution,number,and morphological characteristics of cochlear macrophages change significantly across different inner ear regions under various pathological conditions,including noise exposure,ototoxicity,and age-related ***,the exact mechanism underlying the role of mitochondria in macrophages in auditory function remains ***,we summarize the major factors and mitochondrial signaling pathways(e.g.,metabolism,mitochondrial reactive oxygen species,mitochondrial DNA,and the inflammasome)that influence macrophage activation in the innate immune *** particular,we focus on the properties of cochlear macrophages,activated signaling pathways,and the secretion of inflammatory cytokines after acoustic *** hope this review will provide new perspectives and a basis for future research on cochlear inflammation.

关键词： Macrophage Mitochondria Innate immunity Cochlea Infammation

GhATL68b regulates cotton fiber cell development by ubiquitinating the enzyme required forβ-oxidation of polyunsaturated fatty acids

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Plant Communications 2024年第10期5卷 139-153页

作者： Xin li Gai Huang Yifan Zhou kun Wang Yuxian Zhu College of life Sciences Wuhan UniversityWuhan 430072China Institute for Advanced Studies Wuhan UniversityWuhan 430072China Hubei Hongshan Laboratory Wuhan 430072China TaiKang Center for life and Medical Sciences Wuhan UniversityWuhan 430072China State Key Laboratory of Plant Genomics and National Center for Plant Gene Research Institute of Genetics and Developmental BiologyChinese Academy of SciencesBeijing 100101China

E3 ligases are key enzymes required for protein ***,we identified a C3H2C3 RING domaincontaining E3 ubiquitin ligase gene named *** is preferentially and highly expressed in developing cotton fiber cells and shows greater conservation in plants than in animals or *** four orthologous copies of this gene in various diploid cottons and eight in the allotetraploid *** were found to have originated from a single common ancestor that can be traced back to Chlamydomonas reinhardtii at about 992 million years *** variations in the GhATL68b promoter regions of ***,***,***,and *** are correlated with significantly different methylation pat*** CRISPR-Cas9 knockout cotton lines exhibit significant reductions in fiber quality traits,including upper-half mean length,elongation at break,uniformity,and mature fiber *** vitro ubiquitination and cell-free protein degradation assays revealed that GhATL68b modulates the homeostasis of 2,4-dienoyl-CoA reductase,a rate-limiting enzyme for theβ-oxidation of polyunsaturated fatty acids(PUFAs),via the ubiquitin proteasome *** cells harvested from these knockout mutants contain significantly lower levels of PUFAs important for production of glycerophospholipids and regulation of plasma membrane *** fiber growth defects of the mutant can be fully rescued by the addition of linolenic acid(C18:3),the most abundant type of PUFA,to the ovule culture *** experimentally characterized C3H2C3 type E3 ubiquitin ligase involved in regulating fiber cell elongation may provide us with a new genetic target for improved cotton lint production.

关键词： Gossypium hirsutum E3 ligases polyunsaturated fatty acids β-oxidation fiber development

Face Anti-Spoofing with Unknown Attacks:A Comprehensive Feature Extraction and Representation Perspective

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Journal of Computer Science & Technology 2024年第4期39卷 827-840页

作者： li-Min li Bin-Wu Wang Xu Wang Peng-kun Wang Yu-Dong Zhang Yang Wang School of Software Engineering University of Science and Technology of ChinaHefei 230000China School of Data Science University of Science and Technology of ChinaHefei 23000China Suzhou Institute for Advanced Research University of Science and Technology of ChinaSuzhou 215000China

Face anti-spoofing aims at detecting whether the input is a real photo of a user(living)or a fake(spoofing)*** new types of attacks keep emerging,the detection of unknown attacks,known as Zero-Shot Face Anti-Spoofing(ZSFA),has become increasingly important in both academia and *** ZSFA methods mainly focus on extracting discriminative features between spoofing and living ***,the nature of the spoofing faces is to trick anti-spoofing systems by mimicking the livings,therefore the deceptive features between the known attacks and the livings,which have been ignored by existing ZSFA methods,are essential to comprehensively represent the ***,existing ZSFA models are incapable of learning the complete representations of living faces and thus fall short of effectively detecting newly emerged *** tackle this problem,we propose an innovative method that effectively captures both the deceptive and discriminative features distinguishing between genuine and spoofing *** method consists of two main components:a two-against-all training strategy and a semantic *** two-against-all training strategy is employed to separate deceptive and discriminative *** address the subsequent invalidation issue of categorical functions and the dominance disequilibrium issue among different dimensions of features after importing deceptive features,we introduce a modified semantic *** autoencoder is designed to map all extracted features to a semantic space,thereby achieving a balance in the dominance of each feature *** combine our method with the feature extraction model ResNet50,and experimental results show that the trained ResNet50 model simultaneously achieves a feasible detection of unknown attacks and comparably accurate detection of known *** results confirm the superiority and effectiveness of our proposed method in identifying the living with the interference of both known

关键词： face anti-spoofing spoof detection zero-shot learning convolutional neural network deep learning