Mitochondrial Regulation of Macrophages in Innate Immunity and Diverse Roles of Macrophages During Cochlear Inflammation

作     者：Yuan Zhang Fanglei Ye Xiaolong Fu Shen Li Le Wang Yutian Chen Hongmin Li Shaojuan Hao Kun Zhao Qi Feng Peipei Li 

作者机构：Department of OtologyThe First Afliated Hospital of Zhengzhou UniversityZhengzhou 450052China Shandong Provincial HospitalShandong First Medical UniversityJinan 250000China Department of NeurologyThe First Afliated Hospital of Zhengzhou UniversityZhengzhou 450052China The Department of Endovascular SurgeryThe First Afliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Integrated Traditional and Western NephrologyThe First Afliated Hospital of Zhengzhou UniversityZhengzhou 450052China Henan Province Research Center of Kidney DiseaseZhengzhou 450052China 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2024年第40卷第2期

页      面：255-267页

核心收录：

学科分类：1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：supported by the China Postdoctoral Science Foundation(2022M712892) the Joint project Henan Province Medical Science and Technology Project(LHGJ20210297) 

主　　题：Macrophage Mitochondria Innate immunity Cochlea Infammation 

摘      要：Macrophages are essential components of the innate immune system and constitute a non-specific first line of host defense against pathogens and *** regulate macrophage activation and innate immune responses in various inflammatory diseases,including cochlear *** distribution,number,and morphological characteristics of cochlear macrophages change significantly across different inner ear regions under various pathological conditions,including noise exposure,ototoxicity,and age-related ***,the exact mechanism underlying the role of mitochondria in macrophages in auditory function remains ***,we summarize the major factors and mitochondrial signaling pathways(e.g.,metabolism,mitochondrial reactive oxygen species,mitochondrial DNA,and the inflammasome)that influence macrophage activation in the innate immune *** particular,we focus on the properties of cochlear macrophages,activated signaling pathways,and the secretion of inflammatory cytokines after acoustic *** hope this review will provide new perspectives and a basis for future research on cochlear inflammation.