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Comparative study of the extraction selectivity of PFO-BPy and PCz for small to large diameter single-walled carbon nanotubes

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Nano Research 2022年第9期15卷 8479-8485页

作者： Fang Liu Xingxing Chen Meiqi Xi Nan Wei lan bai Lianmao Peng Yu Cao Xuelei Liang Center for Carbon-Based Electronics Peking UniversityBeijing 100871China Key Laboratory for the Physics and Chemistry of Nanodevices School of ElectronicsPeking UniversityBeijing 100871China Shanxi Institute for Carbon-Based Thin Film Electronics Peking University(SICTFE-PKU)Taiyuan 030012China Taiyuan Laboratory for Carbon-Based Thin Film Electronics Taiyuan 030012China

Semiconducting single-walled carbon nanotubes(s-SWCNTs)are fascinating materials for future electronic and optical *** polymer wrapping is one of the most promising methods for mass production of high purity ***,its chiral selectivity is relatively inferior to other s-SWCNT production *** this paper,the chiral selectivity of two polymers,poly[(9,9-dioctylfluorenyl-2,7-diyl)-alt-co-(6,6′-{2,2′-bipyridine})](PFO-BPy)and poly[9-(1-octylonoyl)-9H-carbazole-2,7-diyl](PCz),which are representatives of widely used polyfluorene and polycarbazole families,respectively,were comparatively *** polymers exhibited high selectivity for a subset of existing chiral species in each of the commercially available raw SWCNT materials(CoMoCAT,HiPco,and arc-discharge)which cover a diameter range of 0.6–1.8 *** chiral species were selected by PFO-BPy from small diameter(1.2 nm)raw *** chiral purity(6,5)(>99%)and(7,5)(>75%)solutions were extracted by PFO-BPy and PCz from CoMoCAT materials,*** different chiral angle and diameter selections for different raw materials by both polymers were ascribed to their different geometrical structures and related polymer-tube *** work provides indispensable information for better understanding the mechanism of polymer wrapping method and improving extraction of single chirality sSWCNTs.

关键词： carbon nanotube polymer wrapping poly[(9 9-dioctylfluorenyl-2 7-diyl)-alt-co-(6 6′-{2 2′-bipyridine})](PFO-BPy) poly[9-(1-octylonoyl)-9H-carbazole-2 7-diyl](PCz) chiral selectivity

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Diverse and precision therapies open new horizons for patients with advanced pancreatic ductal adenocarcinoma

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Hepatobiliary & Pancreatic Diseases International 2022年第1期21卷 10-24页

作者： Ri-lan bai Nan-Ya Wang Ling-Ling Zhao Yong-Fei Zhang Jiu-Wei Cui Cancer Center the First Hospital of Jilin UniversityChangchun 130021China

Pancreatic ductal adenocarcinoma(PDAC)is a common cause of cancer-related death,and most patients are with advanced disease when *** present,despite a variety of treatments have been devel-oped for PDAC,few effective treatment options are available;on the other hand,PDAC shows significant resistance to chemoradiotherapy,targeted therapy,and immunotherapy due to its heterogeneous genetic profile,molecular signaling pathways,and complex tumor immune ***,over the past decades,there have been many new advances in the key theory and understanding of the in-trinsic mechanisms and complexity of molecular biology and molecular immunology in pancreatic can-cer,based on which more and more diverse new means and reasonable combination strategies for PDAC treatment have been developed and preliminary breakthroughs have been *** the continuous ex-ploration,from surgical local treatment to comprehensive medical management,the research-diagnosis-management system of pancreatic cancer is *** review focused on the variety of treatments for advanced PDAC,including traditional chemotherapy,targeted therapy,immunotherapy,microenviron-ment matrix regulation as well as the treatment targeting epigenetics,metabolism and cancer stem *** pointed out the current research bottlenecks and future exploration directions.

关键词： Tumor Pancreatic ductal adenocarcinoma Targeted therapy Immunotherapy Epigenetics Tumor microenvironment

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河北省应急物资储备库选址与管理研究

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物流科技 2024年第14期47卷 178-181页

作者：白兰刘爱秋熊凤山牛星辰河北农业大学经济管理学院河北保定071000 河北农业大学文管学院河北沧州061000

科学的应急物资储备库选址是影响应急物资配送时效和突发公共事件处理效率的关键因素。文章在分析河北省应急物资储备选址问题的基础上,构建集合覆盖模型,并利用启发式算法完成求解。根据模型求解结果,河北省应在保定和廊坊两地建立应... 详细信息

科学的应急物资储备库选址是影响应急物资配送时效和突发公共事件处理效率的关键因素。文章在分析河北省应急物资储备选址问题的基础上,构建集合覆盖模型,并利用启发式算法完成求解。根据模型求解结果,河北省应在保定和廊坊两地建立应急物资储备库,以便能够保证在应急事件发生后6小时内将应急物资运至省内各处。同时,进一步提出了河北省应急物资仓储管理对策,旨在应急灾害发生时能够全面保障河北省的应急物资管理需求。

关键词：应急物资储备库选址集合覆盖模型

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Recent research and development of DYRK1A inhibitors

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Chinese Chemical Letters 2022年第4期33卷 1841-1849页

作者： Liyun Zhao Xuan Xiong Li Liu Qi Liang Rongsheng Tong Xuanlin Feng lan bai Jianyou Shi Personalized Drug Therapy Key Laboratory of Sichuan Province Sichuan Academy of Medical Science&Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610072China College of Medicine Southwest Jiaotong UniversityChengdu 610031China Emergency Intensive Care Unit Personalized Drug Therapy Key Laboratory of Sichuan ProvinceSichuan Academy of Medical Science&Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengdu 610072China

Dual specificity tyrosine phosphorylation regulated kinase 1 A(DYRK1 A) is an evolutionarily conserved protein kinase belonging to the CMGC kinase family, which is closely related to Down syndrome(DS)and Alzheimer’s disease(AD). In recent years, not only the treatment of diabetes, but also the treatment of cancer gradually focuses on targeting DYRK1 A. Therefore, a series of DYRK1 A inhibitors have been developed to treat relevant diseases and clarify their treatment mechanism furtherly. DYRK1 A inhibitors are mainly divided into natural products and synthetic compounds. Among them, harmine is an excellent DYRK1 A inhibitor. Therefore, the synthetic DYRK1 A inhibitors are mainly based on harmine, which greatly enriches the structure and quantity of DYRK1 A inhibitors. The interaction between the inhibitors and the DYRK1 A protein has a guiding significance in predicting the activity of the inhibitors, and plays an irreplaceable role in the design of the compounds. This paper mainly reviews DYRK1 A inhibitors found in recent years and their structure-activity relationship, looking forward to providing a theoretical basis for the development of DYRK1 A inhibitors.

关键词： DYRK1A inhibitor Natural product Synthetic compound Alzheimer’s disease Down syndrome

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Free-moving-state microscopic imaging of cerebral oxygenation and hemodynamics with a photoacoustic fiberscope

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Light(Science & Applications) 2024年第1期13卷 33-46页

作者： Xiaoxuan Zhong Yizhi Liang Xiaoyu Wang Haoying lan Xue bai Long Jin bai-Ou Guan Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications Institute of Photonics TechnologyJinan UniversityGuangzhou510632China

We report the development of a head-mounted photoacoustic fiberscope for cerebral imaging in a freely behaving *** 4.5-gram imaging probe has a 9-µm lateral resolution and 0.2-Hz frame rate over a 1.2-mm wide *** probe can continuously monitor cerebral oxygenation and hemodynamic responses at single-vessel resolution,showing significantly different cerebrovascular responses to external stimuli under anesthesia and in the freely moving *** example,when subjected to high-concentration CO_(2) respiration,enhanced oxygenation to compensate for hypercapnia can be visualized due to cerebral regulation in the freely moving *** studies exhibit significantly weakened compensation capabilities in obese *** new imaging modality can be used for investigating both normal and pathological cerebrovascular functions and shows great promise for studying cerebral activity,disorders and their treatments.

关键词： cerebral anesthesia moving

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天然植物种子制备水处理材料探索型实验设计

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实验室科学 2024年第1期27卷 62-65页

作者：刘静刘麒麟杨璟白蓝王爱群四川大学化学学院四川成都610064

针对当前染料废水体量大、严重威胁人类健康和生态环境安全的现状,设计了以天然辣木籽为基体,制备过程绿色低碳且兼具吸附-降解双功能的复合材料,用于废水中染料的处理。实验应用于本科生探索型化学实验课程,通过文献调研、方案设计、... 详细信息

针对当前染料废水体量大、严重威胁人类健康和生态环境安全的现状,设计了以天然辣木籽为基体,制备过程绿色低碳且兼具吸附-降解双功能的复合材料,用于废水中染料的处理。实验应用于本科生探索型化学实验课程,通过文献调研、方案设计、实验操作、结果分析等一系列的实践环节,全面培养了学生的动手能力和科研素养,有助于培养兼具扎实知识基础和社会责任感的创新型人才。

关键词：辣木籽光降解水处理探索实验人才培养

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Recent Advances in Asymmetric Structural Composites for Excellent Electromagnetic Interference Shielding: A Review

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Chinese Journal of Polymer Science 2024年第6期42卷 693-710页

作者： Ying Zhou bai Xue lan Xie Chang-Mei Wu Qiang Zheng Department of Polymer Materials and Engineering College of Materials and Metallurgy Guizhou University National Engineering Research Center for Compounding and Modification of Polymer Materials National and Local Joint Engineering Research Center for Functional Polymer Membrane Materials and Membrane Processes State Key Laboratory of Public Big Data Guizhou University Department of Polymer Science and Engineering Zhejiang University

Since electromagnetic pollution is detrimental to human health and the environment, numerous efforts have been successively made to achieve excellent electromagnetic interference shielding effectiveness(EMI SE) via designing the hierarchical structures for electromagnetic interference(EMI) shielding polymer composites. Among the plentiful structures, the asymmetric structures are currently a hot spot, principally categorizing into multi-layered, porous, fibrous, and segregated asymmetric structures, which endows the high EMI shielding performance for polymer composites incorporated with magnetic, conductive, and/or dielectric micro/nano-fillers, due to the “absorption-reflection-reabsorption” shielding mechanism. Therefore, this review provides the retrospection and summary of the efforts with respect to abundant asymmetric structures and multifunctional micro/nano-fillers for enhancing EMI shielding properties, which is conducive to the booming development of polymeric EMI shielding materials for the promising prospect in modern electronics and 5-generation(5G) technology.

关键词： Asymmetric structure Microano functional filler Polymer composite Electromagnetic interference shielding

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Role of miRNA-27a in Regulating the Immune Function of Pulmonary Tuberculosis Rat Model

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Chinese Journal of Biomedical Engineering(English Edition) 2022年第3期31卷 112-119,138页

作者： XU bai-lan Department of Respiratory and Critical Care Medicine the First Hospital of QuanzhouQuanzhou Fujian 362000China

Objective:To analyze the role of mi RNA-27a in regulating the immune function of the pulmonary tuberculosis rat ***:40 healthy female rats were divided into 4 groups:healthy control group,model group,silence group,and overexpression group,with 10 rats in each *** control group was not treated,and the other three groups of rats were injected with 200μL of Mycobacterium bacilli suspension through the tail vein to establish a rat model of pulmonary tuberculosis,in which the model group was not treated,and the silence group was injected with 10μL of mi RNA-27 inhibition vector lentiviral suspension,and the overexpression group was injected with 10μL of mi RNA-27 expression vector lentiviral *** expression level of mi RNA-27a,peripheral blood T lymphocyte subsets,thymus index,inflammatory index,and TLR4/NF-κB signal pathway-related protein level in the four groups of rats were compared and ***:Compared with the healthy control group,the expression levels of the silence group and model group were significantly decreased,while the expression level of the overexpression group was significantly increased;Compared with the model group and addiction group,the expression level of the overexpression group was significantly increased,with significant differences(P<0.05).Compared with the healthy control group,CD3+,CD4+,CD4+/CD8+,thymus index,IL-10,and IκB in the model group,silence group,and overexpression group were significantly higher than those in the control group;The levels of CD3+,CD4+,CD4+/CD8+,thymus index,IL-10,IκB decreased significantly,with significant differences(P<0.05);Compared with the overexpression group,CD8+,IL-6,TNF-α,TLR4,NF-κBp65,and p-IκB levels were significantly lower;The levels of CD3+,CD4+,CD4+/CD8+,thymic index,IL-10,and IκB levels were significantly increased,with significant differences(P<0.05).Compared with the silence group,the levels of CD3+,CD4+,CD4+/CD8+,thymic index,IL-10,and IκB were significantly incre

关键词： miRNA-27a pulmonary tuberculosis rats immune function

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转基因抗除草剂大豆ZH10-6转化体特异性定量检测体系的建立

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上海农业学报 2024年第3期40卷 1-7页

作者：白蓝贾军伟陈一帆章寅潘爱虎吴潇上海市农业科学院生物技术研究所上海201106 上海市农业遗传育种重点实验室农业农村部农作物生态环境安全检验测试中心(上海)上海201106 上海市农业生物安全评价与检测专业技术服务平台上海201106 上海市农业科学院畜牧兽医研究所上海201106 农业农村部农业转基因生物安全评价(环境)重点实验室上海201106

以新型转基因抗除草剂大豆ZH10-6外源插入片段的旁侧序列为靶标,建立了转化体特异性实时荧光PCR和单通道微滴式数字PCR精准定量检测体系,并邀请8家农业农村部检测中心对检测方法的准确性进行验证。结果表明:该转化体特异性实时荧光定量... 详细信息

以新型转基因抗除草剂大豆ZH10-6外源插入片段的旁侧序列为靶标,建立了转化体特异性实时荧光PCR和单通道微滴式数字PCR精准定量检测体系,并邀请8家农业农村部检测中心对检测方法的准确性进行验证。结果表明:该转化体特异性实时荧光定量检测方法具有良好的特异性、重复性及广泛的适用性,定量极限达到50 copies∕μL,检测极限达到5 copies∕μL。该检测方法有望作为检测标准用于转基因抗除草剂大豆ZH10-6的定量检测,为该大豆品系的商业化应用及转基因标识等监管提供技术支撑。

关键词：抗除草剂大豆ZH10-6 转化体特异性定量检测实时荧光PCR 微滴式数字PCR

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公民器官捐献供体质量对肝移植术后受体生存率的影响

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实用器官移植电子杂志 2024年第2期12卷 104-108页

作者：张莉莉于涛田彦冯丽彦周彪杨晓静白兰解放军总医院第三医学中心器官移植管理科北京100039 北京大学人民医院医务处北京100039

目的探讨心脏死亡器官捐献(donation after cardiac death,DCD)供体质量对肝移植术后受体生存率的影响。方法回顾性分析2018年1月至2021年1月解放军总医院第三医学中心DCD肝移植手术患者100例,移植术后进行为期1年的随访调查,观察肝移... 详细信息

目的探讨心脏死亡器官捐献(donation after cardiac death,DCD)供体质量对肝移植术后受体生存率的影响。方法回顾性分析2018年1月至2021年1月解放军总医院第三医学中心DCD肝移植手术患者100例,移植术后进行为期1年的随访调查,观察肝移植受者的生存状态,对相关危险因素加以分析。结果100例肝移植受者术后1年病死率为3%(3/100),其死亡因素与供体冷缺血时间、供体脂肪肝、术中出血量、供体白蛋白及总胆红素水平、肝细胞水肿密切相关(P<0.05)。多因素Logistic回归分析发现,供体冷缺血时间≥840 min、脂肪肝是影响肝移植受者生存状态的独立危险因素(P<0.05)。肝移植术后感染率为26%(26/100),其肝移植术后感染率与受体肝功能Child-Pugh评分、术前血红蛋白水平、血小板计数、术中输血量、术后重症监护病房(intensive care unit,ICU)留观时间密切相关(P<0.05)。结论DCD供体质量对肝移植术后受体生存率具有显著影响,供体冷缺血时间、供体脂肪肝对肝移植术后受体生存状态具有重要影响。

关键词：心脏死亡器官捐献供肝供体质量肝移植受体生存率术后感染

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