Free-moving-state microscopic imaging of cerebral oxygenation and hemodynamics with a photoacoustic fiberscope
作者机构：Guangdong Provincial Key Laboratory of Optical Fiber Sensing and CommunicationsInstitute of Photonics TechnologyJinan UniversityGuangzhou510632China
出 版 物：《Light(Science & Applications)》 (光（科学与应用)（英文版）)
年 卷 期：2024年第13卷第1期
页 面：33-46页
核心收录：
学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程] 0702[理学-物理学]
基 金：support from the National Natural Science Foundation of China(62275104 and 62322506) L.J.acknowledges the financial support from the National Natural Science Foundation of China(62122031) B.-O.G.acknowledges the financial support from the National Natural Science Foundation of China(62135006 and 61860206002) the Local Innovative and Research Teams Project of Guangdong Pearl River Talents Program(2019BT02X105)
主 题：cerebral anesthesia moving
摘 要：We report the development of a head-mounted photoacoustic fiberscope for cerebral imaging in a freely behaving *** 4.5-gram imaging probe has a 9-µm lateral resolution and 0.2-Hz frame rate over a 1.2-mm wide *** probe can continuously monitor cerebral oxygenation and hemodynamic responses at single-vessel resolution,showing significantly different cerebrovascular responses to external stimuli under anesthesia and in the freely moving *** example,when subjected to high-concentration CO_(2) respiration,enhanced oxygenation to compensate for hypercapnia can be visualized due to cerebral regulation in the freely moving *** studies exhibit significantly weakened compensation capabilities in obese *** new imaging modality can be used for investigating both normal and pathological cerebrovascular functions and shows great promise for studying cerebral activity,disorders and their treatments.
维普期刊数据库