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Assessing myocardial indices and inflammatory factors to determine anxiety and depression severity in patients with chronic heart failure

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World Journal of Psychiatry 2024年第1期14卷 53-62页

作者： li Zhang Qiang Wang Hong-sheng Cui Yuan-Yuan luo Department of Cardiology Jingzhou HospitalYangtze UniversityJingzhou 434020Hubei ProvinceChina Department of Intensive Care Unit The First Affiliated Hospital of Guangzhou University of Chinese MedicineGuangzhou 510000Guangdong ProvinceChina

BACKGROUnD Patients with chronic heart failure(CHF)have a progressive disease that is associated with poor quality of life and high *** patients experience anxiety and depression(A&D)symptoms,which can further accelerate disease *** hypothesized that indicators of myocardial function and inflammatory stress may reflect the severity of A&D symptoms in patients with *** in these biomarkers could potentially predict whether A&D symptoms will deteriorate further in these *** To measure changes in cardiac and inflammatory markers in patients with CHF to determine A&D severity and predict *** We retrospectively analyzed 233 patients with CHF treated at the Jingzhou Hospital,Yangtze University between 2018-2022 and grouped them according to Self-Rating Anxiety Scale(SAS)and Self-Rating Depression Scale(SDS)*** compared cl.nical data in the no-A&D,mild-A&D,moderate-A&D,and severe-A&D groups,the SAS and SDS scores with the new York Heart Association(nYHA)functional classification,and cardiac markers and inflammatory factors between the no/mild-A&D and moderate/severe-A&D *** analysis was performed on the markers with Pne their ability to predict A&D severity in patients and the area under the receiver operating characteristic curve(AUROC)was used to evaluate their *** In the inter-group comparison,the following variables had an effect on A&D severity in patients with CHF:nYHA class,left ventricular ejection fraction(lVEF),left ventricular end-diastolic diameter,n-terminal pro-brain natriuretic peptide(nT-proBnP),interleukin-6(Il-6),and tumor necrosis factor-alpha(Ples did not differ significantly between the A&D groups(P>0.05).In addition,we found that higher nYHA classes were associated with higher the SAS and SDS scores(Pn analysis showed that lVEF,nTproBnP,and Il-6 were independent risk factors for A&D severity(Png them,nT-pr

关键词： Chronic heart failure Anxiety Depression Cardiac markers Inflammatory factors Prediction

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Electroacupuncture improves myocardial fibrosis in heart failure rats by attenuating ECM collagen deposition through modulation of TGF-β1/Smads signal.ng pathway

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Traditional Medicine Research 2024年第8期9卷 1-10页

作者： Wen-Hui Wang Qian-l.n Zeng Jiao-Jiao Zhang Hao-sheng Wu sheng-Bing Wu Mei-Qi Zhou College of Acupuncture and Massage Anhui University of Chinese MedicineHefei 230038China Anhui Province Key laboratory of Meridian Viscera Correlationship Anhui University of Chinese MedicineHefei 230038China

Background: To explore the effects of electroacupuncture on cardiac function and myocardial fibrosis in rat models of heart failure, and to elucidate the underlying mechanism of electroacupuncture in heart failure treatment. Methods: Healthy male Sprague-Dawley rats were allocated into three groups: Sham group, Model group, and electroacupuncture (Model + EA) group, with each group comprising 8 rats. The model underwent a procedure involving the ligation of the left anterior descending coronary artery to induce a model of heart failure. The Model + EA group was used for 7 consecutive days for electroacupuncture of bilateral Shenmen (HT7) and Tongli (HT5), once a day for 30 min each time. left ventricular parameters in rats were assessed using a small-animal ultrasound machine to analyze changes in left ventricular end-diastolic volume, left ventricular end-systolic volume, left ventricular ejection fraction, and left ventricular fractional shortening. Serum interleukin-1β (Il-1β), cardiac troponin (cTn), and n-terminal brain natriuretic peptide precursor levels were measured using ElISA. Histopathological changes in rat myocardium were observed through HE staining, while collagen deposition in rat myocardial tissue was assessed using the Masson staining method. Picro sirius red staining, immunohistochemical staining, and RT-qPCR were utilized to distinguish between the various types of collagen deposition. The expression level of TGF-β1 and SMAD2/3/4/7 mRnA in rat myocardial tissues was determined using RT-qPCR. Additionally, western blot analysis was conducted to assess the protein expression levels of TGF-β1, SMAD3/7, and p-SMAD3 in rat myocardial tissues. Results: Compared with the Sham group, the left ventricular ejection fraction and left ventricular fractional shortening values of the Model group were significantly decreased (P left ventricular end-diastolic volume and left ventricular end-systolic volume values were remarkably increased (P < 0.01)

关键词： heart failure electroacupuncture heart meridian of Hand-Shaoyin collagen deposition TGF-β1/Smads signal.ng pathway myocardial fibrosis

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Enhancing photoresponsiveness of metal-organic polyhedra by modifying microenvironment

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nano Research 2024年第6期17卷 5712-5717页

作者： l.ng Zheng Peng Tan Qian Song sheng-Tao Wang Min li Xiao-Qin liu l.n-Bing Sun State Key laboratory of Materials-Oriented Chemical Engineering Jiangsu National Synergetic Innovation Center for Advanced Materials(SICAM)College of Chemical EngineeringNanjing Tech UniversityNanjing 211816China

Photoresponsiveness of materials is critical to their tunability and efficiency in terminal *** metal-organic polyhedra(PMOPs)feature intrinsic pores and remote controllability,but aggregation of PMOPs in solid state hampers their photoresponsiveness ***,we report the construction of a new PMOP(Cu_(24)(C_(16)H_(12)n_(2)O_(4))_(12)(C_(18)H_(22)O_(5))12,denoted as MOP-PR-lA),where l.ng alkyl(lA)chains act as the intermolecular poles,propping against adjacent PMOP molecules to create individual microenvironment benefiting the isomerization of photoresponsive(PR)*** ultraviolet(UV)-and visible-light irradiation,MOP-PR-lA is much easier to isomerize than the counterpart MOP-PR without *** propyl.ne adsorption,MOP-PR has a low change of adsorption capacity(9.9%),while that of MOP-PR-lA reaches 58.6%.Density functional theory calculations revealed that PR in the cis state has a negative effect on adsorption,while the trans state of PR favors *** work might open an avenue for the construction of photoresponsive materials with high responsiveness and controllability.

关键词： photoresponsive adsorption metal-organic polyhedra azobenzene l.ng alkyl chains propyl.ne capture

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Dynamic Analysis of A Deepwater Drill.ng Riser with A new Hang-off System

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China Ocean Engineering 2024年第1期38卷 29-41页

作者： lI Yan-wei lIU Xiu-quan WAnG Jin-l.ng CHEn Guo-ming CHAnG Yuan-jiang sheng lei-xiang Centre for Offshore Engineering and Safety Technology China University of PetroleumQingdao 266580China national Engineering laboratory of Offshore Geophysical and Exploration Equipment China University of PetroleumQingdao 266580China China CnOOC Research Institute Co. Ltd.Beijing 100028China

The safety of risers in hang-off states is a vital chall.nge in offshore oil and gas engineering.A new hang-off system installed on top of risers is proposed for improving the security of *** approach leads to a chall.nging problem:coupl.ng the dynamics of risers with a new hang-off system combined with multiple structures and complex *** accurately analyze the dynamic responses of the coupled system,a coupled dynamic model is established based on the Euler-Bernoulli beam-column theory and penalty function method.A comprehensive analysis method is proposed for coupled dynamic analysis by combining the finite element method and the newmarkβ*** analysis program is also developed in MATlAB for dynamic *** simulation results show that the dynamic performances of the risers at the top part are significantly improved by the new hang-off system,especially the novel design,which includes the centralizer and articulation *** bending moment and lateral deformation of the risers at the top part decrease,while the hang-off joint experiences a great bending moment at the bottom of the lateral restraint area which requires particular attention in design and *** platform navigation speed range under the safety limits of risers expands with the new hang-off system in use.

关键词： deepwater drill.ng riser new hang-off system dynamic analysis finite element method penalty function method

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Ti_(3)C_(2)T_(x)/SnO_(2)P–n heterostructure construction boosts room-temperature detecting formaldehyde

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Rare Metals 2024年第1期43卷 267-279页

作者： Yue Zhang Ming-Yue Wang Xiao-Guang San Yan-Bai Shen Guo-sheng Wang lei Zhang Dan Meng College of Chemical Engineering Shenyang University of Chemical TechnologyShenyang 110142China Institute for Superconducting and Electronic Materials(ISEM) Australian Institute for Innovative Materials(AIIM)University ofWollongongWollongongNSW2500Australia College of Resources and Civil Engineering Northeastern UniversityShenyang 110819China

Formaldehyde is a common atmospheric pollutant produced in industrial production and daily ***,the traditional semiconductor formaldehyde gas sensor cannot work at room temperature,which limits its practical ***,developing high-performance gas sensors for rapidly and accurately detecting formaldehyde at room temperature is an important *** this study,Ti_(3)C_(2)Tx/SnO_(2)heterostructures were constructed,which could selectively detect formaldehyde at room temperature with a response value of 29.16%(10×10^(-6)).In addition,the sensor shows a remarkable theoretical detection limit of 5.09×10^(-9)and good l.ngterm *** functional theory(DFT)simulations reveal that SnO_(2)nano spheres provide the majority of adsorption sites that strongly interact with ***,Ti_(3)C_(2)T_(x)acting as a conductive layer facilitates the transfer of charge carriers so that they show a sensing response to formaldehyde at room ***,the formation of p-n heterostructures between SnO_(2)and Ti_(3)C_(2)T_(x)boosts the Schottky barrier at the interface,which is the critical factor in enhancing the sensing properties by turning the Schottky barrier upon introducing formaldehyde *** perspective is expected to provide instructive guidance for utilizing MXene/metal oxide nanocomposites to improve the gas sensing performance at room temperature.

关键词： Ti_(3)C_(2)T_(x)/SnO_(2)nanocomposites p-n heterostructures Formaldehyde sensing Room temperature DFT calculations

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Degradation behaviors of nabumetone and its metabolite during UV/monochloramine process:Experimental and theoretical study

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Journal of Environmental Sciences 2024年第8期142卷 103-114页

作者： Xiang Tu Yunsong Bai Qing Fu sheng Chang Kunfeng Zhang Yang Pan Ruiyang Xiao Yifu Fu Qi Zhang State Key laboratory of Environmental Criteria and Risk Assessment State Environmental Protection Key Laboratory of Drinking Water Source ProtectionResearch Centre of Lake EnvironmentNational Engineering Laboratory for Lake Pollution Control and Ecological RestorationChinese Research Academy of Environmental SciencesBeijing 100012China School of Environmental Science and Engineering Suzhou University of Science and TechnologySuzhou 215009China Institute of Environmental Engineering School of Metallurgy and EnvironmentCentral South UniversityChangsha 410083China School of Forestry Northeast Forestry UniversityHarbin 150040China

This study investigated degradation behaviors of a nonsteroidal anti-inflammatory drug nabumetone(nMT)and its major metabolite 6-methoxy-2-naphthylacetic acid(MnA)in the coupl.ng process of ultraviolet and monochloramine(UV/nH2Cl).The second-order rate constants of the contaminants reacting with reactive radicals(HO·,Cl·,Cl_(2)·-,and CO_(3)·^(-))were determined by laser flash photolysis ***·and Cl·contributed predominantly with 52.3%and 21.7%for nMT degradation and 60.8%and 22.3%for MnA *** presence of chlorides retarded the degradation of nMT,while promoted the destruction of MnA,which was ascribed to the photosensitization effects of MnA under UV *** functional theory(DFT)calculations revealed that radical adduct formation(RAF)was dominant pathway for both HO·and Cl·reacting with the contaminants,and hydrogen atom transfer(HAT)preferred to occur on side chains of nMT and *** reacted with nO_(2)·through single electron transfer(SET)with the second-order rate constant calculated to be 5.35×10^(7)(mol/l)^(-1)sec^(-1),and the contribution of nO_(2)·was predicted to be 13.0%of the total rate constant of nMT in pure water,which indicated that nO_(2)·played a nonnegligible role in the degradation of *** acute toxicity and developmental toxicity of nMT were enhanced after UV/nH_(2)Cl treatment,while those of MnA were *** transformation products of both nMT and MnA exhibited higher mutagenicity than their parent *** study provides a deep understanding of the mechanism of radical degradation of nMT and MnA in the treatment of UV/nH2Cl.

关键词： UV/nH_(2)Cl Reactive species Degradation kinetics Reaction mechanism Degradation products

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Phase composition,conductivity,and sensor properties of cerium-doped indium oxide

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nano Materials Science 2024年第2期6卷 193-200页

作者： M.I.Ikim G.n.Gerasimov V.F.Gromov O.J.Ilegbusi l.I.Trakhtenberg n.n.Semenov Federal Research Center for Chemical Physics of RAS MoscowRussia University of Central Florida OrlandoFLUSA Moscow Institute of Physics and Technology(State University) DolgoprudnyMoscow RegionRussia lomonosov Moscow State University MoscowRussia

The hydrothermal synthesis of In_(2)O_(3)and CeO_(2)–In_(2)O_(3)is investigated as well as the properties of sensor layers based on these *** the synthesis of In_(2)O_(3),intermediate products In(OH)_(3)and InOOH are formed,which are the precursors of stable cubic(c-In_(2)O_(3))and metastable rhombohedral(rh-In_(2)O_(3))phases,respectively.A transition from c-In_(2)O_(3)to rh-In_(2)O_(3)is observed with the addition of CeO_(2).The introduction of cerium into rh-In_(2)O_(3)results in a decrease in the sensor response to hydrogen,while it increases in composites based on c-In_(2)O_(3).The data on the sensor activity of the composites correlate with XPS results in which CeO_(2)causes a decrease in the concentrations of chemisorbed oxygen and oxygen vacancies in rh-In_(2)O_(3).The reverse situation is observed in composites based on c-In_(2)O_(3).Compared to In_(2)O_(3)and CeO_(2)–In_(2)O_(3)obtained by other methods,the synthesized composites demonstrate maximum response to H_(2)at low temperatures by 70–100℃,and have short response time(0.2–0.5 s),short recovery time(6–7 s),and l.ng-term stability.A model is proposed for the dependence of sensitivity on the direction of electron transfer between In_(2)O_(3)and CeO_(2).

关键词： Cerium oxide Indium oxide nanocomposite Hydrothermal method Cubic phase Rhombohedral phase Sensor response Conductivity Hydrogen Response/recovery time

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Exploring dielectric phenomena in sulflower-like nanostructures via Monte Carlo technique

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Communications in Theoretical Physics 2024年第4期76卷 188-198页

作者： n Saber Z Fadil Hussein Sabbah A Mhirech B Kabouchi l Bahmad Chaitany Jayprakash Raorane Siva Sankar Sana Hassan Fouad Mohamed Hashem laboratory of Condensed Matter and Interdiscipl.nary Sciences(laMCScI) Research Unit Labelled CNRSTURL-CNRST-17.Faculty of SciencesPO Box 1014Mohammed Ⅴ University in RabatMorocco College of Engineering and Technology American University of the Middle EastEgaila 54200Kuwait School of Chemical Engineering Yeungnam UniversityGyeongsan38541Republic of Korea Applied Medical Science Department Community CollegeKing Saud UniversityPO Box 11433Riyadh Saudi Arabia Department of Dental Health College of Applied Medical SciencesKing Saud UniversityPO Box 12372RiyadhSaudi Arabia

This research focuses on the electric behavior of a mixed ferrielectric sulflower-like *** structure includes a core with spin S_(i)^(Z)-1 atoms and a shell with spin σ_(j)^(Z)-5/2 *** Blume–Capel model and the Monte Carlo technique(MCt)with the Metropolis algorithm are *** are established for absolute zero,investigating stable spin configurations correlated with various physical *** MCt method explores phase transition behavior and electric hysteresis cycles under different physical parameters.

关键词： sulfower-like nanostructure dielectric characteristics Monte Carlo technique phase transition phase diagrams electric hysteresis

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ligation-assisted endoscopic submucosal resection following unroofing technique for small esophageal subepithelial lesions originating from the muscularis propria

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World Journal of Gastroenterology 2024年第32期30卷 3748-3754页

作者： Quan lu Quan-Zhou Peng Jun Yao li-sheng Wang De-Feng li Department of Gastroenterology Shenzhen People’s HospitalShenzhen 518020Guangdong ProvinceChina Department of Pathology Shenzhen People’s HospitalShenzhen 518020Guangdong ProvinceChina Department of Gastroenterology Shenzhen People’s HospitalThe Second Clinical Medical CollegeJinan UniversityShenzhen 518020Guangdong ProvinceChina The First Affiliated Hospital Southern University of Science and TechnologyShenzhen 518020Guangdong ProvinceChina

BACKGROUnD The majority of esophageal subepithelial lesions originating from the muscularis propria(SEl-MPs)are benign in nature,although a subset may exhibit malignant *** endoscopic resection techniques are time-consuming and lack efficacy for small *** To evaluate the efficacy and safety of ligation-assisted endoscopic submucosal resection(ESMR-l)following unroofing technique for small esophageal *** From January 2021 to September 2023,17 patients diagnosed with esophageal SEl-MPs underwent ESMR-l following unroofing technique at the endoscopy center of Shenzhen People’s *** of cl.nicopathological characteristics and cl.nical outcomes were collected and *** The mean age of the patients was 50.12±12.65 *** mean size of the tumors was 7.47±2.83 mm and all cases achieved en bloc resection *** average operation time was 12.2 minutes without any *** identified 2 lesions(11.8%)as gastrointestinal stromal tumors at very low risk,12 lesions(70.6%)as leiomyoma and 3 lesions(17.6%)as smooth muscle *** recurrence was found during the mean follow-up duration of 14.18±9.62 *** ESMR-l following roofing technique is an effective and safe technique for management of esophageal SEl-MPs smaller than 20 mm,but it cannot ensure en bloc resection and may require further treatment.

关键词： Subepithelial lesions Muscularis propria Esophagus ligation Endoscopic submucosal resection

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High temperature treatment induced production of unreduced 2n poll.n in Camellia oleifera

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Horticultural Pl.nt Journal 2024年第3期10卷 879-896页

作者： Hongda Deng Xiaoyu Zhang Song sheng Yuxun Huang Ziqi Ye Tongyue Zhang Xing liu Zhiqiang Han The laboratory of Forestry Genetics Central South University of Forestry and TechnologyChangshaHunan 410004China Yuelushan laboratory ChangshaHunan 410128China Key laboratory of Cultivation and Protection for non-Wood Forest Trees of Ministry of Education Central South University of Forestry and TechnologyChangshaHunan 410004China national Forest and Seedl.ng Workstation of Hunan Province The Forestry Department of Hunan ProvinceChangshaHunan 410004China

Unreduced gametes through chromosome doubl.ng play a major role in the process of pl.nt *** previous work confirmed that Camellia oleifera can produce natural 2n poll.n,and it is possible to induce the 2n poll.n formation by high temperature *** study focused on the optimization of the 2n poll.n induction technique and the mechanisms of high temperature-induced2n poll.n formation in *** found that the optimal protocol for inducing 2n poll.n via high temperature was to perform 45℃with4 h at the prophaseⅠstage of the poll.n mother cells(PMCs).Meanwhile,high temperature significantly decreased the yield and fertility of2n *** the observation of meiosis,abnormal chromosome and cytological behaviour was discovered under high-temperature treatment,and we confirmed that the formation of 2n poll.n is caused by abnormal cell *** on weighted gene co-expression network analysis,fifteen hub genes related to cell cycle control were *** male flower buds were exposed to heat shock,polygalacturonase gene(CoPGX3)was significantly *** inferred that high temperature causes the CoPGX3 gene to be overexpressed and that CoPGX3 is redistributed into the cytosol where it degrades cytoplasmic pectin,which leads to an abnormal cell ***,abnormal cytokinesis resulted in the formation of dyads and triads,and PMCs divided to produce 2n *** findings provide new insights into the mechanism of 2n poll.n induced by high temperature in a woody pl.nt and lay a foundation for further ploidy breeding of ***.

关键词： Camellia oleifera Poll.n mother cells(PMCs) High temperature Meiosis 2n poll.n CoPGX3

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