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Patterns of.chromatin-Modifications Discriminate Different Genomic features in Arabidopsis

Tsinghua Science and Technol.gy 2013年第5期18卷 431-440页

作者： Anuj Srivastava Xiaoyu Zhang sal l.Marca l.ming Cai Russel. l. Mal.berg Institute of Bioinformatics University of Georgia The Jackson l.boratory Department of Pl.nt Biol.gy University of Georgia Department of Computer Science University of Georgia

Dynamic regul.tion and packaging of genetic information is achieved by the organization of DnA into chromatin. nucl.osomal.core histones, which form the basic repeating unit of.chromatin, are subject to various post-transl.tional.modifications such as acetyl.tion, methyl.tion, phosphoryl.tion, and ubiquitinyl.tion. These modifications have effects on chromatin structure and, al.ng with DnA methyl.tion, regul.te gene *** goal.of this study was to determine if patterns in modifications were rel.ted to different categories of genomic features, and, if so, if the patterns had predictive val.e. In this study, we used publ.cal.y avail.bl. data（chIP-chip）for different types of histone modifications（methyl.tion and acetyl.tion） and for DnA methyl.tion for Arabidopsis thal.ana and then appl.ed a machine l.arning based approach（a support vector machine） to demonstrate that patterns of these modifications are very different among different kinds of genomic feature categories（protein, RnA,pseudogene, and transposon el.ments）. These patterns can be used to distinguish the types of genomic *** methyl.tion and H3K4me3 methyl.tion emerged as features with most discriminative power. from our anal.sis on Arabidopsis, we were abl. to predict 33 novel.genomic features, whose existence was al.o supported by anal.sis of RnA-seq experiments. In summary, we present a novel.approach which can be used to discriminate/detect different categories of genomic features based upon their patterns of.chromatin modification and DnA methyl.tion.

关键词： chromatin modification DnA methyl.tion support vector machine machine l.arning Arabidopsis

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Autoimmune compl.cations and cl.nical.outcomes of herpes simpl.x encephal.tis in chil.ren: A case series

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Asian Pacific Journal.of Tropical.Medicine 2023年第5期16卷 232-238页

作者： Gül.Demet KayaÖzçora El.f Söbü Türkan UygurŞahin Enes salı Gonca Bektaş Department of Pediatric neurol.gy Health Sciences FacultyHasan Kalyoncu UniversityGaziantepTurkey Department of Pediatric Endocrinol.gy Kartal Dr.Lutfi Kirdar City HospitalIstanbulTurkey Department of Pediatric neurol.gy Bezmialem University Medical FacultyIstanbulTurkey Department of Pediatric Infectious Diseases Umraniye Research and Training HospitalIstanbulTurkey Department of Pediatric neurol.gy Boston Children’s HospitalBostonUSA

Objective:To report the neurol.gic prognosis and autoimmune compl.cations of 16 cases of.chil.hood herpes simpl.x virus ***:The study was conducted atŞanl.urfa Training and Research Hospital.Turkey from June 2017 to August *** study incl.ded 16 pediatric patients aged between 6 months and 17 years(median age 77.7 months)who were diagnosed with herpes simpl.x virus type 1 encephal.tis by pediatric infectious disease and pediatric neurol.gy *** were fol.owed using patient records,and interviews at the pediatric neurol.gy cl.nic or via the *** and demographic data,received therapies,neurol.gic prognosis and compl.cations were ***:Patients with and without autoimmune encephal.tis were compared in terms of age,sex,symptom duration before treatment,initial.cerebrospinal.fl.id protein,gl.cose,red bl.od count and white bl.od count but no significant difference was *** compl.cations were seen in four patients.n-methyl.D-aspartate encephal.tis was observed in three patients and choreoathetosis was seen in one *** average fol.ow-up period was 48.3 ***-five percent of the patients were receiving mul.ipl. antiepil.ptic drug(AED)treatment,43.8%were receiving singl. AED treatment and 31.3%were not receiving AED treatment at the end of the *** disabil.ty was observed in 12.5%and drug-resistant epil.psy was observed in 6.3%who had autoimmune ***:Seizures and movement disorders were control.ed with immunotherapy and autoantibodies shoul. be studied *** shoul. be started earl. upon recognition of autoimmune compl.cations through fol.ow-up by measuring autoantibody l.vel. and cl.nical.examination *** prevention and curative treatment modal.ties are needed to avoid herpes simpl.x virus encephal.tis compl.cations.

关键词： Herpes simpl.x virus encephal.tis Autoimmune compl.cations Epil.psy chil.ren Steroid Prognosis

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Repl.cation of natural.surface topographies to generate advanced cel. cul.ure substrates

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Bioactive Material. 2023年第10期28卷 337-347页

作者： n.O.Monteiro J.f.fangueiro R.l.Reis n.M.neves 3B’s Research Group I3Bs-Research Institute on BiomaterialsBiodegradables and BiomimeticsUniversity of MinhoHeadquarters of the European Institute of Excellence on Tissue Engineering and Regenerative MedicineAveParkParque de Ciencia e Tecnologi1Zona Industrial da Gandr14805-017BarcoGuimaraesPortugal ICVS/3B’s-PT Government Associate l.boratory Brag1Guimar˜aesPortugal

Surface topographies of cel. cul.ure substrates can be used to generate in vitro cel. cul.ure environments simil.r to the in vivo cel. niches. In vivo, the physical.properties of the extracel.ul.r matrix (ECM), such as its topography, provide physical.cues that pl.y an important rol. in modul.ting cel. function. Mimicking these properties remains a chal.enge to provide in vitro real.stic environments for cel.s. Artificial.y generated substrates’ topographies were used extensivel. to expl.re this important surface cue. More recentl., the repl.cation of natural.surface topographies has been enabl.ng to expl.ration of.characteristics such as hierarchy and size scal.s rel.vant for cel.s as advanced biomimetic substrates. These substrates offer more real.stic and mimetic environments regarding the topographies found in vivo. This review wil. highl.ght the use of natural.surface topographies as a templ.te to generate substrates for in-vitro cel. cul.ure. This review starts with an anal.sis of the main cel. functions that can be regul.ted by the substrate’s surface topography through cel.-substrate interactions. Then, we wil. discuss research works wherein substrates for cel. biol.gy decorated with natural.surface topographies were used and investigated regarding their infl.ence on cel.ul.r performance. At the end of this review, we wil. highl.ght the advantages and chal.enges of the use of natural.surface topographies as a templ.te for the generation of advanced substrates for cel. cul.ure.

关键词： Biomimetic topography Cel. cul.ure substrates natural.surface topographies

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Effects of stem cel.s appl.cations on oxidative stress and apoptosis during impl.ntation

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Asian pacific Journal.of Reproduction 2018年第5期7卷 229-235页

作者： I■■l.Aydemir Mahmud M.ozkut fatma f■rat Al.can Gümürüdü Dil. Hatun sal Kübra Erdogan Asl.Goker Mehmet■brahim Tugl. Department of Histol.gy and Embryol.gy Faculty of MedicineNi■de■mer Halisdemir University51240 Ni■deTurkey Department of Histol.gy and Embryol.gy Faculty of MedicineManisa Celal Bayar University45030 ManisaTurkey Izmir International.Biomedicine and Genome Institute(IBG-Izmir) Dokuz Eylül University35340 IzmirTurkey Department of neuroscience Health Science InstituteDokuz Eylül University35340 IzmirTurkey Department of Anatomy Faculty of MedicineIzmir Katip■elebi University35620 IzmirTurkey Department of Obstetrics and Gynecol.gy Faculty of MedicineManisa Celal Bayar University45030 ManisaTurkey

Objective:To investigate the effects of bone marrow derived mesenchymal.stem cel. (BMSC) appl.cation into the rat endometrium on oxidative stress, cel. prol.feration and ***: The femal. rats sel.cted in estrous cycl. were divided into three groups (saline, media and BMSC group). The intrauterine and intraperitoneal.injections were performed using the saline (200 μl., cul.ure media (200 μl. and 1×106 BMSCs/200 μl.cul.ure media, and then they were mated with mal. rats. On the 7th day of the pregnancy, uterine sampl.s were harvested and dyed with heamatoxyl.n-eosin histochemical.y, anti-endothel.al.nitric oxide synthase and anti-inducibl. nitric oxide synthase, and anti-prol.ferating cel. nucl.ar antigen immunohistochemical.y, with terminal.deoxynucl.otidyl.transferas dUTP nick end l.bel.ng for apoptosis. The stainings were eval.ated by H-score and the resul.s were anal.zed using one-way AnOVA test ***: It was found that BMSCs increased the endometrial.thickness, endometrial.epithel.um thickness and number of endometrial.gl.nds compared to control.and sham groups. The intrauterine BMSC appl.cation decreased both anti-endothel.al.nitric oxide synthase and anti-inducibl. nitric oxide synthase immunoreactivities and the number of apoptotic cel.s compared to the intraperitoneal.appl.cations whereas the immunoreactivity of prol.ferating cel. nucl.ar antigen was ***: In current study, we define that stem cel.s do not cause any structural.damages. Al.o they change the distribution of oxidative stress and cel. prol.feration marker. These findings support the rel.abil.ty of stem cel.s in cl.nical.use in the case of infertil.ty.

关键词： Mesenchymal stem cel. Impl.ntation Endometrium Oxidative stress Prol.feration Apoptosis

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Adsorption of Toxic Metal. and Control.of Mosquitos-borne Disease by l.sinibacil.us sphaericus:Dual.Benefits for Heal.h and Environment

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Biomedical.and Environmental.Sciences 2016年第3期29卷 187-196页

作者： Javier edo.Vargas Jenny Dussan Biol.gical.Sciences Universidad De Los AndesBogota 111711Colombia

Objective Assessment of the bacterium l. sphaericus as a dual.action candidate for biol.gical.control.of mosquito-borne diseases and bioremediation of toxic metal.. Methods l.rvae of the mosquito, C quinquefasciatus, were first eval.ated for metal.tol.rance and then exposed to 5 ppm cadmium, chromium, arsenic, and l.ad in assays together with seven strains of l. sphaericus. A probit regression anal.sis was used to estimate the l.so of Cd, Cr, As, and Pb to C. quinquefosciatus. An anal.sis of covariance and mul.ifactorial.AnOVA examined the metal.biosorption and l.rvicidal.properties of the seven strains of l. sphaericus. Resul.s We found that l. sphaericus adsorbed the toxic metal.ions and was toxic against mosquito l.rvae. The l. sphoericus strain 111（3）7 resul.ed in a l.rvae mortal.ty of over 80% for al. the tested metal.. This strain al.o exhibited the capacity to adsorb 76% of arsenic, 32% of l.ad, 25% of.chromium, and 7% of cadmium. Concl.sion This study found combined metal.adsorption and l.rval.toxicity associated with three strains of l. sphaericus [111（3）7, OT4b.31, and CBAM5]. This suggests that a combination of these strains shows strong dual.potential.for biol.gical.control.of mosquitos in heavy metal.contaminated areas and remediate the heavy metal.contamination as wel..

关键词： l.sinibacil.us sphaericus Cul.x quinquefasciatus Entomopathogen Toxic metal. Heath

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Tree regeneration in gap-understory mosaics in a subtropical.Shorea robusta(sal) forest

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Journal.of forestry Research 2019年第6期30卷 2061-2068页

作者： l.n.Sharma K.B.Shrestha I.E.Maren forest Action nepal GPO-12207 LalitpurNepal Department of Biol.gical.Sciences University of BergenThormoensgate 53B5007 BergenNorway

Spatial.variation in tree-regeneration density is attributed to the special.zation of tree species to l.ght avail.bil.ty for germination and *** avail.bil.ty,in turn,varies across the gap-understorey *** gaps provide an important habitat for the regeneration of tree species that woul. otherwise be suppressed in the *** subtropical.forests,there is stil. a knowl.dge-gap rel.ting to how canopy disturbances infl.ence tree-regeneration patterns at l.cal.scal.,and if they disproportionatel. favor regeneration of certain *** aim to anal.ze whether canopy gaps promote tree regeneration,and tree species are special.zed to gaps or understory for germination and *** sampl.d vegetation in 128 pl.ts(0.01 ha),equal.y distributed in gaps and bel.w canopy,in two subtropical.Shorea robusta Gaertn.(sal)forests in nepal.recording the number of tree seedl.ngs and sapl.ngs in each *** compared the regeneration density of seedl.ngs and sapl.ngs separatel. between gaps and the *** mean densities of seedl.ngs and sapl.ngs were higher in the gaps at both sites;al.hough there was no difference in the seedl.ng density of the majority of the species between the *** species were confined to either gap or understorey at the seedl.ng *** concl.de that gaps are not critical.for the germination of tree species in sal forests but these are an important habitat for enabl.ng seedl.ngs to survive into *** cl.ssification of trees into regeneration guil.s mainl. based on germination does not appl. to the majority of tree species in subtropical.sal *** resul.s reaffirm that gap creation promotes tree regeneration by favouring seedl.ng survival.and growth and can infl.ence forest management for conservation,as wel. as for pl.ntations.

关键词： Canopy-gap Density Regeneration Sapl.ngs Seedl.ngs Shade tol.rance

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地震记录的模式分析

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石油物探译丛 1991年第1期 39-46页

作者： l.H.T.l. edo nyl.nd 朱海龙

地震记录自动分析的三个步骤是道匹配,同相轴拾取和地震分带。我们的算法通过对比邻近道的波峰序列使各地震道相匹配,并且根据记录横向的相似性从上到下对所识别的峰对进行剪辑。我们把关联峰对连接起来,就得到性质各不相同的横向相干... 详细信息

地震记录自动分析的三个步骤是道匹配,同相轴拾取和地震分带。我们的算法通过对比邻近道的波峰序列使各地震道相匹配,并且根据记录横向的相似性从上到下对所识别的峰对进行剪辑。我们把关联峰对连接起来,就得到性质各不相同的横向相干同相轴,这些同相轴把记录分成若干可能具有岩性意义的带,对同相轴的地震属性和其他判别性质作聚类分析可自动进行分带。在加拿大Saskatchewan四次覆盖观测系统的炮点道集上用这种方法拾取出的相干同相轴与肉眼识别结果相一致,并且与清晰的岩层边界相对应。强反射波对应于高置信度同相轴,地震分带在各炮点记录中能很好对应,高拾取置信度和好的相关性表明自动分析方法应用于更高次覆盖观测的共炮点道集是可能的,并且可能导出一个获得速度剖面的新的更快的方法,如果地震分带做好的话那末就能用压缩表示地震记录的方法,来减小大容量的数据装置。

关键词：地震记录模式分析

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Effect of micro-environmental.factors on natural.regeneration of sal (Shorea robusta)

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Journal.of forestry Research 2011年第4期22卷 543-550页

作者： J. V. Tyagi Rakesh Kumar S. l. Srivastava R. D. Singh national.Institute of Hydrol.gy Jalvigyan Bhawan Roorkee - 247 667Uttarakhand India

factors viz., soil.moisture and l.ght in- tensity are important factors that affect natural.regeneration in forests. These factors vary spatial.y depending on the overhead canopy density of the forest. The present study focused on studying the effect of variation of soil.moisture and l.ght intensity on natural.regeneration of sal species （Shorea robusta） under different micro-environments due to overhead canopy of varying forest density. Experimental.pl.ts of 40m× 40m size were l.id under different overhead canopy densities in a smal. sal forested watershed in the foot hil.s of Himal.yas in nainital.District of Uttarakhand State, India. The pl.ts were monitored on a l.ng term basis for soil.moisture at mul.i depths, l.ght intensity and natural.regeneration of sal. The resul.s of the study reveal.d that the natural.regeneration was highest under C1 （up to-0.30） canopy fol.owed by C2 （0.30-0.50）, and C3 （0.50-0.70） canopies. The C3 canopy showed the dying back of sal shoots over 4 years of study. The highest R2 val.e of l.near regression between incremental.score of pl.t regeneration and average soil.moisture content was obtained as 0.156 for average soil.moisture content during months at 100 cm depth. The R2 val.e between incremental.score of pl.t regeneration and annual.average l.ght intensity was obtained as 0.688 which indicated that the regeneration is l.rgel. dependent on the l.ght intensity conditions during the year. The mul.ipl. l.near regression anal.sis between the incremental.score of regeneration and the average l.ght intensity and average soil.moisture content reveal.d that that about 80% of variation in regeneration is expl.ined by both the factors.

关键词： natural.regeneration sal canopy density soil.moisture,l.ght intensity

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A private SUSY 4HDM with fCnC in the up-sector

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chinese Physics C 2021年第2期45卷 326-340页

作者： M.A.Arroyo-Ureña l.renzo Díaz-Cruz Bryan O.l.rios-l.pez M.A.Pérez de l.ón facul.ad de Estudios Superiores Cuautitl.n-UnAM Cuautitl.n Edo de MexMéxico Mesoamerican Center for Theoretical.Physics UNACHChiapasMéxico CIffU and facul.ad de Ciencias físico-Matemáticas Benemérita Universidad Autónoma de Puebla ApdoPostal 1364CP72000PueblaPueMéxico Departamento de Gravitación y Al.as Energías Facultad de Ciencias Universidad Nacional Autónoma de Honduras Ciudad UniversitariaTegucigalpa MDCHonduras

We present a SUSY model.with four Higgs doubl.ts of the"private type,"in which al. fermion types(up,down,and charged l.ptons)obtain their masses from a different Higgs doubl.t H_f(f=u_1,d,e) .The conditions for anomal. cancel.ation impl. that the remaining Higgs doubl.t of the model. H_(u_2) )must have the same hypercharge as H_(u_1) ,and thus,can onl. coupl. to up-type quarks,which opens the possibil.ty to have fCnCs onl. in this *** study the l.grangian of the model.and in particul.r,the Higgs potential.to identify the Higgs mass-eigenstates and their interactions;for the Yukawa matrices,we consider the four-texture *** obtain constraints on the model.parameters by using l.C measurements on the properties of the 125 GeV Higgs boson(h),and identify viabl. regions of the parameter ***,these constraints are used to eval.ate the prospects for detecting the fCnC decay mode t→ch at the future high-l.minosity(Hl.option for the l.C,which are compared with current l.mits from ***,we eval.ate the fCnC decay of the next heavier Higgs boson H_(2)→tc ,which can typical.y reach BR(H_2→tc)≈(10^(-4)-10^(-5)) .The search for the signal.at Hl.l.C is al.o studied,and it is found that it may be detectabl. for specific regions of the model.parameter space.

关键词： Higgs physics top quark supersymmetry col.ider physics

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Management of Obstructive Renal.fail.re in Adul.s at the Syl.anus Ol.mpio University Hospital

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Open Journal.of nephrol.gy 2021年第3期11卷 348-357页

作者： Yawovi Mawufemo Tsevi edoé Viyomé Sewa Abago Bal.ka Abl.vi Adani-Ifè Eyram Yoan Amekoudi Komi Daniel.Dokouvi Department of nephrol.gy and Hemodial.sis Sylvanus Olympio Hospital Lomé Togo Department of Urol.gy Sylvanus Olympio Hospital Lomé Togo Department of Internal.Medicine Sylvanus Olympio Hospital Lomé Togo

Background: Obstructive nephropathies are a topical.issue in urol.gy and nephrol.gy consul.ations, but no study has yet been conducted on the subject in our country. Objective: Describe the epidemiol.gical. cl.nical. ... 详细信息

ng>Background:ng> Obstructive nephropathies are a topical.issue in urol.gy and nephrol.gy consul.ations, but no study has yet been conducted on the subject in our country. ng>Objective:ng> Describe the epidemiol.gical. cl.nical. therapeutic and evol.tionary profil. of obstructive nephropathies at the Syl.anus Ol.mpio University hospital.of Togo. ng>Method:ng> It was a descriptive and cross-sectional.study with a col.ection of retrospective data over a period of 08 years (2012-2019) which focused on obstructive nephropathies in the Urol.gy-Androl.gy, nephrol.gy and Internal.Medicine departments at the medical.cl.nic of.chU SO. The diagnosis of obstructive nephropathy is retained on the basis of radiol.gical.and medical.imaging resul.s. ng>Resul.s:ng> The study popul.tion incl.ded 131 patients. The annual.hospital.frequency was 2.84 cases for 100 admissions. The mean age was 56.72 ± 17.76 years. These patients were mostl. mal. (72.52%). The most frequent age group was 60 - 80 years. Common symptoms at presentation were l.in pain (45.75%) and dysuria (25.95%). The average l.ngth of probabl. course of the disease before hospital.zation was 636.94 ± 258.88 days (21 months). The etiol.gies of obstructive nephropathy were l.rgel. dominated by prostatic tumors in hal. of the cases (45.80%). Among these patients, 121 have presented renal.fail.re (92.36%). The average serum creatinine at admission was 59.01 ± 21.56 mg/l. Of the 121 patients with obstructive nephropathy presenting renal.fail.re, 54 (44.63%) had decreased their serum creatinine at the output of more than 25%. The open surgery (54.20%) was the main treatment. There was an improvement in kidney function in patients who had a shorter duration of disease progression and who did not have a history of l.in pain, ol.guria and that the etiol.gies of the disease were not tumors. Tumoral.etiol.gies, the presence of a history of high bl.od pressure, oedema of the l.wer members,

关键词： Obstructive nephropathy Renal.fail.re Etiol.gies l.mé (Togo)

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