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Alleviatory effect of isoquercetin on benign prostatic hyperplasia via IGF-1/PI3K/Akt/mTOR pathway

Food Science and Human Wellness 2024年第3期13卷 1698-1710页

作者： Young-jin Choi Meiqi Fan Nishala Erandi Wedamulla Yujiao Tang Eun-kyung kim Department of Food Science and Nutrition Dong-A UniversityBusan 49315Republic of Korea Center for Silver-targeted Biomaterials Brain Busan 21 Plus programDong-A UniversityBusan 49315Republic of Korea Department of Health Sciences the Graduate School of Dong-A UniversityBusan 49315Republic of Korea Division of Food Bioscience College of Biomedical and Health SciencesKonkuk UniversityChungju 27478Republic of Korea Department of Export Agriculture Faculty of Animal Science and Export AgricultureUva Wellassa UniversityBadulla 90000Sri Lanka School of Bio-Science and Food Engineering Changchun University of Science and TechnologyChangchun 130600China Nutritional Education Major Graduate School of EducationDong-A UniversityBusan 49315Republic of Korea Nutrinomics Lab.Co. Ltd.Busan 49315Republic of Korea

We evaluated the effect of isoquercetin(quercetin-O-3-glucoside-quercetin,IQ)as a functional component of Abeliophyllum disistichum Nakai ethanol extract(ADLE)on prostate cell proliferation and apoptosis and its effects on the IGF-1/PI3K/Akt/mTOR pathway in benign prostatic hyperplasia(BPH).Metabolites in ADLE were analyzed using UHPLC-qTOF-MS and *** was orally administered(1 or 10 mg/kg)to a testosterone propionate-induced BPH rat model,and its effects on the prostate weight were *** effect of IQ on androgen receptor(AR)signaling was analyzed in LNCaP *** IGF-1 and IQ affect the IGF-1/PI3K/Akt/mTOR pathway in BPH-1 cells was also *** metabolites in ADLE were identified and quantified,which confirmed that ADLE contained abundant IQ(20.88 mg/g).IQ significantly reduced the prostate size in a concentration-dependent manner in a BPH rat model,and significantly decreased the expression of AR signaling factors in the rat prostate tissue and LNCaP cells in a concentration-dependent *** also inhibited the PI3K/AKT/mTOR pathway activated by IGF-1 treatment in BPH-1 *** BPH-1 cells,IQ led to G0/G1 arrest and suppressed the expression of proliferation factors while inducing ***,IQ shows potential for use as a pharmaceutical and nutraceutical for BPH.

关键词： Isoquercetin Benign prostatic hyperplasia Androgen receptor signaling PI3K/Akt/mtor pathway

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Machine-learned wearable sensors for real-time hand-motion recognition: toward practical applications

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National Science Review 2024年第2期11卷 231-263页

作者： kyung Rok Pyun Kangkyu Kwon Myung jin Yoo Kyun Kyu kim Dohyeon Gong Woon-Hong Yeo Seungyong Han Seung Hwan Ko Department of Mechanical Engineering Seoul National University IEN Center for Human-Centric Interfaces and Engineering Institute for Electronics and NanotechnologyGeorgia Institute of Technology School of Electrical and Computer Engineering Georgia Institute of Technology Department of Chemical Engineering Stanford University Department of Mechanical Engineering Ajou University George W.Woodruff School of Mechanical Engineering Georgia Institute of Technology Institute of Advanced Machinery and Design(SNU-IAMD) Seoul National University

Soft electromechanical sensors have led to a new paradigm of electronic devices for novel motion-based wearable applications in our daily lives. However, the vast amount of random and unidentified signals generated by complex body motions has hindered the precise recognition and practical application of this technology. Recent advancements in artificial-intelligence technology have enabled significant strides in extracting features from massive and intricate data sets, thereby presenting a breakthrough in utilizing wearable sensors for practical applications. Beyond traditional machine-learning techniques for classifying simple gestures, advanced machine-learning algorithms have been developed to handle more complex and nuanced motion-based tasks with restricted training data sets. Machine-learning techniques have improved the ability to perceive, and thus machine-learned wearable soft sensors have enabled accurate and rapid human-gesture recognition, providing real-time feedback to users. This forms a crucial component of future wearable electronics, contributing to a robust human–machine interface. In this review, we provide a comprehensive summary covering materials, structures and machine-learning algorithms for hand-gesture recognition and possible practical applications through machine-learned wearable electromechanical sensors.

关键词： wearable sensor soft electronics artificial intelligence machine learning human–machine interfaces gesture recognition

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Synthesis and pharmacological properties of naturally occurring prenylated and pyranochalcones as potent anti-inflammatory agents

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Chinese Chemical Letters 2016年第5期27卷 698-702页

作者： Kongara Damodar jin-kyung kim Jong-Gab Jun Department of Chemistry and Institute of Natural Medicine Hallym University Department of Biomedical Science College of Natural Science Catholic University of Daegu

An efficient approach has been developed for the synthesis of naturally occurring prenylated chalcones viz. kanzonol C （1）, stipulin （2）, crotaorixin （3）, medicagenin （4）, licoagrochalcone A （5） and abyssinone D （6） along with the pyranochalcones paratocarpin C （7）, anthyllisone （8） and 3-O-methylabyssinone A （9）. The key step of the synthesis is a Claisen-Schmidt condensation. Subsequently, their anti-inflammatory effects were investigated in lipopolysaccharides （LPSs）-induced RAW-264.7 macrophages. Of the synthesized chalcones, compounds 5 （IC50= 10.41 μmol[L）, 6 （IC50= 9.65 μmol/L） and 8 （IC50= 15.34 μmol/L） show remarkable activity with no cytotoxicity. Compound 9 （IC50 = 4.5 μmol/L） exhibits maximum （83.6%） nitric oxide （NO） inhibition, but shows slight cytotoxicity. The results reveal that the chalcones bearing the prenyl group at 3- and/or 5-position on ring A （acetophenone moiety）, i.e., 1-4 and 7 show weak, or no inhibition activity, whereas chalcones having the prenyl group only on ring B （aldehyde part）, i.e., 5, 6 and 8 show significant activity on the production of inflammatory mediated NO with no cytotoxicity.

关键词： Prenylated chalcone Pyranochalcone Claisen-Schmidt condensation Anti-inflammatory Nitric oxide (NO)

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Soleus arthrogenic muscle inhibition following acute lateral ankle sprain correlates with symptoms and ankle disability but not with postural control

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Journal of Sport and Health Science 2024年第4期13卷 559-568,F0003页

作者： kyung-Min kim Joo-Sung kim Alan R.Needle Department of Sport Science Sungkyunkwan UniversitySuwon-si 16419Republic of Korea Department of Health and Human Performance Texas State UniversitySan MarcosTX 78666USA Department of Public Health&Exercise Science Appalachian State UniversityBooneNC 28608USA Department of Rehabilitation Science Appalachian State UniversityBooneNC 28608USA

Background:Acute lateral ankle sprains(ALAS)are associated with long-term impairments and instability tied to altered neural *** muscle inhibition(AMI)has been observed in this population;however,relationships with injury-related impairments are unclear,potentially due to the resting,prone position in which AMI is typically *** AMI during bipedal stance may provide a better understanding of this ***:AMI was assessed in 38 young adults(19 ALAS within 72 h of injury:10 males,21.4±2.7 years;19 healthy controls:10 males,21.9±2.2 years;mean±SD)using the Hoffmann reflex(H-reflex)during bipedal *** stimulation was administered to identify the _(max)imal H-reflex(H_(max))and _(max)imal motor response(M_(max))from the soleus,fibularis longus,and tibialis anterior *** primary outcome measure was the H_(max)/M_(max) *** outcomes included acute symptoms(pain and swelling),postural control during bipedal stance,and self-reported ***:No significant group-by-limb interactions were observed for any ***,a significant group main effect was observed in the soleus muscle(F(1,35)=6.82,p=0.013),indicating significantly lower H_(max)/M_(max) ratios following ALAS(0.38±0.20)compared to healthy controls(0.53±0.16).Furthermore,lower H_(max)/M_(max) ratios in the soleus significantly correlated with acute symptoms and self-reported function but not with postural ***:This study supports previous evidence of AMI in patients with ALAS,providing insight into neurophysiologic impacts of musculoskeletal *** results suggest that assessing AMI in a standing position following acute injury may provide valuable insight into how AMI develops and guide potential therapeutic options to curb and offset the formation of joint instability.

关键词： Acute injuries Balance Hoffmann reflex Neural excitability Patient-reported outcomes

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Molecular mechanisms regulating NLRP3 inflammasome activation

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Cellular & Molecular Immunology 2016年第2期13卷 148-159页

作者： Eun-Kyeong Jo jin kyung kim Dong-Min Shin Chihiro Sasakawa Department of Microbiology Chungnam National University School of Medicine Daejeon 301-747 South Korea Infection Signaling Network Research Center Chungnam National University School of Medicine Daejeon 301-747 South Korea Medical Mycology Research Center Chiba University Chiba 260-8673 Japan Nippon Institute for Biological Science Tokyo 198-0024 Japan

Inflammasomes are multi-protein signaling complexes that trigger the activation of inflammatory caspases and the maturation of interleukin-1β. Among various inflammasome complexes, the NLRP3 inflammasome is best characterized and has been linked with various human autoinflammatory and autoimmune diseases. Thus, the NLRP3 inflammasome may be a promising target for anti-inflammatory therapies. In this review, we summarize the current understanding of the mechanisms by which the NLRP3 inflammasome is activated in the cytosol. We also describe the binding partners of NLRP3 inftammasome complexes activating or inhibiting the inflammasome assembly. Our knowledge of the mechanisms regulating NLRP3 inflammasome signaling and how these influence inflammatory responses offers further insight into potential therapeutic strategies to treat inflammatory diseases associated with dysregulation of the NLRP3 inflammasome,

关键词： inflammasome inflammation interaction mechanism NLRP3

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First synthesis and in vitro biological assessment of isosideroxylin,6,8-dimethylgenistein and their analogues as nitric oxide production inhibition agents

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Chinese Chemical Letters 2017年第5期28卷 1114-1118页

作者： Jong-Woon Jung Kongara Damodar jin-kyung kim Jong-Gab Jun Department of Chemistry and Institute of Applied Chemistry Hallym University Department of Biomedical Science College of Natural ScienceCatholic University of Daegu

A modular and efficient synthesis of the biologically significant C-methylisoflavones isosideroxylin（1）,6,8-dimethylgenistein（2） and their analogues（3-8） is established for the first *** synthesis is realized in 7-8 steps in overall yields of 16%-24%from commercially inexpensive phloroglucinol and features a high yielding Vilsmeier-Haack reaction,Friedel-Crafts acylation,Gammill＇s protocol and Suzuki coupling as the pivotal ***,these compounds evaluated for their inhibitory potency on the production of nitric oxide（NO） in lipopolysaccharide（LPS）-activated RAW-264.7 cells as an indicator of anti-inflammatory *** results showed that all the compounds decreased NO production in a dose-dependent manner without marked cytotoxicity and IC_（50） values are found in the range of 10.17-33.88 μmol/*** note,compounds 3 followed by 1,7 and 8 show comparable inhibitory activity with positive control（N-monomethyl-L-arginine,L-NMMA）.

关键词： Isosideroxylin 6 8-Dimethylgenistein Vilsmeier-Haack reaction Suzuki coupling Nitric oxide(NO) Anti-inflammatory

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An update on the regulatory mechanisms of NLRP3 inflammasome activation

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Cellular & Molecular Immunology 2021年第5期18卷 1141-1160页

作者： Seungwha Paik jin kyung kim Prashanta Silwal Chihiro Sasakawa Eun-Kyeong Jo Department of Microbiology Chungnam National University School of MedicineDaejeonKorea Infection Control Convergence Research Center Chungnam National University School of MedicineDaejeonKorea

The NOD-,LRR-,and pyrin domain-containing protein 3(NLRP3)inflammasome is a multiprotein complex involved in the release of mature interleukin-1βand triggering of pyroptosis,which is of paramount importance in a variety of physiological and pathological *** the past decade,considerable advances have been made in elucidating the molecular mechanisms underlying the priming/licensing(Signal 1)and assembly(Signal 2)involved in NLRP3 inflammasome ***,a number of studies have indicated that the priming/licensing step is regulated by complicated mechanisms at both the transcriptional and posttranslational *** this review,we discuss the current understanding of the mechanistic details of NLRP3 inflammasome activation with a particular emphasis on protein-protein interactions,posttranslational modifications,and spatiotemporal regulation of the NLRP3 inflammasome *** also present a detailed summary of multiple positive and/or negative regulatory pathways providing upstream signals that culminate in NLRP3 inflammasome complex assembly.A better understanding of the molecular mechanisms underlying NLRP3 inflammasome activation will provide opportunities for the development of methods for the prevention and treatment of NLRP3 inflammasome-related diseases.

关键词： NLRP3 inflammasome inflammation mechanism interaction

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Protection of Allergic Asthma in Mice by Black Rice Bran Bioprocessed with Shiitake Mushroom Mycelia

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Food and Nutrition Sciences 2023年第4期14卷 341-368页

作者： Ki Sun Kwon Woon Sang Hwang kyung Hee Lee kyung jin kim Wha Young Lee Jeanman kim Sang Jong Lee Sung Phil kim Mendel Friedman STR Biotech Co. Ltd. Chuncheon Republic of Korea U.S. Department of Agriculture Western Regional Research Center Agricultural Research Services Albany CA USA

We evaluated the potential of orally fed new food formulations to inhibit biomarkers reported to be involved in the causes of allergic asthma in mice. Asthma, a serious non-communicable disease, affects both adults and children and can be undertreated. New functional foods could provide therapeutic approaches. Here, the anti-asthma mechanism of a new functional food and three isolated fractions produced by bioprocessing black rice bran with shiitake mushroom mycelia was evaluated in mast cells, B cells, and orally fed mice and compared with non-bioprocessed black rice bran. In vitro, the treatments inhibited RBL-2H3 cell degranulation and immunoglobulin E (IgE) production. The in vitro anti-asthma effects were confirmed in orally fed mice following asthma induction by alumina and chicken egg ovalbumin (OVA). The suppression of asthma resulted from the inhibition of inflammation- and immune-related substances, including OVA-specific IgE, thymic stromal lymphopoietin, eotaxin, leukotriene C4, prostaglandin D2, and vascular cell adhesion molecule-1 in bronchoalveolar lavage fluid and serum. The treatment also reversed the thickening of the lung airway wall. The inflammation and asthma inhibition seems to be regulated by the balance of the T-helper cells’ Th1/Th2 immune response and the inhibition of multiple biomarkers associated with the cause of asthma. Future human clinical studies with adults and children should determine the potential therapeutic value of the anti-asthma effects of the new functional foods.

关键词： Black Rice Bran Shiitake Mushrooms Bioprocessed Functional Food Mast Cells Mice Feeding Studies Bioassays Cytokines Immunoglobulins Bronchial Lavage Fluid Histology Anti-Inflammatory Effect Asthma Prevention Research Needs

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Particle morphology control for spherical powder fabrication using the ball milling process with DEM simulation

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Particuology 2024年第7期90卷 41-50页

作者： Battsetseg Jargalsaikhan Khulan Uranchimeg Amgalan Bor kyung Sung kim Heekyu Choi Research Institute of Future Convergence Changwon National UniversityChangwonGyoungnam 641-773Republic of Korea Graduate School of Material Science Engineering Changwon National UniversityChangwonGyoungnam 641-773Republic of Korea Department of Chemical and Biological Engineering School of Engineering and Applied SciencesNational University of MongoliaUlaanbaatar 14200Mongolia Department of Mechatronics Convergence Engineering College of Future ConvergenceChangwon National UniversityChangwonGyoungnam 641-773Republic of Korea Graduate School of Convergence on Culture Technology Changwon National UniversityChangwonGyoungnam 641-773Republic of Korea

Characteristics of spherical particles on copper powder and changing sizes were studied in a ball mill under various experimental conditions,such as different ball diameters,high rotation speeds,and milling times,using a discrete element method(DEM)*** experiment has investigated the characteristics of spherical particle morphology evolution involved in the mechanical alloying of copper *** morphological evolution of the copper particle was analyzed using scanning electron microscopy(SEM).A spherical copper particle was shown with a roundness value using imageJ *** DEM was used to simulate the ball motion in a planetary ball mill,and the impact energy and shear energy generated during the collision were analyzed to estimate the contact number between the ball and the ball ***,as the size of the ball decreased,the number of ball-to-ball and ball-to-wall contacts increased accordingly,and the spherical shape of the copper powder changed.

关键词： Planetary ball mill DEM simulation Spherical particle morphology Copper powder Ball diameter

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Protein Arginine Methyltransferase 1 Ablation in Motor Neurons Causes Mitochondrial Dysfunction Leading to Age-related Motor Neuron Degeneration with Muscle Loss

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Research 2024年第1期2023卷 637-649页

作者： Hyun-kyung So Hyebeen kim jinwoo Lee Chang-Lim You Chae-Eun Yun Hyeon-Ju Jeong Eun-Ju jin Yunju Jo Dongryeol Ryu Gyu-Un Bae Jong-Sun Kang Department of Molecular Cell Biology Sungkyunkwan University School of MedicineSuwonKorea Single Cell Network Research Center Sungkyunkwan University School of MedicineSuwonKorea Research Institute of Aging-Related Diseases AniMusCureInc.SuwonKorea Drug Information Research Institute Muscle Physiome Research CenterCollege of PharmacySookmyung Women’s UniversitySeoulKorea

Neuromuscular dysfunction is tightly associated with muscle wasting that occurs with age or due to degenerative ***,the molecular mechanisms underlying neuromuscular dysfunction are currently *** studies have proposed important roles of Protein arginine methyltransferase 1(Prmt1)in muscle stem cell function and muscle *** the current study,we set out to determine the role of Prmt1 in neuromuscular function by generating mice with motor neuron-specific ablation of Prmt1(mnKO)using *** exhibited age-related motor neuron degeneration and neuromuscular dysfunction leading to premature muscle loss and ***1 deficiency also impaired motor function recovery and muscle reinnervation after sciatic nerve *** transcriptome analysis of aged mnKO lumbar spinal cords revealed alterations in genes related to inflammation,cell death,oxidative stress,and ***,mnKO lumbar spinal cords of sciatic nerve injury model or aged mice exhibited elevated cellular stress response in motor ***,Prmt1 inhibition in motor neurons elicited mitochondrial *** findings demonstrate that Prmt1 ablation in motor neurons causes agerelated motor neuron degeneration attributing to muscle ***,Prmt1 is a potential target for the prevention or intervention of sarcopenia and neuromuscular dysfunction related to aging.

关键词： degeneration impaired prevention

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