An update on the regulatory mechanisms of NLRP3 inflammasome activation

作     者：Seungwha Paik Jin Kyung Kim Prashanta Silwal Chihiro Sasakawa Eun-Kyeong Jo 

作者机构：Department of MicrobiologyChungnam National University School of MedicineDaejeonKorea Infection Control Convergence Research CenterChungnam National University School of MedicineDaejeonKorea 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2021年第18卷第5期

页      面：1141-1160页

核心收录：

学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：supported by a National Research Foundation of Korea(NRF)grant funded by the Korean government(MSIT)(No.2017R1A5A2015385) by the framework of an international cooperation program managed by the National Research Foundation of Korea(2015K2A2A6002008) 

主　　题：NLRP3 inflammasome inflammation mechanism interaction 

摘      要：The NOD-,LRR-,and pyrin domain-containing protein 3(NLRP3)inflammasome is a multiprotein complex involved in the release of mature interleukin-1βand triggering of pyroptosis,which is of paramount importance in a variety of physiological and pathological *** the past decade,considerable advances have been made in elucidating the molecular mechanisms underlying the priming/licensing(Signal 1)and assembly(Signal 2)involved in NLRP3 inflammasome ***,a number of studies have indicated that the priming/licensing step is regulated by complicated mechanisms at both the transcriptional and posttranslational *** this review,we discuss the current understanding of the mechanistic details of NLRP3 inflammasome activation with a particular emphasis on protein-protein interactions,posttranslational modifications,and spatiotemporal regulation of the NLRP3 inflammasome *** also present a detailed summary of multiple positive and/or negative regulatory pathways providing upstream signals that culminate in NLRP3 inflammasome complex assembly.A better understanding of the molecular mechanisms underlying NLRP3 inflammasome activation will provide opportunities for the development of methods for the prevention and treatment of NLRP3 inflammasome-related diseases.