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Effects of Helicobacter pylori infection in gastrointestinal tract malignant diseases:From the oral cavity to rectum

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World Journal of Gastrointestinal Oncology 2022年第1期14卷 55-74页

作者： Yang-Che kuo Lo-Yip Yu Horng-Yuan Wang Ming-Jen Chen Ming-Shiang Wu Chun-Jen Liu Ying-Chun Lin Shou-Chuan Shih Kuang-Chun hu Division of Gastroenterology Department of Internal MedicineMacKay Memorial HospitalTaipei 10449TaiwanChina Department of Internal Medicine Healthy Evaluation CenterMackay Memorial HospitalTaipei 10449TaiwanChina Department of Internal Medicine National Taiwan University HospitalTaipei 10051TaiwanChina Department of Internal Medicine Institute of Clinical MedicineNational Taiwan University College of MedicineTaipei 10051TaiwanChina Department of Anesthesia MacKay Memorial HospitalTaipei 10449TaiwanChina Division of Gastroenterology Department of Internal MedicineHealth Evaluate CenterMackay Memorial HospitalTaipei 10449TaiwanChina Department of Internal Medicine Healthy Evaluation CenterMackay Memorial HospitalMacKay Junior College of MedicineNursingand ManagementTaipei 10038TaiwanChina

Helicobacter pylori(***)has infected approximately fifty percent of humans for a long period of ***,improvements in the public health environment have led to a decreased chance of *** ***,a high infection rate is noted in populations with a high incidence rate of gastric cancer(GC).The worldwide fraction of GC attributable to *** is greater than 85%,and a high *** prevalence is noted in gastric mucosa-associated lymphoid tissue lymphoma *** results indicate that the majority of GC cases can be prevented if *** infection is *** *** exhibits oral-oral or fecal-oral transmission,the relationship between this microorganism and other digestive tract malignant diseases has also attracted *** review article provides an overview of *** and the condition of the whole gastrointestinal tract environment to further understand the correlation between the pathogen and the host,thus allowing improved realization of disease presentation.

关键词： Helicobacter pylori Gastrointestinal tract Malignant disease

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Exosome/metformin-loaded self-healing conductive hydrogel rescues microvascular dysfunction and promotes chronic diabetic wound healing by inhibiting mitochondrial fission

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Bioactive Materials 2023年第8期26卷 323-336页

作者： Yue Zhang Meng Li Yunchuan Wang Fei Han kuo Shen Liang Luo Yan Li Yanhui Jia Jian Zhang Weixia Cai Kejia Wang Ming Zhao Jing Wang Xiaowen Gao Chenyang Tian Baolin Guo Dahai hu Department of Burns and Cutaneous Surgery Xijing HospitalFourth Military Medical University127 Changle West RoadXi’anShaanxi710032China State Key Laboratory for Mechanical Behavior of Materials And Frontier Institute of Science and TechnologyXi’an Jiaotong UniversityXi’an710049China Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research College of StomatologyXi’an Jiaotong UniversityXi’an710049China

Chronic diabetic wounds remain a globally recognized clinical *** occur due to high concentrations of reactive oxygen species and vascular function disorders.A promising strategy for diabetic wound healing is the delivery of exosomes,comprising bioactive *** activates the vascular endothelial growth factor pathway,thereby improving angiogenesis in hyperglycemic ***,multifunctional hydrogels loaded with drugs and bioactive substances synergistically promote wound repair has been rarely reported,and the mechanism of their combinatorial effect of exosome and metformin in wound healing remains ***,we engineered dual-loaded hydrogels possessing tissue adhesive,antioxidant,self-healing and electrical conductivity properties,wherein 4-armed SH-PEG cross-links with Ag^(+),which minimizes damage to the loaded goods and investigated their mechanism of promotion effect for wound *** carbon nanotubes exhibiting good conductivity were also incorporated into the hydrogels to generate hydrogen bonds with the thiol group,creating a stable three-dimensional structure for exosome and metformin *** diabetic wound model of the present study suggests that the PEG/Ag/CNT-M+E hydrogel promotes wound healing by triggering cell proliferation and angiogenesis and relieving peritraumatic inflammation and vascular *** mechanism of the dual-loaded hydrogel involves reducing the level of reactive oxygen species by interfering with mitochondrial fission,thereby protecting F-actin homeostasis and alleviating microvascular ***,we propose a drug-bioactive substance combination therapy and provide a potential mechanism for developing vascular function-associated strategies for treating chronic diabetic wounds.

关键词： Dual-loaded hydrogels Adipose-derived mesenchymal stem cell exosomes Metformin Angiogenesis Mitochondrial fission Chronic diabetic wound Wound healing

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冠心病合并2型糖尿病患者糖化血红蛋白与冠状动脉复杂程度相关性研究

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心肺血管病杂志 2017年第7期36卷 507-510页

作者：秦政李月平周阔胡宾施超耿雨胡成平齐静周玉杰方哲首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所心内十二病房 100029

目的:探讨冠心病合并2型糖尿病患者糖化血红蛋白(HbA1c)与冠状动脉复杂程度相关性研究。方法:连续入选2012年1月至2012年6月,在我中心行冠状动脉造影诊断冠心病合并2型糖尿病患者共537例,根据纳入及排除标准,44例被排除,最终493例纳入... 详细信息

目的:探讨冠心病合并2型糖尿病患者糖化血红蛋白(HbA1c)与冠状动脉复杂程度相关性研究。方法:连续入选2012年1月至2012年6月,在我中心行冠状动脉造影诊断冠心病合并2型糖尿病患者共537例,根据纳入及排除标准,44例被排除,最终493例纳入该研究。依据入院时患者HbA1c水平,用四分位数将患者分为四组。冠状动脉病变的复杂程度用SYNTAX评分计算。采用Logistic回归分析HbA1c与冠状动脉病变复杂程度之间的关系。结果:HbA1c四分位组(Q1~Q4)越高,冠状动脉SYNTAX评分越高,冠状动脉病变程度越复杂[Q1:(12.5±7.1)分,Q2:(16.0±7.0)分,Q3:(17.6±7.6)分,Q4:(22.3±6.6)分,P<0.001]。Logistic回归分析发现HbA1c四分位组越高,SYNTAX评分中高组的风险越高,调整年龄、性别、吸烟等相关因素后,高HbA1C分类Q2~Q4相对Q1的OR分别为Q2∶1.47,Q3∶1.96,Q4∶3.91(P<0.001)。结论:糖化血红蛋白与冠状动脉复杂程度密切相关,是冠状动脉病变复杂程度的独立预测因子,有效的血糖管理可能会减轻冠状动脉血管病变复杂性。

关键词： 2型糖尿病糖化血红蛋白冠状动脉病变复杂程度

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Interdiffusion in the Fe_2O_3-TiO_2 system

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International Journal of Minerals,Metallurgy and Materials 2013年第3期20卷 273-278页

作者： Zhong-shan Ren Xiao-jun hu Shen-yang Li Xiang-xin Xue kuo-chih Chou State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing School of Metallurgical Ecological Engineering University of Science and Technology Beijing School of Materials and Metallurgy Northeastern University

Interdiffusion in the Fe203-TiO2 system was investigated by the diffusion couple method in the temperature range of 1323 to 1473 K. The diffusion concentration curves of Ti4＋ cations were obtained by electron probe microanalysis, according to which the Boltzmann-Matano method optimized by Broeder was used to calculate the interdiffusion coeffi- cients. The interdiffusion coefficients almost increased linearly with the mole fraction of Ti4＋ cations increasing, and they were in the range of 10-12-10-11cm2-s-1. The increase of temperature could also lead to the increase of the interdiffusion coefficients at a constant concentration of Ti4＋ cations. It was also found that the thickness growth of the diffusion layer obeyed the parabolic rate law.

关键词： interdiffusion titanium dioxide iron oxides diffusion couples electron probe microanalysis

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Dissolution and diffusion of TiO_2 in the CaO-Al_2O_3-SiO_2 slag

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International Journal of Minerals,Metallurgy and Materials 2014年第4期21卷 345-352页

作者： Zhong-shan Ren Xiao-jun hu Xin-mei Hou Xiang-xin Xue kuo-chih Chou State Key Laboratory of Advanced Metallurgy University of Science and Technology Beijing School of Metallurgical and Ecological Engineering University of Science and Technology Beijing School of Materials and Metallurgy Northeastern University

The dissolution of TiO2 in the CaO-Al2O3-SiO2 slag under static conditions was studied in the temperature range from 1643 K to 1703 K. After TiO2 dissolved, the microstructure of the interface between TiO2 and the slag was observed by scanning electron microscopy, and the concentration profiles of Ti4＋and other ions across the TiO2/slag interfaces were analyzed by energy-dispersive X-ray spectroscopy. On the basis of these results, the dissolution behavior of TiO2 was evaluated, and the diffusivity of Ti4＋in the bulk slag was estimated. Ac-cording to the Stokes-Einstein relation, the viscosity calculated by a previously reported model gave a diffusivity of Ti4＋ions greater than that estimated by the concentration profiles of Ti4＋ions. The mechanism of TiO2 dissolution in the CaO-Al2O3-SiO2 slag is discussed in de-tail.

关键词： slags titanium dioxide dissolution diffusion interface

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冠心病合并2型糖尿病患者经皮冠状动脉介入术后SYNTAX评分与支架内再狭窄的关联性研究

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心肺血管病杂志 2017年第8期36卷 613-616页

作者：秦政李月平周阔胡宾施超耿雨胡成平齐静周玉杰方哲首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所心内科12病房 100029

目的:探讨冠心病合并2型糖尿病患者经皮冠状动脉介入(PCI)术后,SYNTAX评分与冠状动脉支架内再狭窄(ISR)的关联性。方法:连续入选2012年1月至2012年12月,在我中心行PCI术的冠心病合并2型糖尿病患者共437例,对他们进行2年的随访,其中共有... 详细信息

目的:探讨冠心病合并2型糖尿病患者经皮冠状动脉介入(PCI)术后,SYNTAX评分与冠状动脉支架内再狭窄(ISR)的关联性。方法:连续入选2012年1月至2012年12月,在我中心行PCI术的冠心病合并2型糖尿病患者共437例,对他们进行2年的随访,其中共有382例完成了第二次冠状动脉造影检查用来以此评价是否发生了ISR,最终共有368例符合该研究的纳入和排除标准进入统计分析。收集患者第一次行冠状动脉支架置入术时的基线信息,SYNTAX评分由在线计算器计算所得。结果:368例患者(男性108例。女性260例)的平均年龄为(58.7±10.3)岁,其中有74例发生了ISR,发生率为20.1%。ISR组的SYNTAX评分为15分,远高于非狭窄组的11分(P=0.022)。多因素回归分析结果显示,在调整了传统危险因素和其他混杂因素后,SYNTAX评分每增加5分,糖尿病患者ISR的风险增加34%(HR=1.34,95%CI=1.03~1.74,P=0.031)。结论:对于冠心病合并2型糖尿病患者,SYNTAX评分是冠状动脉ISR的一个独立的危险因素,可以作为临床预测冠状动脉ISR的一个指标之一。

关键词：糖尿病支架内再狭窄 SYNTAX评分

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Effects of river flow velocity on the formation of landslide dams

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Journal of Mountain Science 2019年第11期16卷 2502-2518页

作者： CHEN Kun-Ting CHEN Xiao-Qing hu Gui-Sheng kuo Yu-Shu CHEN hua-Yong Key Laboratory of Mountain Hazards and Earth Surface Processes Institute of Mountain Hazards and EnvironmentChinese Academy of SciencesChengdu 610041China Department of Hydraulic and Ocean Engineering National Cheng Kung UniversityTainan 70101Chinese Taipei CAS Center for Excellence in Tibetan Plateau Earth Sciences Beijing 100101China University of Chinese Academy Sciences Beijing 100049China

Natural dams are formed when landslides are triggered by heavy rainfall during extreme weather events in the mountainous areas of *** landslide debris movement,two processes occur simultaneously:the movement of landslide debris from a slope onto the riverbed and the erosion of the debris under the action of high-velocity river *** the rate of landslide deposition in a river channel is higher than the rate of landslide debris erosion by the river flow,the landslide forms a natural dam by blocking the river *** this study,the effects of the rates of river flow erosion and landslide deposition(termed the erosive capacity and depositional capacity,respectively)on the formation of natural dams are quantified using a physics-based approach and are tested using a scaled physical *** define a dimensionless velocity index vde as the ratio between the depositional capacity of landslide debris(vd)and the erosive capacity of water flow(ve).The experimental test results show that a landslide dam forms when landslide debris moves at high velocity into a river channel where the river-flow velocity is low,that is,the dimensionless velocity index vde>*** debris will not have sufficient depositional capacity to block stream flow when the dimensionless velocity index vde<*** depositional capacity of a landslide can be determined from the slope angle and the friction of the sliding surface,while the erosive capacity of a dam can be determined using river flow velocity and rainfall *** methodology described in this paper was applied to seven landslide dams that formed in Taiwan on 8 August 2009 during Typhoon Morakot,the Tangjiashan landslide dam case,and the Yingxiu-Wolong highway K24 landslide *** dimensionless velocity index presented in this paper can be used before a rainstorm event occurs to determine if the formation of a landslide dam is possible.

关键词： Natural dam Landslide Depositional capacity of landslide debris Erosive capacity of water flows

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新型Cu-Fe-(C)复相合金的变形及时效析出行为对比研究

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稀有金属材料与工程 2022年第12期51卷 4666-4674页

作者：杨阔王虎莫永达娄花芬郭明星北京科技大学新金属材料国家重点实验室北京100083 中国铜业工程技术研究院北京102209 中铝科学技术研究院有限公司北京102209 昆明冶金研究院有限公司北京分公司北京102209

采用真空感应熔炼和快速凝固法制备了组织性能优异的新型Cu-Fe-(C)复相合金材料,并通过OM、TEM以及力学性能测试分别对熔铸态、超低温深冷轧态、时效态组织和变形行为进行了研究。结果表明,添加溶质元素C有利于避免Cu-3%Fe(质量分数)合... 详细信息

采用真空感应熔炼和快速凝固法制备了组织性能优异的新型Cu-Fe-(C)复相合金材料,并通过OM、TEM以及力学性能测试分别对熔铸态、超低温深冷轧态、时效态组织和变形行为进行了研究。结果表明,添加溶质元素C有利于避免Cu-3%Fe(质量分数)合金铸态晶界偏析,降低晶内γ-Fe相尺寸,增加其在基体内的数量密度,使得该合金屈服强度较低,而延伸率却较高;超低温深冷轧变形可使Cu-Fe-(C)合金基体内γ-Fe相发生γ-Fe→α-Fe马氏体转变,屈服强度提升至520MPa以上,但是C元素的引入,会使合金残留部分细小γ-Fe相而维持高塑性;进一步经不同温度时效1 h时,2种合金均随温度升高逐渐发生回复再结晶导致硬度降低,不过Cu-Fe-C合金经400℃/1 h处理后发生再结晶的同时,还会析出更多更细小的α-Fe沉淀相,并残留较多位错,最终导致其具有较高的强度和延伸率。此外,对不同状态的沉淀相分布进行了统计和理论强度计算,深入分析了合金强度差异的本质原因。

关键词： Cu-Fe-(C)合金相变变形行为时效析出强化机制

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Insulin resistance is associated with hepatocellular carcinoma in chronic hepatitis C infection

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World Journal of Gastroenterology 2010年第18期16卷 2265-2271页

作者： Chao-hung hung Jing-Houng Wang Tsung-hui hu Chien-hung Chen kuo-Chin Chang Yi-Hao Yen Yuanhung kuo Ming-Chao Tsai Chuan-Mo Lee Division of Hepatogastroenterology Department of Internal MedicineChang Gung Memorial Hospital-Kaohsiung Medical CenterChang Gung University College of Medicine

AIM:To elucidate the role of insulin resistance(IR) and serum adiponectin level in hepatocellular carcinoma(HCC) associated with chronic hepatitis ***:Clinical and biochemical characteristics were collected from 165 consecutive patients with newly diagnosed *** model assessment of IR(HOMA-IR) and serum adiponectin level were investigated in 188 patients with different stages of hepatitis C virus(HCV) ***:Among HCC patients,type 2 diabetics(DM) was more prevalent in HCV subjects(35.6%,n = 59) compared to hepatitis B virus(HBV;12.7%,n = 63) or non-HBV,non-HCV cases(7.1%,n = 28).In patients with chronic hepatitis C,HCC subjects had higher blood sugar(P < 0.001),insulin level(P = 0.003) and HOMAIR(P = 0.018) than those with chronic hepatitis and advanced ***,male sex and body mass index were significantly associated with serum adiponectin level,whereas HOMA-IR was *** on stepwise logistic regression analysis,age(OR:1.124,P < 0.001),serum insulin level(OR:1.585,P < 0.001),HOMA-IR(OR:0.495,P = 0.001),DM(OR:11.601,P = 0.002) and male sex(OR:3.877,P = 0.016) were independently associated with *** result was similar even if the diabetic subjects were excluded for ***:Insulin resistance measured by HOMAIR,regardless of the presence of diabetes,is significantly associated with HCC development in patients with chronic HCV infection.

关键词： Hepatitis C virus Hepatocellular carcinoma Insulin resistance Diabetes Adiponectin

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The Notch pathway attenuates burn-induced acute lung injury in rats by repressing reactive oxygen species

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Burns & Trauma 2022年第1期10卷 570-585页

作者： Weixia Cai kuo Shen Peng Ji Yanhui Jia Shichao Han Wanfu Zhang Xiaolong hu Xuekang Yang Juntao Han Dahai hu Department of Burns and Cutaneous Surgery Xijing HospitalFourth Military Medical UniversityXi’an 710032China

Background:Acute lung injury(ALI)is a common complication following severe *** underlying mechanisms of ALI are incompletely understood;thus,available treatments are not sufficient to repair the lung tissue after ***:To investigate the relationship between the Notch pathway and burn-induced lung injury,we established a rat burn injury model by scalding and verified lung injury via lung injury evaluations,including hematoxylin and eosin(H&E)staining,lung injury scoring,bronchoalveolar lavage fluid and wet/dry ratio analyses,myeloperoxidase immunohistochemical staining and reac-tive oxygen species(ROS)accumulation *** explore whether burn injury affects Notch1 expression,we detected the expression of Notch1 and Hes1 after burn ***,we extracted pulmonary microvascular endothelial cells(PMVECs)and conducted Notch pathway inhibition and activation experiments,via aγ-secretase inhibitor(GSI)and OP9-DLL1 coculture,respectively,to verify the regulatory effect of the Notch pathway on ROS accumulation and apoptosis in burn-serum-stimulated *** investigate the regulatory effect of the Notch pathway on ROS accumulation,we detected the expression of oxidative-stress-related molecules such as superoxide dismutase,nicotinamide adenine dinucleotide phosphate(NADPH)oxidase(NOX)2,NOX4 and cleaved ***4-specific small interfering RNA(siRNA)and the inhibitor GKT137831 were used to verify the regulatory effect of the Notch pathway on ROS via ***:We successfully established a burn model and revealed that lung injury,excessive ROS accumulation and an inflammatory response ***1 detection showed that the expression of Notch1 was significantly increased after burn *** PMVECs challenged with burn serum,ROS and cell death were ***,when the Notch pathway was suppressed by GSI,ROS and cell apoptosis levels were significantly ***,these parameters were reduced when the Notch pathway was activated

关键词： Acute lung injury Notch pathway Reactive oxygen species Pulmonary microvascular endothelial cells Nicotinamide adenine dinucleotide phosphate oxidase 4 Burn

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