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基于矢量基学习的浸出过程在线建模

控制与决策 2011年第4期26卷 629-632页

作者：胡广浩毛志忠何大阔东北大学信息科学与工程学院沈阳110819 东北大学流程工业综合自动化教育部重点实验室沈阳110819

传统的支持向量回归算法因基于批量训练方法而无法适应浸出过程在线建模实时性的要求.在分析研究一种基于矢量基学习的支持向量回归算法的基础上,提出了基于矢量基学习的浸出过程在线建模方法.利用贝叶斯证据框架优化模型参数,分析新样... 详细信息

传统的支持向量回归算法因基于批量训练方法而无法适应浸出过程在线建模实时性的要求.在分析研究一种基于矢量基学习的支持向量回归算法的基础上,提出了基于矢量基学习的浸出过程在线建模方法.利用贝叶斯证据框架优化模型参数,分析新样本矢量与矢量空间的夹角,从而推导出该样本是否为基矢量.将该方法应用于浸出过程浸出率的预测,实验结果表明,该方法不但能很好地跟踪浸出率的变化趋势,而且显著地缩短了运算时间.

关键词：支持向量回归矢量基在线建模浸出过程

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基于云特性的多源卫星日间海雾探测技术研究

热带海洋学报 2023年第6期42卷 15-28页

作者：王钰胡晨悦丘仲锋赵冬至吴到懋廖廓南京信息工程大学江苏南京210044 江苏省宿迁环境监测中心江苏宿迁223800 福建省气象科学研究所福建福州350008

海雾与低云的分离是当前海雾遥感监测的难点,为提高日间海雾监测的准确度和实时性,本文针对2015—2020年在渤海、黄海和东海的11次海雾过程,在分析海雾与低云在云特性、可见光反射率、亮温和亮温差及纹理特征差异的基础上,使用Terra/Aqu... 详细信息

海雾与低云的分离是当前海雾遥感监测的难点,为提高日间海雾监测的准确度和实时性,本文针对2015—2020年在渤海、黄海和东海的11次海雾过程,在分析海雾与低云在云特性、可见光反射率、亮温和亮温差及纹理特征差异的基础上,使用Terra/Aqua卫星MODIS(moderate resolution imaging spectroradiometer)传感器及S-NPP/NOAA-20卫星VIIRS(visible infrared imaging radiometer suite)传感器的云和反射率产品,建立基于云特性的多源卫星日间海雾探测模型,有效分离了海雾与低云。利用CALIOP(cloud aerosol lidar with orthogonal polarization)后向散射和垂直特征对模型进行精度验证,MODIS(Terra)、MODIS(Aqua)、VIIRS(S-NPP)海雾识别的召回率最高为0.97、0.96、0.89,VIIRS(NOAA-20)与VIIRS(S-NPP)精度相当,与VIIRS(S-NPP)一致性超过0.8的VIIRS(NOAA-20)海雾监测结果达到93.15%,表明本文模型能够有效监测日间海雾;同时,基于本文模型,开展了MODIS与VIIRS数据的一致性研究,结果表明该模型对不同传感器有较强的适用性和稳定性,能够实现多源卫星对同一次海雾过程的协同观测。

关键词：海雾云特性云底高度 MODIS VIIRS

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Overexpression of miR-101 suppresses collagen synthesis by targeting EZH2 in hypertrophic scar fibroblasts

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Burns & Trauma 2021年第1期9卷 83-94页

作者： Jie Li Yan Li Yunchuan Wang Xiang He Jing Wang Weixia Cai Yanhui Jia Dan Xiao Jian Zhang Ming Zhao kuo Shen Zichao Li Wenbin Jia Kejia Wang Yue Zhang Linlin Su huayu Zhu Dahai hu Department of Burns and Cutaneous Surgery Xijing HospitalFourth Military Medical UniversityXi’anShaanxi710032China

Background:MicroRNA-101(miR-101)is a tumor suppressor microRNA(miRNA)and its loss is associated with the occurrence and progression of various ***,the biological function and target of miR-101 in the pathogenesis of hypertrophic scars(HS)remains ***:We harvested HS and paired normal skin(NS)tissue samples from patients and cultured their fibroblasts(HSF and NSF,respectively).We used quantitative reverse transcriptase polymerase chain reaction(qRT-PCR),fluorescence in situ hybridization(FISH),enzyme-linked immunosorbent assays(ELISA)and Western blot analyses to measure mRNA levels and protein expression of miR-101,enhancer of zeste homolog 2(EZH2),collagen 1 and 3(Col1 and Col3)andα-smooth muscle actin(α-SMA)in different in vitro *** also used RNA sequencing to evaluate the relevant signaling pathways and bioinformatics analysis and dual-luciferase reporter assays to predict miR-101 *** utilized a bleomycin-induced fibrosis mouse model in which we injected miR-101 mimics to evaluate collagen deposition in ***:We found low expression of miR-101 in HS and HSF compared to NS and *** miR-101 decreased Col1,Col3 andα-SMA expression in *** detected high expression of EZH2 in HS and *** of EZH2 decreased Col1,Col3 andα-SMA in ***,miR-101 targeted the 3-untranslated region(3UTR)of EZH2,as indicated by the decreased expression of *** EZH2 rescued miR-101-induced collagen ***-101 mimics effectively suppressed collagen deposition in the bleomycin-induced fibrosis mouse ***:Our data reveal that miR-101 targets EZH2 in HS collagen production,providing new insight into the pathological mechanisms underlying HS formation.

关键词： Hypertrophic scars miR-101 EZH2 Collagen Fibroblasts Skin Collagen

A Network Signal Timing Design Bilevel Optimization Model with Traveler Trip-Chain Route Choice Behavior Consideration

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Journal of Traffic and Transportation Engineering 2017年第4期5卷 203-216页

作者： Chung-Yung Wang kuo-Chi Yen Shou-Ren hu Chih-Peng Chu Ya-Tin Jhuang Department of Logistics Management National Defense University Taipei City 112 Taiwan R.O.C. Department of Transportation and Communication Management Science National Cheng Kung University Tainan City 701Taiwan R. O. C. " Department of Business Administration National Dong Hwa University Hualien City 9 74 Taiwan R.O.C.

This study proposed a bilevel optimization model for the network signal timing design problem by considering the linkflows reflected by the trip-chain route choice behaviors of road users. The bilevel programming model is formulated based on theinteractions between signal timing control and trip-chain behavior, and a solution algorithm by combining variational inequalitysensitivity analysis, the generalized inverse matrix method, and a gradient projection approach revised for trip-chain user equilibriumis developed for the transportation design problem. The performance of the developed model framework was verified throughnumerical analysis under different test scenarios.

关键词： Signal timing design, bilevel programming model, trip-chain user equilibrium.

The effects of memantine on glutamic receptor associated nitrosative stress in a traumatic brain injury rat model

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The effects of memantine on glutamic receptor associated nit...

第十一届海峡两岸心血管科学研讨会、2017年全国心脑血管药理学术会议、中国卒中学会第一次新药研讨会

作者： Wang Chechuan Wee Hsiao-Yue hu Chiao-Ya Chio Chung-Ching kuo Jinn-Rung Chi-Mei Medical Center Center for General Education Southern Taiwan University of Science and Technology Department of Neurosurgery LiouyingChi-Mei Medical Center Medical Research Chi-Mei Medical Center Departments of Biotechnology Southern Taiwan University of Science and Technology

Background:The main aim of this study is to elucidate whether the neuroprotective effect of memantine,a non-competitive NMDA receptor 2 B(NR2 B) antagonist,affect neuronal nitrosative stress,apoptosis,and NR2 B expression and ultimately improve functional *** and methods:Immediately after the onset of fluid percussion TBI,anesthetized male Sprague-Dawley rats were divided into sham,TBI,and TBI+Memantine *** rats were treated

关键词： The effects of memantine on glutamic receptor associated nitrosative stress in a traumatic brain injury rat model

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基于分步体对角线法的数控机床空间误差补偿

航空制造技术 2023年第23期66卷 79-85页

作者：韩伟崔益铭刘阔陈玉峰陈虎王永青大连理工大学精密与特种加工教育部重点实验室大连116024 科德数控股份有限公司大连116600

空间误差的测量与补偿是提升机床加工精度的重要手段。本文采用一种基于激光多普勒位移测量仪的分步体对角线法测量辨识了机床的几何误差元素。然后,基于齐次坐标变换理论,建立了立式加工中心的空间误差模型,并采用离线修改G代码的方式... 详细信息

空间误差的测量与补偿是提升机床加工精度的重要手段。本文采用一种基于激光多普勒位移测量仪的分步体对角线法测量辨识了机床的几何误差元素。然后,基于齐次坐标变换理论,建立了立式加工中心的空间误差模型,并采用离线修改G代码的方式实施了机床空间误差补偿。与激光干涉仪多线法相比,分步体对角线法更加简便快捷,通过4次测试快速获得12项关键几何误差元素。误差测试与补偿试验结果表明,加工中心的整体精度水平有了大幅度提高,体对角线误差降低为原来的32.5%。

关键词：空间误差分步体对角线法误差补偿误差辨识齐次坐标变换矩阵

MTNR1B polymorphisms with CDKN2A and MGMT methylation status are associated with poor prognosis of colorectal cancer in Taiwan

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World Journal of Gastroenterology 2021年第34期27卷 5737-5752页

作者： Chia-Cheng Lee Yu-Cheng kuo Je-Ming hu Pi-Kai Chang Chien-An Sun Tsan Yang Chuan-Wang Li Chao-Yang Chen Fu-huang Lin Chih-Hsiung Hsu Yu-Ching Chou Division of Colorectal Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina Medical Informatics Office Tri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina School of Public Health National Defense Medical CenterTaipei 114TaiwanChina Department of Public Health College of MedicineFu-Jen Catholic UniversityNew Taipei City 24205TaiwanChina Big Data Research Center College of MedicineFu-Jen Catholic UniversityNew Taipei City 24205TaiwanChina Department of Health Business Administration Meiho UniversityPingtung 91202TaiwanChina Department and Graduate Institute of Microbiology and Immunology National Defense Medical CenterTaipei 114TaiwanChina Institute of Preventive Medicine National Defense Medical CenterNew Taipei City 237TaiwanChina

BACKGROUND Identifying novel colorectal cancer(CRC)prognostic biomarkers is crucial to helping clinicians make appropriate therapy *** plays a major role in managing the circadian rhythm and exerts oncostatic effects on different kinds of *** To explore the relationship between MTNR1B single-nucleotide polymorphism(SNPs)combined with gene hypermethylation and CRC *** A total of 94 CRC tumour tissues were *** for the four MTNR1B SNPs(rs1387153,rs2166706,rs10830963,and rs1447352)was performed using multiplex polymerase chain *** relationships between the MTNR1B SNPs and CRC 5-year overall survival(OS)was assessed by calculating hazard ratios with 95%*** All SNPs(rs1387153,rs2166706,rs10830963,and rs1447352)were correlated with decreased 5-year *** stratified analysis,rs1387153,rs10830963,and rs1447352 risk genotype combined with CDKN2A and MGMT methylation status were associated with 5-year OS.A strong cumulative effect of the four polymorphisms on CRC prognosis was *** haplotypes of MTNR1B SNPs were also associated with the 5-year ***1B SNPs combined with CDKN2A and MGMT gene methylation status could be used to predict shorter CRC *** The novel genetic biomarkers combined with epigenetic biomarkers may be predictive tool for CRC prognosis and thus could be used to individualise treatment for patients with CRC.

关键词： Colorectal cancer Melatonin Hypermethylation Polymorphism Prognosis Biomarker

EFFECT OF UV/OZONE TREATMENT ON PERVAPORATION PERFORMANCE OF PDMS MEMBRANES IN SEPARATION OF ISOPROPANOL AND WATER MIXTURES

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EFFECT OF UV/OZONE TREATMENT ON PERVAPORATION PERFORMANCE OF...

Transportation characteristics of δ^(13)C in the plants-soil-bedrock-cave system in Chongqing karst area

第四届国际高分子化学学术讨论会

作者： Chien-Chieh hu Ywu-Jang Fu kuo-Sung Liao Kueir-Rarn Lee Juin-Yih Lai Graduate school of Materials Applied Technology and Department of Chemical and Materials Engineering Nanya Institute of Technology R&D Center for Membr.Technol.and Department of Chemical Engineering Chung Yuan University Department of Biotechnology Vanung University

Effect of UV-ozone treatment on the performance of isopropanol dehydration by pervaporation through the PDMS membranes was investigated.X-ray photoelectron spectrometer（XPS）and water contact angle were used to characterize the chemical compositions and hydrophilicity of the surface layer of the modified PDMS *** was found that the O/Si atomic ratio of PDMS surface layer increased with increasing UV-ozone treatment time,but C/Si atomic ratio decreased with treatment *** formation of silica like surface layer improved the selectivity of PDMS membrane.

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Science China Earth Sciences 2012年第4期55卷 685-694页

作者： Li TingYong Li HongChun Xiang XiaoJing kuo Tz-Shing Li JunYun Zhou FuLi Chen HongLi Peng LingLi School of Geographical Sciences Southwest UniversityChongqing 400715China State Key Laboratory of Loess and Quaternary Geology Institute of Earth EnvironmentChinese Academy SciencesXi'an 710075China Key Laboratory of the Three Gorges Reservoir Region's Eco-Environment Chongqing University and Southwest UniversityMinistry of EducationChongqing 400715China Department of Geosciences Taiwan UniversityTaipei 10617Taiwan Department of Earth Sciences Cheng-Kung UniversityTainan 70101Taiwan

Here we use an analytical method to determine δ13C in local plants and organic matter in the soils above Furong cave,Chongqing,*** also monitored δ13C in dissolved inorganic carbon(DIC) of drip water,δ13C of active deposits under the drip waters,and the concentration of air CO2(PCO2).Based on these,we preliminarily studied the transportation characteristics of stable carbon isotope(13C) in cave system of the subtropical karst *** average δ13C value of 27 local plant samples,which belong to 16 families,was -32‰ and the weighted δ13C for surface dry biomass was -33‰.We found that for 54 soil samples collected from 5 soil profiles,δ13C of soil organic matters was -22‰,which could be attributed to the different transportation rates of stable carbon isotopes during the decomposition of plants and organic matters in *** relatively lighter 12C tended to transfer into gaseous CO2,which made the relatively heavier 13C concentrated in the *** the basis of monitoring of DIC-δ13C in drip waters from July 2009 to June 2010,we found that values in winter months were heavier and values in summer months were lighter in general,the reason of which was that in summer months,both the temperature and the humidity were comparatively higher,resulted in more CO2 with lighter δ13C generated from organic matters decomposition and plants *** average DIC -δ13C value was -11‰,about 11‰ heavier than the δ13C of organic matters in soils,which proved that part of DIC in cave drip water was sourced from dissolution of inorganic carbonate(host rock,with heavier δ13C).As for the δ13C of active deposits at five drip water sites in Furong cave,they had almost the same variation with relatively light *** other words,these active speleothems were deposited at equilibrium conditions for isotopic *** results suggest that the carbon isotopic information of speleothems could be used to track the evolution of local vegetation in certain situations.

关键词：洞穴滴水中国土壤植物样本岩溶地区交通特性系统二氧化碳浓度稳定碳同位素