MTNR1B polymorphisms with CDKN2A and MGMT methylation status are associated with poor prognosis of colorectal cancer in Taiwan

作     者：Chia-Cheng Lee Yu-Cheng Kuo Je-Ming Hu Pi-Kai Chang Chien-An Sun Tsan Yang Chuan-Wang Li Chao-Yang Chen Fu-Huang Lin Chih-Hsiung Hsu Yu-Ching Chou 

作者机构：Division of Colorectal SurgeryDepartment of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina Medical Informatics OfficeTri-Service General HospitalNational Defense Medical CenterTaipei 114TaiwanChina School of Public HealthNational Defense Medical CenterTaipei 114TaiwanChina Department of Public HealthCollege of MedicineFu-Jen Catholic UniversityNew Taipei City 24205TaiwanChina Big Data Research CenterCollege of MedicineFu-Jen Catholic UniversityNew Taipei City 24205TaiwanChina Department of Health Business AdministrationMeiho UniversityPingtung 91202TaiwanChina Department and Graduate Institute of Microbiology and ImmunologyNational Defense Medical CenterTaipei 114TaiwanChina Institute of Preventive MedicineNational Defense Medical CenterNew Taipei City 237TaiwanChina 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2021年第27卷第34期

页      面：5737-5752页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：the grant from the Ministry of National Defense-Medical Affairs Bureau Taiwan No.MND-MAB-110-109 and No.MND-MAB-D-111059 

主　　题：Colorectal cancer Melatonin Hypermethylation Polymorphism Prognosis Biomarker 

摘      要：BACKGROUND Identifying novel colorectal cancer(CRC)prognostic biomarkers is crucial to helping clinicians make appropriate therapy *** plays a major role in managing the circadian rhythm and exerts oncostatic effects on different kinds of *** To explore the relationship between MTNR1B single-nucleotide polymorphism(SNPs)combined with gene hypermethylation and CRC *** A total of 94 CRC tumour tissues were *** for the four MTNR1B SNPs(rs1387153,rs2166706,rs10830963,and rs1447352)was performed using multiplex polymerase chain *** relationships between the MTNR1B SNPs and CRC 5-year overall survival(OS)was assessed by calculating hazard ratios with 95%*** All SNPs(rs1387153,rs2166706,rs10830963,and rs1447352)were correlated with decreased 5-year *** stratified analysis,rs1387153,rs10830963,and rs1447352 risk genotype combined with CDKN2A and MGMT methylation status were associated with 5-year OS.A strong cumulative effect of the four polymorphisms on CRC prognosis was *** haplotypes of MTNR1B SNPs were also associated with the 5-year ***1B SNPs combined with CDKN2A and MGMT gene methylation status could be used to predict shorter CRC *** The novel genetic biomarkers combined with epigenetic biomarkers may be predictive tool for CRC prognosis and thus could be used to individualise treatment for patients with CRC.