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Fluorescence lifetime imaging of molecular rotors to map microviscosity in cells

Chinese Optics Letters 2010年第10期8卷 926-930页

作者： James A. Levitt Marina K. Kuimova Gokhan Yahioglu Pei-Hua Chung klaus suhling David Phillips Department of Physics King's College London Department of Chemistry Imperial College London PhotoBiotics Ltd.

Fluorescence liftime imaging （FLIM） of modified hydrophobic bodipy dyes that act as fluorescent molecular rotors shows that the fluorescence lifetime of these probes is a function of the microviscosity of their environment. Incubating cells with these dyes, we find a punctate and continuous distribution of the dye in cells. The viscosity value obtained in what appears to be endocytotic vesicles in living cells is around 100 times higher than that of water and of cellular ***-resolved fluorescence anisotropy measurements also yield rotational correlation times consistent with large microviscosity values. In this way, we successfully develop a practical and versatile approach to map the microviscosity in cells based on imaging fluorescent molecular rotors.

关键词： Fluorescence lifetime imaging of molecular rotors to map microviscosity in cells

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Spontaneous emission in non-local materials

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Light(Science & Applications) 2016年第1期5卷 1-10页

作者： Pavel Ginzburg Diane J Roth Mazhar E Nasir Paulina Segovia Alexey V Krasavin James Levitt Liisa M Hirvonen Brian Wells klaus suhling David Richards Viktor A Podolskiy Anatoly V Zayats Department of Physics King’s College LondonStrandLondon WC2R 2LSUK Present address:School of Electrical Engineering Tel Aviv UniversityTel Aviv 69978Israel Department of Physics and Applied Physics University of Massachusetts LowellOne University AveLowellMA 01854USA Present address:Department of Physics University of HartfordWest HartfordCT 06117USA

Light–matter interactions can be strongly modified by the surrounding ***,we report on the first experimental observation of molecular spontaneous emission inside a highly non-local metamaterial based on a plasmonic nanorod *** show that the emission process is dominated not only by the topology of its local effective medium dispersion,but also by the non-local response of the composite,so that metamaterials with different geometric parameters but the same local effective medium properties exhibit different Purcell factors.A record-high enhancement of a decay rate is observed,in agreement with the developed quantitative description of the Purcell effect in a non-local *** engineered material non-locality introduces an additional degree of freedom into quantum electrodynamics,enabling new applications in quantum information processing,photochemistry,imaging and sensing with macroscopic composites.

关键词： composite electromagnetic materials non-local optical properties plasmonic metamaterials quantum electrodynamics spontaneous emission

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