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<i>Low Dose</i>Irbesartan Has a Renoprotective Effect as High Dose Ramipril in Diabetic Rats Treated with Insulin

Open Journal of Endocrine and Metabolic Diseases 2015年第11期5卷 149-161页

作者： Abdulmonim A. Alqasim sami H. Hammadi Ghazi A. Bamagous Essam Eldin M. Noureldin Hussam H. Madi Department of Physiology Faculty of Medicine Umm-Alqura University Makkah Saudi Arabia Department of Internal Medicine Faculty of Medicine Umm-Alqura University Makkah Saudi Arabia Department of Pharmacology & Toxicology Faculty of Medicine Umm-Alqura University MakkahSaudi Arabia Department of Biochemistry Faculty of Medicine Umm-Alqura University Makkah Saudi Arabia Department of Pathology Faculty of Medicine Umm-Alqura University Makkah Saudi Arabia

Objectives: The aim of this study is to compare the efficacy of the anti-angiotensinic drug, ramipril and irbesartan on the vascular protection of kidneys of streptozotocin (STZ)-induced diabetic rats (DR). Methods: 110 male albino rats were divided into 7 main groups. Group-1 (10 normal control rats;NC). Group-2 (10 rats) was injected intra-peritoneally with STZ (Diabetic Rats;DR). Group-3 (10 DR) is controlled by insulin. Groups 4 to 7 (20 DR), each is subdivided into two subgroups that received either low or high dose of ramipril or irbesartan with or without insulin. Two months post treatment, rat-tail blood was collected to measure: Fasting blood sugar, HbA1c, total serum proteins, albumin and lipid profiles. Urine was collected to measure albuminuria. Kidneys were isolated for histopathological study. Results: Biochemically, both ramipril and irbesartan (without insulin) lowered albumin concentration in urine samples especially at high doses. Histopathologically, there is no beneficial response of both drugs without insulin. Combination of insulin together with either drug has beneficial effects biochemically and histopathologically at high doses. Low dose irbesartan only has renoprotective effect in DR treated with insulin. The other biochemical parameters showed negligible response to both drugs. Conclusion: Low dose irbesartan and high doses of both drugs have renoprotective effect in DR treated with insulin.

关键词： Diabetic Nephropathy Albuminurea Ramipril Irbesartan

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Primary Thyroid Non-Hodgkin’s Lymphoma

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Open Journal of Pathology 2015年第4期5卷 114-116页

作者： Madiha Mahfoudhi Khaled Khammassi Imen Gorsane Mounira El Euch sami Turki Mamia Ben Salah Taieb Ben Abdallah Department of Internal Medicine Charles Nicolle Hospital Tunis Tunisia Department of Oto-Rhino-Laryngology Charles Nicolle Hospital Tunis Tunisia

Primary non-Hodgkin’s lymphoma of the thyroid gland was rarely described. We report the case of a 44-year-old man admitted for an anterior neck swelling, hoarseness and dyspnea. The chest radiograph showed a trachea deviation. He had no clinical, biological or radiological sign of other lymphoma locations. Ultrasound examination of the neck revealed a bilateral heterogeneous thyroid lesion. Cytology revealed lymphoid cells having high nuclear-cytoplasmic ratio with multiple and irregular nucleoli. An urgent thyroid surgery consisting of total thyroidectomy had been performed since the presence of compressive signs due to the tumor. The histopathological examination of a biopsy from the thyroid tissue confirmed a high-grade non-Hodgkin’s lymphoma. Then, L-thyroxin substitution therapy, chemotherapy and radiotherapy were initiated. A prolonged remission was noted.

关键词： Thyroid Gland Lymphoma Immunohistochemistry

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Adult Onset Still’s Disease: Articular Manifestations in Twenty Cases

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Open Journal of Clinical Diagnostics 2015年第2期5卷 41-45页

作者： Madiha Mahfoudhi Imen Gorsane Amel Gaieb Battikh Rafik Shimi sami Turki Fathi Ben Hamida Taieb Ben Abdallah Internal medicine A department.Charles Nicolle Hospital TunisTunisia Research Unit of Kidney Diseases(LR00SP01) Charles Nicolle HospitalTunisTunisia

The adult onset Still’s disease is a rare inflammatory pathology of unknown pathogeny. The clinical features are variable. The diagnosis is difficult since exclusion of infectious, systemic and tumoral pathologies should be done. The articular complications are frequent and can be revelatory of this pathology. The articular prognosis depends on the diagnosis delay and the treatment efficiency. Our study aims to analyze different aspects of articular manifestations complicating adult onset Still’s disease to define epidemiological, clinical and evolving characteristics of these complications. It was a cross-sectional study concerning 20 cases of adult onset Still’s disease diagnosed from 1990 to 2015 in the internal medicine A department of Charles Nicolle Hospital in Tunis, meeting Yamaguchi criteria. We identified clinical, radiological, evolving and therapeutic profile of the articular manifestations occurred in these patients. There were 13 women and 7 men. The average age was 25 years. The arthralgias were reported in all cases;while, the arthritis interested fifteen patients. A hand deformation was found in four patients. A wrist ankylosis was noted in one case and a flexion elbow in one patient. The standard articular radiographs were normal in twelve cases. The treatment associated essentially non-steroidal anti-inflammatory and/or corticosteroids and/or methotrexate. Concerning the evolving profile, the monocyclic form was present in 25% of the cases, the intermittent form in 45% and the chronic articular form in 30% of our patients. The adult onset Still’s disease is rare and heterogeneous. The articular disturbances are frequent and have various outcomes.

关键词： Adult Onset Still’s Disease Arthritis Fever Corticosteroids Biotherapy Prognosis

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Behavior and Flexural Prediction of Special Cementitious Bonding Material for Fiber Reinforced Strengthening Systems

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Journal of Civil Engineering and Architecture 2017年第3期11卷 232-239页

作者： Judy M. I. Soliman Tarek K. Hassan Amr A. Abdelrahman Osama Hamdy sami H. Rizkalla Civil Engineering at the Concrete Unit Faculty of Engineering Ain Shams University Cairo 1156 Egypt Civil Engineering &Construction Director of the Constructed Facilities Laboratory (CFL) North Carolina State University Raleigh Campus Box 7533 2414 Campus Shore Drive Raleigh NC USA

Strengthening of RC structures with externally bonded FRP （fiber reinforced polymers） has become an important challenge in civil engineering. Epoxy is the main bonding agent used so far, but in the case of a fire, it is subjected to complete loss of his bonding capabilities. Mineral based composites strengthening systems consist of FRPs and a cementitious bonding agent which form a repair or strengthening system that is more compatible with the concrete substrata, and roved its efficiency. The current research introduces the use of a special cementitious material ＂Grancrete＂ as a bonding agent. Test results of 32 T-section RC beams strengthened with various FRG （fiber reinforced Grancrete） strengthening systems are presented. The results demonstrated that most of the specimens were likely to fail by debonding of the FRP from the concrete either at the ends or at intermediate flexural cracks. This paper presents an in-depth study aimed at the development of a better understanding of debonding failures in RC beams strengthened with externally bonded FRP systems. Different analytical models, published in the literature for plate end debonding, are reviewed and compared to test results. The results also demonstrated that when using U-wraps, the specimens were likely to fail by FRP sheet rupture.

关键词： C Beam concrete debonding intermediate crack debonding FRP Grancrete strengthening.

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Modeling the Spatio-Temporal Dynamics of Local Context for a Contextualized Diffusion of Agroecological Intensification Options in Niger

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International Journal of Geosciences 2024年第3期15卷 270-301页

作者： Nouhou Salifou Jangorzo Maud Loireau Abou-Souﬁanou Sadda Ousmane sami Mari Abdoul-Aziz Saïdou Hassane Bil-Assanou Issoufou Département des Sciences du Sol et Télédétection Université Dan Dicko Dankoulodo de Maradi UMR DAP Maradi Niger Unité mixte de Recherche Diversité et Adaptation des Plantes (UMR DAP) Université Dan Dicko Dankoulodo de Maradi Maradi Niger Institut de Recherche pour le Développement UMR Espace-DEV Université de Perpignan Via Domitia (UPVD) Perpignan France Institut de Recherche pour le Développement Représentation Niamey Niger Centre Imaan de Support en Recherche Transdisciplinaire UMR DAP/UDDM Niamey Niger Département des Sciences et Techniques de Productions Végétales Université Dan Dicko Dankoulodo de Maradi UMR DAP Maradi Niger

Spatio-temporal variability and dynamics in Sahelian agro-pastoral zones make each local situation a special case. These specificities must be considered to guide the dissemination of agricultural options with a view to sustainable development. The territorial scale of municipalities is not sufficient for this necessary contextualization;the scale of the “village terroir” seems to be a better option. This is the hypothesis we put forward in the framework of the Global Collaboration for Resilient Food Systems program (CRFS), i.e. local context is spatially defined by village terroir. The study is based on data collected through participatory mapping and surveys in “village terroirs” in three regions of Niger (Maradi, Dosso and Tillabéri). Then the links between farm managers and their cultivated land, as well as the spatio-temporal dynamics of local context are analyzed. This study provides evidence of the existence and functional usefulness of the village terroir for farmers, their land management and their activities. It demonstrates the usefulness of contextualizing agricultural options at this scale. Their analysis elucidates the links between “terroirs village” and the specific functioning of the agrosocio-ecosystems acting on each of them, thus laying the systemic and geographical foundations for a model of the spatio- temporal dynamics of “village terroirs”. This initial work has opened up new perspectives in modeling and sustainable development.

关键词： Niger Option by Context Local Condition Complex System Multiscale Conceptual Modeling

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Minimally Invasive Hind-Foot Fusion in Charcot Patients

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Open Journal of Orthopedics 2023年第11期13卷 477-484页

作者： sami Nogdallah Mohanad Osman Ibrahim Abd-Elseed Alaa Mohamed Mohamed Khairy Osama Gamal Nubi Montaser Fatooh Hozifa Mohammed Ali Abd-Elmaged Department of Orthopedics Alneelain University Khartoum Sudan Department of Orthopedics Orthopaedic Registrar Sudan Medical Specialization Board Khartoum Sudan Department of Orthopedics Bashaer University Hospital MBBS Al Neelan University Khartoum Sudan Department of Orthopedics Alzaiem Alazhari University Khartoum Sudan

Background: Hindfoot fusion, is a fusion of the talonavicular, talocalcaneal, and calcaneocuboid joints and is commonly performed for patients complaining of pain, chronic instability and gross deformity as a result of hindfoot pathology. Objective: This study aimed to assess the functional outcomes of the patients underwent hindfoot fusion, the post-operative complications and patient’s satisfaction. Methodology: This study is a prospective cohort study was conducted in Future hospital, in Khartoum, Sudan. It involved 30 patients from July 2015-July 2022. Data was collected by the primary researcher using data collection sheet, then it was cleaned and entered into Microsoft excel data sheet and was analysed using SPSS version 28 software. Results: 33.3% of the patients are aged 51 - 60 years, and >60 years. Male: Female equals 1:1. 56.7% are for the left side, only 23.3% developed complications. 63.3% patients are fully satisfied. There is a significant correlation between the AOFAS score before and after the operation. Also, a significant correlation between the means of AOFAS score after with the complications and the satisfaction of the patients. Conclusion: Minimally invasive tibio-talo-calcaneal is an alternative procedure for the treatment of severe Charcot arthropathy of the ankle. The expected functional outcome is impressive and comparable with the open surgery. However, the post-operative complications are prevalent in 23.3% of patients. Most candidates are fully satisfied with the procedure.

关键词： Ankle Sudan Patient Satisfaction Arthropathy Neurogenic

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生物多样性和碳存储政策:对欧洲生活用纸行业的影响

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生活用纸 2023年第11期23卷 31-32页

作者： Hampus Morner Carolina Berg-Rustas sami Pastila AFRY咨询公司

由于欧盟目前正在对可持续发展和林业政策进行大规模的调整,对于生活用纸等行业来说,可能无法再像以前那样使用木浆纤维。本文详述了政策调整对欧洲木浆纤维供应以及生活用纸行业的潜在影响。

关键词：木浆纤维林业政策生活用纸可持续发展碳存储生物多样性潜在影响欧洲

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New Nodule-Newer Etiology

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World Journal of Transplantation 2016年第1期6卷 215-219页

作者： Atul C Mehta Juan Wang sami Abuqayyas Puneet Garcha Charles Randy Lane Wayne Tsuang Marie Budev Olufemi Akindipe Respiratory Institute Cleveland Clinic

AIM: To evaluate frequency and temporal relationship between pulmonary nodules(PNs) and transbronchial biopsy(TBBx) among lung transplant recipients(LTR). METHODS: We retrospectively reviewed 100 records of LTR who underwent flexible bronchoscopy(FB) with TBBx, looking for the appearance of peripheral pulmonary nodule(PPN). If these patients had chest radiographs within 50 d of FB, they were included in the study. Data was compared with 30 procedures performed among non-transplant patients. Information on patient's demographics, antirejection medications, anticoagulation, indication and type of lung transplantation, timing of the FB and the appearance and disappearance of the nodules and its characteristics were ***: Nineteen new PN were found in 13 procedures performed on LTR and none among nontransplant patients. Nodules were detected between 4-47 d from the procedure and disappeared within 84 d after appearance without ***: FB in LTR is associated with development of new, transient PPN at the site of TBBxin 13% of procedures. We hypothesize that these nodules are related to local hematoma and impaired lymphatic drainage. Close observation is a reasonable management approach.

关键词： Peripheral pulmonary nodule Flexible bronchoscopy Transbronchial biopsy Lung transplant

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Metabolomic profiling revealed general and specific chemical elicitors of rice defense response against Magnaporthe oryzae

Metabolomic profiling revealed general and specific chemical...

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中国植物病理学会第十一届全国会员代表大会暨2018年学术年会

作者： Justice Norvienyeku Lin Lili sami Rukaiya Aliyu Chen Xiaomin LinLianyu Franklin Jagero ZhouJie Wang Zonghua Fujian University Key Laboratory for Plant-Microbe Interaction the School of Life SciencesCollege of Plant ProtectionFujian Agriculture and Forestry University State Key Laboratory for Ecological Pest Control of Fujian and Taiwan Crops College of Plant ProtectionFujian Agriculture and Forestry University Minjiang University

Generally,plants exposed to persistent irritations from microbial pathogens,insect pest,parasitic plants and unfavorable environmental factors(biotic and abiotic stress) tend to generate and accumulate a host of phytochemicals(secondary metabolites) in different tissues as reactive chemicals to ward-off or kill invading pathogens and *** secondary metabolites also serve as a signaling cue for initiating hormonal signaling processes necessary for mitigating their successful adaptation and subsequent survival under harsh environmental *** metabolomics studies identified metabolomics divergence between japonica and indica rice *** insights gained from population genetic studies as well as rice blast disease epidemiology studies showed that japonica and indica rice species exhibit different levels of resistance and susceptibility against cosmopolitan and the most economically destructive rice blast pathogen ***,the impact of metabolomics differentiations on differential resistance of different rice cultivars from japonica and indica species against *** is still not well *** this study,we used UPLC-TOFF mediated non-targeted whole metabolome profiling techniques to investigate metabolomics divergence prevailing between whole leaf tissues and leaf trichome of four homogeneously susceptible and five differentially resistant rice cultivars from both japonica and indica *** also monitored differential *** mediated metabolomics reprogramming and reconstitution events occurring in respective rice cultivars during host-pathogen *** study identified set of metabolites that functions as phytochemicals in susceptible and resistant rice species under infection,among the disease resistance related phytochemicals identified exclusively resistant rice seedlings inoculated with the blast fungus includes,sakuranin(sakuranetin) and other reactive *** leaf trichome metabolome an

关键词： Phytochemical Saponin Metabolomics reprogramming UPLC-TOFF

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Species of Lasiodiplodia associated with papaya stem-end rot in Brazil

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Fungal Diversity 2014年第4期67卷 127-141页

作者： Mariote S.B.Netto Iraíldes P.Assuncao Gaus S.A.Lima Marília W.Marques Waléria G.Lima Jean H.A.Monteiro Valdir de Queiroz Balbino sami J.Michereff Alan J.L.Phillips Marcos P.S.Camara Departamento de Agronomia Universidade Federal Rural de Pernambuco52171-900 RecifePernambucoBrazil Centro de Ciencias Agrárias Universidade Federal de Alagoas57100-000 Rio LargoAlagoasBrazil Departamento de Genética Universidade Federal de Pernambuco50732-970 RecifeBrazil Centro de Recursos Microbiológicos Departamento de Ciencias da VidaFaculdade de Ciencias e TecnologiaUniversidade Nova de Lisboa2829-516 CaparicaPortugal

This study aims to identify and characterize species of Lasiodiplodia associated with stem-end rot of papaya in six different populations in the Northeast of *** identifications were made using a combination of morphology together with a phylogenetic analysis based on partial translation elongation factor 1-αsequence(EF-1α)and internal transcribed spacers(ITS).Five species of Lasiodiplodia were identified:Lasiodiplodia brasiliense ***.,***,*** ***.,*** and *** *** had previously been reported in papaya,while all the other species are reported for the first time in association with this host in Brazil and *** theobromae was the most prevalent *** species of Lasiodiplodia were pathogenic on papaya fruit,with *** being the most virulent.

关键词： Botryosphaeriaceae Carica papaya Fruit rot EF1-α ITS Phylogeny Virulence

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