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Effects of Microstructural Modification Using Friction Stir Processing on Fatigue Strength of Butt-Welded Joints for High-Strength Steels

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Materials Sciences and Applications 2018年第7期9卷 625-636页

作者： Hajime Yamamoto kazuhiro ito Joining and Welding Research Institute Osaka University Osaka Japan

Friction stir processing (FSP) is an effective surface-microstructure modification technique using a rotational tool to refine and homogenize microstructure of metallic materials. In this study, FSP was conducted on the surface of the heat-affected zone (HAZ), which is a region exhibiting degraded mechanical properties and shown to have microstructural changes, of butt-welded joints for two high-strength steels with tensile strength grades of 490 MPa and 780 MPa (hereafter HT490 and HT780, respectively). Inhomogeneous mixing of materials derived from weld metals and base metals (BMs) in a stir zone (SZ) produced inhomogeneous distribution of elements and microstructure depending on the set of the advancing side and retreating side in the SZs. The welded joints with FSP for HT490 exhibited higher hardness than that of the BM through whole of the SZ surface (fine polygonal ferrite grains and bainite structure with laths at the Mn-rich and Mn-poor regions, respectively). On the other hand, those for HT780 exhibited the minimum hardness value similar to that of the BM at the SZ surface (a few polygonal ferrite grains in the matrix of martensite laths). Fatigue strength increased by about 35 MPa and 15 MPa in stress amplitude at 107 cycles as fatigue limit due to FSP. Fatigue failure occurred at the BM and the SZ, respectively, in the welded joints modified by FSP for HT490 and HT780, in comparison with the HAZs in the as-welded joints for both grade steels. The difference in fatigue strength increase due to FSP and failure location between the welded joints for HT490 and HT780 can be attributed to the topmost SZ microstructures and their distribution.

关键词： Friction Stir Processing (FSP) High-Strength Steel Fatigue Strength Grain Refinement Post-Weld Treatment

Outpatient hybrid endoscopic submucosal dissection with SOUTEN for early gastric cancer,followed by endoscopic suturing of the mucosal defect:A case report

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World Journal of Gastrointestinal Surgery 2023年第8期15卷 1831-1837页

作者： Renma ito kazuhiro Miwa Yutaka Matano Internal Medicine Komatsu Municipal HospitalKomatsu 923-0961Japan

BACKGROUND Although endoscopic submucosal dissection(ESD)is becoming more common for early gastric cancer,it requires more advanced techniques and a longer treatment duration than endoscopic mucosal *** ESD using a multifunctional snare(SOUTEN)has been reported to be effective for colorectal lesions,as it can reduce treatment *** suturing of post-ESD mucosal defects has been reported to reduce the incidence of ESD-related *** SUMMARY This study reports outpatient hybrid ESD for early gastric cancer using SOUTEN,followed by endoscopic suturing of post-ESD mucosal defects in an 86-year-old *** referral for ESD,a 10-mm flat,depressed lesion was found on the posterior wall of the gastric antrum,the depth of which was expected to be *** his history of delirium,we performed outpatient endoscopic *** procedure used was hybrid ESD using SOUTEN to reduce the duration of treatment and endoscopic suturing of post-ESD mucosal ESD defects to reduce *** procedure time was 62 min and the lesion was completely resected based on histopathological examination,with no reported postoperative *** This safe and useful procedure may be especially important for outpatient endoscopic treatment.

关键词： Outpatient treatment Hybrid endoscopic submucosal dissection Multifunctional snare Early gastric cancer Endoscopic suturing Case report

Diagnosis and management of insulinoma

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World Journal of Gastroenterology 2013年第6期19卷 829-837页

作者： Takehiro Okabayashi Yasuo Shima Tatsuaki Sumiyoshi Akihito Kozuki Satoshi ito Yasuhiro Ogawa Michiya Kobayashi kazuhiro Hanazaki Department of Surgery Kochi Health Sciences CenterKochi 781-8555Japan Department of Radiology Kochi Medical SchoolNankoku 783-8505Japan Department of Surgery Kochi Medical SchoolNankoku 783-8505Japan

Insulinomas,the most common cause of hypoglycemia related to endogenous hyperinsulinism,occur in 1-4 people per million of the general *** autonomic symptoms of insulinoma include diaphroresis,tremor,and palpitations,whereas neuroglycopenenic symptoms include confusion,behavioural changes,personality changes,visual disturbances,seizure,and *** of suspected cases is based on standard endocrine tests,especially the prolonged fasting ***-invasive imaging procedures,such as computed tomography and magnetic resonance imaging,are used when a diagnosis of insulinoma has been made to localize the source of pathological insulin *** modalities,such as endoscopic ultrasonography and arterial stimulation venous sampling,are highly accurate in the preoperative localization of insulinomas and have frequently been shown to be superior to noninvasive localization *** range of techniques available for the localization of insulinomas means thatblind resection can be *** manual palpation of the pancreas by an experienced surgeon and intraoperative ultrasonography are both sensitive methods with which to finalize the location of insulinomas.A high proportion of patients with insulinomas can be cured with *** patients with malignant insulinomas,an aggressive medical approach,including extended pancreatic resection,liver resection,liver transplantation,chemoembolization,or radiofrequency ablation,is recommended to improve both survival and quality of *** patients with unresectable or uncontrollable insulinomas,such as malignant insulinoma of the pancreas,several techniques should be considered,including administration of ocreotide and/or continuous glucose monitoring,to prevent hypoglycemic episodes and to improve quality of life.

关键词： Pancreas Insulinoma Neuroendocrine pancreatic tumor Diagnosis Management Continuous blood glucose monitoring

Microarray Analysis of the Developing Rat Mandible

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Acta Biochimica et Biophysica Sinica 2007年第6期39卷 399-405页

作者： Hideo KABURAGI Naoyuki SUGANO Maiko OSHIKAWA Ryosuke KOSHI Naoki SENDA kazuhiro KAWAMOTO Koichi ito Department of Periodontology. Nihon University School of Dentistry Tokyo 101-8310 Japan Department of Periodontology. Nihon University School of Dentistry Tokyo 101-8310 Japan Division of Advanced Dental Treatment Dental Research Center Nihon University School of Dentistry Tokyo 101-8310 Japan Department of Periodontology. Nihon University School of Dentistry Tokyo 101-8310 JapanDivision of Advanced Dental Treatment Dental Research Center

To analyze the molecular events that occur in the developing mandible, we examined the expression of 8803 genes from samples taken at different time points during rat postnatal mandible development. Total RNA was extracted from the mandibles of 1-day-old, 1-week-old, and 2-week-old rats. Complementary RNA (cRNA) was synthesized from cDNA and biotinylated. Fragmented cRNA was hybridized to RGU34A GeneChip arrays. Among the 8803 genes tested, 4344 were detectable. We identified 148 genes with significantly increased expression, and 19 genes with significantly decreased expression. A comprehensive analysis appears to be an effective method of studying the complex process of development.

关键词： gene expression microarray rat mandible

Compared with insulin glargine, insulin degludec narrows the day-to-day variability in the glucose-lowering effect rather than lowering blood glucose levels

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Journal of Diabetes Mellitus 2013年第4期3卷 244-251页

作者： Susumu Ogawa kazuhiro Nako Masashi Okamura Miho Senda Takuya Sakamoto Sadayoshi ito Division of Nephrology Endocrinology and Vascular Medicine Tohoku University Hospital Sendai Japan

Background: Changes in the day-to-day variability in the glucose-lowering effect of insulin [fluctuations of blood glucose levels (BG) seen during the same time period] that occur when insulin glargine (glargine) is replaced with insulin degludec (degludec) have not been sufficiently evaluated. Subjects: Five diabetics with unstable BG undergoing basal-bolus treatment using insulin glargine as basal insulin. Methods: Basal insulin was changed from glargine to same-dose degludec. The subjects’ HbA1c, glycoalbumin, and 1.5-anhydro-D-glucitol were measured before and after the switchover. Fasting blood glucose concentration (FBG) and predinner blood glucose concentration (PDBG) were measured continuously for 28 days immediately before the switchover, and 28 days immediately thereafter, to compare and evaluate 1) the changes in their mean values and standard deviations (SDs) before and after the switchover, and 2) the frequency of appearance of BG of over 180 mg/dL (BG ≥ 180) and under 70 mg/dL (BG Results: The levels of HbA1c, glycoalbumin, FBG’s mean value, SDs, BG ≥ 180 and BG Conclusion: The possibility was shown that degludec, to a greater extent than glargine, suppressed daily fluctuations of FBG and PDBG, suppressed the occurrence frequency of hyperglycemia and hypoglycemia, and exerted more steady hypoglycemic actions.

关键词： Degludec Glargine Hyperglycemia Hypoglycemia The Day-to-Day Variability in the Glucose-Lowering Effect of Insulin

Effect of zinc supplementation in patients with type C liver cirrhosis

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Open Journal of Gastroenterology 2011年第2期1卷 28-34页

作者： kazuhiro Katayama Mitsuru Sakakibara Kazuho Imanaka Kazuyoshi Ohkawa Takashi Matsunaga Masafumi Naito Toshifumi ito 不详

Zinc is often deficient in patients with liver cirrhosis, and treatment with zinc provides short-term improvement in protein metabolism. However, the long-term effects of zinc have not been fully clarified. The present study aimed to analyze the effect of zinc on the long-term clinical course, especially hepatocarcinogenesis, in type C liver cirrhosis. Am- ong patients with type C liver cirrhosis visiting our hospital between June 1998 and January 2009, th- ose with a serum albumin level ≤3.5 g/dL and a serum zinc level ≤70 μg (1.07 μmol)/dL were selected. Thirty-seven patients were randomly divided into 2 groups: group B (12 g/day branched-chain amino acid granules) and group BZ (same as group B plus 100 mg/day - 600 mg/day zinc sulfate or 150 mg/day - 225 mg/day polaprezinc). Multivariate analysis revealed that the administration of zinc was not a significant determinant, but pretreatment serum zinc levels (hazard ratio [HR], 0.921;95% confidence interval [CI], 0.853–0.994) and serum zinc levels less than 80 μg (1.22 μmol)/dL 12 months after beginning this study (HR, 6.866;95% CI, 1.399 - 33.707) were significant determinants of carcinogenesis and death. Serum albumin levels in patients whose serum zinc levels had not increased up to 80 μg/dL by the third year of this study were significantly lower (p = 0.023) than those of patients that had increased up to 80 μg/dL. Conclusions: In type C liver cirrhosis with zinc deficiency, administration of zinc does not improve cancer-free survival. However, serum zinc levels can predict outcomes in patients with type C liver cirrhosis. However, although zinc may play a role in hepatocarcinogenesis, the precise implications remain to be clarified.

关键词： Hepato-Carcinogenesis Trace Element Protein Metabolism

Urinary type IV collagen excretion predicts an increased urinary albumin-to-creatinine ratio in normoalbuminuric patients with diabetes

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Journal of Diabetes Mellitus 2012年第4期2卷 413-426页

作者： Susumu Ogawa Masato Matsushima Masashi Okamura Miho Senda Takuya Sakamoto kazuhiro Nako Sadayoshi ito Division of Clinical Epidemiology Jikei University School of Medicine Tokyo Japan Division of Nephrology Endocrinology and Vascular Medicine Tohoku University Hospital Sendai Japan

Aims: We evaluated whether urinary excretion of type IV collagen (U-COL) may predict an increase in the urinary albumin-to-creatinine ratio (ACR) and what factors regulate U-COL in 145 normoalbuminuric patients with type 2 diabetes. Methods: We measured HbA1c, systolic blood pressure (SBP), urinary 8-hydroxydeoxyguanosine (8-OHdG) and monocyte chemoattractant protein (MCP)-1 at start of this study (Baseline), ACR and U-COL in addition to these measurements at one year later (Evaluation-1), and ACR and SBP after two years of the Evaluation-1 (Evaluation-2). The relationships were investigated between the increase of ACR and the U-COL. The effect of angiotensin receptor blockers (ARB) treatment on the correlations between U-COL and ACR at Evaluation-2 on one hand, and between U-COL and percent change of ACR on the other, was also analyzed. Furthermore, we investigated whether the increase in 8-OHdG and in MCP-1 in a year prior to the Evaluation-1 were risk factors of the rise in U-COL levels. Results: Both U-COL and SBP at Evaluation-1, but not ARB treatment, were independent risk factors for an increased ACR after 2 years. ARB treatment significantly suppressed the increase in ACR after 2 years in patients with higher U-COL excretion. The percentage changes in 8-OHdG (%8-OHdG) and MCP-1 (%MCP-1) in one year prior to Evaluation-1 measurements are independent risk factors for U-COL. HbA1c and SBP values one year prior to Evaluation-1 are independent risk factors not only for %8-OHdG but also, for baseline U-COL. The %8-OHdG is an independent risk factor for %MCP-1. Conclusions: U-COL may predict an increase in the ACR. The U-COL seems to be increased with oxidative stress and inflammation induced by past hyperglycemia.

关键词： Type IV Collagen Diabetic Nephropathy Oxidative Stress Monocyte Chemoattractant Protein-1

Antithrombin Ⅲ injection via the portal vein suppresses liver damage

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World Journal of Gastroenterology 2012年第16期18卷 1884-1891页

作者： Masayuki Miyazaki Masaki Kato Masatake Tanaka Kosuke Tanaka Shinichiro Takao Motoyuki Kohjima Tetsuhide ito Munechika Enjoji Makoto Nakamuta kazuhiro Kotoh Ryoichi Takayanagi Department of Medicine and Bioregulatory Science Graduate School of Medical SciencesKyushu UniversityFukuoka 812-8582Japan Department of Gastroenterology Kyushu Medical CenterNational Hospital OrganizationFukuoka 810-0065Japan Department of Clinical Pharmacology Faculty of Pharmaceutical SciencesFukuoka UniversityFukuoka 814-0180Japan

AIM:To investigate the effects of antithrombin Ⅲ(AT Ⅲ) injection via the portal vein in acute liver ***:Thirty rats were intraperitoneally challenged with lipopolysaccharide(LPS) and D-galactosamine(GalN) and divided into three groups:a control group;a group injected with AT Ⅲ via the tail vein;and a group injected with AT Ⅲ via the portal *** Ⅲ(50 U/kg body weight) was administrated 1 h after challenge with LPS and *** levels of inflammatory cytokines and fibrin degradation products,hepatic fibrin deposition,and hepatic mRNA expression of hypoxiarelated genes were ***:Serum levels of alanine aminotransferase,tumor necrosis factor-α and interleukin-6 decreased significantly following portal vein AT Ⅲ injection compared with tail vein injection,and control *** vein AT Ⅲ injection reduced liver cell destruction and decreased hepatic fibrin *** treatment also significantly reduced hepatic mRNA expression of lactate dehydrogenase and heme ***:A clinically acceptable dose of AT Ⅲ injection into the portal vein suppressed liver damage,probably through its enhanced anticoagulant and antiinflammatory activities.

关键词： Antithrombin Ⅲ Acute liver failure Intravascular coagulation Portal vein

Conservation and utilization of pig resources by xenografting to mice

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Conservation and utilization of pig resources by xenograftin...