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BK nephropathy in the native kidneys of patients with organ transplants: Clinical spectrum of BK infection

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World Journal of Transplantation 2016年第3期6卷 472-504页

作者： Darlene Vigil Nikifor K Konstantinov Marc Barry Antonia M Harford Karen S Servilla Young Ho Kim Yijuan Sun kavitha ganta Antonios H Tzamaloukas Nephrology Section Medicine Service Raymond G. Murphy VA Medical Center and Department of Medicine University of New Mexico School of Medicine Department of Medicine University of Minnesota School of Medicine Department of Pathology University of New Mexico School of Medicine Division of Nephrology Department of Medicine University of New Mexico School of Medicine Division of Nephrology University of North Carolina School of Medicine

Nephropathy secondary to BK virus, a member of the Papoviridae family of viruses, has been recognized for some time as an important cause of allograft dysfunction in renal transplant recipients. In recent times, BK nephropathy(BKN) of the native kidneys has being increasingly recognized as a cause of chronic kidney disease in patients with solid organ transplants, bone marrow transplants and in patients with other clinical entities associated with immunosuppression. In such patients renal dysfunction is often attributed to other factors including nephrotoxicity of medications used to prevent rejection of the transplanted organs. Renal biopsy is required for the diagnosis of BKN. Quantitation of the BK viral load in blood and urine are surrogate diagnostic methods. The treatment of BKN is based on reduction of the immunosuppressive medications. Several compounds have shown antiviral activity, but have not consistently shown to have beneficial effects in BKN. In addition to BKN, BK viral infection can cause severe urinary bladder cystitis, ureteritis and urinary tract obstruction as well as manifestations in other organ systems including the central nervous system, the respiratory system, the gastrointestinal system and the hematopoietic system. BK viral infection has also been implicated in tumorigenesis. The spectrum of clinical manifestations from BK infection and infection from other members of the Papoviridae family is widening. Prevention and treatment of BK infection and infections from other Papovaviruses are subjects of intense research.

关键词： BK viral infection BK nephropathy Cardiac transplant Bone marrow transplant Liver transplant Pancreatic transplant Lung transplant

Computational Fluid Dynamics Study of a Compound Flow Field for Proton Exchange Membrane Fuel Cell(PEMFC) Performance Enhancement

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Journal of Thermal Science 2022年第6期31卷 2374-2384页

作者： Venkateswarlu VELISALA Gandhi PULLAGURA Naveen Kumar CHINNAM Raju ganta Automobile Engineering Section Damacharla Anjaneyulu Government PolytechnicOngole 523002Andhra PradeshIndia GITAM Institute of Technology Visakhapatnam 530045Andhra PradeshIndia Vishnu Institute of Technology Bhimavaram 534202Andhra PradeshIndia BVC Engineering College Odalarevu 533210Andhra PradeshIndia

The aim of the present work is to evaluate proton exchange membrane(PEM) fuel cell performance with a modified serpentine flow field with right angle turn by numerical modeling. A 3-D PEM fuel cell model of size 50 cm^(2) active area is developed. A conventional serpentine flow field is modified and the same is considered for the supply of reactants. Computational fluid dynamics(CFD) based simulations were conducted to analyse the pressure drop, distribution of reactants(H_(2) and O_(2)), liquid water activity, current flux density and water content in the membrane. From the simulation results, polarization curve is drawn to validate the literature data of PEMFC with the conventional serpentine flow field. Comparison of simulated polarization curve with literature data revealed that modified serpentine flow field performance is better than conventional serpentine flow field as it offers better water exclusion and uniform sharing of reactants. From this study, it is concluded that model of flow field pattern influences the functioning of fuel cell and utmost care must take while selecting a pattern for flow field of PEM fuel cell.

关键词： PEM fuel cell CFD current density water removal modified serpentine flow field membrane water content

Numerical Investigation of Sound Generation due to Laminar Flow Past Elliptic Cylinders

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Numerical Mathematics(Theory,Methods and Applications) 2020年第1期13卷 27-62页

作者： Bikash Mahato Naveen ganta Yogesh G.Bhumkar Scientific Computing Laboratory School of Mechanical SciencesIndian Institute of Technology BhubaneswarOdishaIndia

Numerical investigation of sound generation due to unsteady laminar flow past elliptic cylinders has been carried out using direct numerical simulation(DNS)approach at a free-stream Mach number of *** of aspect ratio(0.6≤AR≤1.0)and Reynolds number(100≤Re≤160)on the characteris-tics of radiated sound fields are ***-dimensional compressible fluid flow equations are solved on a refined grid using high resolution dispersion relation pre-serving(DRP)*** present DNS data,equivalent noise sources as given by various acoustic analogies are *** and frequencies associated with these noise sources are further related to characteristics of disturbance pressure *** pressure fields are intensified with increase in Reynolds number and aspect ***,radiated sound power increases with increase in Reynolds number and aspect *** various cases studied here,minimum and max-imum values of radiated sound power are found at Re=120&AR=0.6 and Re=160&AR=1.0,*** patterns show that the generated sound fields are dominated by the lift dipole for all ***,proper orthogonal decomposition(POD)technique has been implemented for decomposing distur-bance pressure *** POD modes associated with the lift and the drag dipoles have been *** analyses also clearly display that the radiated sound fields are dominated by the lift dipole ***,acoustic and hydrodynamic modes obtained using Doak’s decomposition method have confirmed the patterns of radiated sound field intensities.

关键词： Computational aeroacoustics acoustic analogies aeolian tones proper orthogonal decomposition Doak’s decomposition

Factors influencing adoption of soil and water conservation practices in the northwest Ethiopian highlands

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International Soil and Water Conservation Research 2020年第1期8卷 80-89页

作者： Agere Belachew Wuletaw Mekuria kavitha Nachimuthu Department of Rural Development and Agricultural Extension University of GondarP.O.Box 196GondarEthiopia RD National Arts and Science(Co-education)College ErodeTamilnaduIndia

Soil erosion has long been a problem in the Ethiopian highlands in general and Dembecha district in particular. The objective of this study was to identify factors influencing adoption of soil and water conservation practices. Both quantitative and qualitative data were collected from primary and sec-ondary sources. The primary data were collected from respondent samples and key informants through interview and personal observation. The secondary data were collected from sources such as books, journals, statistical reports and official documents. A multistage sampling technique was applied to select sample households. Sample sizes of 150 households were selected using simple random sampling. Both descriptive statistics and a multivariate probit econometric model were employed to analyze the data. The model results revealed that the likelihood of decisions to adopt soil bund, stone bund, check dam and strip cropping were 74, 56, 29 and 56%respectively. The joint probability of adopting the selected soil and water conservation practices was 14.2%. The model results also confirmed that age, sex, education level, household size, livestock holding, land size, access to credit, access to extension service and training were significant factors that affected the adoption of soil and water conservation practices in the study area. Based on our findings, the study suggests that the government and stakeholders should focus on strengthening the provision of formal and non-formal training and facilitate an effective extension service.

关键词： Adoption Multivariate probit model Soil degradation Strip cropping

OSCILLATORY BEHAVIOR OF SOLUTIONS OF CERTAIN THIRD ORDER MIXED NEUTRAL DIFFERENCE EQUATIONS

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Acta Mathematica Scientia 2013年第1期33卷 218-226页

作者： E.THANDAPANI N.kavitha Ramanujan Institute for Advanced Study in Mathematics University of MadrasChennai 600 005India

The objective of this paper is to study the oscillatory and asymptotic properties of the mixed type third order neutral difference equation of the form△（an△^2（xn＋bnxn-τ1＋cnxn＋τ2））＋qnx^βn＋1-σ1＋pnx^^βn＋1＋σ2=0,where （an）, （bn}, （cn}, （qn} and （pn} are positive real sequences, β is a ratio of odd positive integers, τ1, τ2, and σ2 are positive integers. We establish some sufficient conditions which ensure that all solutions are either oscillatory or converges to zero. Some examples are presented to illustrate the main results.

关键词： oscillation third order mixed type neutral difference equation

Dengue virus infections and anti-dengue virus activities of Andrographis paniculata

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Asian Pacific Journal of Tropical Medicine 2020年第2期13卷 49-55页

作者： Mohamed Ali-Seyed kavitha Vijayaraghavan Department of Clinical Biochemistry Faculty of MedicineUniversity of TabukTabukSaudi ArabiaTabuk 71491Saudi Arabia Department of Chemical Engineering Agni College of TechnologyChennaiTamil NaduIndia

Dengue is a debilitating disease that poses a perpetual threat to human health and increases the global economic burden every *** advances in medical sciences,dengue virus(DENV)infects approximately 200 million people every *** date,no effective antiviral is valiable to treat DENV in individuals despite great efforts in accomplishing these *** approaches have been used in the search for dengue antiviral like screening of combinatorial compounds against DENV enzymes and structurebased computational *** recent years,investigators have turned their focus into medicinal plants,trying to identify compounds that can be used as dengue *** represents a great reservoir of potential substances that can be explored with the aim of discovering new drugs that can be either used directly as pharmaceuticals or can provide drug leads,which can be scrutinized further for the development of new anti-dengue natural *** previous investigations have dealt with numerous plant extracts or bioactive principles for their antiviral property as they normally considered being safer when compared to synthetic *** paniculata belongs to family Acanthaceae and is generally known as‘king of bitters’.Diverse bioactive compounds from this plant such as diterpenes,flavonoids,xanthones,noriridoides and other miscellaneous compounds have exhibited their potential as therapeutics for various chronic as well as infectious *** review is based on literature review on scientific journals,books and electronic sources,which highlights the pathogenesis of DENV and describe an assortment of bioactive principles that have been possessing antiviral potential,which include dengue and discuss the therapeutic efficacy and mechanism of action of Andrographis ***,a detailed and more comprehensive clinical trial on mammalian tissues and organs is needed in future studies.

关键词： Andrographis paniculata Dengue Phytochemicals Natural products Andrographolide

A Sensitive Wavebands Identification System for Smart Farming

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Computer Systems Science & Engineering 2022年第10期43卷 245-257页

作者： M.kavitha M.Sujaritha Department of Computer Science and Engineering Sri Krishna College of Engineering and TechnologyCoimbatore641025India

Sensing the content of macronutrients in the agricultural soil is an essential task in precision *** helps the farmers in the optimal use of *** reduces the cost of food production and also the negative environmentalimpacts on atmosphere and water bodies due to indiscriminate dosageof *** traditional chemical-based laboratory soil analysis methodsdo not serve the purpose as they are hardly suitable for site specific soil ***,the spectral range used in the chemical-based laboratory soil analysismay be of 350-2500 nm,which leads to redundancy and *** sensors based on the discovery of spectral wavebands that respondto soil macronutrient concentrations,on the other hand,is an innovative and successfultechnology since the results are dependable and *** goal of thisarticle is to use a supervised neuro-fuzzy based dimensionality reduction approachin the sensor development process to determine sensitive wavebands of ***,the spectral signatures of the soil are collected inan outdoor environment and mapped with its macronutrient *** thisspectral analysis,the spectral reflectance of 424 wavelengths has been obtainedand these wavelengths are evaluated through combined and individual modesas *** wavelengths are selected in each case by minimizing the fuzzy reflectance assessment *** effectiveness of these selected wavelengthsin each mode is validated by modeling the relation between the reduced reflectancespace and each macronutrient concentration using Partial Least Squares Multi Variable Regression(PLS-MVR)*** of optimal wavebands areidentified and the results are compared with the existing systems.

关键词： Sensitive waveband determination macronutrients feuro-fuzzy based dimensionality reduction partial least squares multi variable regression reflectance

Deep Learning Enabled Financial Crisis Prediction Model for Small-Medium Sized Industries

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Intelligent Automation & Soft Computing 2023年第1期35卷 521-536页

作者： kavitha Muthukumaran K.Hariharanath SSN School of Management KalavakkamChennai603110India

Recently,data science techniques utilize artificial intelligence(AI)techniques who start and run small and medium-sized enterprises(SMEs)to take an influence and grow their *** SMEs,owing to the inexistence of consistent data and other features,evaluating credit risks is difficult and *** the other hand,it becomes necessary to design efficient models for predicting business failures orfinancial crises of *** data classification approaches forfinancial crisis prediction(FCP)have been presented for predicting thefinancial status of the organization by the use of past data.A major process involved in the design of FCP is the choice of required features for enhanced classifier *** this motivation,this paper focuses on the design of an optimal deep learning-basedfinancial crisis prediction(ODL-FCP)model for *** proposed ODL-FCP technique incorporates two phases:Archimedes optimization algorithm based feature selection(AOA-FS)algorithm and optimal deep convo-lution neural network with long short term memory(CNN-LSTM)based data *** ODL-FCP technique involves a sailfish optimization(SFO)algorithm for the hyperparameter optimization of the CNN-LSTM *** performance validation of the ODL-FCP technique takes place using a benchmarkfinancial dataset and the outcomes are inspected in terms of various *** experimental results highlighted that the proposed ODL-FCP technique has out-performed the other techniques.

关键词： Small medium-sized enterprises deep learning FCP financial sector prediction metaheuristics sailfish optimization

Employment of Jacobian elliptic functions for solving problems in nonlinear dynamics of microtubules

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Chinese Physics B 2014年第2期23卷 178-182页

作者： Slobodan Zekovi Annamalai Muniyappan Slobodan Zdravkovi Louis kavitha Institut za nuklearne nauke Vina Laboratorija za atomsku fiziku 040Univerzitet u Beogradu Department of Physics Periyar University Center for Nanoscience and Nanotechnology Periyar University

We show how Jacobian elliptic functions （JEFs） can be used to solve ordinary differential equations （ODEs） describing the nonlinear dynamics of microtubules （MTs）. We demonstrate that only one of the JEFs can be used while the remaining two do not represent the solutions of the crucial differential equation. We show that a kinkbtype soliton moves along MTs. Besides this solution, we also discuss a few more solutions that may or may not have physical meanings. Finally, we show what kind of ODE can be solved by using JEFs.

关键词： Jacobian elliptic functions ordinary differential equations microtubules kink soliton