Dengue virus infections and anti-dengue virus activities of Andrographis paniculata

作     者：Mohamed Ali-Seyed Kavitha Vijayaraghavan Mohamed Ali-Seyed;Kavitha Vijayaraghavan

作者机构：Department of Clinical BiochemistryFaculty of MedicineUniversity of TabukTabukSaudi ArabiaTabuk 71491Saudi Arabia Department of Chemical EngineeringAgni College of TechnologyChennaiTamil NaduIndia 

出 版 物：《Asian Pacific Journal of Tropical Medicine》 (亚太热带医药杂志（英文版）)

年 卷 期：2020年第13卷第2期

页      面：49-55页

核心收录：

学科分类：1008[医学-中药学(可授医学、理学学位)] 1006[医学-中西医结合] 100602[医学-中西医结合临床] 10[医学] 

主　　题：Andrographis paniculata Dengue Phytochemicals Natural products Andrographolide 

摘      要：Dengue is a debilitating disease that poses a perpetual threat to human health and increases the global economic burden every *** advances in medical sciences,dengue virus(DENV)infects approximately 200 million people every *** date,no effective antiviral is valiable to treat DENV in individuals despite great efforts in accomplishing these *** approaches have been used in the search for dengue antiviral like screening of combinatorial compounds against DENV enzymes and structurebased computational *** recent years,investigators have turned their focus into medicinal plants,trying to identify compounds that can be used as dengue *** represents a great reservoir of potential substances that can be explored with the aim of discovering new drugs that can be either used directly as pharmaceuticals or can provide drug leads,which can be scrutinized further for the development of new anti-dengue natural *** previous investigations have dealt with numerous plant extracts or bioactive principles for their antiviral property as they normally considered being safer when compared to synthetic *** paniculata belongs to family Acanthaceae and is generally known as‘king of bitters’.Diverse bioactive compounds from this plant such as diterpenes,flavonoids,xanthones,noriridoides and other miscellaneous compounds have exhibited their potential as therapeutics for various chronic as well as infectious *** review is based on literature review on scientific journals,books and electronic sources,which highlights the pathogenesis of DENV and describe an assortment of bioactive principles that have been possessing antiviral potential,which include dengue and discuss the therapeutic efficacy and mechanism of action of Andrographis ***,a detailed and more comprehensive clinical trial on mammalian tissues and organs is needed in future studies.