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Using Transgenic Entomopathogenic Fungi to Prevent dengue Fever: Current Status, Challenges and Perspectives

Advances in Entomology 2025年第1期13卷 48-60页

作者： Etienne M. Bilgo Houeffa Adeline Tatiana Dokpomiwa Abdoulaye Diabate Biomedical and Public Health Department Institute of Research in Health Sciences (IRSS) Western Regional Directorate Bobo-Dioulasso Burkina Faso Muraz Center National Institute of Public Health (INSP) Bobo Dioulasso Burkina Faso Rural Development Institute (IDR) Nazi Boni University (UNB) Bobo Dioulasso Burkina Faso

Over the last few decades, dengue fever epidemics have increased in frequency and intensity worldwide, making it a major global concern for public health. Its prevention, which is essentially vector-based control, is already being compromised by reports of resistance of the main vector Aedes aegypti to insecticides. To tackle the rapid increase in insecticide resistance and outbreaks, the biological vector control is a promising approach. One of the strategies of this approach is the use of entomopathogenic fungi because of their great efficacy and their eco-friendly aspects. However, some aspects of their use, such as the low efficiency, the high cost of production and the sensitivity to various adverse conditions, need to be addressed for their successful large-scale application. Therefore, innovative technologies based on strains of transgenic fungi with improved biocontrol potentials by genetic engineering are actively pursued. Although these modified mycoinsecticides are acclaimed for their better effectiveness against target insects, the main concern remains their potential adverse effects on the environment and human health. The present review is dedicated to giving an update on recent developments in transgenic entomopathogenic fungi (TEF) for Aedes mosquito control. Future perspectives are also proposed to address the safety concerns related to the release of transgenic entomopathogenic fungi into the environment.

关键词： Transgenic Entomopathogenic Fungi dengue Control

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Investigating Sexual Auto-Dissemination of Native Strain of Metarhizium pingshaense from Burkina Faso within Aedes aegypti Mosquitoes for dengue Control Perspectives

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Advances in Entomology 2025年第1期13卷 61-67页

作者： Etienne Bilgo Domonbabele François de Sales Hien Souro Abel Millogo Edounou Jacques Gnambani Seni Ilboudo Abdoulaye Diabate Institut de Recherche en Sciences de la Sante (IRSS) Direction Rgionale de lOuest (DRO)/CNRST Bobo-Dioulasso Burkina Faso Centre Muraz Institut National de Sant Publique (INSP) Bobo Dioulasso Burkina Faso Sciences and Techniques Dpartment Institut du Dvelopement Rural Universit Nazi Boni Bobo-Dioulasso Burkina Faso

In Burkina Faso, recent dengue outbreaks were exacerbated by Aedes aegypti mosquitoes, which have developed resistance to conventional insecticides. This study investigates the potential of Metarhizium pingshaense Met_S26, a fungus from Burkina Faso, for controlling both endophilic and exophilic Aedes mosquitoes. Traditional interventions are less effective against mosquitoes resting outdoors, and the ability of the fungus to be sexually transmitted could enhance its efficacy. Aedes mosquitoes were reared and exposed to various concentrations of Metarhizium pingshaense to assess its virulence. The fungus showed significant efficacy, with lethal times (LT80) ranging from 8.67 to 11.83 days depending on the concentration. Furthermore, bioassays demonstrated effective sexual auto-dissemination, with substantial transmission of fungal spores between infected and uninfected mosquitoes, leading to lower survival rates in uninfected mates. This study highlights Metarhizium pingshaense Met_S26 as a promising tool for controlling both indoor and outdoor Aedes populations, complementing existing vector control strategies such as the Sterile Insect Technique (SIT) and Wolbachia-based approaches. Future research should explore integrating this fungus with other control methods for a comprehensive vector management strategy.

关键词： Sexual Dissemination Metarhizium pingshaense Aedes aegypti dengue Burkina Faso

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dengue outbreak in Swat and Mansehra,Pakistan 2013;an epidemiological and diagnostic perspective

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Asian Pacific Journal of Tropical Medicine 2016年第4期9卷 371-375页

作者： Muhammad Suleman Rani Faryal Uzma Bashir Aamir Muhammad Masroor Alam Nadia Nisar Salmaan Sharif Shahzad Shaukat Adnan Khurshid Mehar Angez Massab Umair Ghulam Mujtaba Mian Muhammad Sufian Yasir Arshad Lubna Rehman Syed Sohail Zahoor Zaidi Department of Microbiology.Quaid-i-Azam University Department of Virology National Institute of Health

Objective:To High light some epidemiological,clinical and diagnostic features of dengue fever during an outbreak and the role of different diagnostic techniques to achieve the highest level of accuracy in ***:Blood samples(n=323) were collected along with epidemiological and clinical data from suspected dengue patients who visited different hospitals in Swat and Mansehra district of Pakistan between May-November 2013 during a dengue *** were tested for the detection of viral nucleic acid by real-lime *** structural protein-1(NS1antigen and IgM antibodies by ***:Out of 323 cases with clinical dengue infection,304 were positive by one or more diagnostic parameter:201 samples were positive by real-time PCR,209 were positive by NS1 ELISA and 190 were positive by IgM *** of real-time PCR and NS1 *** were comparable for early diagnosis of dengue virus *** antibody detection assay was found useful for the diagnosis in the samples collected later than day 5 of ***:The use of real-lime PCR or detection of non stnictural protein NS 1 by ELISA followed by IgM antibodies detection can be recommended for early diagnosis of dengue virus infection with a high level of accuracy.

关键词： dengue virus NS1 Antigen Pakistan Diagnosis Epidemiology Khyber Pakhtunkhwa

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Potential impacts of climate change on dengue fever distribution using RCP scenarios in China

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Advances in Climate Change Research 2019年第1期10卷 1-8页

作者： FAN Jing-Chun LIU Qi-Yong School of Public Health Gansu University of Chinese MedicineLanzhou730000China State Key Laboratory of Infectious Disease Prevention and Control Collaborative Innovation Center for Diagnosis and Treatinent of Infectious DiseasesNational Institute for Communicable Disease Control and PreventionChinese Center for Disease Control and Prevention(China CDC)Beijing102206China Shandong University Climate Change and Health Center School of Public HealthShandong UniversitJinan250012China

This study projected dengue distribution risk map using representative concentration pathways(RCP2.6,RCP4.5,RCP6.0,RCP8.5)in China in 2020s,2030s,2050s and *** on the biological characteristics of Aedes albopictus and the dengue epidemic process,dengue transmission biological model was developed to project the risk epidemic *** temperature data in 1981-2016 at 740 stations and grid data of 0.5°×0.5°(15°-55.5°N,70°-140.5E)under selected RCPs in 2020s,2030s,2050s and 2100s were *** to 142 counties and 168 million people living in the projected high risk area of dengue in the climate condition of 1981-2016,dengue high risk areas in China would expand under same RCP scenarios in the 21st century with time past except RCP2.6 with a turning down point in *** under RCP8.5 which global mean temperature would increase by 4.9 C till 2100s,the high risk area and population for dengue transmission would expand additional 34 counties(20 million)in 2020s,114 counties(60 million)in 2030s,208 counties(160 million)in 2050 and 456 counties(490 million)in 2100s respectively than those of *** RCP8.5 in 2100s,the population and expanded high risk areas would increase 4.2-fold and 2.9-fold than the 1981-2016 *** newly added high risk areas should prepare for controlling and preventing dengue in different period according to projected dengue risk map.

关键词： dengue fever Climate change Aedes albopictus Representative concentration pathways(RCPs) Risk distribution

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dengue virus infections and anti-dengue virus activities of Andrographis paniculata

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Asian Pacific Journal of Tropical Medicine 2020年第2期13卷 49-55页

作者： Mohamed Ali-Seyed Kavitha Vijayaraghavan Department of Clinical Biochemistry Faculty of MedicineUniversity of TabukTabukSaudi ArabiaTabuk 71491Saudi Arabia Department of Chemical Engineering Agni College of TechnologyChennaiTamil NaduIndia

dengue is a debilitating disease that poses a perpetual threat to human health and increases the global economic burden every *** advances in medical sciences,dengue virus(DENV)infects approximately 200 million people every *** date,no effective antiviral is valiable to treat DENV in individuals despite great efforts in accomplishing these *** approaches have been used in the search for dengue antiviral like screening of combinatorial compounds against DENV enzymes and structurebased computational *** recent years,investigators have turned their focus into medicinal plants,trying to identify compounds that can be used as dengue *** represents a great reservoir of potential substances that can be explored with the aim of discovering new drugs that can be either used directly as pharmaceuticals or can provide drug leads,which can be scrutinized further for the development of new anti-dengue natural *** previous investigations have dealt with numerous plant extracts or bioactive principles for their antiviral property as they normally considered being safer when compared to synthetic *** paniculata belongs to family Acanthaceae and is generally known as‘king of bitters’.Diverse bioactive compounds from this plant such as diterpenes,flavonoids,xanthones,noriridoides and other miscellaneous compounds have exhibited their potential as therapeutics for various chronic as well as infectious *** review is based on literature review on scientific journals,books and electronic sources,which highlights the pathogenesis of DENV and describe an assortment of bioactive principles that have been possessing antiviral potential,which include dengue and discuss the therapeutic efficacy and mechanism of action of Andrographis ***,a detailed and more comprehensive clinical trial on mammalian tissues and organs is needed in future studies.

关键词： Andrographis paniculata dengue Phytochemicals Natural products Andrographolide

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dengue virus non-structural 1 protein interacts with heterogeneous nuclear ribonucleoprotein H in human monocytic cells

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Asian Pacific Journal of Tropical Medicine 2016年第2期9卷 109-114页

作者： Drishya Diwaker Mishra K P Ganju L Singh S B Immunomodulation Lab Defence Institute of Physiology & Allied Sciences

Objective: To study protein-protein interaction between heterogeneous nuclear ribonucleoprotein H(hn RNP H) and dengue virus(DENV) proteins. Methods: DENV proteins were screened against the host hn RNP H protein, in order to identify the host-viral protein-protein interactions in DENV infected THP-1 cells by co-immunoprecipitation. The co-localization of the interacting proteins was further confirmed by immunofluorescence microscopy. Results: The host protein hn RNP H was found to interact with DENV nonstructural 1 protein and help the virus to multiply in the cell. Conclusions: The non-structural 1 glycoprotein is a key modulator of host immune response and is also involved in viral replication. Therefore, disruption of this key interaction between hn RNP H and DENV nonstructural 1 could be an important therapeutic strategy for management of DENV infection.

关键词： dengue virus Non-structural 1 protein Heterogeneous nuclear ribonucleoprotein H Protein interactions

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dengue fever presenting as acute liver failure-a case report

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Asian Pacific Journal of Tropical Medicine 2011年第4期4卷 323-324页

作者： Rajat Jhamb Bineeta Kashyap Ranga GS Kumar A Department of Medicine University College of Medical Sciences & Guru Tegh Bahadur Hospital Department of Microbiology University College of Medical Sciences & Guru Tegh Bahadur Hospital

dengue fever(DF) and dengue haemorrhagic fever(DHF) are important mosquito-borne viral diseases of humans and recognized as important emerging infectious diseases in the tropics and *** to nine reporting countries in the 1950s,today the geographic distribution includes more than 100 countries *** viral infections are known to present a diverse clinical spectrum,ranging from asymptomatic illness to fatal dengue shock syndrome. Mild hepatic dysfunction in dengue haemorrhagic fever is ***,its presentation as acute liver failure(ALF) is *** report a patient with dengue shock syndrome who presented with acute liver failure and hepatic encephalopathy in a recent outbreak of dengue fever in Delhi,India.

关键词： Arboviral dengue Haemorrhagic fever Hepatic disfunction Mosquito borne disease

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Frequent Import and Multiple Sources of dengue Fever have Changed the Epidemic Situation of the Disease in Fujian Province,China

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Biomedical and Environmental Sciences 2020年第2期33卷 123-132页

作者： WANG Jin Zhang YOU Li Bin KAN Nai Peng LIN Qi WENG Yu Wei ZHENG Kui Cheng Fujian Provincial Key Laboratory of Zoonosis Research Fujian Provincial Center for Disease Control and PreventionFuzhou 350001FujianChina

Objective The aim of this study was to update the epidemic situation of dengue fever(DF) and provide new insights for the consideration of disease control in Fujian province,*** Details about DF cases in Fujian reported during 2004–2017 were collected and *** envelope(E) genes of isolates of dengue virus(DENV) were sequenced for phylogenetic *** The number of imported DF cases had increased dramatically since 2013,and the source regions expanded from Southeast Asia to South Asia,America,Oceania,and Africa,as well as the surrounding *** resulted in local outbreaks and indigenous cases of DF that occurred more frequently,with 10 of 13 local outbreaks and 85.9%(1,252/1,458) of indigenous cases reported in2013–*** with only two coastal cities before 2013,four coastal and one inland city in 2013–2017 experienced the local DF *** phylogenetic analysis of E genes confirmed that the import of DENV,not only from abroad but also from the surrounding provinces,played an important role in dissemination and local outbreaks of DF in *** The frequent import of DF cases from not only abroad but also the surrounding provinces resulted in increased incidence,frequent local outbreaks,and expansion of distribution in Fujian in recent *** is a need for urgent measures to improve disease control in this province.

关键词： dengue fever Epidemic dengue virus Phylogenetic analysis

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Antiviral activity of traditional Chinese medicinal plants Dryopteris crassirhizoma and Morus alba against dengue virus

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Journal of Integrative Agriculture 2020年第4期19卷 1085-1096页

作者： Maqsood MARYAM Kian Keong TE Fai Chu WONG Tsun Thai CHAI Gary K K LOW Seng Chiew GAN Hui Yee CHEE Department of Medical Microbiology and Parasitology Faculty of Medicine and Health SciencesUniversiti Putra MalaysiaSerdang 43400Malaysia Faculty of Natural Sciences SBK Women's University QuettaBalochistan 87300Pakistan Department of Chinese Medicine Faculty of Medicine and Health SciencesUniversiti Tunku Abdul RahmanSungai Long CampusKajang 43000Malaysia Department of Chemical Science Faculty of ScienceUniversiti Tunku Abdul Rahman(Kampar Campus)Kampar 31900Malaysia Department of Population Medicine Faculty of Medicine and Health SciencesUniversiti Tunku Abdul Rahman(Sungai Long Campus)Kajang 43000Malaysia Department of Pre-Clinical Sciences Faculty of Medicine and Health SciencesUniversiti Tunku Abdul Rahman(Sungai Long Campus)Kajang 43000Malaysia

dengue virus(DENV) has emerged as a major virus that is spread by mosquitoes. Recently, it has spread to more than a hundred nations but continues to lack specific treatable medication. Many traditional Chinese medicinal(TCM) plants are in practice for dengue fever in dengue endemic regions. These traditional medicines persevere with treatments, which modern medicines lack. The study aims to substantiate the anti-dengue potential of some traditional herbs and make them available for further studies to facilitate TCM users. Twelve TCM plants aqueous extracts were evaluated, which are described as cool herbs used for the diseases with high fever. Lead plants were established through detailed in vitro foci forming unit reduction analysis(FFURA) against all four serotypes and validated through quantitative real-time RT-PCR(q RT-PCR). Four plants potentially inhibited the virus in primary phenotypic in vitro evaluation. Two lead plants Dryopteris crassirhizoma(DC) and Morus alba(MA) were identified with half minimal inhibitory concentration(IC50) 130 and 221 μg m L^-1, respectively, while the selectivity indices(SI) were 4.21 and 4.62, respectively. Lead plants equally inhibited all four serotypes of DENV. Time-of-addition analysis suggested that, DC was active at later stages of viral replication, whereas MA was active during the early stages and even showed some prophylactic activity. Liquid chromatography-mass spectrometry(HPLC/MS) analysis revealed presence of flavonoids. DC and MA are identified as potential anti-dengue plants, active against varied stages of dengue virus replication cycle. These results may serve as the base knowledge for further investigation on their combined treatments or integrative treatment with western medicines, which may improve the overall anti-dengue activity in future.

关键词： dengue virus traditional Chinese medicines TCM complementary medicines plant extracts anti-dengue

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Electroporation-Mediated Immunization of a Candidate DNA Vaccine Expressing dengue Virus Serotype 4 prM-E Antigen Confers Long-Term Protection in Mice

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Virologica Sinica 2019年第1期34卷 88-96页

作者： Ziyang Sheng Hui Chen Kaihao Feng Na Gao Ran Wang Peigang Wang Dongying Fan Jing An Department of Microbiology School of Basic Medical SciencesCapital Medical University Center of Epilepsy Beijing Institute for Brain Disorders

dengue fever, caused by dengue viruses(DENVs), is a widespread mosquito-borne zoonotic disease; however, there is no available anti-dengue vaccine for worldwide use. In the current study, a DNA vaccine candidate(pV-D4 ME) expressing prM-E protein of DENV serotype 4(DENV-4) was constructed, and its immunogenicity and protection were evaluated in immunocompetent BALB/c mice. The pV-D4 ME candidate vaccine induced effective humoral and cellular immunity of mice against DENV-4 in vivo when administered both at 50 μg and 5 μg through electroporation. Two weeks after receiving three immunizations, both doses of pV-D4 ME DNA were shown to confer effective protection against lethal DENV-4 challenge. Notably, at 6 months after the three immunizations, 50 μg, but not 5 μg, of pV-D4 ME could provide stable protection(100% survival rate) against DENV-4 lethal challenge without any obvious clinical signs. These results suggest that immunization with 50 μg pV-D4 ME through electroporation could confer effective and long-term protection against DENV-4, offering a promising approach for development of a novel DNA vaccine against DENVs.

关键词： dengue virus (DENV) DNA vaccine Long-term protection Electroporation Mouse

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