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World Journal of Gastroenterology 2017年第11期23卷 2086-2089页

作者： Philip G Ferstl Claudia Reinheimer katalin Jozsa Stefan Zeuzem Volkhard AJ Kempf Oliver Waidmann Georgios Grammatikos Department for Internal Medicine I/Gastroenterology and Hepatology University Hospital Frankfurt Institute for Medical Microbiology and Infection Control University Hospital Frankfurt University Center for Infectious Diseases(UCI) University Hospital Frankfurt

Massive global spread of multidrug-resistant(MDR) Salmonella spp. expressing extended-spectrum beta-lactamase(ESBL) and additional resistance to fluoroquinolones has often been attributed to high international mobility as well as excessive use of oral antibiotics in livestock farming. However, MDR Salmonella spp. have not been mentioned as a widespread pathogen in clinical settings so far. We demonstrate the case of a 25-year-old male with primary sclerosing cholangitis who tested positive for MDR Salmonella enterica serotype Choleraesuis expressing ESBL and fluoroquinolone resistance. The pathogen was supposedly acquired during a trip to Thailand, causing severe fever, cholangitis andpancreatitis. To our knowledge, this is the first report of Salmonella enterica serotype Choleraesuis in Europe expressing such a multidrug resistance pattern. ESBL resistance of Salmonella enterica spp. should be considered in patients with obstructive biliary tract pathology and travel history in endemic countries.

关键词： Biliary physiology Infectious disease Multidrug resistance Primary sclerosing cholangitis Salmonella choleraesuis

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2023年诺贝尔生理学或医学奖简介

解剖学报 2024年第1期55卷 1-2页

作者： katalin Karik Drew Weissman 陈至鑫(编译) 曾武威(审校) 章静波(审校) 匈牙利塞格德(Szeged)大学美国宾夕法尼亚大学宾夕法尼亚RNA创新研究所北京大学国际医院中国医学科学院基础医学研究所

2023年诺贝尔生理学或医学奖授予两位科学家katalin Kariko和Drew Weissman,以表彰他们对于核苷碱基修饰的发现,从而使得开发针对新型冠状病毒肺炎(corona virus disease 2019,COVID-19)的有效mRNA疫苗成为可能。两位诺贝尔奖获得者的... 详细信息

2023年诺贝尔生理学或医学奖授予两位科学家katalin Kariko和Drew Weissman,以表彰他们对于核苷碱基修饰的发现,从而使得开发针对新型冠状病毒肺炎(corona virus disease 2019,COVID-19)的有效mRNA疫苗成为可能。两位诺贝尔奖获得者的发现对于开发针对在2020年初开始流行的COVID-19的有效mRNA疫苗起到了至关重要的作用。他们的突破性发现从根本上改变了我们对mRNA如何与机体免疫系统相互作用的理解,获奖者在现代人类健康面临最大威胁之一的关键性时刻,为疫苗开发做出了前所未有的杰出贡献。

关键词：机体免疫系统诺贝尔生理学或医学奖疫苗开发碱基修饰诺贝尔奖获得者

Effects of Mechanical Impacts on Hatchability of Broiler Breeders

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Journal of Agricultural Science and Technology(A) 2014年第6期4卷 535-540页

作者： Timea Torma katalin Gafil Kovhcsn Aviagen Kfi Gy6r 9028 Hungary Institute of Animal Sciences Faculty of Agricultural and Food Sciences University of West Hungary Mosonmagyar6var 9200Hungary

Transporting hatching eggs from Hungary and incubating them abroad revealed lower hatchability compared to when the eggs were incubated in Hungary. Following transport, there were higher embryo losses and, notably, more malformed embryos. The aim of these initial trials was to determine if a testing device （crazy fit massage machine （CFM machine）） was able to replicate and model the mechanical impacts experienced during transport and reproduce the reduction in hatchability and increase the level of malformed embryos as observed in commercial practice. Tinytag~ high sensitivity shock and vibration loggers were used to monitor the impacts under field and trial conditions. Applying single 10 min treatments on the CFM machine, which used the same frequency （10-30 Hz） as the eggs experience under field conditions, induced the negative effect of transport, and lower hatching results were experienced. Three trials were conducted. Treated eggs in Trials 1 and 2 received automatically and periodical changing vibration in a range between 10-30 Hz for 10 min while in Trial 3 two different levels of impact were applied at 20 Hz and 30 Hz, respectively. Hatchability decreased due to the treatment significatly only in Trial 3. Significant differences were also detected in early dead levels in Trials 2 and 3 and the occurrences of malformation in Trials 1 and 3. All these results are in accordance with the field experience. Thus, the trials which examined the equipment were able to produce mechanical impacts that were repeatable in order to set up statistically reliable trials on hatching eggs.

关键词： Mechanical impacts hatchability loggers.

Celiac disease and microscopic colitis:A report of 4 cases

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World Journal of Gastroenterology 2011年第16期17卷 2150-2154页

作者： Zsolt barta Eva Zold Arpad Nagy Margit Zeher Istvan Csipo 3rd Department of Medicine Institute for Internal MedicineMedical and Health Science CenterUniversity of Debrecen

Celiac disease (CD) is an autoimmune disorder of the small intestine that occurs in genetically predisposed people at all ***,it can be associated also to other immunopathological disorders,and may be associated with abnormal histology in segments of the gut other than the small bowel including colonic *** guidelines for endoscopic investigation of the jejunum are well defined,no indication is defined for colonic *** describe four cases of concurrent CD and microscopic colitis (MC) diagnosed at our department over a 10-year period and analyzed the main features and outcomes of CD in this *** symptoms of these patients were improved initially by a gluten-free diet before the onset of MC *** of the patients were siblings and had an atypical form of *** other two patients with CD and MC also presented with fibrosing alveolitis and were anti-Saccharomyces cerevisiae antibody *** co-existence of immune-mediated small bowel and colonic inflammatory and pulmonary diseases are not well-known,and no systematic approach has been used to identify the lifelong patterns of these immune-based *** can develop,or present with CD at any stage in life,which can co-exist with other gastrointestinal diseases of (auto-) immune *** addition,the fa-milial co-existence and prevalence of MC in patients with a prior diagnosis of CD are *** managing celiac disease should be aware of these associations and understand when to consider colon investigation.

关键词： Collagen colitis Lymphocytic colitis Celiac disease Fibrosing alveolitis Anti-saccharomyces cerevisiae antibody

Classification of submucosal tumors in the gastrointestinal tract

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World Journal of Gastroenterology 2007年第24期13卷 3311-3315页

作者： Laura Graves Ponsaing katalin Kiss Mark Berner Hansen Department ofSurgical Gastroenterology K Bispebjerg University Hospital ofCopenhagen Denmark Department of Pathology Herlev UniversityHospital Gentofte Denmark

This review is part two of three, which will present an update on the classification of gastrointestinal submucosal tumors. Part one treats of the diagnosis and part three of the therapeutic methods regarding gastrointestinal submucosal tumors. In the past there has been some confusion as to the classification of gastrointestinal submucosal tumors. Changes in classifications have emerged due to recent advances in mainly immunohistochemistry and electron microscopy. The aim of this paper is to update the reader on the current classification. Literature searches were performed to find information related to classification of gastrointestinal submucosal tumors. Based on these searches the twelve most frequent submucosal tumor types were chosen for description of their classification. The factors that indicate whether tumors are benign or malignant are mainly size and number of mitotic counts. Gastrointestinal stromal tumors are defined mainly by their CD117 positivity. In the future, there should be no more confusion between gastrointestinal stromal tumors and other types of submucosal tumors.

关键词： Submucosal tumor Immunohistochemistry Smooth muscle derived submucosal tumors Submucosal tumors of neurogenic origin Gastrointestinal stromal tumor Malignant Benign

Discrepancies between clinical and autopsy findings in patients who had an acute stroke

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Stroke & Vascular Neurology 2022年第3期7卷 215-221页

作者： Lilla Hudák Attila Csaba Nagy Sarolta Molnár Gábor Méhes katalin Erzsébet Nagy LászlóOláh LászlóCsiba Department of Neurology University of Debrecen Faculty of MedicineDebrecenHungary Department of Preventive Medicine University of Debrecen Faculty of Public HealthDebrecenHungary Department of Pathology University of Debrecen Clinical CenterDebrecenHungary Doctoral School of Neuroscience University of Debrecen Faculty of MedicineDebrecenHungary

Objectives According to international observations,the incidence of clinical autopsies is declining worldwide,plummeting below 5%in the USA and many European *** is an unfavourable trend as,in 7%-12%of cases,recent clinicopathological studies found discrepancies that might have changed the therapy or the outcome if known *** previous large-scale observations have examined varied patient populations,we aimed to focus on the differences between the clinical and pathological diagnostic findings in only patients who had a *** and methods We assessed the postmortem non-neuropathological and neuropathological findings of 534 consecutive patients who had a stroke who passed *** neoplasms,pneumonias,thromboembolisms and haemorrhagic transformations revealed only by autopsy were considered severe abnormalities;in addition,benign abnormalities important from an educational or scientific point of view were also *** In 26 of the 534 cases(4.9%),the presence of systemic neoplasms had already been confirmed in the clinical stage;however,8(1.5%)malignant tumours were only detected during ***,80(15%)thromboembolic events,73(13.6%)pneumonias and 66(18%)haemorrhagic transformations were only diagnosed at *** hospital stay(from admission to death)resulted in fewer discrepancies between clinical and autopsy diagnosis of thromboembolic events and pneumonias(p<0.01).In 169 cases,benign findings were *** While the type of acute stroke is reliably diagnosed with imaging techniques,postmortem autopsies are also important in patients who had a stroke as autopsies may reveal clinically silent diseases(eg,tumour),and contribute to knowing the actual incidence of stroke-related thromboembolic and pneumonia complications.

关键词： neoplasms clinical finding

Gut region-specific TNFR expression:TNFR2 is more affected than TNFR1 in duodenal myenteric ganglia of diabetic rats

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World Journal of Diabetes 2023年第1期14卷 48-61页

作者： Bence Pál barta Benita Onhausz Afnan AL Doghmi Zita Szalai János Balázs Mária Bagyánszki Nikolett Bódi Department of Physiology Anatomy and NeuroscienceUniversity of SzegedSzeged 6726Hungary

BACKGROUND Cytokines are essential in autoimmune inflammatory processes that accompany type 1 *** necrosis factor alpha plays a key role among others in modulating enteric neuroinflammation,however,it has a dual role in cell degeneration or survival depending on different *** general,TNFR1 is believed to trigger apoptosis,while TNFR2 promotes cell *** importance of the neuronal microenvironment has been recently highlighted in gut region-specific diabetic enteric neuropathy,however,the expression and alterations of different TNFRs in the gastrointestinal tract has not been *** To investigate the TNFR1 and TNFR2 expression in myenteric ganglia and their environment in different intestinal segments of diabetic *** Ten weeks after the onset of hyperglycemia,gut segments were taken from the duodenum,ileum and colon of streptozotocin-induced(60 mg/body weight kg i.p.)diabetic(n=17),insulin-treated diabetic(n=15)and sex-and age-matched control(n=15)*** plexus whole-mount preparations were prepared from different gut regions for TNFR1/HuCD or TNFR2/HuCD double-labeling fluorescent ***1 and TNFR2 expression was evaluated by post-embedding immunogold electron microscopy on ultrathin sections of myenteric *** levels were measured by enzyme-linked immunosorbent assay in muscle/myenteric plexus-containing(MUSCLE-MP)tissue homogenates from different gut segments and experimental *** A distinct region-dependent TNFRs expression was detected in *** density of TNFR1-labeling gold particles was lowest,while TNFR2 density was highest in duodenal ganglia and a decreased TNFRs expression from proximal to distal segments was observed in MUSCLE-MP *** diabetics,the TNFR2 density was only significantly altered in the duodenum with decrease in the ganglia(0.32±0.02 vs 0.45±0.04,P<0.05),while no significant changes in TNFR1 density was *** diabetic MUSCLE-MP h

关键词： Tumor necrosis factor alpha receptors Myenteric ganglia Enteric neurons Neuronal environment Diabetes Insulin

Graphene Oxide Application in Cement-Bound Materials-State of the Art

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材料科学与工程（中英文B版） 2021年第4期11卷 144-155页

作者： katalin Kopecskó Zaid Ali Abdulhussein Khaiqani Faculty of Civil Engineering Budapest University of Technology and EconomicsMűegyetem rakpart 3Budapest 1111Hungary

In recent years,the incorporation of nanoparticles in the cementitious matrix has been regarded as a prominent strategy in the research *** paper reviews the influences of the nanomaterial GO(graphene oxide)in cement bound materials,as GO has become one of the most well-known inclusion nanoparticles in the cementitious matrix in the last few *** study describes(i)the influences of the GO on enhancing hydration mechanism in the cementitious materials;and(ii)the improved performance of the cementitious materials,which are highly dependent on the functionalizing behavior of the *** this improves the properties of the *** paper reports the influences of GO on the workability of the mixtures and the durability enhancement of the cementitious ***,it demonstrates promising results of employing GO in the fabrication of novel building ***,tremendous progress in utilizing GO in scientific domains like materials technology has achieved a significant *** progress has been achieved by applying the GO in different fields such as solar cells and super ***,more intensive research is required to achieve comparable improvement in building materials which constitutes a significant future challenge.

关键词： materials. durability utilizing

基于短视频平台的企业广告内容特征对用户品牌认知的影响研究

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基于短视频平台的企业广告内容特征对用户品牌认知的影响研究

作者： katalin CHEN 上海交通大学

学位级别：硕士

随着移动互联网的迅速发展,用户的触媒习惯也在逐渐发生改变,集碎片化和内容化于一体的移动短视频成为用户接受各类信息的主要载体。用户对优质内容的巨大需求及其时间碎片化现象的日趋明显,使短视频与短视频平台在有效传递信息及提升... 详细信息

随着移动互联网的迅速发展,用户的触媒习惯也在逐渐发生改变,集碎片化和内容化于一体的移动短视频成为用户接受各类信息的主要载体。用户对优质内容的巨大需求及其时间碎片化现象的日趋明显,使短视频与短视频平台在有效传递信息及提升用户认知方面极具潜力;因此,本研究从企业广告内容的角度出发,旨在探讨企业广告内容特征对用户品牌认知的影响。本研究使用实证研究法,设计了两组组间实验,探讨了企业广告内容的关键特征(幽默和热情)与用户品牌认知之间的主效应关系;此外还将沉浸体验与卷入度纳入研究,探讨两者在主关系中是否具有中介作用与调节作用。通过对实验数据的分析,证实了企业广告内容关键特征对用户的品牌认知具有显著且直接的影响;实验1通过独立样本T检验证明了幽默特征与热情特征的广告内容分别对用户的品牌认知存在直接影响。此外通过实验2验证了沉浸体验在该关系中具有中介作用,即企业广告内容关键特征显著正向影响个体的沉浸体验,进而显著正向影响其品牌认知。但对调节作用的分析表明,卷入度在该关系中仅起到部分调节作用,即在热情特征对用户的品牌认知的影响中,卷入度具有显著的调节作用;但在幽默特征对用户品牌认知的影响中,卷入度不具有显著性,亦说明其不具有调节作用。

关键词：短视频广告内容特征沉浸体验卷入度品牌认知

Correlation between severity of endoscopic findings and apnea-hypopnea index in patients with gastroesophageal reflux disease and obstructive sleep apnea

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World Journal of Gastroenterology 2005年第6期11卷 839-841页

作者： Pál Demeter katalin Várdi Visy Pál Magyar Department of Gastroenterology Department of Pulmonology

AIM: To assess the relationship between severity of gastroesophageal reflux disease and apnea-hypopnea index (AHI) as an indicator of the severity of obstructive sleep apnea. METHODS: Data of 57 patients with proven obstructive sleep apnea and gastroesophageal reflux disease were analyzed. Patients were divided into two groups according to severity of the sleep apnea: 'mild-moderate' (A)-AHI 5≥5-30, n=27, 'severe' (B)-AHI >30, n=30. All patients underwent apnea monitoring during the night, upper panendoscopy and were asked about typical reflux symptoms. RESULTS: All examined patients in both groups showed a significant overweight and there was a positive correlation between body mass index and the degree of sleep apnea (P = 0.0002). The occurence of erosive reflux disease was significantly higher in 'severe' group (P = 0.0001). Using a logistic regression analysis a positive correlation was found between the endoscopic severity of reflux disease and the AHI (P = 0.016). Forty-nine point five percent of the patients experienced the typical symptoms of reflux disease at least three times a week and there was no significant difference between the two groups. CONCLUSION: A positive correlation can be found between the severity of gastroesophageal reflux disease and obstructive sleep apnea.

关键词： Obstructive sleep apnea Gastroesophageal reflux disease Severity Correlation