检索结果-南通市图书馆

Serum outperforms plasma in small extracellular vesicle microRNA biomarker studies of adenocarcinoma of the esophagus

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2020年第20期26卷 2570-2583页

作者： karen Chiam George C mayne Tingting Wang David I Watson Tanya S Irvine Tim Bright Lorelle T Smith Imogen A Ball Joanne m Bowen Dorothy m Keefe Sarah K Thompson Damian J Hussey Discipline of Surgery College of Medicine and Public HealthFlinders University of South AustraliaAdelaideSA 5042Australia Flinders Health and medical Research Institute Cancer Program College of Medicine and Public HealthFlinders UniversityAdelaideSA 5042Australia Discipline of Surgery The University of AdelaideAdelaideSA 5005Australia Adelaide medical School The University of AdelaideAdelaideSA 5005Australia Faculty of Health Sciences The University of AdelaideAdelaideSA 5005Australia

BACKGROUND Circulating microRNAs(miRNAs)are potential biomarkers for many ***,they can originate from non-disease specific sources,such as blood cells,and compromise the investigations for miRNA *** small extracellular vesicles(sEVs)have been suggested to provide a purer source of circulating miRNAs for biomarkers discovery,the most suitable blood sample for sEV miRNA biomarker studies has not been *** To compare the mi RNA profiles between matched serum and plasma s EV preparations to determine their suitability for biomarker *** matched serum and plasma samples were obtained from 10 healthy controls and10 patients with esophageal adenocarcinoma.s EV isolates were prepared from serum and plasma using Exo Quick Tm and quantified using Nano *** was extracted from s EV preparations with the mi RNeasy Serum/Plasma kit and profiled using the Taqman Openarray q *** overall mi RNA content and theexpression of specific mi RNAs of reported vesicular and non-vesicular origins were compared between serum and plasma s EV *** diagnostic performance of a previously identified multi-mi RNA biomarker panel for esophageal adenocarcinoma was also *** The overall mi RNA content was higher in plasma s EV preparations(480 mi RNAs)and contained 97.5%of the mi RNAs found in the serum s EV preparations(412 mi RNAs).The expression of commonly expressed mi RNAs was highly correlated(Spearman’s R=0.87,Pma and serum s EV preparations,but was consistently higher in the plasma s EV *** blood-cell mi RNAs(hsa-mi R-223-3 p,hsa-mi R-451 a,mi R-19 b-3 p,hsa-mi R-17-5 p,hsa-mi R-30 b-5 p,hsa-mi R-106 a-5 p,hsa-mi R-150-5 p and hsa-mi R-92 a-3 p)were expressed at 2.7 to 9.6 fold higher levels in the plasma s EV preparations compared to serum s EV preparations(Pma s EV preparations,the percentage of protein-associated mi RNAs expressed at relatively higher levels(Ct

关键词： Biomarkers Exosomes Extracellular vesicles Circulating microRNA microRNAs Plasma Serum Blood cells Real-time polymerase chain reaction Adenocarcinoma of esophagus

Computed tomography of Crohn's disease:The role of three dimensional technique

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Radiology 2013年第5期5卷 193-201页

作者： Siva P Raman karen m Horton Elliot K Fishman Department of Radiology Johns Hopkins University School of MedicineJohns Hoplins Outpatient CenterBaltimoreMD 21287United States

Crohn's disease,a transmural inflammatory bowel disease,remains a difficult entity to diagnose *** the last decade,multidetector computed tomography(CT) has become the method of choice for noninvasive evaluation of the small bowel,and has proved to be of significant value in the diagnosis of Crohn's *** in CT enterography protocol design,three dimensional(3-D) post-processing software,and CT scanner technology have allowed increasing accuracy in diagnosis,and the acquisition of studies at a much lower radiation *** cases in this review will illustrate that the use of 3-D technique,proper enterography protocol design,and a detailed understanding of the different manifestations of Crohn's disease are all critical in properly diagnosing the full range of possible complications in Crohn's *** particular,CT enterography has proven to be effective in identifying involvement of the small and large bowel(including active inflammation,stigmata of chronic inflammation,and Crohn's-related bowel neoplasia) by Crohn's disease,as well as the extra-enteric manifestations of the disease,including fistulae,sinus tracts,abscesses,and urologic/hepatobiliary/osseous ***,the proper use of 3-D technique(including volume rendering and maximum intensity projection) as a routine component of enterography interpretation can play a vital role in improving diagnostic accuracy.

关键词： Crohn’s disease Computed tomography angiography multidetector computed tomography Three dimensional technique Volume rendering maximum intensity projection Fistula Dose reduction

Systemic IL-27 administration prevents abscess formation and osteolysis via local neutrophil recruitment and activation

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Bone Research 2022年第4期10卷 826-837页

作者： Yugo morita motoo Saito Javier Rangel-moreno Anthony m.Franchini John R.Owen John C.martinez John L.Daiss karen L.de mesy Bentley Stephen L.Kates Edward m.Schwarz Gowrishankar muthukrishnan Center for musculoskeletal Research University of Rochester Medical CenterRochesterNYUSA Division of Allergy Immunology and RheumatologyDepartment of MedicineUniversity of Rochester Medical CenterRochesterNYUSA Department of Environmental medicine University of Rochester School of Medicine and DentistryRochesterNYUSA Department of Orthopedic Surgery Virginia Commonwealth UniversityRichmondVAUSA Department of Orthopedics University of Rochester Medical CenterRochesterNYUSA Department of Pathology and Laboratory medicine University of Rochester Medical CenterRochesterNYUSA

Interleukin-27 is a pleiotropic cytokine whose functions during bacterial infections remain controversial,and its role in patients with *** osteomyelitis is *** address this knowledge gap,we completed a clinical study and observed elevated serum IL-27 levels(20-fold higher,Pmpared with healthy ***,IL-27 serum levels were 60-fold higher in patients immediately following septic death than in uninfected patients(Pmyelitis in WT and IL-27Rα^(−/−)mice with and without exogenous IL27 induction by intramuscular injection of rAAV-IL-27p28 or rAAV-GFP,*** found that IL-27 was induced at the surgical site within 1 day of *** infection of bone and was expressed by m0,m1 and m2 macrophages and osteoblasts but not by ***,exogenous IL-27p28(~2 ng·mL^(−1) in serum)delivery ameliorated soft tissue abscesses and periimplant bone loss during infection,accompanied by enhanced local IL-27 expression,significant accumulation of RORγt^(+)neutrophils at the infection site,a decrease in RANK^(+) cells,and compromised osteoclast *** effects were not observed in IL-27Rα^(−/−)mice compared with WT mice,suggesting that IL-27 is dispensable for immunity but mediates redundant immune and bone cell functions during *** vitro studies and bulk RNA-seq of infected tibiae showed that IL-27 increased nos1,nos2,il17α,il17f,and rorc expression but did not directly stimulate ***,these results identify a novel phenomenon of IL-27 expression by osteoblasts immediately following *** infection of bone and suggest a protective role of systemic IL-27 in osteomyelitis.

关键词： abscess protective immunity

Comparison of Obesity Prevalence among middle and High School Graduates before and after the COVID-19 Lockdown

在线全文

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2022年第12期35卷 1145-1149页

作者： LU Yan Hui DOU Zi Yan ZHAO Kai Ping YAN Dong CHEN Shuo CHENG Jun Xia Glen m.BLAKE karen HIND ZHANG Jing Bo CHENG Xiao Guang WU Jing Department of Endocrinology the Second Medical CenterChinese PLA General HospitalNational Clinical Research Center for Geriatric DiseaseBeijing 100000China Beijing Physical Examination Center Beijing 100000China Department of medical Record management and Statistics Beijing Jishuitan HospitalBeijing 100000China Department of Radiology Beijing Jishuitan HospitalBeijing 100000China National Center for Chronic and Noncommunicable Disease Control and Prevention Chinese Center for Disease Control and PreventionBeijing 100000China School of Biomedical Engineering&Imaging Sciences King’s College LondonSt Thomas’HospitalLondon SE17EHUnited Kingdom Department of Sport and Exercise Sciences Durham UniversityDurham 27704United Kingdom

The world has been engulfed in a COVID-19 pandemic that has significantly affected the health and economics of the *** Chinese authorities imposed lockdown measures to limit the spread of COVID-19 and stopped school programs for children and *** measures have been associated with increased sedentary time and reduced physical activity[1-3].An online questionnaire study of youth in China compared activity patterns before and after the COVID-19 lockdown.

关键词： before middle stopped

在线全文

学校读者我要写书评

暂无评论

苯基功能化介孔二氧化硅薄膜

稀有金属材料与工程 2008年第A2期37卷 1-7页

作者： Benjamin m.D.O'Driscoll Adrian m. Hawley Stephen J. Roser karen J. Edler 巴斯大学化学系

采用共凝法制备了自发形成的苯基功能化的介孔二氧化硅薄膜。利用中子反射技术及布儒斯特角显微镜(Brewster Angle microscopy)检测所得薄膜,并利用中子小角散射技术检测溶液中的胶束。结果表明:随着苯基功能化先驱体含量的增多,薄膜发... 详细信息

采用共凝法制备了自发形成的苯基功能化的介孔二氧化硅薄膜。利用中子反射技术及布儒斯特角显微镜(Brewster Angle microscopy)检测所得薄膜,并利用中子小角散射技术检测溶液中的胶束。结果表明:随着苯基功能化先驱体含量的增多,薄膜发生结构损失,这种变化会附有非团聚双层结构的形成。当苯基含量较高时,该双层结构随表面活性剂烷基链的倾斜而稳定。上述结果均同制备含筒状胶束薄膜的无烷基系统形成进行了对比。

关键词：薄膜二氧化硅共凝法

Influence of Sugarcane Bagasse Fiber Size on Biodegradable Composites of Thermoplastic Starch

在线全文

学校读者我要写书评

暂无评论

Journal of Renewable materials 2018年第2期6卷 176-182页

作者： Bruno Henrique dos Santos karen de Souza do Prado Asaph Armando Jacinto marcia Aparecida da Silva Spinace Federal University of ABC Center of Natural and Human SciencesAv.dos Estados5001Santa Terezinha09.210-170 Santo AndréSão PauloBrazil

Although thermoplastic starch(TPS)is biodegradable,its low mechanical resistance limits its wide *** bagasse(SB)fibers can be used as reinforcement in TPS matrix composites,but the influence of fiber size on the properties of the composite is still *** this study,TPS composites reinforced with SB short fibers of four sizes were processed and characterized in order to analyze the influence of fiber size on the mechanical properties of the TPS/SB *** was observed that the interaction between fiber and matrix was good and optimized when the fibers are sifted in sieves between 30 and 50 mesh,obtaining fibers with average length of 1569±640μm and average diameter of 646±166μ*** these composites,increases of more than 660%in the modulus and more than 100%in the maximum tension were verified when compared to the pure TPS.

关键词： Sugarcane bagasse thermoplastic starch composite fiber size

management of critically ill patients with type 2 diabetes:The need for personalised therapy

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Diabetes 2015年第5期6卷 693-706页

作者： Palash Kar karen L Jones michael Horowitz Adam m Deane Discipline of Acute Care medicine Level 5Eleanor Harrald BuildingUniversity of Adelaide Intensive Care Unit Level 4Emergency Services BuildingRoyal Adelaide Hospital Centre for Research Excellence University of Adelaide Discipline of medicine Level 6Eleanor Harrald BuildingUniversity of Adelaide

Critical illness in patients with pre-existing diabetes frequently causes deterioration in glycaemic *** the prevalence of diabetes in patients admitted to hospital and intensive care units,the ideal management of hyperglycaemia in these groups is *** are data that suggest that acute hyperglycaemia in critically ill patients without diabetes is associated with increased mortality and *** insulin to keep blood glucose concentrations mmol/L is accepted as standard of care in this ***,preliminary data have recently been reported that suggest that chronic hyperglycaemia may result in conditioning,which protects these patients against damage mediated by acute ***,acute glucose-lowering to mmol/L in patients with diabetes with inadequate glycaemic control prior to their critical illness appears to have the capacity to cause *** review focuses on glycaemic control in critically ill patients with type 2 diabetes,the potential for harm from glucose-lowering and the rationale for personalised therapy.

关键词： Diabetes Critically ill Intensive care management Personalised therapy

Impact of androgen deprivation therapy on sexua function： a response

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Asian Journal of Andrology 2012年第5期14卷 793-794页

作者： Erik Wibowo Richard Wassersug karen Warkentin Lauren Walker John Robinson Lori Brotto Thomas Johnson Department of Anatomy&Neurobiology Dalhousie UniversityHalifaxNS B3H 4R2Canada men's Health Initiative of B.C. Department of Urologic SciencesUniversity of British ColumbiaVancouverBC V5Z 1M9Canada Department of Biology Boston UniversityBostonMA 02215USA Department of Psychology University of CalgaryCalgaryAB T2N 1N4Canada Department of Psychosocial Resources Tom Baker Cancer CentreCalgaryAB T2S 3C1Canada UBC Sexual Health Lab Gordon&Leslie Diamond Health Care CentreDepartment of Obstetrics/GynecologyDivision of Gynecologic OncologyVancouverBC V5Z 1M9Canada Department of Anthropology California State UniversityFultonCA 95439-0050USA

Dear Editors, We appreciate the growing patients and survivors. mazzola interest in sexual health for cancer and mulhall＇s recent paper,a however, creates the impression that rewarding sex is not possible for prostate cancer patients on androgen deprivation therapy （ADT）. This impression, we believe, is not scientifically justified,

关键词： androgen therapy estosterone

Importance of adapted digestion conditions to simulate in vitro lipid digestion of broilers in different life stages

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Animal Nutrition 2023年第1期12卷 151-158页

作者： Daphne michels Sarah H.E.Verkempinck Agnese Panozzo karen Vermeulen marc E.Hendrickx Liesbet Thijs Tara Grauwet Laboratory of Food Technology and Leuven Food Science and Nutrition Research Centre(LFoRCe) Department of Microbial and Molecular Systems(M2S)KU LeuvenLeuven3001Belgium Kemin Animal Nutrition and Health Kemin Europa N.V.Herentals2200Belgium

In vitro digestion studies demonstrate large potential to gain more and quicker insights into the underlying mechanisms of feed additives,allowing the optimization of feed ***,current in vitro digestion models relevant for broiler chickens lack sufficient description in terms of protocols and standardisation ***,no distinction is made between the different life phases of these animals(starter,grower,and finisher).Hence,our research aimed to establish adapted in vitro digestion conditions,corresponding to the 3 life phases in broilers,with specific focus on lipid *** effect of 3 different bile salt concentrations of 2,10,and 20 mm,and 3 different lipase activities of 5,20,and 100 U/mL,on in vitro lipid digestion kinetics were evaluated using a full factorial *** values were selected to represent starter,grower,and finisher birds,*** findings showed that the extent of lipid digestion was mainly influenced by lipase *** rate of lipid digestion was affected by an interplay between bile salt concentration and lipase activity,due to possible lipase inhibition at certain bile salt ***,this work resulted in 3 in vitro lipid digestion models representative for starter,grower,and finisher *** conclusion,this research showed the impact of adapted in vitro digestion conditions on lipid digestion kinetics and thus the need for these conditions relevant for each life phase of broilers.

关键词： Lipolysis Lipase activity Bile salt In vitro digestion Broiler chicken Emulsion