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proton pump inhibitors and all-cause mortality risk among cancer patients

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World Journal of Clinical Oncology 2025年第1期16卷 34-42页

作者： arunkumar krishnan Carolin Victoria Schneider Declan Walsh Department of Supportive Oncology Atrium Health Levine CancerCharlotteNC 28204United States Department of Medicine Section of Hematology and OncologyWake Forest University School of MedicineWinston-SalemNC 27101United States Department of Medicine Ⅲ GastroenterologyMetabolic Diseasesand Intensive CareUniversity Hospital RWTH AachenAachen 52074Germany

BACkGROUND proton pump inhibitors(ppIs)are widely used,including among cancer patients,to manage gastroesophageal reflux and other gastric acid-related *** evidence suggests associations between long-term ppI use and higher risks for various adverse health outcomes,including greater *** To investigate the association between ppI use and all-cause mortality among cancer patients by a comprehensive analysis after adjustment for various confounders and a robust methodological approach to minimize *** This retrospective cohort study used data from the TriNetX research network,with electronic health records from multiple healthcare *** study employed a new-user,active comparator design,which compared newly treated ppI users with non-users and newly treated histamine2 receptor antagonists(H2RA)users among adult cancer *** prescribed ppIs(esomeprazole,lansoprazole,omeprazole,pantoprazole,or rabeprazole)users were compared to non-users or newly prescribed H2RAs(cimetidine,famotidine,nizatidine,or ranitidine)*** primary outcome was all-cause *** patient in the main group was matched to a patient in the control group using 1:1 propensity score matching to reduce confounding *** Cox regression models were used to estimate hazard ratios(HRs)and 95% confidence interval(CI).RESULTS During the follow-up period(median 5.4±1.8 years for ppI users and 6.5±1.0 years for non-users),ppI users demonstrated a higher all-cause mortality rate than non-users after 1 year,2 years,and at the end of follow up(HRs:2.34-2.72).Compared with H2RA users,ppI users demonstrated a higher rate of all-cause mortality HR:1.51(95%CI:1.41-1.69).Similar results were observed across sensitivity analyses by excluding deaths from the first 9 months and 1-year post-exposure,confirming the robustness of these *** a sensitivity analysis,we analyzed all-cause mortality outcomes between former ppI users and individual

关键词： All-cause mortality Cancer Histamine-2 receptor antagonists Mortality Malignancy proton pump inhibitors Carcinoma Outcome

Tribological and vibrational characteristics of AISI 316L tested at elevated temperature and 600 Torr vacuum

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Defence Technology（防务技术） 2019年第1期15卷 58-64页

作者： k.Arul Raj M.p.arunkumar p.k.C.kanigalpula M.karthikeyan Department of Mechanical Engineering Koneru Lakshmaiah Education Foundation Department of Mechanical Engineering RajaRajeswari College of Engineering

Friction and wear studies enable the investigation of material interaction between two sliding surfaces in contact. In the present investigation, the coefficient of friction and the wear resistance of AISI 316 L parts were studied under self-mating, dry sliding conditions using a pin-on-disc type configuration. The experiments were conducted at vacuum based high temperature pin-on-disc tribometer. The 4 mm diameter pin and 180 mm diameter disc were subjected to varying sliding velocities(0.5, 0.75 and 1.5 m/s) and were operated in 200, 400, 500 and 580 ℃ temperature at 600 Torr vacuum. The variation of specific wear rates with sliding velocities and different environmental conditions was studied. The morphology of sliding/rubbed surfaces was observed using Scanning Electron Microscope. In summary, it was found that a severe to mild wear transition occurred in sliding under operating conditions. Increased wear rates have been observed for 500 and 580 ℃ with increasing sliding velocity. Adhesive wear has been found to be predominant at 500 and 580 ℃ where as de-lamination has been observed at ambient temperature,200 and 400 ℃ in vacuum. The present paper also carried out the numerical analysis of the vibration behavior of AISI 316 L under thermal environment. Results revealed that at high temperature vibrational amplitude and natural frequency is significantly reduced. This can be attributed to the reduction in stiffness of the material at elevated temperatures. This high amplitude vibration during service can lead to high wear rate.

关键词： pin-on-disc Sliding wear Vacuum De-lamination Scanning electron microscope Vibration

Sensitivity of digital elevation models:The scenario from two tropical mountain river basins of the Western Ghats,India

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Geoscience Frontiers 2014年第6期5卷 893-909页

作者： Jobin Thomas Sabu Joseph k.p.Thrivikramji k.S.arunkumar Inter University Centre for Geospatial Information Science and Technology University of KeralaThiruvananthapuramKeralaIndia Department of Environmental Sciences University of KeralaThiruvananthapuramKeralaIndia Department of Geology University of KeralaThiruvananthapuramKeralaIndia Department of Geology MES CollegePonnaniMalappuramKeralaIndia

The paper evaluates sensitivity of various spaceborne digital elevation models （DEMs）, viz., Advanced Spaceborne Thermal Emission and Reflection Radiometer （ASTER）, Shuttle Radar Topography Mapping Mission （SRTM） and Global Multi-resolution Terrain Elevation Data 2010 （GMTED）, in comparison with the DEM （TOpO） derived from contour data of 20 m interval of Survey of India topographic sheets of 1 ： 50,000 scale. Several topographic attributes, such as elevation （above mean sea level）, relative relief, slope, aspect, curvature, slope-length and -steepness （LS） factor, terrain ruggedness index （TRI）, topo- graphic wetness index （TWI）, hypsometric integral （lhyp） and drainage network attributes （stream number and stream length） of two tropical mountain river basins, viz. Muthirapuzha River Basin and pambar River Basin are compared to evaluate the variations. Though the basins are comparable in extent, they differ in respect of terrain characteristics and climate. The result.,; suggest that ASTER and SRTM provide equally reliable representation of topography portrayed by TOp（） and the topographic attributes extracted from the spaceborne DEMs are in agreement with those derived from TOpO. Despite the coarser resolution, SRTM shows relatively higher vertical accuracy （RMSE -- 23 and 20 m respectively in MRB and pRB） compared to ASTER （RMSE - 33 and 24 m） and GMTED （RMSE - 59 and 48 m）. Vertical accuracy of all the spaceborne DEMs is influenced by relief of the terrain as well as type of vegetation. Further, GMTED shows significant deviation for most of the attributes, indicating its inability for mountain-river-basin-scale studies.

关键词： DEM ASTER SRTM GMTEDTropical mountain river basins Western Ghats

Robust multifocus deep neural network for progression prediction on patient trajectory data

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International Journal of Intelligent Computing and Cybernetics 2022年第4期15卷 589-598页

作者： k.arunkumar S.Vasundra Department of CSE JNTUAAnanthapuramIndia Department of CSE JNTUACEAAnanthapuramIndia

purpose-patient treatment trajectory data are used to predict the outcome of the treatment to particular disease that has been carried out in the *** order to determine the evolving disease on the patient and changes in the health due to treatment has not considered existing *** deep learning models to trajectory data mining can be employed to identify disease prediction with high accuracy and less computation ***/methodology/approach-Multifocus deep neural network classifiers has been utilized to detect the novel disease class and comorbidity class to the changes in the genome pattern of the patient trajectory data can be identified on the layers of the *** is employed to learn extracted feature set with activation and weight function and then merged on many aspects to classify the undetermined sequence of diseases as a new *** performance of disease progression learning progress utilizes the precision of the constituent classifiers,which usually has larger generalization benefits than those optimized ***-Deep learning architecture uses weight function,bias function on input layers and max *** of the input layer has applied to hidden layer to generate the multifocus characteristics of the disease,and multifocus characterized disease is processed in activation function using ReLu function along hyper parameter tuning which produces the effective outcome in the output layer of a fully connected *** results have proved using cross validation that proposed model outperforms methodologies in terms of computation time and ***/value-proposed evolving classifier represented as a robust architecture on using objective function to map the data sequence into a class distribution of the evolving disease class to the patient ***,the generative output layer of the proposed model produces the progression outcome of the disease of the particular pa

关键词： patient trajectory data Deep learning representatives Disease evolution Unstructured hierarchical data Cluster reconstruction error

Comparative study on transverse shrinkage, mechanical and metallurgical properties of AA2219 aluminium weld joints prepared by gas tungsten arc and gas metal arc welding processes

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Defence Technology（防务技术） 2015年第3期11卷 262-268页

作者： S.arunkumar p.RANGARAJAN k.DEVAkUMARAN p.SATHIYA Department of production Engineering National Institute of Technology Welding Research Institute BHEL

Aluminium alloy AA2219 is a high strength alloy belonging to 2000 series. It has been widely used for aerospace applications, especially for construction of cryogenic fuel tank. However, arc welding of AA2219 material is very critical. The major problems that arise in arc welding of AA2219 are the adverse development of residual stresses and the re-distribution as well as dissolution of copper rich phase in the weld *** effects increase with increase in heat input. Thus, special attention was taken to especially thick section welding of AA2219-T87 aluminium alloy. Hence, the present work describes the 25 mm-thick AA2219-T87 aluminium alloy plate butt welded by GTAW and GMAW processes using multi-pass welding procedure in double V groove design. The transverse shrinkage, conventional mechanical and metallurgical properties of both the locations on weld joints were studied. It is observed that the fair copper rich cellular(CRC) network is on Side-A of both the weldments. Further, it is noticed that, the severity of weld thermal cycle near to the fusion line of HAZ is reduced due to low heat input in GTAW process which results in non dissolution of copper rich phase. Based on the mechanical and metallurgical properties it is inferred that GTAW process is used to improve the aforementioned characteristics of weld joints in comparison to GMAW process.

关键词：焊接工艺设计铝合金焊接冶金性能横向收缩性能对比金属机械天然气

Microstructures and mechanical properties of nanocrystalline NiTi intermetallics formed by mechanosynthesis

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International Journal of Minerals,Metallurgy and Materials 2018年第1期25卷 80-87页

作者： S.arunkumar p.kumaravel C.Velmurugan V.Senthilkumar Vinayaka Mission's kimpananda Variyar Engineering College Salem 636308TamilnaduIndia Institute of Road and Transport Technology Erode 638316TamilnaduIndia National Institute of Technology Trichy 620015TamilnaduIndia

The formulation of nanocrystallinc NiTi shape memory alloys has potential effects in mechanical stimulation and medical im- plantology. The present work elucidates the effect of milling time on the product＇s structural characteristics, chemical composition, and mi- crohardness for NiTi synthesized by mechanical alloying for different milling durations. Increasing the milling duration led to the formation of a nanocrystalline NiTi intermetallic at a higher level. The formation of nanocrystalline materials was directed through cold fusion, fractur- ing, and the development of a steady state, which were influenced by the accumulation of strain energy. In the morphological study, uninter- rupted cold diffusion and fracturing were visualized using transmission electron microscopy. particle size analysis revealed that the mean particle size was reduced to -93 μm after 20 h of milling. The mechanical strength was enhanced by the formation of a nanocrystalline in- termetallic phase at longer milling time, which was confirmed by the results of Vickers hardness analyses.

关键词： nickel-titanium shape memory alloy lattice strain nano-crystalline mechanical alloying microstructural characterization

COVID-19: An overview and a clinical update

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World Journal of Clinical Cases 2021年第1期9卷 8-23页

作者： arunkumar krishnan James p Hamilton Saleh A Alqahtani Tinsay A Woreta Division of Gastroenterology and Hepatology Johns Hopkins School of MedicineBaltimoreMD 21287United States Liver Transplant Center King Faisal Specialist Hospital&Research CenterRiyadh 12713Saudi Arabia

The outbreak of coronavirus disease-2019(COVID-19,previously known as 2019 nCoV)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection in Wuhan City,China,has spread rapidly around the *** patients from the first cluster had an epidemiological connection to the Wuhan's Huanan Seafood Wholesale *** evidence has shown that SARSCoV-2 can be easily transmitted from person to person through close contact and respiratory droplets,posing a substantial challenge to public *** present,the research on SARS-CoV-2 is still in the primary ***,dexamethasone and remdesivir are appeared to be promising medical ***,there is no definite specific treatment,and the mainstay of treatment is still focused on supportive ***,over 150 vaccines are under *** is necessary to understand the nature of the virus and its clinical characteristics in order to find effectively manage the *** knowledge about this virus is rapidly evolving,and clinicians must update themselves *** present review comprehensively summarizes the epidemiology,pathogenesis,clinical characteristics,and management of COVID-19 based on the current evidence.

关键词： Coronaviruses COVID-19 SARS-CoV-2 Epidemiology Symptoms Laboratory Imaging Treatment Vaccines prevention

Immunological characterization of recombinant Wuchereria bancrofti cuticular collagen(COL-4)as putative vaccine candidate for human lymphatic filariasis

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Asian pacific Journal of Tropical Medicine 2014年第7期7卷 505-512页

作者： Chakkaravarthy arunkumar pandurangan pandiaraja p.R.prince perumal kaliraj Centre for Biotechnology Anna University

Objective:To elucidate immunoprophylactic potential of recombinant Wuchereria bancrofti(***)cuticular collagen(COL-4)in BALB/c mice and filarial clinical ***:col-4 gene was pCR amplified from *** L3 cDNA library and cloned in pRSET B *** COL-4 was over expressed in salt inducible system and was purified by nickel afiinity *** and cellular responses were measured by EUSA and peripheral blood mononuclear cells(pBMC)of various filarial clinical samples respectively using purified recombinant COL-4 *** the protective immune responses of COL-4 immunized BALB/c mice were ***:Sequence analysis of COL-4 with human host proteins reveals lack of *** recombinant COL-4 was found to be at 15 kDa fusion *** affinity purified COL-4 showed significant reactivity with putatively immune sere and in a similar fashion it demonstrated marked proliferation in pBMC *** studies in experimental filarial host(mice)elicited significant liters with protective antibody isotype profile(IgM and IgG).Cellular immune responses were also significant in terms of splenocytes proliferation assay on mice ***:Our immunological findings in experimental host suggest Th2mediated immune ***,we propose that *** COL-4 could be an efficacious vaccine candidate against lymphatic filariasis.

关键词： Lymphatic filariasis Wuchereria banerofti Cuticular collagen Vaccine

Autism Spectrum Disorder Diagnosis Using Ensemble ML and Max Voting Techniques

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Computer Systems Science & Engineering 2022年第4期41卷 389-404页

作者： A.arunkumar D.Surendran Computer science and Engineering Sri Krishna College of Engineering and TechnologyCoimbatore641008India Computer Science and Engineering KPR Institute of Engineering and TechnologyCoimbatore641407India

Difﬁculty in communicating and interacting with other people are mainly due to the neurological disorder called autism spectrum disorder(ASD)*** diseases can affect the nerves at any stage of the human being in childhood,adolescence,and *** is known as a behavioral disease due to the appearances of symptoms over theﬁrst two years that continue until *** of the studies prove that the early detection of ASD helps improve the behavioral characteristics of patients with *** detection of ASD is a very challenging task among various *** learning(ML)algorithms still act very intelligent by learning the complex data and pre-dicting quality *** this paper,ensemble ML techniques for the early detec-tion of ASD are *** this detection,the dataset isﬁrst processed using three ML algorithms such as sequential minimal optimization with support vector machine,kohonen self-organizing neural network,and random forest *** prediction results of these ML algorithms(ensemble)further use the bagging concept called max voting to predict theﬁnal *** accuracy,sensitivity,and speciﬁcity of the proposed system are calculated using confusion *** pro-posed ensemble technique performs better than state-of-the art ML algorithms.

关键词： SVM autism disorder kohonen SONN max voting ensemble machine learning technique random forest SMO–SVM bootstrap gradient boosting