Heat shock proteins: Molecules with assorted functions

作     者：Surajit SARKAR MDhruba SINGH Renu YADAV K.P.ARUNKUMAR Geoffrey W.PITTMAN 

作者机构：Department of GeneticsUniversity of DelhiSouth CampusBenito Juarez RoadNew Delhi-110021India Division of BiologyMC156-29California Institute of Technology1200 East California BoulevardPasadenaCA 91125USA 

出 版 物：《Frontiers in Biology》 (生物学前沿（英文版）)

年 卷 期：2011年第6卷第4期

页      面：312-327页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Department of Biotechnology(DBT) Department of Science and Technology(DST) New Delhi and Delhi University Research and Development Grant to SS.DST-BOYSCAST fellowship to SS is also gratefully acknowledged 

主　　题：heat shock protein chaperone chaperonin Hsp100 Hsp90 Hsp70 Hsp60 sHsps fertility apoptosis cytoskeleton 

摘      要：Heat shock proteins (Hsps) or molecular chaperones, are highly conserved protein families present in allstudied organisms. Following cellular stress, the intracellular concentration of Hsps generally increases several *** undergo ATP-driven conformational changes to stabilize unfolded proteins or unfold them for translocationacross membranes or mark them for degradation. They are broadly classified in several families according to theirmolecular weights and functional properties. Extensive studies during the past few decades suggest that Hsps play avital role in both normal cellular homeostasis and stress response. Hsps have been reported to interact with numeroussubstrates and are involved in many biological functions such as cellular communication, immune response, proteintransport, apoptosis, cell cycle regulation, gametogenesis and aging. The present review attempts to provide a briefoverview of various Hsps and summarizes their involvement in diverse biological activities.