检索结果-南通市图书馆

Nucleoside modified mRNA-lipid nanoparticles as a new delivery platform for the repair of the injured spinal cord

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第8期20卷 2311-2312页

作者： krisztián Pajer Tamás Bellák Antal Nógrádi department of Anatomy Histology and EmbryologyAlbert Szent-Györgyi Medical SchoolUniversity of SzegedSzegedHungary

Spinal cord injury and treatment opportunities:The adult mammalian spinal cord has a very limited capacity for spontaneous regeneration due to various intrinsic molecular and cellular *** the spinal cord neurons have the capacity to regenerate their axons,the expression of growth inhibitory factors,lack or suppression of proper guidance cues,and profound inflammatory responses do not permit successful regeneration(khyeam et al.,2021).

关键词： injured capacity modified

Proteomic Analysis of Bovine Nucleolus

在线全文

学校读者我要写书评

暂无评论

Genomics, Proteomics & Bioinformatics 2010年第3期8卷 145-158页

作者： Amrutlal k.patel doug Olson Suresh k.Tikoo Vaccine and Infectious disease Organization University of Saskatchewan department of Veterinary Microbiology Western College of Veterinary Medicine University of Saskatchewan National Research Council Plant Biotechnology Institute University of Saskatchewan School of Public Health University of Saskatchewan

Nucleolus is the most prominent subnuclear structure, which performs a wide variety of functions in the eukaryotic cellular processes. In order to understand the structural and functional role of the nucleoli in bovine cells, we analyzed the proteomic composition of the bovine nucleoli. The nucleoli were isolated from Madin darby bovine kidney cells and subjected to proteomic analysis by LC-MS/MS after fractionation by SdS-PAGE and strong cation exchange chromatography. Analysis of the data using the Mascot database search and the GPM database search identified 311 proteins in the bovine nucleoli, which contained 22 proteins previously not identified in the proteomic analysis of human nucleoli. Analysis of the identified proteins using the GoMiner software suggested that the bovine nucleoli contained proteins involved in ribosomal biogenesis, cell cycle control, transcriptional, translational and post-translational regulation, transport, and structural organization.

关键词： bovine nucleolus proteomics 1d SdS-PAGE SCX LC-MS/MS

Breccia-cored columnar rosettes in a rubbly pahoehoe lava flow,Elephanta Island,deccan Traps,and a model for their origin

在线全文

学校读者我要写书评

暂无评论

Geoscience Frontiers 2017年第6期8卷 1299-1309页

作者： Hetu Sheth Ishita Pal Vanit patel Hrishikesh Samant Joseph d'Souza department of Earth Sciences Indian Institute of Technology Bombay(IITB) Institute of Geophysics and Planetary Physics Scripps Institution of OceanographyUniversity of California San Diego department of Geology St.Xavier's College

Rubbly pahoehoe lava flows are abundant in many continental flood basalts including the deccan ***,structures with radial joint columns surrounding cores of flow-top breccia(FTB),reported from some deccan rubbly pahoehoe flows,are yet unknown from other basaltic provinces.A previous study of these deccan "breccia-cored columnar rosettes" ruled out explanations such as volcanic vents and lava tubes,and showed that the radial joint columns had grown outwards from cold FTB inclusions incorporated into the hot molten *** the highly vesicular(thus low-density)FTB blocks might have sunk into the flow interiors has remained a *** we describe a new example of a deccan rubbly pahoehoe flow with FTB-cored rosettes,from Elephanta Island in the Mumbai *** that(1)thick rubbly pahoehoe flows probably form by rapid inflation(involving many lava injections into a largely molten advancing flow),and(2)such flows are transitional to 'a'a flows(which continuously shed their top clinker in front of them as they advance),we propose a model for the FTB-cored *** suggest that the deccan flows under study were shedding some of their FTB in front of them as they advanced and,with high-eruption rate lava injection and inflation,frontal breakouts would incorporate this FTB rubble,with thickening of the flow carrying the rubble into the flow *** implies that,far from sinking into the molten interior,the FTB blocks may have been rising,until lava supply and inflation stopped,the flow began solidifying,and joint columns developed outward from each cold FTB inclusion as already inferred,forming the FTB-cored *** rubbly pahoehoe flows which began recycling most of their FTB became the 'a'a flows of the deccan.

关键词： Rubbly pahoehoe Columnar jointing Flow-top breccia Volcanism Flood basalt deccan Traps

Bio-Nanocarriers for Lung Cancer Management:Befriending the Barriers

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2021年第9期13卷 238-291页

作者： Shruti Rawal Mayur patel department of Pharmaceutics Institute of PharmacyNirma UniversitySG HighwayChharodiAhmedabadGujarat 382481India

ABSTRACT Lung cancer is a complex thoracic malignancy developing consequential to aberrations in a myriad of molecular and biomolecular signaling *** is one of the most lethal forms of cancers accounting to almost 1.8 million new annual incidences,bearing overall mortality to incidence ratio of *** dismal prognostic scenario at advanced stages of the disease and metastatic/resistant tumor cell populations stresses the requisite of advanced translational interdisciplinary interventions such as *** review article deliberates insights and apprehensions on the recent prologue of nanobioengineering and bionanotechnology as an approach for the clinical management of lung *** role of nanobioengineered(bio-nano)tools like bio-nanocarriers and nanobiodevices in secondary prophylaxis,diagnosis,therapeutics,and theranostics for lung cancer management has been ***,bioinspired,and biomimetic bio-nanotools of considerate translational value have been *** on existent oncostrategies,their critical comparison with bio-nanocarriers,and issues hampering their clinical bench side to bed transformation have also been summarized.

关键词： Biomimetic nanoparticles Exosomes Circulating tumor cells Mesenchymal stem cells Theranostics

Renewable hydrogen production from butanol:a review

在线全文

学校读者我要写书评

暂无评论

Clean Energy 2017年第1期1卷 90-101页

作者： Ronak patel Sanjay patel Chemical Engineering department Institute of TechnologyNirma UniversityAhmedabadGujarat 382481India Chemical Engineering department L.D.College of EngineeringAhmedabadGujarat 380015India

Hydrogen production from butanol is a promising alternative when it is obtained from bio-butanol or bio-oil due to the higher hydrogen content compared to other oxygenates such as methanol,ethanol or *** and operating conditions play a crucial role in hydrogen *** and Rh are metals mainly used for butanol steam reforming,oxidative steam reforming and partial *** such as Cu can improve catalytic activity in many ***,support-metal interaction and catalyst preparation technique also play a decisive role in the stability and hydrogen production capacity of *** reforming technique as an option is more frequently researched due to higher hydrogen production capability in comparison to other thermochemical techniques despite its endothermic *** use of the oxidative steam reforming and partial oxidation has the advantages of requiring less energy and longer stability of ***,the hydrogen yield is *** article brings together and examines the latest research on hydrogen production from butanol via steam reforming,oxidative steam reforming and partial oxidation *** addition,the review examines a few thermodynamic studies based on sorption-enhanced steam reforming and dry reforming where there is potential for hydrogen extraction.

关键词： butanol hydrogen production steam reforming oxidative steam reforming partial oxidation

development of forced degradation and stability indicating studies of drugs——A review

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2014年第3期4卷 159-165页

作者： Blessy M Ruchi d.patel Prajesh N.Prajapati Y.k.Agrawal department of Pharmaceutical Analysis Institute of Research and DevelopmentGujarat Forensic Sciences University Sector-18ANr.Police BhavanGandhinagar 382007GujaratIndia

Forced degradation is a degradation of new drug substance and drug product at conditions more severe than accelerated conditions. It is required to demonstrate specificity of stability indicating methods and also provides an insight into degradation pathways and degradation products of the drug substance and helps in elucidation of the structure of the degradation products. Forced degradation studies show the chemical behavior of the molecule which in turn helps in the development of formulation and package. In addition, the regulatory guidance is very general and does not explain about the performance of forced degradation studies. Thus, this review discusses the current trends in performance of forced degradation studies by providing a strategy for conducting studies on degradation mechanisms and also describes the analytical methods helpful for development of stability indicating method.

关键词： degradation conditionsdegradation product Forced degradation Stability indicatingmethod Stress testing

Comparative study of intertrochanteric fracture fixation using proximal femoral nail with and without distal interlocking screws

在线全文

学校读者我要写书评

暂无评论

World Journal of Orthopedics 2022年第3期13卷 267-277页

作者： Nadeem A Lil Vipul R Makwana Tirth d patel Arjav R patel department of Orthopaedics NHL Medical CollegeAhmedabad 380006GujaratIndia

BACkGROUNd Intertrochanteric(IT)fracture is one of the most common fractures seen in an orthopaedic *** femoral nailing(PFN)is a common modality of fixing IT femur *** retrospectively studied whether a PFN with two proximal lag screws can be done without distal interlocking screws in the 31-A1 and 31-A2 fracture patterns according to the Arbeitsgemeinschaft für Osteosynthesefragen/Orthopaedic Trauma Association(AO/OTA)guidelines for IT femur *** To compare the outcomes of IT fractures(AO/OTA 31-A1 and 31-A2)treated by PFN with and without distal interlocking *** We carried out a retrospective study of 140 patients in a tertiary care centre who had AO/OTA type 31-A1 and 31-A2 IT *** divided the patients into two groups,in which one of the groups received distal interlocking screws(group 1)and the other group did not(group 2).The subjects were followed up for a mean period of 14 mo and assessed for radiological union time,fracture site collapse,mechanical stability of implant,and complications associated with the PFN with distal interlocking and without distal ***,the results were *** PFN without distal interlocking screws has several advantages and gives better results over PFN with distal interlocking screws in the AO/OTA 31-A2 fracture ***,similar results were observed in both groups with the fracture pattern AO/OTA *** patients with fracture pattern AO/OTA 31-A2 treated by PFN without distal interlocking screws,there were minimal proximal lockrelated complications and no risk of distal interlock-related *** operative time,IITV radiation time and time to radiological union were *** patients also had better rotational alignment of the proximal femur,and the anatomy of the proximal femur was well *** was also noted that in the cases where distal interlocking was performed,there was a gradual decrease in neck shaft angle,which led to varus

关键词： Intertrochanteric fracture Arbeitsgemeinschaft für Osteosynthesefra-gen/Orthopaedic Trauma Association 31-A1 and 31-A2 Proximal femoral nail distal interlocking screws Without distal interlocking screws Outcome

Comparison of cross sectional optical coherence tomography images of elevated optic nerve heads across acquisition devices and scan protocols

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Eye and Vision 2018年第1期5卷 163-171页

作者： Megh d.patel Fareshta khushzad Heather E.Moss department of Ophthalmology Stanford University2370 Watson Courtsuite 200Palo AltoCA 94303USA department of Neurology and Neurological Sciences Stanford University2370 Watson Courtsuite 200Palo AltoCA 94303USA

Background:Optic nerve head measurements extracted from optical coherence tomography(OCT)show promise for monitoring clinical conditions with elevated optic nerve *** aim of this study is to compare reliability within and between raters and between image acquisition devices of optic nerve measurements derived from OCT scans in eyes with varying degrees of optic nerve ***:Wide angle line scans and narrow angle radial scans through optic nerve heads were obtained using three spectral domain(Sd)OCT devices on 5 subjects(6 swollen optic nerves,4 normal optic nerves).Three raters independently semi-manually segmented the internal limiting membrane(ILM)and Bruch’s membrane(BM)on each scan using customized *** rater segmented each scan *** were qualitatively and quantitatively ***-rater,intra-rater and inter-device reliability was assessed for the optic nerve cross sectional area calculated from the ILM and BM segmentations using intraclass correlation coefficients and graphical ***:Line scans from all devices were qualitatively *** scans for which frame rate could not be adjusted were of lower ***-rater reliability for segmentation and optic nerve cross sectional area was better than inter-rater reliability,which was better than inter-device reliability,though all ICC exceeded *** was not impacted by the degree of optic nerve ***:Sd-OCT devices acquired similar quality scans of the optic nerve head,with choice of scan protocol affecting the *** image derived markers,variability between devices was greater than that attributable to inter and intra-rater differences.

关键词： Optic nerve head Optical coherence tomography Bruch’s membrane Inner limiting membrane Comparison

3d biofabrication of vascular networks for tissue regeneration:A report on recent advances

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2018年第5期8卷 277-296页

作者： M.d.Sarker Saman Naghieh N.k.Sharma Xiongbiao Chen division of Biomedical Engineering College of Engineering University of Saskatchewan department of Mechanical Engineering College of Engineering University of Saskatchewan

Rapid progress in tissue engineering research in past decades has opened up vast possibilities to tackle the challenges of generating tissues or organs that mimic native structures. The success of tissue engineered constructs largely depends on the incorporation of a stable vascular network that eventually anastomoses with the host vasculature to support the various biological functions of embedded cells. In recent years, significant progress has been achieved with respect to extrusion, laser, micro-molding, and electrospinning-based techniques that allow the fabrication of any geometry in a layer-by-layer fashion. Moreover, decellularized matrix, self-assembled structures, and cell sheets have been explored to replace the biopolymers needed for scaffold fabrication. While the techniques have evolved to create specific tissues or organs with outstanding geometric precision, formation of interconnected, functional, and perfused vascular networks remains a challenge. This article briefly reviews recent progress in 3d fabrication approaches used to fabricate vascular networks with incorporated cells, angiogenic factors, proteins, and/or peptides. The influence of the fabricated network on blood vessel formation, and the various features, merits, and shortcomings of the various fabrication techniques are discussed and summarized.

关键词： 3d bioprinting Tissue engineering Vascularization Extrusion Laser-based printing Co-axial printing